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The map label for this gene is ThrA2 [H]

Identifier: 20808965

GI number: 20808965

Start: 2512886

End: 2514142

Strand: Reverse

Name: ThrA2 [H]

Synonym: TTE2620

Alternate gene names: 20808965

Gene position: 2514142-2512886 (Counterclockwise)

Preceding gene: 20808966

Following gene: 20808964

Centisome position: 93.48

GC content: 38.98

Gene sequence:

>1257_bases
ATGAAAATTGGACTGATGGGACTAGGTACTGTAGGAACAGGTGTAGTTCACTTGATAGATCAGAATGGAAGAAATATTGA
AAAAAAGATAGGCGAAAAAATTGAGATAAAGAAAATACTTGTAAAAGACCCCAATAAAAAAAGAACTCCTCTTGCAGAAG
GGAAGATAACTTTTAATGCAGAAGATATTTTGGAAGACGAGGAAATAGACGTTGTGGTAGAAGTGATGGGGAAAGAGCAT
CCCGCTTTAGAATATATAACAAAAGCATTACAAAAAGGCAAACATGTGGTAACTGCCAATAAAGAAGTTATAGCAAAGCA
CGGAAAAGAACTTATAAAGCTTGCGACAGAAAAGAAGGTACATCTTCTTTATGAAGCCTCAGTAGGGGGCGGTATCCCCA
TCATAAGGCCTTTGAAGCAGTGCCTTGCTGCGAACAAAATATACGAGATAAAAGGAATTTTAAACGGTACGACTAATTAT
ATCCTTACAGAAATGAAGGAGAAAGGCCTTGACTTCGATGATGTTTTAAAAGATGCGCAGCAAAAAGGGTATGCAGAGGC
AGATCCCACAGACGATATAGAAGGCTTTGATGCAGCAAGGAAGCTTGCCATTTTGTGCATGCTGGCTTTTAACAAATTTG
TTCTTCCAGAGAAAATCTACACAAAAGGGATAAGTTTTATTTCTAAATCAGATATACAGTATGCAGAAGAGATGGGTTAT
ACCATAAAGCTTCTGGCCTATGCCAGAATTGACGAGAAAGAACGCTTAGAAGCCTGGGTTCATCCCGTCATGATAAGAAA
GACCAACCCTTTAAACGGAGTCAATGGCGTTTTTAATGCAATACTTGTGGATGGAAATGCGGTAGGAGAAGTTATGTTTT
ACGGGCAGGGCGCCGGCATGATGCCTACTGCCAGCGCAGTGGTTGCCGACATAATGGATGTGAAAAATCACATAGTAATA
CAAAATGGCTGTGAAGAGGTAGACTTAATACCTATTGAAGATACTTTTTCCAAATACTATATAAGGCTTATCGCTTTTGA
CAGGCCTGGTGTCATGAGCAAAATCACAGGAGTTTTGGGAAATAAAGGAATAAGCCTTCTTTCAGTAGTTCAAAAAGGGT
CTTTGGGAGAGACAGCGGAAATTGTATTGGTGACTCACATTGCAAATACAGGTAAGGTTTTGGAAGCTTTAAAGGAGATA
GAGGAGCTAAAGGAAGTAGAAAAAATAGAAAGTGTGATAAAAGTGAGGGAAGATTAA

Upstream 100 bases:

>100_bases
CGCAGTATATGGAGATAAGCATTGAAGATTTTATAGAGGAACTTTCGAAACAGCCTGGAGTTAGAAAAATAGAAGTTTTG
GGAGAATAAGGAGGAAGAAT

Downstream 100 bases:

>100_bases
AATGGCGTACGAAGGAATTATAAAAGCTTATAGAGAGTTTTTGCCTCCTATAAGAGATGAAAATATTGTCACGTTAAAAG
AGGGCAACACACCTTTAATT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKIGLMGLGTVGTGVVHLIDQNGRNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFNAEDILEDEEIDVVVEVMGKEH
PALEYITKALQKGKHVVTANKEVIAKHGKELIKLATEKKVHLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGLDFDDVLKDAQQKGYAEADPTDDIEGFDAARKLAILCMLAFNKFVLPEKIYTKGISFISKSDIQYAEEMGY
TIKLLAYARIDEKERLEAWVHPVMIRKTNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEEVDLIPIEDTFSKYYIRLIAFDRPGVMSKITGVLGNKGISLLSVVQKGSLGETAEIVLVTHIANTGKVLEALKEI
EELKEVEKIESVIKVRED

Sequences:

>Translated_418_residues
MKIGLMGLGTVGTGVVHLIDQNGRNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFNAEDILEDEEIDVVVEVMGKEH
PALEYITKALQKGKHVVTANKEVIAKHGKELIKLATEKKVHLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGLDFDDVLKDAQQKGYAEADPTDDIEGFDAARKLAILCMLAFNKFVLPEKIYTKGISFISKSDIQYAEEMGY
TIKLLAYARIDEKERLEAWVHPVMIRKTNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEEVDLIPIEDTFSKYYIRLIAFDRPGVMSKITGVLGNKGISLLSVVQKGSLGETAEIVLVTHIANTGKVLEALKEI
EELKEVEKIESVIKVRED
>Mature_418_residues
MKIGLMGLGTVGTGVVHLIDQNGRNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFNAEDILEDEEIDVVVEVMGKEH
PALEYITKALQKGKHVVTANKEVIAKHGKELIKLATEKKVHLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGLDFDDVLKDAQQKGYAEADPTDDIEGFDAARKLAILCMLAFNKFVLPEKIYTKGISFISKSDIQYAEEMGY
TIKLLAYARIDEKERLEAWVHPVMIRKTNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEEVDLIPIEDTFSKYYIRLIAFDRPGVMSKITGVLGNKGISLLSVVQKGSLGETAEIVLVTHIANTGKVLEALKEI
EELKEVEKIESVIKVRED

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=25.4189944134078, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786183, Length=139, Percent_Identity=35.2517985611511, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322599, Length=131, Percent_Identity=32.824427480916, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46085; Mature: 46085

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGLMGLGTVGTGVVHLIDQNGRNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFNA
CEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEECH
EDILEDEEIDVVVEVMGKEHPALEYITKALQKGKHVVTANKEVIAKHGKELIKLATEKKV
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCEE
HLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNYILTEMKEKGLDFDDVLKDAQ
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHH
QKGYAEADPTDDIEGFDAARKLAILCMLAFNKFVLPEKIYTKGISFISKSDIQYAEEMGY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TIKLLAYARIDEKERLEAWVHPVMIRKTNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGM
EEEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCHHHEEEEECCCCEEEEEEEECCCCC
MPTASAVVADIMDVKNHIVIQNGCEEVDLIPIEDTFSKYYIRLIAFDRPGVMSKITGVLG
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEECHHHHHHEEEEEEEECCCCHHHHHHHHHC
NKGISLLSVVQKGSLGETAEIVLVTHIANTGKVLEALKEIEELKEVEKIESVIKVRED
CCCHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIGLMGLGTVGTGVVHLIDQNGRNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFNA
CEEEEEECCCCCCCEEEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEECH
EDILEDEEIDVVVEVMGKEHPALEYITKALQKGKHVVTANKEVIAKHGKELIKLATEKKV
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCEE
HLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNYILTEMKEKGLDFDDVLKDAQ
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEHEECCCCHHHHHHHHHHHCCCHHHHHHHHH
QKGYAEADPTDDIEGFDAARKLAILCMLAFNKFVLPEKIYTKGISFISKSDIQYAEEMGY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TIKLLAYARIDEKERLEAWVHPVMIRKTNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGM
EEEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCHHHEEEEECCCCEEEEEEEECCCCC
MPTASAVVADIMDVKNHIVIQNGCEEVDLIPIEDTFSKYYIRLIAFDRPGVMSKITGVLG
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEECHHHHHHEEEEEEEECCCCHHHHHHHHHC
NKGISLLSVVQKGSLGETAEIVLVTHIANTGKVLEALKEIEELKEVEKIESVIKVRED
CCCHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]