Click here to switch to the map view.

The map label for this gene is MIS1 [H]

Identifier: 20808755

GI number: 20808755

Start: 2278072

End: 2279739

Strand: Reverse

Name: MIS1 [H]

Synonym: TTE2391

Alternate gene names: 20808755

Gene position: 2279739-2278072 (Counterclockwise)

Preceding gene: 20808756

Following gene: 20808754

Centisome position: 84.77

GC content: 42.63

Gene sequence:

>1668_bases
ATGAAATCAGATATTGAAATAGCTCAGGAAGCGAAGATGCTGCACATAAGAGATGTGGCAGCAAAATTGGGCATTGAGGA
GGATTATCTGGAATATTACGGCAAATACAAAGCTAAGATTTCCCCCGCTTTGTGGGATAAAATTAAAGACAGGAAAGACG
GAAAACTCATCTTAGTTACAGCTATAACTCCCACTCCTGCTGGAGAGGGAAAGACCACGACGACTGTAGGACTGGGGCAA
GCTCTTGCAAAATTAGGGAAAAAAGCCATGATTGCCTTGAGAGAGCCTTCTTTAGGTCCTTCCTTTGGAATAAAAGGAGG
AGCAGCTGGAGGCGGTTATTCTCAAGTAGTACCTATGGAAGATATAAATTTGCATTTTACTGGAGATATACATGCCATTA
CAGCGGCTCACAATTTGCTGGCTGCTATGATTGACAATCACATTCACCATGGGAATGAGCTAAATATCGATATAAGGACT
ATAACGTGGAAAAGAGCAATGGACATGAATGACAGGGCTTTAAGGGAAATAATAGTAGGGCTAGGAGGAAAAGCTAACGG
CTATCCAAGGCAGGACGGCTTTATAATAACTGTTGCCTCGGAGATAATGGCAATTCTGTGCCTTTCTCACGATTTAATGG
ATTTAAAGAGAAGGCTGGGGGATATAATAGTAGCTTATGACAAAGATGGAAGTCCTGTAACTGCAAGGGATTTAAAAGCA
GACGGGGCAATGGCAGTGCTTTTAAAGGATGCTATAAAGCCTAATTTGGTACAGACGATTGAAAACGTTCCAGCTTTTGT
CCATGGAGGCCCTTTTGCAAATATCGCTCACGGATGCAACAGCTTGATTGCGACAAAATATGGGTTAAAGCTTGCAGATT
ATCTGGTGACAGAAGCAGGTTTTGGAGCAGATCTGGGAGCAGAAAAATTTTTCGATGTGAAGGCGAGGTTTGGAGGTCTC
ACTCCAAATGCTGCTGTAGTTGTGGCAACGGTAAGGGCTTTGAAAATGCACGGGGGAGTGAAGAAGGAGGATTTGCAGAA
GGAGGACGTAGAGGCAGTAAGAAGGGGAATAGAAAACCTTGAAAAACAAGTGGAAAATGTAAGGAAATTTGGCGTGCCTG
TGGTGGTTGCGCTTAACAAATTTGTCTTTGATACAGAAAGAGAAATTGAAGAAGTGAGAAAAGCTTGTGACAGAATAGGT
GTAGATATGGCGGTGGCAGAGGTTTGGGAGAAAGGTGGAGAAGGCGGAATAGAACTTGCCGAAAAAGTGATAAAAGCTGC
GGACACTCCCTCTAATTTCAGATTCCTATACGATGTAAACTTGCCTATAAAGGATAAGCTCCACATAATCGCTACTGAGA
TATACGGAGCTGACGGCGTAGAATATACTGCAAGTGCTTTAAAGGATATAGCTAATATAGAGAAATTAGGACTTGACAAG
ATGCCTATAGTAGTAGCTAAGACCCAGTATTCCCTGTCAGATGACCCCAAGCTTTTAGGGCGTCCTAGAGGATTTAAGAT
AACCGTAAGAGAATTAAGAATTTCTAGAGGTGCCGGGTTTATAGTTGCTCTGACAGGTGACATAATGACAATGCCAGGGC
TTCCAAAACACCCTGCCGCTGAGAACATAGATATAGATGAAAATGGTAGAATAAAGGGGTTGTTCTAG

Upstream 100 bases:

>100_bases
ATATGTACAACGGAGACCTTAAAATTTACAGCAAGAAAGGGAAAGGAACTCTTGTAAAGGTTGTTTTGGGAGAAAAATAA
AAAGCTGGAGGGGATTTGTT

Downstream 100 bases:

>100_bases
GGACTGAAAATGAGGAGAGAGGTTTTGAAGATAGATAATTTATCGGAGGCCAAAAGAGAGCTAAGCCAAATAAAAGCTGA
AGAGATTTCTGTTGATATAA

Product: formyltetrahydrofolate synthetase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKSDIEIAQEAKMLHIRDVAAKLGIEEDYLEYYGKYKAKISPALWDKIKDRKDGKLILVTAITPTPAGEGKTTTTVGLGQ
ALAKLGKKAMIALREPSLGPSFGIKGGAAGGGYSQVVPMEDINLHFTGDIHAITAAHNLLAAMIDNHIHHGNELNIDIRT
ITWKRAMDMNDRALREIIVGLGGKANGYPRQDGFIITVASEIMAILCLSHDLMDLKRRLGDIIVAYDKDGSPVTARDLKA
DGAMAVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDVKARFGGL
TPNAAVVVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNKFVFDTEREIEEVRKACDRIG
VDMAVAEVWEKGGEGGIELAEKVIKAADTPSNFRFLYDVNLPIKDKLHIIATEIYGADGVEYTASALKDIANIEKLGLDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRISRGAGFIVALTGDIMTMPGLPKHPAAENIDIDENGRIKGLF

Sequences:

>Translated_555_residues
MKSDIEIAQEAKMLHIRDVAAKLGIEEDYLEYYGKYKAKISPALWDKIKDRKDGKLILVTAITPTPAGEGKTTTTVGLGQ
ALAKLGKKAMIALREPSLGPSFGIKGGAAGGGYSQVVPMEDINLHFTGDIHAITAAHNLLAAMIDNHIHHGNELNIDIRT
ITWKRAMDMNDRALREIIVGLGGKANGYPRQDGFIITVASEIMAILCLSHDLMDLKRRLGDIIVAYDKDGSPVTARDLKA
DGAMAVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDVKARFGGL
TPNAAVVVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNKFVFDTEREIEEVRKACDRIG
VDMAVAEVWEKGGEGGIELAEKVIKAADTPSNFRFLYDVNLPIKDKLHIIATEIYGADGVEYTASALKDIANIEKLGLDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRISRGAGFIVALTGDIMTMPGLPKHPAAENIDIDENGRIKGLF
>Mature_555_residues
MKSDIEIAQEAKMLHIRDVAAKLGIEEDYLEYYGKYKAKISPALWDKIKDRKDGKLILVTAITPTPAGEGKTTTTVGLGQ
ALAKLGKKAMIALREPSLGPSFGIKGGAAGGGYSQVVPMEDINLHFTGDIHAITAAHNLLAAMIDNHIHHGNELNIDIRT
ITWKRAMDMNDRALREIIVGLGGKANGYPRQDGFIITVASEIMAILCLSHDLMDLKRRLGDIIVAYDKDGSPVTARDLKA
DGAMAVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDVKARFGGL
TPNAAVVVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNKFVFDTEREIEEVRKACDRIG
VDMAVAEVWEKGGEGGIELAEKVIKAADTPSNFRFLYDVNLPIKDKLHIIATEIYGADGVEYTASALKDIANIEKLGLDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRISRGAGFIVALTGDIMTMPGLPKHPAAENIDIDENGRIKGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=46.3651050080775, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=47.6575121163166, Blast_Score=497, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=46.7094703049759, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=46.7094703049759, Blast_Score=496, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=45.0793650793651, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=46.24, Blast_Score=495, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=45.6310679611651, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=45.6310679611651, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=45.6310679611651, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=45.6310679611651, Blast_Score=494, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60248; Mature: 60248

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQEAKMLHIRDVAAKLGIEEDYLEYYGKYKAKISPALWDKIKDRKDGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCHHHHHHHCCCCCCCEEEEE
AITPTPAGEGKTTTTVGLGQALAKLGKKAMIALREPSLGPSFGIKGGAAGGGYSQVVPME
EECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDIHAITAAHNLLAAMIDNHIHHGNELNIDIRTITWKRAMDMNDRALREIIVG
CCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHCCCCHHHHHHHHHH
LGGKANGYPRQDGFIITVASEIMAILCLSHDLMDLKRRLGDIIVAYDKDGSPVTARDLKA
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCC
DGAMAVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAG
CCHHHHHHHHHCCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCC
FGADLGAEKFFDVKARFGGLTPNAAVVVATVRALKMHGGVKKEDLQKEDVEAVRRGIENL
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHH
EKQVENVRKFGVPVVVALNKFVFDTEREIEEVRKACDRIGVDMAVAEVWEKGGEGGIELA
HHHHHHHHHHCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHH
EKVIKAADTPSNFRFLYDVNLPIKDKLHIIATEIYGADGVEYTASALKDIANIEKLGLDK
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRISRGAGFIVALTGDIMTMPGLPKHPAA
CCEEEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCEEECCCCCCCCCC
ENIDIDENGRIKGLF
CCCCCCCCCCEECCC
>Mature Secondary Structure
MKSDIEIAQEAKMLHIRDVAAKLGIEEDYLEYYGKYKAKISPALWDKIKDRKDGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCHHHHHHHCCCCCCCEEEEE
AITPTPAGEGKTTTTVGLGQALAKLGKKAMIALREPSLGPSFGIKGGAAGGGYSQVVPME
EECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDIHAITAAHNLLAAMIDNHIHHGNELNIDIRTITWKRAMDMNDRALREIIVG
CCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHCCCCHHHHHHHHHH
LGGKANGYPRQDGFIITVASEIMAILCLSHDLMDLKRRLGDIIVAYDKDGSPVTARDLKA
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCC
DGAMAVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAG
CCHHHHHHHHHCCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCC
FGADLGAEKFFDVKARFGGLTPNAAVVVATVRALKMHGGVKKEDLQKEDVEAVRRGIENL
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHH
EKQVENVRKFGVPVVVALNKFVFDTEREIEEVRKACDRIGVDMAVAEVWEKGGEGGIELA
HHHHHHHHHHCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHH
EKVIKAADTPSNFRFLYDVNLPIKDKLHIIATEIYGADGVEYTASALKDIANIEKLGLDK
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRISRGAGFIVALTGDIMTMPGLPKHPAA
CCEEEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCEEECCCCCCCCCC
ENIDIDENGRIKGLF
CCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA