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The map label for this gene is FusA2 [H]

Identifier: 20808699

GI number: 20808699

Start: 2214761

End: 2216863

Strand: Reverse

Name: FusA2 [H]

Synonym: TTE2333

Alternate gene names: 20808699

Gene position: 2216863-2214761 (Counterclockwise)

Preceding gene: 20808700

Following gene: 20808698

Centisome position: 82.43

GC content: 40.99

Gene sequence:

>2103_bases
ATGTATAGAATAATAAATATTAAAGACTATTTGCTAAAGAACAGGGGGATAATTATGAAGGATTACAAAACTAGCCAAAT
AAGGAATGTAGGATTAGTTTCCCATGGGGGAGCTGGAAAAACTACACTGGCAGAAGCACTTCTTTTTACCACAAAGGCCA
TCGATAGAATGGGAAGAGTAGAGAATGGCACAACGGTTTCCGATTACGACCCGGAGGAGATTGCAAGGCAAATTTCTATT
TCTACTTCTGTAATTCCCATTGAGTGGAAAGACTGTAAAATTAATATATTAGACATGCCGGGATATTTTGACTTCTACGG
GGAAGTGATGAGCGGTTTGAGGGTTTCAGACAGCGTAGTGATACCTGTGTGCGCTGCATCAGGAGTAGAAGTTGGAACAG
AAAAAGTTTTTGACCTGGCCAAAAAGAGCAAATTGCCTATCATGTTTTTTGTAAACAAGATGGATAGAGAAAATGCGGAT
TTTTTCAAGACTCTAGACCAGTTGAGAGAGAAATTTGGGAACAAAGTAATTCCTCTGGCGTTTCCTATAGGGAAAGAGCA
AAGCTTTACAGGATATGTTGACGTTATTACTCAGAAGGCATACGTTTACGACGAGAAAGGGGTAAAAGAGGCGGAAATAC
CTGCTGACTTAATGGATAAAGTGCTGTCTGCCAGAGAAGAATTAATTGAAAGCGTTGCTGAAAACGATGAAACTTTGATG
GAAAAGTATTTTAACGGCGAAGAATTCACTTTGGAAGAAATAAAAGAAGGGATTAAAGCTGGTATTAAAATGGGAGATTT
GATGCCTGTACTCTGCGGTTCTAGCCTTAAGAACATAGGTGTAGATAATTTGCTCAATGCAATAGTGGAGTTTCTGCCAT
CGCCTTTGGAGATAGAAAGAGAAGGGGAGAAAGTTAAAGAGGATGGCCCTCTCTCTTTAGTAGTTTTCAAAACAATAGCA
GACCCTTATGTGGGCAGGCTTTCAATATTTAAAGTGATTTCTGGGGTTTTGAAGCCAGATACAGTCCTTTTTAATTCTAA
TAAAAAAGCTCAAGAAAAAATTTCACAGATATTCTTTTTAAGAGGTAAAAAGCAAATACCTGCTTCTCAAATAGTTGCTG
GAGATATAGGAGCAGTCTCAAAGCTACAGGTCACTCTCACAGGAGATACTTTGTGCGACCCATCTAATCCTATGGTTCTC
CCTTCCATCGAATTTCCCGTCCCTAATCTGGCTTTAGCAATTGAACCAAAGTCCAAGGGAGATGAAGAGAAAATAAGCAA
TGGGCTTCAGAGATTACAGGAGGAGGACCCCACTTTTAAAGTAGAGAAAAATCTGGAGACAGGGCAAGTGATAGTTTATG
GCATGGGTGAACAGCACATTGAAGTGATTTCCAAAAAGCTCATGAGCAAGTTCGGTGTAGAATGCACTCTTTCTGACCCC
ATTGTTCCATATAGGGAGACTATTAAAGGGAAAGTCAAAGTTGAAGGAAAGCACAAGAAACAGACAGGTGGACACGGTCA
GTACGGCCATGTGTGGATAGAGTTTGAGCCTAATCCCAACAGCGAATTTGAATTTGAGGACAAGATTTTTGGCGGAGCGG
TTCCCAAGCAGTACATCCCAGCGGTAGAAAAGGGTTTGAGGGAGAGCATGAGAGAAGGAGTGCTGGCTAGATACCCTGTT
GTGAATATTAAAGCTACACTGGTGGATGGGTCTTATCATCCAGTAGACTCTTCAGAGTTGGCTTTTAAGATTGCAGCCTC
CATTGCGTTTAAAAAAGGTATGGAACAAGCAAATCCAGTGCTTTTAGAGCCCATCATGAGAGTCGAGGTGATAGTGCCTG
AAGAATATATGGGAGACATCATAGGGGACCTGAACAAGAGAAGGGGAAGAATACTTGGAATGGAAGCCCATGGAGGAATG
GAGATAATTACAGCAGAAGTGCCTTTGGCAGAAATGAATAGGTATGCGACGGATTTACGGTCTTTGACACAAGCAAGAGG
AGATTTTAGAATGAGTTTTGCGCGCTATGAAGAGGCTCCGCCTAACGTTGCTCAGAAAATAATAGAGGAAAGGAAAAAAT
TAAAAGAAAAAGAAGAAGGCTAA

Upstream 100 bases:

>100_bases
AAAATGATGAAGGACGTGATAAAAGATATTGGCTAAGTCTCTGGCTCTGCCAGAGATTTTTTATTAAAAAATTATCAAAA
AAATAAAGGAAAATCTCAAA

Downstream 100 bases:

>100_bases
GCCTGCTTAAGCAGGCTTCTTTTTTCTTGAGGGGAAATAAGGTATAATATAAGAAAACCCTTTTTATTAAGGAGGATTTT
ATGGATCTTAAAAAAGAAGC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MYRIINIKDYLLKNRGIIMKDYKTSQIRNVGLVSHGGAGKTTLAEALLFTTKAIDRMGRVENGTTVSDYDPEEIARQISI
STSVIPIEWKDCKINILDMPGYFDFYGEVMSGLRVSDSVVIPVCAASGVEVGTEKVFDLAKKSKLPIMFFVNKMDRENAD
FFKTLDQLREKFGNKVIPLAFPIGKEQSFTGYVDVITQKAYVYDEKGVKEAEIPADLMDKVLSAREELIESVAENDETLM
EKYFNGEEFTLEEIKEGIKAGIKMGDLMPVLCGSSLKNIGVDNLLNAIVEFLPSPLEIEREGEKVKEDGPLSLVVFKTIA
DPYVGRLSIFKVISGVLKPDTVLFNSNKKAQEKISQIFFLRGKKQIPASQIVAGDIGAVSKLQVTLTGDTLCDPSNPMVL
PSIEFPVPNLALAIEPKSKGDEEKISNGLQRLQEEDPTFKVEKNLETGQVIVYGMGEQHIEVISKKLMSKFGVECTLSDP
IVPYRETIKGKVKVEGKHKKQTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMREGVLARYPV
VNIKATLVDGSYHPVDSSELAFKIAASIAFKKGMEQANPVLLEPIMRVEVIVPEEYMGDIIGDLNKRRGRILGMEAHGGM
EIITAEVPLAEMNRYATDLRSLTQARGDFRMSFARYEEAPPNVAQKIIEERKKLKEKEEG

Sequences:

>Translated_700_residues
MYRIINIKDYLLKNRGIIMKDYKTSQIRNVGLVSHGGAGKTTLAEALLFTTKAIDRMGRVENGTTVSDYDPEEIARQISI
STSVIPIEWKDCKINILDMPGYFDFYGEVMSGLRVSDSVVIPVCAASGVEVGTEKVFDLAKKSKLPIMFFVNKMDRENAD
FFKTLDQLREKFGNKVIPLAFPIGKEQSFTGYVDVITQKAYVYDEKGVKEAEIPADLMDKVLSAREELIESVAENDETLM
EKYFNGEEFTLEEIKEGIKAGIKMGDLMPVLCGSSLKNIGVDNLLNAIVEFLPSPLEIEREGEKVKEDGPLSLVVFKTIA
DPYVGRLSIFKVISGVLKPDTVLFNSNKKAQEKISQIFFLRGKKQIPASQIVAGDIGAVSKLQVTLTGDTLCDPSNPMVL
PSIEFPVPNLALAIEPKSKGDEEKISNGLQRLQEEDPTFKVEKNLETGQVIVYGMGEQHIEVISKKLMSKFGVECTLSDP
IVPYRETIKGKVKVEGKHKKQTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMREGVLARYPV
VNIKATLVDGSYHPVDSSELAFKIAASIAFKKGMEQANPVLLEPIMRVEVIVPEEYMGDIIGDLNKRRGRILGMEAHGGM
EIITAEVPLAEMNRYATDLRSLTQARGDFRMSFARYEEAPPNVAQKIIEERKKLKEKEEG
>Mature_700_residues
MYRIINIKDYLLKNRGIIMKDYKTSQIRNVGLVSHGGAGKTTLAEALLFTTKAIDRMGRVENGTTVSDYDPEEIARQISI
STSVIPIEWKDCKINILDMPGYFDFYGEVMSGLRVSDSVVIPVCAASGVEVGTEKVFDLAKKSKLPIMFFVNKMDRENAD
FFKTLDQLREKFGNKVIPLAFPIGKEQSFTGYVDVITQKAYVYDEKGVKEAEIPADLMDKVLSAREELIESVAENDETLM
EKYFNGEEFTLEEIKEGIKAGIKMGDLMPVLCGSSLKNIGVDNLLNAIVEFLPSPLEIEREGEKVKEDGPLSLVVFKTIA
DPYVGRLSIFKVISGVLKPDTVLFNSNKKAQEKISQIFFLRGKKQIPASQIVAGDIGAVSKLQVTLTGDTLCDPSNPMVL
PSIEFPVPNLALAIEPKSKGDEEKISNGLQRLQEEDPTFKVEKNLETGQVIVYGMGEQHIEVISKKLMSKFGVECTLSDP
IVPYRETIKGKVKVEGKHKKQTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMREGVLARYPV
VNIKATLVDGSYHPVDSSELAFKIAASIAFKKGMEQANPVLLEPIMRVEVIVPEEYMGDIIGDLNKRRGRILGMEAHGGM
EIITAEVPLAEMNRYATDLRSLTQARGDFRMSFARYEEAPPNVAQKIIEERKKLKEKEEG

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=712, Percent_Identity=33.9887640449438, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI19923640, Length=715, Percent_Identity=30.4895104895105, Blast_Score=326, Evalue=5e-89,
Organism=Homo sapiens, GI25306287, Length=715, Percent_Identity=28.6713286713287, Blast_Score=287, Evalue=3e-77,
Organism=Homo sapiens, GI25306283, Length=444, Percent_Identity=31.3063063063063, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI217272894, Length=135, Percent_Identity=34.0740740740741, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI217272892, Length=135, Percent_Identity=34.0740740740741, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI157426893, Length=158, Percent_Identity=31.6455696202532, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI94966754, Length=144, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=32, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789738, Length=697, Percent_Identity=44.1893830703013, Blast_Score=576, Evalue=1e-165,
Organism=Escherichia coli, GI1790835, Length=459, Percent_Identity=27.8867102396514, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI48994988, Length=169, Percent_Identity=33.7278106508876, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17533571, Length=698, Percent_Identity=34.2406876790831, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17556745, Length=714, Percent_Identity=25.3501400560224, Blast_Score=238, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17506493, Length=834, Percent_Identity=24.7002398081535, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557151, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=700, Percent_Identity=32.7142857142857, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322359, Length=787, Percent_Identity=27.0648030495553, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324707, Length=830, Percent_Identity=23.4939759036145, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320593, Length=830, Percent_Identity=23.4939759036145, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24582462, Length=690, Percent_Identity=37.3913043478261, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI221458488, Length=705, Percent_Identity=27.0921985815603, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24585709, Length=842, Percent_Identity=23.7529691211401, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585711, Length=842, Percent_Identity=23.7529691211401, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585713, Length=842, Percent_Identity=23.7529691211401, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI78706572, Length=152, Percent_Identity=32.8947368421053, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 77975; Mature: 77975

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRIINIKDYLLKNRGIIMKDYKTSQIRNVGLVSHGGAGKTTLAEALLFTTKAIDRMGRV
CEEEEEHHHHHHHCCCEEEECCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC
ENGTTVSDYDPEEIARQISISTSVIPIEWKDCKINILDMPGYFDFYGEVMSGLRVSDSVV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCEE
IPVCAASGVEVGTEKVFDLAKKSKLPIMFFVNKMDRENADFFKTLDQLREKFGNKVIPLA
EEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
FPIGKEQSFTGYVDVITQKAYVYDEKGVKEAEIPADLMDKVLSAREELIESVAENDETLM
ECCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
EKYFNGEEFTLEEIKEGIKAGIKMGDLMPVLCGSSLKNIGVDNLLNAIVEFLPSPLEIER
HHHCCCCCEEHHHHHHHHHHCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCCCCCEECC
EGEKVKEDGPLSLVVFKTIADPYVGRLSIFKVISGVLKPDTVLFNSNKKAQEKISQIFFL
CCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
RGKKQIPASQIVAGDIGAVSKLQVTLTGDTLCDPSNPMVLPSIEFPVPNLALAIEPKSKG
CCCCCCCHHHEEECCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCCCCC
DEEKISNGLQRLQEEDPTFKVEKNLETGQVIVYGMGEQHIEVISKKLMSKFGVECTLSDP
CHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCC
IVPYRETIKGKVKVEGKHKKQTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIP
CCCHHHCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCCHHHHH
AVEKGLRESMREGVLARYPVVNIKATLVDGSYHPVDSSELAFKIAASIAFKKGMEQANPV
HHHHHHHHHHHCCCEEECCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
LLEPIMRVEVIVPEEYMGDIIGDLNKRRGRILGMEAHGGMEIITAEVPLAEMNRYATDLR
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHH
SLTQARGDFRMSFARYEEAPPNVAQKIIEERKKLKEKEEG
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYRIINIKDYLLKNRGIIMKDYKTSQIRNVGLVSHGGAGKTTLAEALLFTTKAIDRMGRV
CEEEEEHHHHHHHCCCEEEECCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC
ENGTTVSDYDPEEIARQISISTSVIPIEWKDCKINILDMPGYFDFYGEVMSGLRVSDSVV
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCEE
IPVCAASGVEVGTEKVFDLAKKSKLPIMFFVNKMDRENADFFKTLDQLREKFGNKVIPLA
EEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
FPIGKEQSFTGYVDVITQKAYVYDEKGVKEAEIPADLMDKVLSAREELIESVAENDETLM
ECCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
EKYFNGEEFTLEEIKEGIKAGIKMGDLMPVLCGSSLKNIGVDNLLNAIVEFLPSPLEIER
HHHCCCCCEEHHHHHHHHHHCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCCCCCEECC
EGEKVKEDGPLSLVVFKTIADPYVGRLSIFKVISGVLKPDTVLFNSNKKAQEKISQIFFL
CCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
RGKKQIPASQIVAGDIGAVSKLQVTLTGDTLCDPSNPMVLPSIEFPVPNLALAIEPKSKG
CCCCCCCHHHEEECCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCCCCC
DEEKISNGLQRLQEEDPTFKVEKNLETGQVIVYGMGEQHIEVISKKLMSKFGVECTLSDP
CHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCC
IVPYRETIKGKVKVEGKHKKQTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIP
CCCHHHCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCCHHHHH
AVEKGLRESMREGVLARYPVVNIKATLVDGSYHPVDSSELAFKIAASIAFKKGMEQANPV
HHHHHHHHHHHCCCEEECCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
LLEPIMRVEVIVPEEYMGDIIGDLNKRRGRILGMEAHGGMEIITAEVPLAEMNRYATDLR
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHH
SLTQARGDFRMSFARYEEAPPNVAQKIIEERKKLKEKEEG
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA