Click here to switch to the map view.

The map label for this gene is hgdC [H]

Identifier: 20808394

GI number: 20808394

Start: 1939129

End: 1940112

Strand: Reverse

Name: hgdC [H]

Synonym: TTE1991

Alternate gene names: 20808394

Gene position: 1940112-1939129 (Counterclockwise)

Preceding gene: 20808396

Following gene: 20808392

Centisome position: 72.14

GC content: 42.58

Gene sequence:

>984_bases
ATGGAAGGTTACATGGGAATAGACGTGGGGTCAGTCAGCACAAATATTGCTGTCATTGATGAGGAGAACAATGTCATAGA
TTATGTCTACATAAGGACCAGAGGGCAGCCGATAAAAGCTGTTCAAGAAGCTTTGAGGGAAATAAAAGAAAAAATAGGCG
ATGTAGAGATTAAAGGAGTCGGCACTACTGGAAGTGCCAGGCAGTTAACAGGGCTTATGGTAGGAGCGGATATTGTAAAA
AATGAGATTACTGCTCATGCGGTGGCTGCTTCCAGCATAGTAAAGGATGTAAGGACAGTGATTGAGATTGGCGGGCAGGA
CTCAAAGATAATAATTTTGCGAAATGGCGTTGTAGTGGATTTTGCAATGAATACAGTATGTGCGGCTGGAACCGGGTCAT
TTTTAGACCAACAGGCTTACAGATTAAATATACCAATTGAGGAATTTGGAGATTTGGCACTAAAATCCAAAAACCCTGTA
AGGATTGCAGGAAGGTGTAGCGTATTTGCAGAGTCCGACATGATTCACAAACAGCAGATGGGATATGCCCTTCCTGACAT
AATAAGCGGCTTGTGTGACGCCTTAGTGAGGAATTATCTGAACAATGTGGGAAAAGGAAAGGATATTAAGGAGCCCATTG
TATTTCAGGGAGGTGTCGCTGCCAACAAAGGAATAAAAGCTGCATTTGAAAAGGCTTTGGGAATGAAGGTATATGTTCCC
AAATACTACGGTGTTATGGGGGCGATTGGCGCAGCGATATTGGCAAAAGATGCAGTCAAAGAAAAAGGTTACACTTCATT
TAAAGGCTTTGAAGTAAGCGATTTGGAGTACAAAGCGTTAGGGTTCGAGTGCACCGCTTGTCCCAATCACTGTGAGGTAG
TAGAATTTATACAGGGAGATGAAGTTATTTCCAGATGGGGAGATAAGTGCGGAAGGTGGTCTAATAGTCCAAGCAAAAAA
ATTCACGCAGGTTCTATAGTTTAG

Upstream 100 bases:

>100_bases
TTTTGCTTATTGATGGGATTTATTCGCAAAACTTCAAAAGTATAAAAAATGATTTTGAAGGCAAAAATGTAAAATAAATG
AACTGTTTAGGAGGTTTAAT

Downstream 100 bases:

>100_bases
CCCGACGCCTTTGTAAATTAGGTGTCGGGCTATATGATTTCTATCACATCTCCGGGATGAAGCAAATCAGTGTAGGAGGC
TTTCTTGCCATTTATTTTCA

Product: 2-hydroxyglutaryl-CoA dehydratase activator

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MEGYMGIDVGSVSTNIAVIDEENNVIDYVYIRTRGQPIKAVQEALREIKEKIGDVEIKGVGTTGSARQLTGLMVGADIVK
NEITAHAVAASSIVKDVRTVIEIGGQDSKIIILRNGVVVDFAMNTVCAAGTGSFLDQQAYRLNIPIEEFGDLALKSKNPV
RIAGRCSVFAESDMIHKQQMGYALPDIISGLCDALVRNYLNNVGKGKDIKEPIVFQGGVAANKGIKAAFEKALGMKVYVP
KYYGVMGAIGAAILAKDAVKEKGYTSFKGFEVSDLEYKALGFECTACPNHCEVVEFIQGDEVISRWGDKCGRWSNSPSKK
IHAGSIV

Sequences:

>Translated_327_residues
MEGYMGIDVGSVSTNIAVIDEENNVIDYVYIRTRGQPIKAVQEALREIKEKIGDVEIKGVGTTGSARQLTGLMVGADIVK
NEITAHAVAASSIVKDVRTVIEIGGQDSKIIILRNGVVVDFAMNTVCAAGTGSFLDQQAYRLNIPIEEFGDLALKSKNPV
RIAGRCSVFAESDMIHKQQMGYALPDIISGLCDALVRNYLNNVGKGKDIKEPIVFQGGVAANKGIKAAFEKALGMKVYVP
KYYGVMGAIGAAILAKDAVKEKGYTSFKGFEVSDLEYKALGFECTACPNHCEVVEFIQGDEVISRWGDKCGRWSNSPSKK
IHAGSIV
>Mature_327_residues
MEGYMGIDVGSVSTNIAVIDEENNVIDYVYIRTRGQPIKAVQEALREIKEKIGDVEIKGVGTTGSARQLTGLMVGADIVK
NEITAHAVAASSIVKDVRTVIEIGGQDSKIIILRNGVVVDFAMNTVCAAGTGSFLDQQAYRLNIPIEEFGDLALKSKNPV
RIAGRCSVFAESDMIHKQQMGYALPDIISGLCDALVRNYLNNVGKGKDIKEPIVFQGGVAANKGIKAAFEKALGMKVYVP
KYYGVMGAIGAAILAKDAVKEKGYTSFKGFEVSDLEYKALGFECTACPNHCEVVEFIQGDEVISRWGDKCGRWSNSPSKK
IHAGSIV

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=257, Percent_Identity=32.6848249027237, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 35206; Mature: 35206

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGYMGIDVGSVSTNIAVIDEENNVIDYVYIRTRGQPIKAVQEALREIKEKIGDVEIKGV
CCCCEEEEECCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEE
GTTGSARQLTGLMVGADIVKNEITAHAVAASSIVKDVRTVIEIGGQDSKIIILRNGVVVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEE
FAMNTVCAAGTGSFLDQQAYRLNIPIEEFGDLALKSKNPVRIAGRCSVFAESDMIHKQQM
EEHHHHHHCCCCHHHCCCCEEEECCHHHHCCEEECCCCCEEEEEEEEEEECCHHHHHHHC
GYALPDIISGLCDALVRNYLNNVGKGKDIKEPIVFQGGVAANKGIKAAFEKALGMKVYVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCEEECC
KYYGVMGAIGAAILAKDAVKEKGYTSFKGFEVSDLEYKALGFECTACPNHCEVVEFIQGD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECEEEECCCCHHHHHHHHCCH
EVISRWGDKCGRWSNSPSKKIHAGSIV
HHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEGYMGIDVGSVSTNIAVIDEENNVIDYVYIRTRGQPIKAVQEALREIKEKIGDVEIKGV
CCCCEEEEECCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEE
GTTGSARQLTGLMVGADIVKNEITAHAVAASSIVKDVRTVIEIGGQDSKIIILRNGVVVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEE
FAMNTVCAAGTGSFLDQQAYRLNIPIEEFGDLALKSKNPVRIAGRCSVFAESDMIHKQQM
EEHHHHHHCCCCHHHCCCCEEEECCHHHHCCEEECCCCCEEEEEEEEEEECCHHHHHHHC
GYALPDIISGLCDALVRNYLNNVGKGKDIKEPIVFQGGVAANKGIKAAFEKALGMKVYVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCEEECC
KYYGVMGAIGAAILAKDAVKEKGYTSFKGFEVSDLEYKALGFECTACPNHCEVVEFIQGD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECEEEECCCCHHHHHHHHCCH
EVISRWGDKCGRWSNSPSKKIHAGSIV
HHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]