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The map label for this gene is ArgD [H]

Identifier: 20808705

GI number: 20808705

Start: 2223481

End: 2224902

Strand: Reverse

Name: ArgD [H]

Synonym: TTE2339

Alternate gene names: 20808705

Gene position: 2224902-2223481 (Counterclockwise)

Preceding gene: 20808706

Following gene: 20808704

Centisome position: 82.73

GC content: 38.12

Gene sequence:

>1422_bases
ATGGATGAAAAAGTAAAAATAAAAGAGGAAATTCCTGAATACATTACTTTGGAGGAAGCTTTAACTTTAAATAAAAATCA
AGTGAAGGAAAATTATAAGGAGTATATAAATTCAGTTTTTGTATCAATGCTTTCTATGCTTCAATTTGATAAACTTTTTG
TAAGAGCCAAAGGGGTTTCTGTATGGGACAGTGAAGGAAATGAGTATTATGACTTTTTAGGTGGGTATGGTGCCTTAAAT
TTAGGGCACAATCCTGATGAGGTAATTGAAGCAGTTGAAAAAGTGAAGGACATGCCTAACCTTTTGCAGGCTTCTATAGG
GAATCTTCCAGGTGTTCTTGCTCACAACCTTGCAAGAGTTACCCCAGGAAATTTAAAGAGGAGCTTTTTTTGCAACAGCG
GGGCAGAAGCAGTTGAAGGAGCTTTAAAGCTTGCCAAGATTGCATCGGGGAAGAAAAAGATAGTTTACTGCGAGAACTCT
TTTCACGGAAAGTCAATGGGGGCCCTCTCTGTAACCGGTAGAAGAAAATACCAAAAATATTTTGAACCTTTGGTGCCAGA
GACTGTAGCTGTTCCCTTTGGGGATGAAAAAGCGTTGGAGGAAGCTTTAAAAGAGAAAGATGTAGCTGCTTTTATAGTTG
AGCCCATTCAAGGAGAAGGTGGAGTTATCGTGCCGCCTGAGGGGTATTTAAGAAAAGCAAGAGAGCTTTGTACAAAGTAC
GAAGCATATCTCATTGTGGATGAGATACAGACAGGTTTTGGAAGAACAGGAAAAATGTTTGCTTGTGAGCATGAGGAAGT
TGTGCCAGACATAATGACTCTTGCAAAATCTCTAGGTGGAGGAGTTATGCCAATAGGGGCATATATTACCACCGATGAGA
TATGGCAAAAAGCCTATGGTACAATGGAAAAAGCATTACTGCATACTTCTACTTTTGGCGGTAATACCTATGCTTGTGCA
GCTGCGATTGCTTCAATACAAGCTATTATAGAGAAAAAACTTTCTGAGGCTGCCAAAGAAAAGGGTGAATACTTTTTAGG
TCGACTGAAAGAATTAAAAGAAAAACATCCAAAACTTATAAAAGATGTTAGGGGAAAAGGACTTTTGATAGGAATAGAAT
TTAATCAACCGGAAGGAGGGCTTTTAGATAAGCTTTCAGGAGGAGCTATTTCTAAACTTTCAAGTGAATATATAGGCTCT
TTGATTGCGGCAGAGCTACAGAACAAGCATAGAATTATAACGGCTTATACTTTAAACAATCCAAATGTTATAAGATTGGA
ACCGCCTTTAATTGTCACGAAAGAGCAAATTGACAAAGTGGTAGATGCTTTGGATGAAATTTTAACGCGCAATAGCAGTT
TCTTGGGGATAACTGTTTCAGGTGCAAAAACAGTGTTAGGCTCTTTATTTAAAAGACAGTAA

Upstream 100 bases:

>100_bases
AAGAAAGAGTGAAAAGAGAGTTAGACAATCTATTTGCTGATGCTTCTCATCATCACCATCATTGCCATCATCATGAGCAC
TAAGTAAGGGGGAGAGGAAA

Downstream 100 bases:

>100_bases
AGGAGGAAAGCTCTTTGAGCTTAAAAGATTTATTTGAAAAAGGGCTTACTTTTGATGAATTTATAGAGACTTCTGAAGAT
GATATTACAAGACAGCGTAT

Product: PLP-dependent aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MDEKVKIKEEIPEYITLEEALTLNKNQVKENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDSEGNEYYDFLGGYGALN
LGHNPDEVIEAVEKVKDMPNLLQASIGNLPGVLAHNLARVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKKKIVYCENS
FHGKSMGALSVTGRRKYQKYFEPLVPETVAVPFGDEKALEEALKEKDVAAFIVEPIQGEGGVIVPPEGYLRKARELCTKY
EAYLIVDEIQTGFGRTGKMFACEHEEVVPDIMTLAKSLGGGVMPIGAYITTDEIWQKAYGTMEKALLHTSTFGGNTYACA
AAIASIQAIIEKKLSEAAKEKGEYFLGRLKELKEKHPKLIKDVRGKGLLIGIEFNQPEGGLLDKLSGGAISKLSSEYIGS
LIAAELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRNSSFLGITVSGAKTVLGSLFKRQ

Sequences:

>Translated_473_residues
MDEKVKIKEEIPEYITLEEALTLNKNQVKENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDSEGNEYYDFLGGYGALN
LGHNPDEVIEAVEKVKDMPNLLQASIGNLPGVLAHNLARVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKKKIVYCENS
FHGKSMGALSVTGRRKYQKYFEPLVPETVAVPFGDEKALEEALKEKDVAAFIVEPIQGEGGVIVPPEGYLRKARELCTKY
EAYLIVDEIQTGFGRTGKMFACEHEEVVPDIMTLAKSLGGGVMPIGAYITTDEIWQKAYGTMEKALLHTSTFGGNTYACA
AAIASIQAIIEKKLSEAAKEKGEYFLGRLKELKEKHPKLIKDVRGKGLLIGIEFNQPEGGLLDKLSGGAISKLSSEYIGS
LIAAELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRNSSFLGITVSGAKTVLGSLFKRQ
>Mature_473_residues
MDEKVKIKEEIPEYITLEEALTLNKNQVKENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDSEGNEYYDFLGGYGALN
LGHNPDEVIEAVEKVKDMPNLLQASIGNLPGVLAHNLARVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKKKIVYCENS
FHGKSMGALSVTGRRKYQKYFEPLVPETVAVPFGDEKALEEALKEKDVAAFIVEPIQGEGGVIVPPEGYLRKARELCTKY
EAYLIVDEIQTGFGRTGKMFACEHEEVVPDIMTLAKSLGGGVMPIGAYITTDEIWQKAYGTMEKALLHTSTFGGNTYACA
AAIASIQAIIEKKLSEAAKEKGEYFLGRLKELKEKHPKLIKDVRGKGLLIGIEFNQPEGGLLDKLSGGAISKLSSEYIGS
LIAAELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRNSSFLGITVSGAKTVLGSLFKRQ

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=403, Percent_Identity=32.7543424317618, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=33.5384615384615, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI13994255, Length=477, Percent_Identity=30.188679245283, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=30.5687203791469, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=30.5687203791469, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=27.4231678486998, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=30.8860759493671, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI188536080, Length=388, Percent_Identity=24.4845360824742, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38679950, Length=388, Percent_Identity=24.4845360824742, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38679946, Length=388, Percent_Identity=24.4845360824742, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI145693181, Length=445, Percent_Identity=44.0449438202247, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1788044, Length=438, Percent_Identity=34.0182648401827, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=35.6962025316456, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=31.9711538461538, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=29.6037296037296, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786991, Length=305, Percent_Identity=31.4754098360656, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=28.695652173913, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=405, Percent_Identity=34.8148148148148, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI25144274, Length=395, Percent_Identity=32.1518987341772, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=29.9065420560748, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=26.8348623853211, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=472, Percent_Identity=25.635593220339, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71981843, Length=152, Percent_Identity=30.2631578947368, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=34.4339622641509, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324432, Length=420, Percent_Identity=32.8571428571429, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=451, Percent_Identity=25.9423503325942, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=381, Percent_Identity=25.7217847769029, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=33.5731414868106, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=28.8056206088993, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI28574759, Length=481, Percent_Identity=28.8981288981289, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI161085790, Length=471, Percent_Identity=28.6624203821656, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281366494, Length=388, Percent_Identity=23.9690721649485, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667139, Length=388, Percent_Identity=23.9690721649485, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667143, Length=388, Percent_Identity=23.9690721649485, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 51979; Mature: 51979

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKVKIKEEIPEYITLEEALTLNKNQVKENYKEYINSVFVSMLSMLQFDKLFVRAKGVS
CCCCEEHHHHCCHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VWDSEGNEYYDFLGGYGALNLGHNPDEVIEAVEKVKDMPNLLQASIGNLPGVLAHNLARV
EECCCCCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
TPGNLKRSFFCNSGAEAVEGALKLAKIASGKKKIVYCENSFHGKSMGALSVTGRRKYQKY
CCCCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECHHHHHHHH
FEPLVPETVAVPFGDEKALEEALKEKDVAAFIVEPIQGEGGVIVPPEGYLRKARELCTKY
HHCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHHH
EAYLIVDEIQTGFGRTGKMFACEHEEVVPDIMTLAKSLGGGVMPIGAYITTDEIWQKAYG
HHEEEEEHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEECCEEEHHHHHHHHHH
TMEKALLHTSTFGGNTYACAAAIASIQAIIEKKLSEAAKEKGEYFLGRLKELKEKHPKLI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KDVRGKGLLIGIEFNQPEGGLLDKLSGGAISKLSSEYIGSLIAAELQNKHRIITAYTLNN
HHCCCCEEEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
PNVIRLEPPLIVTKEQIDKVVDALDEILTRNSSFLGITVSGAKTVLGSLFKRQ
CCEEEECCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MDEKVKIKEEIPEYITLEEALTLNKNQVKENYKEYINSVFVSMLSMLQFDKLFVRAKGVS
CCCCEEHHHHCCHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VWDSEGNEYYDFLGGYGALNLGHNPDEVIEAVEKVKDMPNLLQASIGNLPGVLAHNLARV
EECCCCCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
TPGNLKRSFFCNSGAEAVEGALKLAKIASGKKKIVYCENSFHGKSMGALSVTGRRKYQKY
CCCCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECHHHHHHHH
FEPLVPETVAVPFGDEKALEEALKEKDVAAFIVEPIQGEGGVIVPPEGYLRKARELCTKY
HHCCCCCEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHHH
EAYLIVDEIQTGFGRTGKMFACEHEEVVPDIMTLAKSLGGGVMPIGAYITTDEIWQKAYG
HHEEEEEHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEECCEEEHHHHHHHHHH
TMEKALLHTSTFGGNTYACAAAIASIQAIIEKKLSEAAKEKGEYFLGRLKELKEKHPKLI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KDVRGKGLLIGIEFNQPEGGLLDKLSGGAISKLSSEYIGSLIAAELQNKHRIITAYTLNN
HHCCCCEEEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
PNVIRLEPPLIVTKEQIDKVVDALDEILTRNSSFLGITVSGAKTVLGSLFKRQ
CCEEEECCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA