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The map label for this gene is fbp [H]

Identifier: 209395872

GI number: 209395872

Start: 5385274

End: 5386272

Strand: Reverse

Name: fbp [H]

Synonym: ECH74115_5751

Alternate gene names: 209395872

Gene position: 5386272-5385274 (Counterclockwise)

Preceding gene: 209400523

Following gene: 209396030

Centisome position: 96.67

GC content: 50.65

Gene sequence:

>999_bases
ATGAAAACGTTAGGTGAATTTATTGTCGAAAAGCAGCACGAGTTTTCTCATGCTACCGGTGAGCTCACTGCTTTGCTGTC
GGCAATAAAACTGGGCGCCAAGATTATCCATCGCGATATCAACAAAGCAGGACTGGTTGATATCCTGGGTGCCAGCGGTG
CTGAGAACGTGCAGGGCGAGGTTCAGCAAAAACTCGACTTGTTCGCTAATGAAAAACTGAAAGCCGCACTGAAAGCACGC
GATATCGTTGCAGGCATTGCCTCTGAAGAAGAAGATGAGATTGTTGTCTTTGAAGGCTGTGAACATGCAAAATACGTGGT
GCTGATGGACCCACTGGATGGCTCGTCCAACATCGATGTTAACGTCTCTGTCGGTACCATTTTCTCCATCTACCGCCGAG
TTACGCCCGTCGGCACGCCGGTAACGGAAGAAGATTTCCTCCAGCCTGGTAACAAACAGGTTGCGGCAGGTTACGTGGTA
TACGGCTCCTCTACCATGCTGGTTTACAGTACCGGATGCGGTGTTCACGCTTTTACTTACGATCCTTCGCTCGGCGTTTT
CTGCCTGTGCCAGGAACGGATGCGCTTCCCGGAGAAAGGCAAAACCTACTCCATCAACGAAGGAAACTACATTAAGTTTC
CGAACGGGGTGAAGAAGTACATTAAATTCTGCCAGGAAGAAGATAAATCCACCAACCGCCCGTATACCTCACGTTATATC
GGCTCACTGGTTGCGGATTTCCACCGTAACCTACTGAAAGGCGGTATTTATCTCTACCCAAGCACCGCCAGCCACCCGGA
CGGCAAACTGCGTTTGCTGTATGAGTGCAACCCGATGGCATTCCTGGCGGAACAAGCGGGCGGTAAAGCGAGCGATGGCA
AAGAGCGTATTCTGGATATTATCCCGGAAACCCTGCACCAGCGCCGTTCATTCTTTGTCGGCAACGACCATATGGTTGAA
GATGTCGAACGCTTTATCTGTGAGTTCCCGGACGCGTAA

Upstream 100 bases:

>100_bases
TCCGTAATTTGCTGGCGCGATTCACCTGAGCGCAACATTGAGATTATTTGTTAAGATTGTTGCGGTCGCTTTACTCCATA
AACATTGCAGGGAAAGTTTT

Downstream 100 bases:

>100_bases
TCTCCTGCGCCTCTCCACACGGAGAGGCGATTTTATTGCTGCGCAATGTTGACTCTTGTCACAGGCGAACTCTGACGATT
CTCCCACAGCACCGTTAATC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYSTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFICEFPDA

Sequences:

>Translated_332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYSTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFICEFPDA
>Mature_332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYSTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFICEFPDA

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=326, Percent_Identity=44.7852760736196, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI16579888, Length=326, Percent_Identity=44.7852760736196, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI22907028, Length=329, Percent_Identity=43.7689969604863, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1790679, Length=332, Percent_Identity=99.3975903614458, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=47.0948012232416, Blast_Score=302, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6323409, Length=315, Percent_Identity=44.1269841269841, Blast_Score=268, Evalue=7e-73,
Organism=Drosophila melanogaster, GI45550998, Length=324, Percent_Identity=47.8395061728395, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI19921562, Length=324, Percent_Identity=47.8395061728395, Blast_Score=297, Evalue=7e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 36767; Mature: 36767

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYSTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
CCCCCCEEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPETLHQRRSFFVGNDHMVEDVERFICEFPDA
HHHHHHHHHHEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYSTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
CCCCCCEEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPETLHQRRSFFVGNDHMVEDVERFICEFPDA
HHHHHHHHHHEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA