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The map label for this gene is ZntA2 [H]

Identifier: 20808822

GI number: 20808822

Start: 2356690

End: 2358666

Strand: Reverse

Name: ZntA2 [H]

Synonym: TTE2467

Alternate gene names: 20808822

Gene position: 2358666-2356690 (Counterclockwise)

Preceding gene: 20808823

Following gene: 20808821

Centisome position: 87.7

GC content: 36.22

Gene sequence:

>1977_bases
ATGCAAAATAATAAAAGGGCCTTTGTTTTAGAGAGGTTTGGCTGTAAAAGTTGTGCCCTAGATGCAAAAGAAAGTCCACT
GAACGCAAATTGTGATTCTGATAGTTGTAAGCTTTCTTTTGAGAATGATGACTCTAATAAAGTATACAGGAGAATCATTC
AATATGGGATTTCTGCTATCTTGTTTGCAATAGCATTGCTATTTAATTTATTGGGTTATATCAAATTTACCTTATTTTTT
ATAAGTTATATAATCGCAGGAGGAGATGTCGTCTTAAAAGCTACCAAAAATATTTTGAAAGGGCAGATTTTTGATGAGTA
TTTTCTCATGAGCATAGCGACAATTGGTGCTTTTGCTATTGGAGAGTATCCTGAGAGTGTAGCTGTAATGCTTTTTTACC
AAATTGGGGAACTTCTGCAGGATATTGCTGTTGATCATTCGAAAAGGTCTATTAAAGAGTTAATGAATATTCGTCCCGAT
TATGCTAACTTAAAAATTGGATATAAAATAAAGAGGGTTTCACCACAAGAAGTAAGACCGGGAGACGTCATCATAGTAAA
GCCTGGTGAAAAAATACCACTTGATGGGAAGGTAATCGAAGGGGAATCGATGGTGGATACTTCTGCATTAACAGGAGAAT
CTGTTTTAAAAGAGGTTTATAAAGGCGCGGACGTTTTAAGTGGCTTTATAAATAAAAATGGACTTCTCACAATAGAAGTA
ACCAGAGAGTTTGCAGAATCAACTGTTTCAAAAATACTAGGACTTATTGAAGAGGCTAGCAGTAAGAAAGCTCCTACAGA
AAAATTTATGACAAAGTTTGCCAAATATTACACTCCTATTGTTGTTTTTTTGGCATTGATTATTGCAGTAATTCCTCCTT
TAATTATACCAGCAGCAACCTTCAAGGAATTTATATATAGAGCACTTATTTTTCTTATTATATCGTGTCCCTGTGCACTG
GTGTTATCGATTCCTTTAAGCTTTTTTGCTGGTATAGGTGCTGCCTCAAAAAATGGCATCCTTGTAAAAGGAAGTAACTA
TTTGGAAGCGTTAAGCAATGTAGAAACTGTTGTATTTGATAAAACAGGTACCCTTACAAAAGGGGTATTTAAGGTGACGA
AAATTAAATCTGTAAATGGCATGAGCAGGGATGCGCTTTTAGAATATGCGGCATATGCCGAAAGTTTTTCAAATCATCCT
ATAGCAGAATCCATTTTAGAAGCCTATGGGAAAGAAGTAGACAGATCTAAAATAAAAAAGTATGAAGAAATTTCAGGAAA
TGGCGTAAGAGCAAATATAGAAGGAAAAGAAGTCCTTGTGGGCAATGCTAAATTAATGAAGATGGAAAATATTGATTGTG
TTACCGGTGACTCAACAGGCACTATCATCCATGTAGCTATAGATAACAAATACTGTGGTTATATCCTCATATCTGATGAG
GTAAAGGAAGATTCCCCAAAAGCTATAGAAAGTCTCAGGAAAATGGGCATTAAAAGGATTGTCATGCTTACGGGGGATAA
CAAAGTTGTAAGCGATAAAATCGCTGCTTCATTAGGGATTGATGAAGTGTATTCACAACTTCTTCCAAATGAGAAAGTTG
GCGTACTTGAGAAATTGTATGCTGACAATAAAAAAGGCAAGCTCATATTTGTCGGTGATGGCATAAATGATGCACCGGTT
TTAGCGAGATCTGATGTGGGTGTTGCAATGGGAGGAATCGGGTCAGATGCTGCTATAGAAGCAGCCGATGTAGTTTTAAT
GACAGATGAACCGTCAAAACTGGTAACAGCTATAAAGATATCCAAAAGGACAAAGTTAATAGTATGGGAAAATATTCTTC
TTGCATTAGGAGTAAAAATAGTGGTTTTAGCACTTGGTGCTTTAGGGGTTGCTACAATGTGGGAAGCTGTGTTCGCCGAC
GTAGGTGTTGCACTCCTTGCAGTCCTTAATTCCTTAAGATTGCTTAATAAAAAATAA

Upstream 100 bases:

>100_bases
GGAAAAGTGGTTTATTATTCTTTGGCGGATGACCATGTAAAGAAAATATTTGAACAGGGTTTTGACCATATTAATGAATG
AATCAGGAAAGGTGAATATT

Downstream 100 bases:

>100_bases
AAATATTATTAACTTTTAAAAAAGGAGGATATGAATCATGGGTTTGTTTGGACCTAAGGGTGAGACTATCGTCATAAATG
TTAAGGGGATGACATGCAAC

Product: cation transport ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MQNNKRAFVLERFGCKSCALDAKESPLNANCDSDSCKLSFENDDSNKVYRRIIQYGISAILFAIALLFNLLGYIKFTLFF
ISYIIAGGDVVLKATKNILKGQIFDEYFLMSIATIGAFAIGEYPESVAVMLFYQIGELLQDIAVDHSKRSIKELMNIRPD
YANLKIGYKIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLIISCPCAL
VLSIPLSFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKVTKIKSVNGMSRDALLEYAAYAESFSNHP
IAESILEAYGKEVDRSKIKKYEEISGNGVRANIEGKEVLVGNAKLMKMENIDCVTGDSTGTIIHVAIDNKYCGYILISDE
VKEDSPKAIESLRKMGIKRIVMLTGDNKVVSDKIAASLGIDEVYSQLLPNEKVGVLEKLYADNKKGKLIFVGDGINDAPV
LARSDVGVAMGGIGSDAAIEAADVVLMTDEPSKLVTAIKISKRTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK

Sequences:

>Translated_658_residues
MQNNKRAFVLERFGCKSCALDAKESPLNANCDSDSCKLSFENDDSNKVYRRIIQYGISAILFAIALLFNLLGYIKFTLFF
ISYIIAGGDVVLKATKNILKGQIFDEYFLMSIATIGAFAIGEYPESVAVMLFYQIGELLQDIAVDHSKRSIKELMNIRPD
YANLKIGYKIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLIISCPCAL
VLSIPLSFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKVTKIKSVNGMSRDALLEYAAYAESFSNHP
IAESILEAYGKEVDRSKIKKYEEISGNGVRANIEGKEVLVGNAKLMKMENIDCVTGDSTGTIIHVAIDNKYCGYILISDE
VKEDSPKAIESLRKMGIKRIVMLTGDNKVVSDKIAASLGIDEVYSQLLPNEKVGVLEKLYADNKKGKLIFVGDGINDAPV
LARSDVGVAMGGIGSDAAIEAADVVLMTDEPSKLVTAIKISKRTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK
>Mature_658_residues
MQNNKRAFVLERFGCKSCALDAKESPLNANCDSDSCKLSFENDDSNKVYRRIIQYGISAILFAIALLFNLLGYIKFTLFF
ISYIIAGGDVVLKATKNILKGQIFDEYFLMSIATIGAFAIGEYPESVAVMLFYQIGELLQDIAVDHSKRSIKELMNIRPD
YANLKIGYKIKRVSPQEVRPGDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAATFKEFIYRALIFLIISCPCAL
VLSIPLSFFAGIGAASKNGILVKGSNYLEALSNVETVVFDKTGTLTKGVFKVTKIKSVNGMSRDALLEYAAYAESFSNHP
IAESILEAYGKEVDRSKIKKYEEISGNGVRANIEGKEVLVGNAKLMKMENIDCVTGDSTGTIIHVAIDNKYCGYILISDE
VKEDSPKAIESLRKMGIKRIVMLTGDNKVVSDKIAASLGIDEVYSQLLPNEKVGVLEKLYADNKKGKLIFVGDGINDAPV
LARSDVGVAMGGIGSDAAIEAADVVLMTDEPSKLVTAIKISKRTKLIVWENILLALGVKIVVLALGALGVATMWEAVFAD
VGVALLAVLNSLRLLNKK

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=595, Percent_Identity=30.7563025210084, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI115529486, Length=611, Percent_Identity=31.2602291325696, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI55743073, Length=522, Percent_Identity=31.8007662835249, Blast_Score=240, Evalue=4e-63,
Organism=Homo sapiens, GI297374799, Length=182, Percent_Identity=26.3736263736264, Blast_Score=66, Evalue=1e-10,
Organism=Homo sapiens, GI83700225, Length=182, Percent_Identity=26.3736263736264, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789879, Length=599, Percent_Identity=37.7295492487479, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1786691, Length=571, Percent_Identity=31.1733800350263, Blast_Score=269, Evalue=5e-73,
Organism=Escherichia coli, GI1786914, Length=484, Percent_Identity=28.3057851239669, Blast_Score=142, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17556548, Length=574, Percent_Identity=30.1393728222997, Blast_Score=219, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17541776, Length=236, Percent_Identity=26.6949152542373, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=544, Percent_Identity=30.5147058823529, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=555, Percent_Identity=26.8468468468468, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6325221, Length=641, Percent_Identity=23.4009360374415, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321430, Length=517, Percent_Identity=23.5976789168279, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321271, Length=268, Percent_Identity=30.2238805970149, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221329854, Length=368, Percent_Identity=30.4347826086957, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=28.6624203821656, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=28.6624203821656, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=28.6624203821656, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=28.6624203821656, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=28.6624203821656, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 71551; Mature: 71551

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNKRAFVLERFGCKSCALDAKESPLNANCDSDSCKLSFENDDSNKVYRRIIQYGISAI
CCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
LFAIALLFNLLGYIKFTLFFISYIIAGGDVVLKATKNILKGQIFDEYFLMSIATIGAFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEYPESVAVMLFYQIGELLQDIAVDHSKRSIKELMNIRPDYANLKIGYKIKRVSPQEVRP
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
GDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
CCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAAT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FKEFIYRALIFLIISCPCALVLSIPLSFFAGIGAASKNGILVKGSNYLEALSNVETVVFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEE
KTGTLTKGVFKVTKIKSVNGMSRDALLEYAAYAESFSNHPIAESILEAYGKEVDRSKIKK
CCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
YEEISGNGVRANIEGKEVLVGNAKLMKMENIDCVTGDSTGTIIHVAIDNKYCGYILISDE
HHHCCCCCEEEECCCCEEEECCCEEEEECCCCEEECCCCCCEEEEEECCCCEEEEEEECC
VKEDSPKAIESLRKMGIKRIVMLTGDNKVVSDKIAASLGIDEVYSQLLPNEKVGVLEKLY
CCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH
ADNKKGKLIFVGDGINDAPVLARSDVGVAMGGIGSDAAIEAADVVLMTDEPSKLVTAIKI
CCCCCCEEEEEECCCCCCCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHEEE
SKRTKLIVWENILLALGVKIVVLALGALGVATMWEAVFADVGVALLAVLNSLRLLNKK
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNNKRAFVLERFGCKSCALDAKESPLNANCDSDSCKLSFENDDSNKVYRRIIQYGISAI
CCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
LFAIALLFNLLGYIKFTLFFISYIIAGGDVVLKATKNILKGQIFDEYFLMSIATIGAFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEYPESVAVMLFYQIGELLQDIAVDHSKRSIKELMNIRPDYANLKIGYKIKRVSPQEVRP
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
GDVIIVKPGEKIPLDGKVIEGESMVDTSALTGESVLKEVYKGADVLSGFINKNGLLTIEV
CCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
TREFAESTVSKILGLIEEASSKKAPTEKFMTKFAKYYTPIVVFLALIIAVIPPLIIPAAT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FKEFIYRALIFLIISCPCALVLSIPLSFFAGIGAASKNGILVKGSNYLEALSNVETVVFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEE
KTGTLTKGVFKVTKIKSVNGMSRDALLEYAAYAESFSNHPIAESILEAYGKEVDRSKIKK
CCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
YEEISGNGVRANIEGKEVLVGNAKLMKMENIDCVTGDSTGTIIHVAIDNKYCGYILISDE
HHHCCCCCEEEECCCCEEEECCCEEEEECCCCEEECCCCCCEEEEEECCCCEEEEEEECC
VKEDSPKAIESLRKMGIKRIVMLTGDNKVVSDKIAASLGIDEVYSQLLPNEKVGVLEKLY
CCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH
ADNKKGKLIFVGDGINDAPVLARSDVGVAMGGIGSDAAIEAADVVLMTDEPSKLVTAIKI
CCCCCCEEEEEECCCCCCCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHEEE
SKRTKLIVWENILLALGVKIVVLALGALGVATMWEAVFADVGVALLAVLNSLRLLNKK
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]