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The map label for this gene is HisI

Identifier: 20808522

GI number: 20808522

Start: 2049493

End: 2050110

Strand: Reverse

Name: HisI

Synonym: TTE2132

Alternate gene names: 20808522

Gene position: 2050110-2049493 (Counterclockwise)

Preceding gene: 20808523

Following gene: 20808518

Centisome position: 76.23

GC content: 33.5

Gene sequence:

>618_bases
ATGATTGACATAAAAGAGCTTAAGTTTGACGAAAAGGGTCTTATACCGGCAATTGTGCAAGATTATTACACAAAGCAGGT
TTTAATGCTTGCATATATGAATGAGGAGAGTTTGAAGCTTACATTAGAAAAAGGAGAGACATATTTTTTTAGTAGAAGCA
GAGGCAAGATATGGCACAAGGGGGAAACCTCAGGGAATACGCAGAAGGTAAAAAAGATATTTTATGACTGCGATGAAGAT
GCTCTTTTAATTCAAGTAGAAGCAAAAGGCCCTGCCTGTCATACAGGCAATATAAGCTGTTTTTATAGAAGTTTCGATGA
AGAAACTGAAGATGGCATAGAGATTCTAAATAAGCTTTATGAAAGGATAAAAGGCAGAAAAATAAACCCTGTAGAAGGAT
CCTATACAAACTATCTCTTTGAAAAAGGCATAGACAAAATATTAAAAAAAGTTGGAGAGGAAGCTACAGAAGTGGTTATC
GCTTCGAAAAATGATTCAAAAGATGAGATAGTGTATGAAGTATCTGACCTAATTTATCATTTGATGGTGCTTTTGGTTGA
GAAAAATATTACATTAAATGACATATACAATGAACTTGAAAGGCGATATAAAAAATAA

Upstream 100 bases:

>100_bases
CTTCTGTATTTCACTATGGAGAGCTTGATATAAAAGAGTTGAAAAGATATTTAAAGGATGAGGGTATACCGGTAAGATTG
TAGGAGAAAGGATGTAGAGG

Downstream 100 bases:

>100_bases
TCAGACAAAAGGAACCGTCCCTTTTGTCTGTCACCATGTACGGAGTGGAGAGTAACTATTTGAAAAAGGTCTACGCGTTT
ATTGGCAATGAAGAAGTGGT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIDIKELKFDEKGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHKGETSGNTQKVKKIFYDCDED
ALLIQVEAKGPACHTGNISCFYRSFDEETEDGIEILNKLYERIKGRKINPVEGSYTNYLFEKGIDKILKKVGEEATEVVI
ASKNDSKDEIVYEVSDLIYHLMVLLVEKNITLNDIYNELERRYKK

Sequences:

>Translated_205_residues
MIDIKELKFDEKGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHKGETSGNTQKVKKIFYDCDED
ALLIQVEAKGPACHTGNISCFYRSFDEETEDGIEILNKLYERIKGRKINPVEGSYTNYLFEKGIDKILKKVGEEATEVVI
ASKNDSKDEIVYEVSDLIYHLMVLLVEKNITLNDIYNELERRYKK
>Mature_205_residues
MIDIKELKFDEKGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHKGETSGNTQKVKKIFYDCDED
ALLIQVEAKGPACHTGNISCFYRSFDEETEDGIEILNKLYERIKGRKINPVEGSYTNYLFEKGIDKILKKVGEEATEVVI
ASKNDSKDEIVYEVSDLIYHLMVLLVEKNITLNDIYNELERRYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=201, Percent_Identity=40.7960199004975, Blast_Score=154, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6319819, Length=196, Percent_Identity=35.7142857142857, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_THETN (Q8R886)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623693.1
- ProteinModelPortal:   Q8R886
- SMR:   Q8R886
- GeneID:   997442
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2132
- NMPDR:   fig|273068.3.peg.2236
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- ProtClustDB:   PRK02759
- BioCyc:   TTEN273068:TTE2132-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 23865; Mature: 23865

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIKELKFDEKGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHK
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEEECCCEEEEECCCCCEEEC
GETSGNTQKVKKIFYDCDEDALLIQVEAKGPACHTGNISCFYRSFDEETEDGIEILNKLY
CCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ERIKGRKINPVEGSYTNYLFEKGIDKILKKVGEEATEVVIASKNDSKDEIVYEVSDLIYH
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCHHHHHHHHHHHHH
LMVLLVEKNITLNDIYNELERRYKK
HHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDIKELKFDEKGLIPAIVQDYYTKQVLMLAYMNEESLKLTLEKGETYFFSRSRGKIWHK
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEEECCCEEEEECCCCCEEEC
GETSGNTQKVKKIFYDCDEDALLIQVEAKGPACHTGNISCFYRSFDEETEDGIEILNKLY
CCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ERIKGRKINPVEGSYTNYLFEKGIDKILKKVGEEATEVVIASKNDSKDEIVYEVSDLIYH
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCHHHHHHHHHHHHH
LMVLLVEKNITLNDIYNELERRYKK
HHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336