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The map label for this gene is HyuA2 [H]

Identifier: 20808940

GI number: 20808940

Start: 2476191

End: 2478335

Strand: Reverse

Name: HyuA2 [H]

Synonym: TTE2591

Alternate gene names: 20808940

Gene position: 2478335-2476191 (Counterclockwise)

Preceding gene: 20808941

Following gene: 20808939

Centisome position: 92.15

GC content: 36.6

Gene sequence:

>2145_bases
TTGAAGGTAAGAATCGGGATAGATGTTGGAGGAACATTTACAGATGCAGTTGCTATAGATAATGACACTTATGAATTGAT
AGGGACAATAAAGGTACCGACGACACATACAGCGAAAGAGGGTGTTGCAAAAGGCATTGTAGAAGCCCTTATGAAACTCA
TGGAAGAACACAATATAAATCCAGAAGATGTTCTATTTATAGCCCATGGTACAACACAGGCAACAAATGCCTTATTAGAG
GGTGATGTTGTTCCTGTTGGTATTATAGCTGCAGGGAAAGGTCTTGAAGGTATTAAAGTAAAAAGCGATACAAATATACA
AGATATAGAACTTGCACCAGGCAAGATATTAAAAATTGCAAGTCAATATATTGAATTAGATGAGGAATTTGAAAAAAAGG
TAGAAATGAAAATTGAAGAATTCAAAAATCAAGAGATAGGGGCGATTGTTGCAGCTCAGGCCTTTTCAGTTGATGATCCC
ACTATTGAAAATAAAATAGTTGAAATAGCAGAGCAAAAAGGACTTCCAGCGACGGCAACGCATGAAATAACAAAGCTATA
TGGATTAAAGATAAGGACAAGGACTGCAGCAATAAACGCATGTATACTTCCCAAAATGATAGAGACAGCAAACATGACAG
AAGATAGCGTAAAAAAATCTGGCATAAAAGCACCTCTCATGATAATGAGAGGCGATGGAGGAGTAATGAATATAGCGGAA
GTGAGAAAAAGACCGATATTAACTCTTCTTTCAGGCCCTGCTGCAGGTGTAGCAGGTGCTCTTATGTACGAAAAAGTGTC
TGACGGCATATTCCTTGAAGTTGGTGGAACAAGTACAGACATTTCTGCAATAAAGGCAGGCAAAGTAATGGTAAACTATG
CAGAAATTGGTGGGCATAAAACATATCTTAACTCCCTTGACGTAAGAACGGTAGGAATAGCAGGGGGAAGTATGATAAGA
CTGGGTGACAAAGACATAGAAGACGTTGGACCGAGAAGCGCCCACATTGCAGGTTTACCATATGCAGTTTACAGCGATCC
TGAAGAAATAATAGAACCTGAAATAGTATATATAAAACCAAAAAAGAACGATCCTGATAATTATGTTGCAATCAAAAGCA
AAAATGGGAAAATATTTGCGGTAACTGTATCCTGCGCGGCAAACGTATTAGGATATGTAAAACCAGAAGATTACGCCTAT
GGTAATCAAGAGGCTGCAAGAAAGGCCTTAGAACCAATTGCCAAAAAACTCAATAAAACAGTTGAAGAAGTAGCTGAGAG
GATAATGAATATTGCCAGCATGAAAGTGGCAAAAGTTGTTGAACAACTTCTTAATGATTACAAACTTGACAAAGATACGA
CAATACTTGTAGGTGGAGGAGGAGGAAGTGCTTCAATAGTTCCCTATGTTGCAAAAATTATGGGTATGCACCATAGAATA
GCCAAAAACGCTCAGGTAATCTCTACAATAGGAGTAGCCCTTGCGATGGTAAGAGAAATAGTAGAGCGCACAATACAAAA
CCCCACTGAAAAAGATATATTGTCAATAAGAAATGAGGCAAAAGAAGCAGTAATAAAATCAGGGGCATTAGAAGAAACGG
TAGAAATATACGTAGAAATAGACTCACAAAAAAATATAGTAAGAGCAATTGCTACAGGAGCTACAGAATTACGTTCCAAA
GATATACTAAACAAAAACTTAGGAGAAGAAGAAATAAAGAAAATAGCAGCTCAAGCAATGAAGCTAGAATCGATAAAAAA
CCTTCAAATAATCGATAAAACAGGTTCAATGTATATCATAAAAGGCATAGAATACAGAAAGAGATTCTTTGGGCTATTAT
CACAAAAGCAGGAAAGAGTAGTAGTAATAAACAAAGAAGGGGTTATAAGACTTCACAAAAATAACGGCAAAGTATATAGA
ACAACCATTAAAACCTTTGAAAATGATTTAAACAAAGCATTAGAGCAAAACATATTTTATGGCGATGGCGGAGCTGAAAT
CCCTGATTGCTTTATCATACTGCCAAATAGAATAGTAGACCTATCAGGACTTATCGACAAAGAACAAATAATTTCACTGG
CAAAAGTAGAAATAAGTGGCTTATCTGATAATGACCGAATACTCATATTATTAAGCAAAAGGTGA

Upstream 100 bases:

>100_bases
AGTTACAGGTAATAGTCCAAATCAATTAGAAAGAGTTACAAGTGAATATAGAAAAGCTATCGACAGGCTTTAATGTGATT
TTTAGAAGGAGGAGATAATA

Downstream 100 bases:

>100_bases
TGGAATGGTACCCTCTGTATTTCTTGATAAACAACAATTAATTTCACAAGAATTAGAGTTTGATATTTATTATAACAGAA
TATCCCAACATAATCTTGAT

Product: N-methylhydaintoinase A

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MKVRIGIDVGGTFTDAVAIDNDTYELIGTIKVPTTHTAKEGVAKGIVEALMKLMEEHNINPEDVLFIAHGTTQATNALLE
GDVVPVGIIAAGKGLEGIKVKSDTNIQDIELAPGKILKIASQYIELDEEFEKKVEMKIEEFKNQEIGAIVAAQAFSVDDP
TIENKIVEIAEQKGLPATATHEITKLYGLKIRTRTAAINACILPKMIETANMTEDSVKKSGIKAPLMIMRGDGGVMNIAE
VRKRPILTLLSGPAAGVAGALMYEKVSDGIFLEVGGTSTDISAIKAGKVMVNYAEIGGHKTYLNSLDVRTVGIAGGSMIR
LGDKDIEDVGPRSAHIAGLPYAVYSDPEEIIEPEIVYIKPKKNDPDNYVAIKSKNGKIFAVTVSCAANVLGYVKPEDYAY
GNQEAARKALEPIAKKLNKTVEEVAERIMNIASMKVAKVVEQLLNDYKLDKDTTILVGGGGGSASIVPYVAKIMGMHHRI
AKNAQVISTIGVALAMVREIVERTIQNPTEKDILSIRNEAKEAVIKSGALEETVEIYVEIDSQKNIVRAIATGATELRSK
DILNKNLGEEEIKKIAAQAMKLESIKNLQIIDKTGSMYIIKGIEYRKRFFGLLSQKQERVVVINKEGVIRLHKNNGKVYR
TTIKTFENDLNKALEQNIFYGDGGAEIPDCFIILPNRIVDLSGLIDKEQIISLAKVEISGLSDNDRILILLSKR

Sequences:

>Translated_714_residues
MKVRIGIDVGGTFTDAVAIDNDTYELIGTIKVPTTHTAKEGVAKGIVEALMKLMEEHNINPEDVLFIAHGTTQATNALLE
GDVVPVGIIAAGKGLEGIKVKSDTNIQDIELAPGKILKIASQYIELDEEFEKKVEMKIEEFKNQEIGAIVAAQAFSVDDP
TIENKIVEIAEQKGLPATATHEITKLYGLKIRTRTAAINACILPKMIETANMTEDSVKKSGIKAPLMIMRGDGGVMNIAE
VRKRPILTLLSGPAAGVAGALMYEKVSDGIFLEVGGTSTDISAIKAGKVMVNYAEIGGHKTYLNSLDVRTVGIAGGSMIR
LGDKDIEDVGPRSAHIAGLPYAVYSDPEEIIEPEIVYIKPKKNDPDNYVAIKSKNGKIFAVTVSCAANVLGYVKPEDYAY
GNQEAARKALEPIAKKLNKTVEEVAERIMNIASMKVAKVVEQLLNDYKLDKDTTILVGGGGGSASIVPYVAKIMGMHHRI
AKNAQVISTIGVALAMVREIVERTIQNPTEKDILSIRNEAKEAVIKSGALEETVEIYVEIDSQKNIVRAIATGATELRSK
DILNKNLGEEEIKKIAAQAMKLESIKNLQIIDKTGSMYIIKGIEYRKRFFGLLSQKQERVVVINKEGVIRLHKNNGKVYR
TTIKTFENDLNKALEQNIFYGDGGAEIPDCFIILPNRIVDLSGLIDKEQIISLAKVEISGLSDNDRILILLSKR
>Mature_714_residues
MKVRIGIDVGGTFTDAVAIDNDTYELIGTIKVPTTHTAKEGVAKGIVEALMKLMEEHNINPEDVLFIAHGTTQATNALLE
GDVVPVGIIAAGKGLEGIKVKSDTNIQDIELAPGKILKIASQYIELDEEFEKKVEMKIEEFKNQEIGAIVAAQAFSVDDP
TIENKIVEIAEQKGLPATATHEITKLYGLKIRTRTAAINACILPKMIETANMTEDSVKKSGIKAPLMIMRGDGGVMNIAE
VRKRPILTLLSGPAAGVAGALMYEKVSDGIFLEVGGTSTDISAIKAGKVMVNYAEIGGHKTYLNSLDVRTVGIAGGSMIR
LGDKDIEDVGPRSAHIAGLPYAVYSDPEEIIEPEIVYIKPKKNDPDNYVAIKSKNGKIFAVTVSCAANVLGYVKPEDYAY
GNQEAARKALEPIAKKLNKTVEEVAERIMNIASMKVAKVVEQLLNDYKLDKDTTILVGGGGGSASIVPYVAKIMGMHHRI
AKNAQVISTIGVALAMVREIVERTIQNPTEKDILSIRNEAKEAVIKSGALEETVEIYVEIDSQKNIVRAIATGATELRSK
DILNKNLGEEEIKKIAAQAMKLESIKNLQIIDKTGSMYIIKGIEYRKRFFGLLSQKQERVVVINKEGVIRLHKNNGKVYR
TTIKTFENDLNKALEQNIFYGDGGAEIPDCFIILPNRIVDLSGLIDKEQIISLAKVEISGLSDNDRILILLSKR

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901900, Length=417, Percent_Identity=25.8992805755396, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550492, Length=564, Percent_Identity=23.936170212766, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 77729; Mature: 77729

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRIGIDVGGTFTDAVAIDNDTYELIGTIKVPTTHTAKEGVAKGIVEALMKLMEEHNIN
CEEEEEEEECCCEECEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PEDVLFIAHGTTQATNALLEGDVVPVGIIAAGKGLEGIKVKSDTNIQDIELAPGKILKIA
HHHEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCCCCEEEECCCCHHHHHH
SQYIELDEEFEKKVEMKIEEFKNQEIGAIVAAQAFSVDDPTIENKIVEIAEQKGLPATAT
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHH
HEITKLYGLKIRTRTAAINACILPKMIETANMTEDSVKKSGIKAPLMIMRGDGGVMNIAE
HHHHHHHCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCCEEEHHH
VRKRPILTLLSGPAAGVAGALMYEKVSDGIFLEVGGTSTDISAIKAGKVMVNYAEIGGHK
HCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHEECCEEEEEEHHHCCCC
TYLNSLDVRTVGIAGGSMIRLGDKDIEDVGPRSAHIAGLPYAVYSDPEEIIEPEIVYIKP
HHHCCCCEEEEEECCCCEEEECCCCHHHCCCCCEEEECCCCCEECCHHHHCCCEEEEEEC
KKNDPDNYVAIKSKNGKIFAVTVSCAANVLGYVKPEDYAYGNQEAARKALEPIAKKLNKT
CCCCCCCEEEEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEEVAERIMNIASMKVAKVVEQLLNDYKLDKDTTILVGGGGGSASIVPYVAKIMGMHHRI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AKNAQVISTIGVALAMVREIVERTIQNPTEKDILSIRNEAKEAVIKSGALEETVEIYVEI
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
DSQKNIVRAIATGATELRSKDILNKNLGEEEIKKIAAQAMKLESIKNLQIIDKTGSMYII
CCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
KGIEYRKRFFGLLSQKQERVVVINKEGVIRLHKNNGKVYRTTIKTFENDLNKALEQNIFY
ECHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCEE
GDGGAEIPDCFIILPNRIVDLSGLIDKEQIISLAKVEISGLSDNDRILILLSKR
CCCCCCCCCEEEECCCCEEEHHCCCCHHHHHHHHEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure
MKVRIGIDVGGTFTDAVAIDNDTYELIGTIKVPTTHTAKEGVAKGIVEALMKLMEEHNIN
CEEEEEEEECCCEECEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PEDVLFIAHGTTQATNALLEGDVVPVGIIAAGKGLEGIKVKSDTNIQDIELAPGKILKIA
HHHEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCCCCEEEECCCCHHHHHH
SQYIELDEEFEKKVEMKIEEFKNQEIGAIVAAQAFSVDDPTIENKIVEIAEQKGLPATAT
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHH
HEITKLYGLKIRTRTAAINACILPKMIETANMTEDSVKKSGIKAPLMIMRGDGGVMNIAE
HHHHHHHCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCCEEEHHH
VRKRPILTLLSGPAAGVAGALMYEKVSDGIFLEVGGTSTDISAIKAGKVMVNYAEIGGHK
HCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHEECCEEEEEEHHHCCCC
TYLNSLDVRTVGIAGGSMIRLGDKDIEDVGPRSAHIAGLPYAVYSDPEEIIEPEIVYIKP
HHHCCCCEEEEEECCCCEEEECCCCHHHCCCCCEEEECCCCCEECCHHHHCCCEEEEEEC
KKNDPDNYVAIKSKNGKIFAVTVSCAANVLGYVKPEDYAYGNQEAARKALEPIAKKLNKT
CCCCCCCEEEEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEEVAERIMNIASMKVAKVVEQLLNDYKLDKDTTILVGGGGGSASIVPYVAKIMGMHHRI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AKNAQVISTIGVALAMVREIVERTIQNPTEKDILSIRNEAKEAVIKSGALEETVEIYVEI
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
DSQKNIVRAIATGATELRSKDILNKNLGEEEIKKIAAQAMKLESIKNLQIIDKTGSMYII
CCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
KGIEYRKRFFGLLSQKQERVVVINKEGVIRLHKNNGKVYRTTIKTFENDLNKALEQNIFY
ECHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCEE
GDGGAEIPDCFIILPNRIVDLSGLIDKEQIISLAKVEISGLSDNDRILILLSKR
CCCCCCCCCEEEECCCCEEEHHCCCCHHHHHHHHEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]