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The map label for this gene is CsdB2 [H]

Identifier: 20809118

GI number: 20809118

Start: 2678449

End: 2679591

Strand: Reverse

Name: CsdB2 [H]

Synonym: TTE2789

Alternate gene names: 20809118

Gene position: 2679591-2678449 (Counterclockwise)

Preceding gene: 20809119

Following gene: 20809117

Centisome position: 99.63

GC content: 41.47

Gene sequence:

>1143_bases
ATGATATATTTTGACAATGCTGCTACTACCTGGCCTAAACCTGAAGAGGTATATTTGGAAGTGGACAGAATGTTGAGAAA
CTGTGGCAATCCGGGAAGAGGAGGCCACAGAATGGCTTTGGAGGCCAGCAGGGTAATTTTTGAAGCGAGGCAAGAGATAG
CTTCTCTTTTCAATATCAAAGACCCTATGAGGGTAGTTTTTACATTAAATACCACAGAAGCGTTGAACATAGCTCTAAAA
GGCGTGTTAAAAGAAGGAGACCATGTGATAACATCCAGTATGGAACATAATTCCGTCGCACGACCCTTGAGCAGACTAAA
GGAACAAGGAGTAGAAGTTACAATAGTCAAAGGGAGCGAAGAAGGAAAGATTGACCCTGAGGATATTAAAAGAGCCGTAA
AAAAGAACACAAAAATGATTGCAATTACTCACGCTTCTAACGTCACAGGTACTATCATGCCAATTGAGGAGATAGGAAAT
ATTGCCCGGGAAATGAATTTAATTTTTTTAGTGGATGCCGCTCAGACAGCAGGAGTTTTACCTATAGATGTCGAAAAATA
TAATATAAGTTTGCTGGCTTTCCCAGGGCATAAGGGACTCTATGGACCCCAGGGTACAGGCGGGCTTTATGTCAAAGAAG
GTATAGAGCTTGTTCCATTAAAAGAAGGAGGTACAGGAAGTAGGTCTGAACTTACACTTCAGCCCGATTTGATGCCCGAC
AAGCTGGAAAGTGGGACATTGAACACTCCGGGTATCGCTGGCCTTAAAGAAGGAGTGAAGTTTGTAAAAAAAGTAGGCGT
AAATTCAATTAGGGAGCGTGAGGTCAAACTTACAGAATTGCTTATAGAGGGCCTGAGAGAGATAAAAAAGGTGAGAGTTT
ACGGTCCTCAGAAAATAGAGGATAGAGTGGGGGTAGTTTCAATAACGGTAGAAGGGATGGATGTTGGAGAAGTAAGCCAT
ATACTGGATAGAGAATTTGACATTGCTACAAGGGCAGGGCTTCACTGTGCACCACTGGCTCATTCTACTATAGGTACTTT
AAAGAGCGGAACTTTGAGGTTTGGGATTGGATACTTTAACACGGAAGAGGAAATAATTAAAGCGGTAGAAGCTATTGAAA
CAATTATTCAAAAAAACTTTTAA

Upstream 100 bases:

>100_bases
GGATTATGAATAGGTATAAAATTATAGTAGAAGGTAATCCCTTTGAAGGTGTAAGTGCATATATTAAATTAAAGAAAATA
ATTAAAAGGGGAATTGGTGA

Downstream 100 bases:

>100_bases
AGAACTGGAGGAGAGGATATGCAGAACTTTTTAGAACTTGTATACAGCAATCTTCCACTTTTTACATTGGCACTGGCGGT
TTTAGCAATCTTTGAGTTGA

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MIYFDNAATTWPKPEEVYLEVDRMLRNCGNPGRGGHRMALEASRVIFEARQEIASLFNIKDPMRVVFTLNTTEALNIALK
GVLKEGDHVITSSMEHNSVARPLSRLKEQGVEVTIVKGSEEGKIDPEDIKRAVKKNTKMIAITHASNVTGTIMPIEEIGN
IAREMNLIFLVDAAQTAGVLPIDVEKYNISLLAFPGHKGLYGPQGTGGLYVKEGIELVPLKEGGTGSRSELTLQPDLMPD
KLESGTLNTPGIAGLKEGVKFVKKVGVNSIREREVKLTELLIEGLREIKKVRVYGPQKIEDRVGVVSITVEGMDVGEVSH
ILDREFDIATRAGLHCAPLAHSTIGTLKSGTLRFGIGYFNTEEEIIKAVEAIETIIQKNF

Sequences:

>Translated_380_residues
MIYFDNAATTWPKPEEVYLEVDRMLRNCGNPGRGGHRMALEASRVIFEARQEIASLFNIKDPMRVVFTLNTTEALNIALK
GVLKEGDHVITSSMEHNSVARPLSRLKEQGVEVTIVKGSEEGKIDPEDIKRAVKKNTKMIAITHASNVTGTIMPIEEIGN
IAREMNLIFLVDAAQTAGVLPIDVEKYNISLLAFPGHKGLYGPQGTGGLYVKEGIELVPLKEGGTGSRSELTLQPDLMPD
KLESGTLNTPGIAGLKEGVKFVKKVGVNSIREREVKLTELLIEGLREIKKVRVYGPQKIEDRVGVVSITVEGMDVGEVSH
ILDREFDIATRAGLHCAPLAHSTIGTLKSGTLRFGIGYFNTEEEIIKAVEAIETIIQKNF
>Mature_380_residues
MIYFDNAATTWPKPEEVYLEVDRMLRNCGNPGRGGHRMALEASRVIFEARQEIASLFNIKDPMRVVFTLNTTEALNIALK
GVLKEGDHVITSSMEHNSVARPLSRLKEQGVEVTIVKGSEEGKIDPEDIKRAVKKNTKMIAITHASNVTGTIMPIEEIGN
IAREMNLIFLVDAAQTAGVLPIDVEKYNISLLAFPGHKGLYGPQGTGGLYVKEGIELVPLKEGGTGSRSELTLQPDLMPD
KLESGTLNTPGIAGLKEGVKFVKKVGVNSIREREVKLTELLIEGLREIKKVRVYGPQKIEDRVGVVSITVEGMDVGEVSH
ILDREFDIATRAGLHCAPLAHSTIGTLKSGTLRFGIGYFNTEEEIIKAVEAIETIIQKNF

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=385, Percent_Identity=30.9090909090909, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI156713448, Length=296, Percent_Identity=31.0810810810811, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1787970, Length=388, Percent_Identity=30.9278350515464, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI48994898, Length=392, Percent_Identity=31.3775510204082, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=27.979274611399, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25143064, Length=383, Percent_Identity=28.4595300261097, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=29.0123456790123, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=32.6530612244898, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129463, Length=384, Percent_Identity=29.9479166666667, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41652; Mature: 41652

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYFDNAATTWPKPEEVYLEVDRMLRNCGNPGRGGHRMALEASRVIFEARQEIASLFNIK
CEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC
DPMRVVFTLNTTEALNIALKGVLKEGDHVITSSMEHNSVARPLSRLKEQGVEVTIVKGSE
CCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCC
EGKIDPEDIKRAVKKNTKMIAITHASNVTGTIMPIEEIGNIAREMNLIFLVDAAQTAGVL
CCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHHHHHHCEEEEEEECCCCCCCE
PIDVEKYNISLLAFPGHKGLYGPQGTGGLYVKEGIELVPLKEGGTGSRSELTLQPDLMPD
EEEEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCEEEECCCCCCC
KLESGTLNTPGIAGLKEGVKFVKKVGVNSIREREVKLTELLIEGLREIKKVRVYGPQKIE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHH
DRVGVVSITVEGMDVGEVSHILDREFDIATRAGLHCAPLAHSTIGTLKSGTLRFGIGYFN
CCCCEEEEEEECCCHHHHHHHHCCCCCHHHHCCCEECCHHHHHHHHCCCCCEEEEEEEEC
TEEEIIKAVEAIETIIQKNF
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIYFDNAATTWPKPEEVYLEVDRMLRNCGNPGRGGHRMALEASRVIFEARQEIASLFNIK
CEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC
DPMRVVFTLNTTEALNIALKGVLKEGDHVITSSMEHNSVARPLSRLKEQGVEVTIVKGSE
CCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCC
EGKIDPEDIKRAVKKNTKMIAITHASNVTGTIMPIEEIGNIAREMNLIFLVDAAQTAGVL
CCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHHHHHHCEEEEEEECCCCCCCE
PIDVEKYNISLLAFPGHKGLYGPQGTGGLYVKEGIELVPLKEGGTGSRSELTLQPDLMPD
EEEEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCEEEECCCCCCC
KLESGTLNTPGIAGLKEGVKFVKKVGVNSIREREVKLTELLIEGLREIKKVRVYGPQKIE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHH
DRVGVVSITVEGMDVGEVSHILDREFDIATRAGLHCAPLAHSTIGTLKSGTLRFGIGYFN
CCCCEEEEEEECCCHHHHHHHHCCCCCHHHHCCCEECCHHHHHHHHCCCCCEEEEEEEEC
TEEEIIKAVEAIETIIQKNF
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]