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The map label for this gene is cscR [H]

Identifier: 209396088

GI number: 209396088

Start: 3309981

End: 3310976

Strand: Reverse

Name: cscR [H]

Synonym: ECH74115_3595

Alternate gene names: 209396088

Gene position: 3310976-3309981 (Counterclockwise)

Preceding gene: 209400997

Following gene: 209397537

Centisome position: 59.42

GC content: 51.71

Gene sequence:

>996_bases
ATGGCTTCATTAAAGGATGTCGCACGCCTGGCGGGAGTGTCGATGATGACAGTCTCCCGGGTGATGCATAATGCAGAATC
TGTGCGTCCTGCAACGCGTGACCGCGTATTGCAGGCAATCCAGACCCTGAATTATGTTCCTGATCTTTCCGCCCGTAAGA
TGCGCGCTCAAGGACGTAAGCCGTCGACTCTCGCCGTGCTGGCGCAGGACACTGCTACCACTCCTTTCTCTGTTGATATT
CTGCTTGCCATTGAGCAAACCGCCAGCGAGTTCGGCTGGAATAGTTTTTTAATCAATATTTTTTCTGAAGATGACGCTGC
CCGCGCGGCACGTCAGCTGCTTGCCCACCGTCCGGATGGCATTATCTATACTACAATGGGGCTGCGACATATCACGCTAC
CTGAGTCTCTGTATGGTGAAAATATTGTATTGGCGAACTGTGTGGCGGATGACCCAGCGTTACCCAGTTATATCCCTGAT
GATTACACTGCACAATATGAATCAACACAGCATTTGCTCGCGGCGGGCTATCGTCAACCGTTATGCTTCTGGCTACCGGA
AAGTGCGTTGGCAACAGGGTATCGTCGGCAGGGATTTGAGCAGGCCTGGCGTGATGCTGGACGAGATCTGGCTGAGGTGA
AACAATTTCACATGGCAACAGGTGATGATCACTACACCGATCTCGCAAGTTTACTCAATGACCACTTCAAATCGGGCAAA
CCAGATTTTGATGTTCTGATATGTGGTAACGATCGCGCAGCCTTTGTGGCTTATCAGGTTCTCCTGGCTAAGGGGGTACG
TATCCCGCAGGATGTCGCCGTAATGGGCTTTGATAATCTGGTTGGCGTCGGGCATCTGTTTTTACCGCCGCTGACCACAA
TTCAGCTTCCACATGACATTATCGGGCGGGAAGCTGCATTGCATATTATTGAAGGTCGTGAAGGGGGAAGTGTGACGCGG
ATCCCTTGCCCGCTGTTGATCCGTTGTTCCACCTGA

Upstream 100 bases:

>100_bases
TATTGCCGTGTCGGGTGATAGGGCGTCGAGAATTTCGTTGGATCTCGCCAGTGACGTCTGTTTCTGCTACAGTGCCCGTT
TTACGGCAAACGGCTTGGGT

Downstream 100 bases:

>100_bases
TATTATGTTAACCCAGTTGCCAGAGTGCTCCATGTTGCACCACAGCCACTCCGTGGGAGGCATAAAGCGACAGTTCCCGT
TCTTCTGGCTGCGGATAGAT

Product: sugar binding transcriptional regulator, LacI family

Products: NA

Alternate protein names: Csc operon regulatory protein [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRKPSTLAVLAQDTATTPFSVDI
LLAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDGIIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPD
DYTAQYESTQHLLAAGYRQPLCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGK
PDFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDIIGREAALHIIEGREGGSVTR
IPCPLLIRCST

Sequences:

>Translated_331_residues
MASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRKPSTLAVLAQDTATTPFSVDI
LLAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDGIIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPD
DYTAQYESTQHLLAAGYRQPLCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGK
PDFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDIIGREAALHIIEGREGGSVTR
IPCPLLIRCST
>Mature_330_residues
ASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRKPSTLAVLAQDTATTPFSVDIL
LAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDGIIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPDD
YTAQYESTQHLLAAGYRQPLCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGKP
DFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDIIGREAALHIIEGREGGSVTRI
PCPLLIRCST

Specific function: Repressor for the csc operon. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=338, Percent_Identity=30.1775147928994, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790194, Length=332, Percent_Identity=27.4096385542169, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787948, Length=321, Percent_Identity=26.4797507788162, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789202, Length=309, Percent_Identity=28.4789644012945, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=26.1829652996845, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786540, Length=346, Percent_Identity=26.0115606936416, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789068, Length=316, Percent_Identity=27.5316455696203, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787580, Length=327, Percent_Identity=23.5474006116208, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994940, Length=323, Percent_Identity=26.0061919504644, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=27.3584905660377, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36446; Mature: 36315

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRK
CCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
PSTLAVLAQDTATTPFSVDILLAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDG
CCEEEEEECCCCCCCEEEEEEEEEHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCC
IIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPDDYTAQYESTQHLLAAGYRQP
EEEEECCEEEEECCHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGK
EEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
PDFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDI
CCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHEEECCHHHHHCCHHHCCCCCEEECCHHH
IGREAALHIIEGREGGSVTRIPCPLLIRCST
HCCHHEEEEEECCCCCCEEEECCCEEEEECC
>Mature Secondary Structure 
ASLKDVARLAGVSMMTVSRVMHNAESVRPATRDRVLQAIQTLNYVPDLSARKMRAQGRK
CCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
PSTLAVLAQDTATTPFSVDILLAIEQTASEFGWNSFLINIFSEDDAARAARQLLAHRPDG
CCEEEEEECCCCCCCEEEEEEEEEHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCC
IIYTTMGLRHITLPESLYGENIVLANCVADDPALPSYIPDDYTAQYESTQHLLAAGYRQP
EEEEECCEEEEECCHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LCFWLPESALATGYRRQGFEQAWRDAGRDLAEVKQFHMATGDDHYTDLASLLNDHFKSGK
EEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
PDFDVLICGNDRAAFVAYQVLLAKGVRIPQDVAVMGFDNLVGVGHLFLPPLTTIQLPHDI
CCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHEEECCHHHHHCCHHHCCCCCEEECCHHH
IGREAALHIIEGREGGSVTRIPCPLLIRCST
HCCHHEEEEEECCCCCCEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA