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The map label for this gene is fabF [H]

Identifier: 209395803

GI number: 209395803

Start: 4447062

End: 4448231

Strand: Direct

Name: fabF [H]

Synonym: ECH74115_4811

Alternate gene names: 209395803

Gene position: 4447062-4448231 (Clockwise)

Preceding gene: 209396015

Following gene: 209397892

Centisome position: 79.81

GC content: 60.34

Gene sequence:

>1170_bases
ATGATTTATATTTCCGCCGTCGGCATGATCAACGCCCTGGGAAATAACCTTGACGAAATCGCAACCAACCTGACTCGCGG
TGTTGCTCCCGGCATGCGCCCGCGCGCAGGCTGGTTGCAGGGGCATCCGCAGGCGGTCCTGGCTGGCGTGGATGGCGAGC
TTCCGCTTATCCCGGAAAAATTCGCTGCGCACCGCTCGCGCAACAATCAGATCCTGCTGGCGGCGCTGGCGCAGATCCAG
CCGCAGGTTGATGACGCCATTGCGAAATATGGCCGCGAGCGCATTGCGATTGTGCTTGGTACCAGCACCTCCGGCCTGCA
TGAAGGCGACACGCACGTTAACCTGCGCACCCACGGGCAGCCGAGCACCACATGGCACTACGCGCAACAGGAACTCGGCG
ATCCGTCGCGTTTTCTCAGCCACTGGCTGGCGCTCGACGGCCCGGCCTATACCCTTTCAACCGCCTGCTCTTCCAGCGCC
AGAGCGATAATCAGCGGGCGCAGGCTTATCGAAGCGGGGCTGGTCGATGCCGCCATTGTGGGTGGCGCAGACACCCTGAG
CCGGATGCCGATTAACGGTTTTCACAGCCTCGAATCGCTGTCGCCAACCTTATGTCAGCCGTTTGGTCGTGACCGCGCAG
GTATCACCATTGGTGAAGGGGCGGGGCTAATGCTGCTGACCCGGGAACCGCAGCCCATCGCGTTGCTGGGCGTTGGTGAA
TCGAGCGACGCTTACCATATTTCAGCCCCGCATCCGCAGGGCGAAGGAGCGATCCGCGCTATTAATCAGGCGCTGACCGA
TGCGCAGCTTACGCCAGATGACGTCGGCTATATCAACCTGCACGGCACCGCCACACAACTCAACGATCAGATTGAATCAA
TGGTGGTTAACGCCCTGTTTGGCGAACGCGTACCGTGCAGCTCCACCAAACATTTGACCGGACACACGCTGGGCACAGCG
GGCATTACCGAGGCGGCAATTAGTATGTTGATTTTACAGCGTGATTTACCGCTGCCCGCTCAGGACTTCAGCCTGTCGCC
GCGCGATCCCACGCTGCCACCGTGTGGCATTATCGAAAAACCGCAGCCGCTGGCACGTCCGGTGATCCTGTCCAATTCCT
TCGCCTTTGGCGGCAATAACGCCAGCATTCTGCTCGGGAGGGTTTCGTGA

Upstream 100 bases:

>100_bases
GAAATCACCTATCTGAATCGCAAGGGCAAACGCGTGCCAATCAGCATTGAGCAGCATGTCTTTAAATACCACATCACCAT
TCAATACTTAGGTGACTGAT

Downstream 100 bases:

>100_bases
GCCACTATTTATCCCCCGGCGCTTATCTGCCCCACGACGCGCCCATGTTACTGCTGGAAGACGTGGTGAGCGTCAGCGAT
GACAGCGCGGTGTGCCGCGT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGHPQAVLAGVDGELPLIPEKFAAHRSRNNQILLAALAQIQ
PQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSA
RAIISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGE
SSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALFGERVPCSSTKHLTGHTLGTA
GITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS

Sequences:

>Translated_389_residues
MIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGHPQAVLAGVDGELPLIPEKFAAHRSRNNQILLAALAQIQ
PQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSA
RAIISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGE
SSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALFGERVPCSSTKHLTGHTLGTA
GITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS
>Mature_389_residues
MIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGHPQAVLAGVDGELPLIPEKFAAHRSRNNQILLAALAQIQ
PQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSA
RAIISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGE
SSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALFGERVPCSSTKHLTGHTLGTA
GITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=296, Percent_Identity=34.7972972972973, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI41872631, Length=261, Percent_Identity=30.6513409961686, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787337, Length=268, Percent_Identity=34.3283582089552, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788663, Length=262, Percent_Identity=29.0076335877863, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983541, Length=406, Percent_Identity=27.5862068965517, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=32.183908045977, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=260, Percent_Identity=24.2307692307692, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212642053, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=264, Percent_Identity=34.0909090909091, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644341, Length=264, Percent_Identity=34.469696969697, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI221330659, Length=263, Percent_Identity=26.9961977186312, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19920632, Length=263, Percent_Identity=26.9961977186312, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24581345, Length=397, Percent_Identity=21.4105793450882, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41121; Mature: 41121

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGHPQAVLAGVDGELPLIPEK
CEEEEEHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHH
FAAHRSRNNQILLAALAQIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQ
HHHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEECCC
PSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSARAIISGRRLIEAGLVDAAIV
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCHHHHHCCHHHEEE
GGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGE
CCHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCEEEECCCCEEEEECCCCCEEEEEECC
SSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALF
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
GERVPCSSTKHLTGHTLGTAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQPLARPVILSNSFAFGGNNASILLGRVS
CCHHCCCEEEECCEEECCCCCEEEEEECC
>Mature Secondary Structure
MIYISAVGMINALGNNLDEIATNLTRGVAPGMRPRAGWLQGHPQAVLAGVDGELPLIPEK
CEEEEEHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHH
FAAHRSRNNQILLAALAQIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQ
HHHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEECCC
PSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSARAIISGRRLIEAGLVDAAIV
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCHHHHHCCHHHEEE
GGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGVGE
CCHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCEEEECCCCEEEEECCCCCEEEEEECC
SSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESMVVNALF
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
GERVPCSSTKHLTGHTLGTAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQPLARPVILSNSFAFGGNNASILLGRVS
CCHHCCCEEEECCEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]