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The map label for this gene is CysK2 [H]

Identifier: 20808833

GI number: 20808833

Start: 2364948

End: 2365886

Strand: Reverse

Name: CysK2 [H]

Synonym: TTE2478

Alternate gene names: 20808833

Gene position: 2365886-2364948 (Counterclockwise)

Preceding gene: 20808835

Following gene: 20808829

Centisome position: 87.97

GC content: 36.32

Gene sequence:

>939_bases
ATGTCGGGAAGAGAAAATAAAATTTATGAGGATATAACTCAGCTTATAGGCAATACACCTATGATTAGGTTGAATAAAGT
TGTTCCTGAAAATTCAGCGGAGGTCATAGTAAAATTAGAGTCTTTTAACCCAGGTGGAAGTGTTAAGGACAGAATTGCAT
TAAATATGATAAAAAGAGCTGAGGAAGAAGGAAGATTAAAACCTGGTGGGACAATTGTTGAACCTACCAGTGGAAATACA
GGCATTGGTCTTGCGATGGTTAGTGCTGTAAAAGGGTATAAGTTGATTCTTGTAATGCCTGATACGATGAGTATAGAACG
ACGAAATTTACTTTTGTCATATGGAGCAGAGCTTGTTTTAACACCCGGTGCAGAGGGTATGAAAGGAGCCATAAAAAAGG
CACAAGAAATTTTGGAATTAAATCCTGATTATATAATGTTAGATCAGTTTAAAAATCCTGCGAATCCAGAAATACATGAA
CTTACAACGGCAAAAGAAATATTAAAAGATACAAATGGAATAGTAGATGCATTTGTAGCAGGTGTAGGCACAGGGGGAAC
AATATCCGGAGTAGGGAAAGTTTTAAAGCAATATAACAAAGATATAAAAATTTTTGCAGTAGAACCAGAGGAATCTCCTG
TATTGTCAGGCGGCAAACCTGGACCTCATAAGATACAAGGAATAGGAGCTGGATTTATTCCTGACACATTAAATCTTGAC
GTTATCGATGAAATTATAAAGGTAAAAGAGAGAGATGCTTTTGAAATGTCAATGAAACTTGCAAAACAAGAAGGGATTCT
TTGTGGTATTTCTTCAGGCGCAAATGTTTTTGCGGCAGTTGAAGTTGCAAATCGCCTCGGGAAAGGAAAACGAGTTGTAA
CAGTACTACCTGATACTGGGGAAAGATATTTAAGTATGCACAAATTTTTTGAATATTGA

Upstream 100 bases:

>100_bases
GTTGTTAAACTGTTGACAATCAACTGAGATTGTGATATCTTAAAATAAAATCATAGTATTCCTATCTAAATACTATGAAT
TAAAAGGAGGCAAAAAAATT

Downstream 100 bases:

>100_bases
ACGCCATAATGAATTTAATCCTAATGGAAGAATGACAGCACTTCGTTGTGGAGCAAATGTTGTAATGCCCAATGTGACAG
AGGGAGAATGCAGAAAGTTG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSGRENKIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIMLDQFKNPANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY

Sequences:

>Translated_312_residues
MSGRENKIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIMLDQFKNPANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY
>Mature_311_residues
SGRENKIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNTG
IGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIMLDQFKNPANPEIHEL
TTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLDV
IDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=43.9490445859873, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=43.9490445859873, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=43.9490445859873, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=53.8216560509554, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=43.3333333333333, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=52, Blast_Score=300, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=50.5050505050505, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=49.3377483443709, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI115535073, Length=302, Percent_Identity=52.9801324503311, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=48.3443708609272, Blast_Score=248, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=50, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=38.125, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=37.1069182389937, Blast_Score=170, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=46.6101694915254, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539800, Length=336, Percent_Identity=26.4880952380952, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=38.6075949367089, Blast_Score=201, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=35.9281437125749, Blast_Score=156, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=42.1725239616613, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=42.1725239616613, Blast_Score=218, Evalue=3e-57,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33710; Mature: 33578

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRENKIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRA
CCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEPTSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPDYIMLDQFKNPANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC
>Mature Secondary Structure 
SGRENKIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRA
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEPTSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPDYIMLDQFKNPANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA