Click here to switch to the map view.

The map label for this gene is HtpX2

Identifier: 20808211

GI number: 20808211

Start: 1739943

End: 1740842

Strand: Reverse

Name: HtpX2

Synonym: TTE1794

Alternate gene names: 20808211

Gene position: 1740842-1739943 (Counterclockwise)

Preceding gene: 20808212

Following gene: 20808210

Centisome position: 64.73

GC content: 40.67

Gene sequence:

>900_bases
ATGACAAAGAGGACATTGTATGAACTTCAGGCAGAAAATGTGAGGAAAACATATCTTTTTATAGTTCTCTTTTCCCTCAT
ACTCTTTGCAGTGGGCTATTTTTTTGTCTGGTATTTTAACTGGGGAATTACAGGCATCATCTTTTTAGCAATTTTTATTG
TGCTATACAACTGGATAGCCTATGAGCAGTCTGATAAAATAGCTTTAACGTCGGTAGGAGCTGTGCCCGCCGATCCGGAG
AAATTTTATGTACTTCACAACATAGTGGAGGAAGTGGCTCTTGCGGCTGGAGTGCCTAAGCCGAAAGTGTATGTAATGAA
TGAACCTCAGCCAAACGCTTTTGCTACCGGAAAAGACCCCAAACATGCTTCCATATGTGTTACTACAGGGCTTTTGCAGA
TGATGAATAGGGAAGAACTGCAGGGAGTTATAGCCCATGAGATGTCTCACATAAGAAATAGAGATATACTCCTTATGACC
GTGGTAGCAATAGTAGCTGGGCTCATCATACTTCTAAGGGATGTCTTTTTAAGAAGCATGTGGTGGGGAATAGGAGGGGA
AAGAAGAAGAGATAAAAATGACAACCTTGGCATTATTCTTCTCCTAATAGGGCTTATACTCTCTATAATAGCACCTATAG
TAGTTTTAATAATAAGGTCGGCTATTTCAAGGCAAAGGGAATATCTGGCGGATGCTACAGGGGCTTACATTGTGAGGGAC
CCTTACGGACTCGCTTCCGCTTTAGAAAAGATAGGAAATTATACAAGGCCGATGAGAACTGCTTCCAGTGCCACTGCCCA
CATGTTTATATCAAACCCTTTTGGAAAAGTAGAATATCTTTTTGCAACTCATCCACCAATTGAAGAGAGAATAAAAAGGT
TGAAGAGTCTTACAATTTGA

Upstream 100 bases:

>100_bases
GCTAAAATGATGGGTTTGACTCCAAAAGAATATTACCCAGTAGATGAAGGGGAAAGAGGCCCTATTAATGTTCAATTTTA
AATTGTAAGGGATGATGCGC

Downstream 100 bases:

>100_bases
TAAATATTTATGTGAGAGGTTGAATAAAAAAGAAAGTAGCTGCAGGAGAGATGCTTGATATTCAAGATATGCCTGAACTG
TGAAAGCAGGTGGTCTCATC

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTKRTLYELQAENVRKTYLFIVLFSLILFAVGYFFVWYFNWGITGIIFLAIFIVLYNWIAYEQSDKIALTSVGAVPADPE
KFYVLHNIVEEVALAAGVPKPKVYVMNEPQPNAFATGKDPKHASICVTTGLLQMMNREELQGVIAHEMSHIRNRDILLMT
VVAIVAGLIILLRDVFLRSMWWGIGGERRRDKNDNLGIILLLIGLILSIIAPIVVLIIRSAISRQREYLADATGAYIVRD
PYGLASALEKIGNYTRPMRTASSATAHMFISNPFGKVEYLFATHPPIEERIKRLKSLTI

Sequences:

>Translated_299_residues
MTKRTLYELQAENVRKTYLFIVLFSLILFAVGYFFVWYFNWGITGIIFLAIFIVLYNWIAYEQSDKIALTSVGAVPADPE
KFYVLHNIVEEVALAAGVPKPKVYVMNEPQPNAFATGKDPKHASICVTTGLLQMMNREELQGVIAHEMSHIRNRDILLMT
VVAIVAGLIILLRDVFLRSMWWGIGGERRRDKNDNLGIILLLIGLILSIIAPIVVLIIRSAISRQREYLADATGAYIVRD
PYGLASALEKIGNYTRPMRTASSATAHMFISNPFGKVEYLFATHPPIEERIKRLKSLTI
>Mature_298_residues
TKRTLYELQAENVRKTYLFIVLFSLILFAVGYFFVWYFNWGITGIIFLAIFIVLYNWIAYEQSDKIALTSVGAVPADPEK
FYVLHNIVEEVALAAGVPKPKVYVMNEPQPNAFATGKDPKHASICVTTGLLQMMNREELQGVIAHEMSHIRNRDILLMTV
VAIVAGLIILLRDVFLRSMWWGIGGERRRDKNDNLGIILLLIGLILSIIAPIVVLIIRSAISRQREYLADATGAYIVRDP
YGLASALEKIGNYTRPMRTASSATAHMFISNPFGKVEYLFATHPPIEERIKRLKSLTI

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=282, Percent_Identity=31.5602836879433, Blast_Score=111, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_THETN (Q8R936)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623382.1
- ProteinModelPortal:   Q8R936
- MEROPS:   M48.004
- GeneID:   996890
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1794
- NMPDR:   fig|273068.3.peg.1324
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK04897
- BioCyc:   TTEN273068:TTE1794-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 33761; Mature: 33630

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 147-147

Signals:

None

Transmembrane regions:

HASH(0xe3dda10)-; HASH(0xf29b554)-; HASH(0xf42728c)-; HASH(0xb53704c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRTLYELQAENVRKTYLFIVLFSLILFAVGYFFVWYFNWGITGIIFLAIFIVLYNWIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEQSDKIALTSVGAVPADPEKFYVLHNIVEEVALAAGVPKPKVYVMNEPQPNAFATGKDP
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
KHASICVTTGLLQMMNREELQGVIAHEMSHIRNRDILLMTVVAIVAGLIILLRDVFLRSM
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WWGIGGERRRDKNDNLGIILLLIGLILSIIAPIVVLIIRSAISRQREYLADATGAYIVRD
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
PYGLASALEKIGNYTRPMRTASSATAHMFISNPFGKVEYLFATHPPIEERIKRLKSLTI
CHHHHHHHHHHHCHHCCHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCH
>Mature Secondary Structure 
TKRTLYELQAENVRKTYLFIVLFSLILFAVGYFFVWYFNWGITGIIFLAIFIVLYNWIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEQSDKIALTSVGAVPADPEKFYVLHNIVEEVALAAGVPKPKVYVMNEPQPNAFATGKDP
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
KHASICVTTGLLQMMNREELQGVIAHEMSHIRNRDILLMTVVAIVAGLIILLRDVFLRSM
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WWGIGGERRRDKNDNLGIILLLIGLILSIIAPIVVLIIRSAISRQREYLADATGAYIVRD
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
PYGLASALEKIGNYTRPMRTASSATAHMFISNPFGKVEYLFATHPPIEERIKRLKSLTI
CHHHHHHHHHHHCHHCCHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336