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The map label for this gene is AccA2 [H]

Identifier: 20808749

GI number: 20808749

Start: 2272499

End: 2274049

Strand: Reverse

Name: AccA2 [H]

Synonym: TTE2385

Alternate gene names: 20808749

Gene position: 2274049-2272499 (Counterclockwise)

Preceding gene: 20808750

Following gene: 20808748

Centisome position: 84.55

GC content: 44.1

Gene sequence:

>1551_bases
ATGAGCGTCCAGGAAAAGATAGAAGAGCTGAAAAAGAGGAGGGCAAAAGCAGAAGAGGGCGGCGGAGAAGCAAGAATTAA
AGCGCAGCACGAAAAGGGGAAGCTCACAGCGAGAGAGAGAATAAATATCCTCCTTGACAAGGGAAGTTTTGTAGAGCTGG
ACCCTTTTGTGGAGCACCGCTGCTATGACTTTGGAATGGAAAAACAAAAGTACCCGGGAGAAGGAGTTGTGACAGGGTAC
GGAACGATTGATGGAAGGCTCGTTTACGTGTATGCTCAAGATTTTACCGTCTTAGGAGGGTCTTTGGGAGAATACCACGC
AAAGAAAATAACAAAAGTCATGGACATGGCTATGAAAATGGGAGCACCCTTAATTGGGCTAAATGACTCGGGAGGAGCCA
GAATACAGGAAGGTGTGGATGCTCTTTCAGGCTACGGCCAAATATTTTACAGAAATACTCTGGCCTCAGGAGTTATACCT
CAGATTTCCGTAATAATGGGCCCCAGTGCAGGAGGAGCAGTGTACTCTCCAGCCCTTACTGACTTTATATTCATGGTAGA
CAAAACCAGCCAGATGTTCATAACAGGCCCTCAAGTGATAAAAGCTGTTACAGGAGAAGAGGTTACTCCAGAAGAGTTAG
GTGGTTCTATCACTCACAACAGAGTGAGCGGAGTTGCTCATTTTAGAGGACCCAATGACGAAGAAGTATTAAAAATGGTC
AGAAAGCTTCTAAGCTACCTCCCTTCAAATAATCTGGAAGACCCACCTCGGTATGAAACGGGAGACGATCCCAACAGGAC
TTCAGAAAGGCTTATGGAAATAGTGCCAGACAATCCTAATAAACCCTATGACATGAAGGAATTGATTAGGGAGATAGTGG
ATAGAGGCGAAATCTTTGAATCACAGGAGATGTACGCAGAAAATATAATTACCGCTTTTGCGAGGTTGAACGGCAGAACC
ATTGGAATTGTCGCCAATCAGCCTAGGGTTTTAGCAGGGGTACTTGATATAAATGCTTCTGACAAGGCAGCGAGGTTTAT
ACGGTTTTGCGATGCCTTCAATATTCCAATATTGAGCATTGTAGATGTTCCAGGTTTTTTACCGGGGACAAATCAAGAGT
ACGGCGGAATAATAAGGCATGGGGCTAAGATGCTTTACGCGTATTCAGAAGCCACAGTTCCAAAAGTCACTCTAATTGTG
AGAAAAGCCTATGGCGGAGCCTATCTTGCTATGTGCAGTAAGGATTTAGGAGCAGATATAGTTTTTGCATGGCCCACTGC
TGAAATTGCAGTTATGGGTCCAGAAGGAGCAGCTAATATAGTGTTTAAAAATGAGATAAACGAAGCGGAAAATCCAGCTG
AAGTAAGAGAGCAGAAAATAAAGGAGTACAGAGAAAATTTTGCAAATCCCTACAGGGCTGCAGCAAGAGGCTATGTGGAC
GATGTGATAATTCCGTCTGAGACAAGGCCGAGACTCATTTCTGCTTTTGAGATGTTAAGAAGTAAAAGAGAAACAAGGCC
AGCTAAGAAGCATGGCAATATTCCTCTATAG

Upstream 100 bases:

>100_bases
GAAGTGAAAGTTGTTGAGCTTTTTCTTCTAGTATGTTATATTATAGTAGGTACTAATAATAACTGCTACTAAAACTTTAT
TTTATTAAGGAGGCGTCTTG

Downstream 100 bases:

>100_bases
GGTGATAAAATATGGAAGGGATTTTAAAATTTTTTAAAAAGGCGTTTGAAGAAGAAAAAAAGCAGGAAATAGAAGAAAGA
GAAGAGGTAAAGGATGAACT

Product: Acetyl-CoA carboxylase alpha subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSVQEKIEELKKRRAKAEEGGGEARIKAQHEKGKLTARERINILLDKGSFVELDPFVEHRCYDFGMEKQKYPGEGVVTGY
GTIDGRLVYVYAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIP
QISVIMGPSAGGAVYSPALTDFIFMVDKTSQMFITGPQVIKAVTGEEVTPEELGGSITHNRVSGVAHFRGPNDEEVLKMV
RKLLSYLPSNNLEDPPRYETGDDPNRTSERLMEIVPDNPNKPYDMKELIREIVDRGEIFESQEMYAENIITAFARLNGRT
IGIVANQPRVLAGVLDINASDKAARFIRFCDAFNIPILSIVDVPGFLPGTNQEYGGIIRHGAKMLYAYSEATVPKVTLIV
RKAYGGAYLAMCSKDLGADIVFAWPTAEIAVMGPEGAANIVFKNEINEAENPAEVREQKIKEYRENFANPYRAAARGYVD
DVIIPSETRPRLISAFEMLRSKRETRPAKKHGNIPL

Sequences:

>Translated_516_residues
MSVQEKIEELKKRRAKAEEGGGEARIKAQHEKGKLTARERINILLDKGSFVELDPFVEHRCYDFGMEKQKYPGEGVVTGY
GTIDGRLVYVYAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIP
QISVIMGPSAGGAVYSPALTDFIFMVDKTSQMFITGPQVIKAVTGEEVTPEELGGSITHNRVSGVAHFRGPNDEEVLKMV
RKLLSYLPSNNLEDPPRYETGDDPNRTSERLMEIVPDNPNKPYDMKELIREIVDRGEIFESQEMYAENIITAFARLNGRT
IGIVANQPRVLAGVLDINASDKAARFIRFCDAFNIPILSIVDVPGFLPGTNQEYGGIIRHGAKMLYAYSEATVPKVTLIV
RKAYGGAYLAMCSKDLGADIVFAWPTAEIAVMGPEGAANIVFKNEINEAENPAEVREQKIKEYRENFANPYRAAARGYVD
DVIIPSETRPRLISAFEMLRSKRETRPAKKHGNIPL
>Mature_515_residues
SVQEKIEELKKRRAKAEEGGGEARIKAQHEKGKLTARERINILLDKGSFVELDPFVEHRCYDFGMEKQKYPGEGVVTGYG
TIDGRLVYVYAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIPQ
ISVIMGPSAGGAVYSPALTDFIFMVDKTSQMFITGPQVIKAVTGEEVTPEELGGSITHNRVSGVAHFRGPNDEEVLKMVR
KLLSYLPSNNLEDPPRYETGDDPNRTSERLMEIVPDNPNKPYDMKELIREIVDRGEIFESQEMYAENIITAFARLNGRTI
GIVANQPRVLAGVLDINASDKAARFIRFCDAFNIPILSIVDVPGFLPGTNQEYGGIIRHGAKMLYAYSEATVPKVTLIVR
KAYGGAYLAMCSKDLGADIVFAWPTAEIAVMGPEGAANIVFKNEINEAENPAEVREQKIKEYRENFANPYRAAARGYVDD
VIIPSETRPRLISAFEMLRSKRETRPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=517, Percent_Identity=60.7350096711799, Blast_Score=628, Evalue=1e-180,
Organism=Homo sapiens, GI295821216, Length=537, Percent_Identity=58.4729981378026, Blast_Score=617, Evalue=1e-176,
Organism=Homo sapiens, GI11545863, Length=505, Percent_Identity=34.8514851485148, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI134142062, Length=400, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679977, Length=394, Percent_Identity=24.3654822335025, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679967, Length=394, Percent_Identity=24.3654822335025, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679974, Length=392, Percent_Identity=24.234693877551, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679971, Length=392, Percent_Identity=24.234693877551, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679960, Length=340, Percent_Identity=25.2941176470588, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788655, Length=197, Percent_Identity=30.4568527918782, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=59.1085271317829, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=59.1085271317829, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17552936, Length=510, Percent_Identity=35.6862745098039, Blast_Score=301, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI71997163, Length=391, Percent_Identity=25.3196930946292, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=371, Percent_Identity=22.911051212938, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=35.0096711798839, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56997; Mature: 56866

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQEKIEELKKRRAKAEEGGGEARIKAQHEKGKLTARERINILLDKGSFVELDPFVEHR
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCCEEEEECCCCEEEECHHHHHH
CYDFGMEKQKYPGEGVVTGYGTIDGRLVYVYAQDFTVLGGSLGEYHAKKITKVMDMAMKM
HHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHH
GAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIPQISVIMGPSAGGAVYSPALT
CCCEEEECCCCCCHHHHHHHHHHCCCHHEEHHHHHHCCCCEEEEEECCCCCCCEECHHHH
DFIFMVDKTSQMFITGPQVIKAVTGEEVTPEELGGSITHNRVSGVAHFRGPNDEEVLKMV
HHHHEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCCCHHHHCCEEECCCCCHHHHHHHH
RKLLSYLPSNNLEDPPRYETGDDPNRTSERLMEIVPDNPNKPYDMKELIREIVDRGEIFE
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHH
SQEMYAENIITAFARLNGRTIGIVANQPRVLAGVLDINASDKAARFIRFCDAFNIPILSI
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
VDVPGFLPGTNQEYGGIIRHGAKMLYAYSEATVPKVTLIVRKAYGGAYLAMCSKDLGADI
ECCCCCCCCCCCHHCHHHHHCHHHEEEECCCCCCEEEEEEEHHCCCEEEEEHHHCCCCCE
VFAWPTAEIAVMGPEGAANIVFKNEINEAENPAEVREQKIKEYRENFANPYRAAARGYVD
EEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
DVIIPSETRPRLISAFEMLRSKRETRPAKKHGNIPL
CEECCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SVQEKIEELKKRRAKAEEGGGEARIKAQHEKGKLTARERINILLDKGSFVELDPFVEHR
CHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCCEEEEECCCCEEEECHHHHHH
CYDFGMEKQKYPGEGVVTGYGTIDGRLVYVYAQDFTVLGGSLGEYHAKKITKVMDMAMKM
HHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHH
GAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIPQISVIMGPSAGGAVYSPALT
CCCEEEECCCCCCHHHHHHHHHHCCCHHEEHHHHHHCCCCEEEEEECCCCCCCEECHHHH
DFIFMVDKTSQMFITGPQVIKAVTGEEVTPEELGGSITHNRVSGVAHFRGPNDEEVLKMV
HHHHEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCCCHHHHCCEEECCCCCHHHHHHHH
RKLLSYLPSNNLEDPPRYETGDDPNRTSERLMEIVPDNPNKPYDMKELIREIVDRGEIFE
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHH
SQEMYAENIITAFARLNGRTIGIVANQPRVLAGVLDINASDKAARFIRFCDAFNIPILSI
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
VDVPGFLPGTNQEYGGIIRHGAKMLYAYSEATVPKVTLIVRKAYGGAYLAMCSKDLGADI
ECCCCCCCCCCCHHCHHHHHCHHHEEEECCCCCCEEEEEEEHHCCCEEEEEHHHCCCCCE
VFAWPTAEIAVMGPEGAANIVFKNEINEAENPAEVREQKIKEYRENFANPYRAAARGYVD
EEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
DVIIPSETRPRLISAFEMLRSKRETRPAKKHGNIPL
CEECCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]