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The map label for this gene is pgi

Identifier: 20808223

GI number: 20808223

Start: 1752204

End: 1753559

Strand: Reverse

Name: pgi

Synonym: TTE1806

Alternate gene names: 20808223

Gene position: 1753559-1752204 (Counterclockwise)

Preceding gene: 20808226

Following gene: 20808221

Centisome position: 65.2

GC content: 38.35

Gene sequence:

>1356_bases
ATGAAAAAGCTGATAAGTTTTGATTATTCAAAAGCTTTGCCTTTTATTCACCCTCACGAGATTGAGTATATGGAAAAACA
TGCTAAATTATCTCTAGAGATGGTGTTGAAGGCAAATGCCCAAGGCAATGGCTTTTTGGGATGGGTAAATTTGCCTAGAG
ACTATGATAGGGCAGAGTTTGAAAGGATTAAAAAGGCAGCGCATAAAATTCAGTCCGATTCTGATGTCTTGGTAGTTATA
GGGATAGGAGGTTCTTATTTAGGTGCTAGAGCTGCCATTGAGATGCTGTCCCACTCTTTCTATAACCTACTTCCAAAGGG
TAAAAGAAACACGCCAGAAATATACTTTGCAGGCAATAGCATAAGTTCTACCTACTTAAAGGACCTTCTAGAGCTCATAG
CGGACAAAGAAGTCTCTATAAATGTGATTTCAAAATCTGGCACGACAACAGAACCTGCAATAGCTTTTAGAGTATTCAGA
GATTTTATGGAGAAAAAATACGGCAAAGATAAGGCCAGGTCTAGAATATATGTTACTACAGATAGAGAAAAAGGTGCTTT
GAAAAAATTAGCTGATTCCGAAGGGTATGAGACTTTTGTGATACCTGATGATGTAGGGGGAAGGTATTCTGTACTCACCG
CAGTAGGACTTTTGCCTATAGCAGTAGCGGGTATAAATATAGACGAAATGATGGAAGGAGCATATGAGGCTTCAACTGTA
TACACAAAGGAAGATTTAAGTGAGAATATAAGCATGCAGTATGCTATTTTGAGGAATATTCTTTACAGAAAAGGGAAAGC
CATAGAGATACTGGTAAATTACGAACCAAGACTTCACTATTTTGCTGAATGGTGGAAACAGTTATTTGGCGAAAGCGAGG
GAAAAGACCAAAAAGGGATTTACCCTGCTTCTGTAGATTTTACTACTGACCTTCATTCTATGGGACAGTTCATACAGGAA
GGCAGCAGAAACATATTTGAGACTGTATTAAATGTGGAGAAACCTGCGAAAGATATCATCATAAACGAAGATAGAGACAA
CATAGATGGGCTTAACTTCCTGGCAGGGAAGACGATAGATTTTGTAAACAAAAAAGCTTTTGAGGGGACGCTTCTTGCTC
ATACAGACGGAGGAGTGCCCAATTTAGTGGTTAACATTCCAGAAATAACTCCTTTCTACTTTGGAAATTTAGTTTACTTC
TTTGAAATGGCTTGTGCAATAAGCGGATATATAAATGGCGTTAATCCTTTTGACCAGCCGGGAGTAGAAGCTTATAAGAA
AAACATGTTTGCACTTTTAGGAAGACCAGGATTTGAAAAAGAAAGGGAAGAACTAGAAAGGAGATTAAGAGGATAG

Upstream 100 bases:

>100_bases
AAAAAAGATTGTGAGAGGAATTAACTTTGCTAAACTTGTGCAATATAGTTTTATGGTATAAAATTATTATGTAAATAAAA
GAAAATGGAGGTTTACATAT

Downstream 100 bases:

>100_bases
TAAAAAGTCCGGGCATTCACCCGGACTTTTTATTTGGTATACATGAGGTCATAATATTCTTGAAGCATTCTGTTTGCAGA
AAAGGCTTCAAAAGTAGTTC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKKLISFDYSKALPFIHPHEIEYMEKHAKLSLEMVLKANAQGNGFLGWVNLPRDYDRAEFERIKKAAHKIQSDSDVLVVI
GIGGSYLGARAAIEMLSHSFYNLLPKGKRNTPEIYFAGNSISSTYLKDLLELIADKEVSINVISKSGTTTEPAIAFRVFR
DFMEKKYGKDKARSRIYVTTDREKGALKKLADSEGYETFVIPDDVGGRYSVLTAVGLLPIAVAGINIDEMMEGAYEASTV
YTKEDLSENISMQYAILRNILYRKGKAIEILVNYEPRLHYFAEWWKQLFGESEGKDQKGIYPASVDFTTDLHSMGQFIQE
GSRNIFETVLNVEKPAKDIIINEDRDNIDGLNFLAGKTIDFVNKKAFEGTLLAHTDGGVPNLVVNIPEITPFYFGNLVYF
FEMACAISGYINGVNPFDQPGVEAYKKNMFALLGRPGFEKEREELERRLRG

Sequences:

>Translated_451_residues
MKKLISFDYSKALPFIHPHEIEYMEKHAKLSLEMVLKANAQGNGFLGWVNLPRDYDRAEFERIKKAAHKIQSDSDVLVVI
GIGGSYLGARAAIEMLSHSFYNLLPKGKRNTPEIYFAGNSISSTYLKDLLELIADKEVSINVISKSGTTTEPAIAFRVFR
DFMEKKYGKDKARSRIYVTTDREKGALKKLADSEGYETFVIPDDVGGRYSVLTAVGLLPIAVAGINIDEMMEGAYEASTV
YTKEDLSENISMQYAILRNILYRKGKAIEILVNYEPRLHYFAEWWKQLFGESEGKDQKGIYPASVDFTTDLHSMGQFIQE
GSRNIFETVLNVEKPAKDIIINEDRDNIDGLNFLAGKTIDFVNKKAFEGTLLAHTDGGVPNLVVNIPEITPFYFGNLVYF
FEMACAISGYINGVNPFDQPGVEAYKKNMFALLGRPGFEKEREELERRLRG
>Mature_451_residues
MKKLISFDYSKALPFIHPHEIEYMEKHAKLSLEMVLKANAQGNGFLGWVNLPRDYDRAEFERIKKAAHKIQSDSDVLVVI
GIGGSYLGARAAIEMLSHSFYNLLPKGKRNTPEIYFAGNSISSTYLKDLLELIADKEVSINVISKSGTTTEPAIAFRVFR
DFMEKKYGKDKARSRIYVTTDREKGALKKLADSEGYETFVIPDDVGGRYSVLTAVGLLPIAVAGINIDEMMEGAYEASTV
YTKEDLSENISMQYAILRNILYRKGKAIEILVNYEPRLHYFAEWWKQLFGESEGKDQKGIYPASVDFTTDLHSMGQFIQE
GSRNIFETVLNVEKPAKDIIINEDRDNIDGLNFLAGKTIDFVNKKAFEGTLLAHTDGGVPNLVVNIPEITPFYFGNLVYF
FEMACAISGYINGVNPFDQPGVEAYKKNMFALLGRPGFEKEREELERRLRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=447, Percent_Identity=24.1610738255034, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790457, Length=386, Percent_Identity=26.1658031088083, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996703, Length=392, Percent_Identity=25.2551020408163, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71996708, Length=392, Percent_Identity=25.2551020408163, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319673, Length=375, Percent_Identity=26.1333333333333, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24651916, Length=384, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24651914, Length=384, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737445, Length=384, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_THETN (Q8R924)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623394.1
- ProteinModelPortal:   Q8R924
- SMR:   Q8R924
- GeneID:   996986
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1806
- NMPDR:   fig|273068.3.peg.1336
- HOGENOM:   HBG615843
- OMA:   KACAMSA
- ProtClustDB:   PRK14097
- BioCyc:   TTEN273068:TTE1806-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 50872; Mature: 50872

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 291-291 ACT_SITE 312-312 ACT_SITE 426-426

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLISFDYSKALPFIHPHEIEYMEKHAKLSLEMVLKANAQGNGFLGWVNLPRDYDRAEF
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEECCCCCCCHHHH
ERIKKAAHKIQSDSDVLVVIGIGGSYLGARAAIEMLSHSFYNLLPKGKRNTPEIYFAGNS
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
ISSTYLKDLLELIADKEVSINVISKSGTTTEPAIAFRVFRDFMEKKYGKDKARSRIYVTT
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
DREKGALKKLADSEGYETFVIPDDVGGRYSVLTAVGLLPIAVAGINIDEMMEGAYEASTV
CCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHEE
YTKEDLSENISMQYAILRNILYRKGKAIEILVNYEPRLHYFAEWWKQLFGESEGKDQKGI
EEHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
YPASVDFTTDLHSMGQFIQEGSRNIFETVLNVEKPAKDIIINEDRDNIDGLNFLAGKTID
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHCCCHH
FVNKKAFEGTLLAHTDGGVPNLVVNIPEITPFYFGNLVYFFEMACAISGYINGVNPFDQP
HHHHHHCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVEAYKKNMFALLGRPGFEKEREELERRLRG
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLISFDYSKALPFIHPHEIEYMEKHAKLSLEMVLKANAQGNGFLGWVNLPRDYDRAEF
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEECCCCCCCHHHH
ERIKKAAHKIQSDSDVLVVIGIGGSYLGARAAIEMLSHSFYNLLPKGKRNTPEIYFAGNS
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
ISSTYLKDLLELIADKEVSINVISKSGTTTEPAIAFRVFRDFMEKKYGKDKARSRIYVTT
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
DREKGALKKLADSEGYETFVIPDDVGGRYSVLTAVGLLPIAVAGINIDEMMEGAYEASTV
CCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHEE
YTKEDLSENISMQYAILRNILYRKGKAIEILVNYEPRLHYFAEWWKQLFGESEGKDQKGI
EEHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
YPASVDFTTDLHSMGQFIQEGSRNIFETVLNVEKPAKDIIINEDRDNIDGLNFLAGKTID
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHCCCHH
FVNKKAFEGTLLAHTDGGVPNLVVNIPEITPFYFGNLVYFFEMACAISGYINGVNPFDQP
HHHHHHCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVEAYKKNMFALLGRPGFEKEREELERRLRG
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336