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The map label for this gene is acpS

Identifier: 20808555

GI number: 20808555

Start: 2091226

End: 2091609

Strand: Reverse

Name: acpS

Synonym: TTE2171

Alternate gene names: 20808555

Gene position: 2091609-2091226 (Counterclockwise)

Preceding gene: 20808556

Following gene: 20808554

Centisome position: 77.77

GC content: 38.02

Gene sequence:

>384_bases
ATGGAAATTTTTGTTGGAACAGACATAATGGAAGTAGAAAGGATAAAAAAAATATTGGAGAAAAGGCCGCATTTTCTTGA
AAGAATTTTTACGGAAAAGGAAAGGGAGTTTTTAAGGAAAAAGAAAAACCCATGGCCCCACTTAGCAGGATTTTTTTCAG
CAAAAGAGAGCGTTTCAAAAGTTTTGGGGACGGGGATAAGAGGATTTAGTTGGCAGGACATAGAGATAATACACAATGAG
TACGGTAAGCCCGAAGTCGTACTAAAAGGAAAGGCTAAGGCTATAGCAGCAGAAAAAGGGATAAAAGAGATAAAATTGTC
CATTTCTCATACCTCTGATTATGCGATGAGCGTTGCTATTGCAGTAGGAGGTGAAAACAGTTGA

Upstream 100 bases:

>100_bases
TGGCGATTTAAAAGAAGGTGTTACGCCTTCTTTTTTTTTGAAGGAATTTGCGAAATAAAAGAGAATAATATTATTGGAGA
TTTACTGTTGGAGGGATGAG

Downstream 100 bases:

>100_bases
TAGTGTTAACATCGCAACAGATGAGGGAAGTTGAGAGGATAGCTATAGAAAAGATGGGGATTCCTTCTATATGCTTGATG
GAAAATGCCGGAAAAGAAGT

Product: 4'-phosphopantetheinyl transferase

Products: NA

Alternate protein names: Holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSKVLGTGIRGFSWQDIEIIHNE
YGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAIAVGGENS

Sequences:

>Translated_127_residues
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSKVLGTGIRGFSWQDIEIIHNE
YGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAIAVGGENS
>Mature_127_residues
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSKVLGTGIRGFSWQDIEIIHNE
YGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAIAVGGENS

Specific function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein

COG id: COG0736

COG function: function code I; Phosphopantetheinyl transferase (holo-ACP synthase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. AcpS family

Homologues:

Organism=Escherichia coli, GI1788916, Length=118, Percent_Identity=30.5084745762712, Blast_Score=66, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325025, Length=115, Percent_Identity=37.3913043478261, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACPS_THETN (Q8R857)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623726.1
- ProteinModelPortal:   Q8R857
- SMR:   Q8R857
- GeneID:   997491
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2171
- NMPDR:   fig|273068.3.peg.2314
- HOGENOM:   HBG734479
- OMA:   NSSAIAY
- ProtClustDB:   PRK00070
- BioCyc:   TTEN273068:TTE2171-MONOMER
- BRENDA:   2.7.8.7
- GO:   GO:0005737
- HAMAP:   MF_00101
- InterPro:   IPR008278
- InterPro:   IPR002582
- InterPro:   IPR004568
- ProDom:   PD004282
- TIGRFAMs:   TIGR00516
- TIGRFAMs:   TIGR00556

Pfam domain/function: PF01648 ACPS; SSF56214 4-PPT_transf

EC number: =2.7.8.7

Molecular weight: Translated: 14386; Mature: 14386

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSK
CEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VLGTGIRGFSWQDIEIIHNEYGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAI
HHHCCCCCCCCCHHHHEECCCCCCEEEECCCHHHHHHHCCHHHHEEEECCCCCCEEEEEE
AVGGENS
EECCCCC
>Mature Secondary Structure
MEIFVGTDIMEVERIKKILEKRPHFLERIFTEKEREFLRKKKNPWPHLAGFFSAKESVSK
CEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VLGTGIRGFSWQDIEIIHNEYGKPEVVLKGKAKAIAAEKGIKEIKLSISHTSDYAMSVAI
HHHCCCCCCCCCHHHHEECCCCCCEEEECCCHHHHHHHCCHHHHEEEECCCCCCEEEEEE
AVGGENS
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336