Click here to switch to the map view.

The map label for this gene is engA

Identifier: 20808046

GI number: 20808046

Start: 1572275

End: 1573594

Strand: Reverse

Name: engA

Synonym: TTE1619

Alternate gene names: 20808046

Gene position: 1573594-1572275 (Counterclockwise)

Preceding gene: 20808047

Following gene: 20808045

Centisome position: 58.51

GC content: 36.67

Gene sequence:

>1320_bases
ATGTCAAGAGCGATGGTAGCTATTGTCGGAAGACCAAACGTTGGGAAATCCACTCTTTTTAACAGAATTCTTAAAAGAAG
GATATCAATTGTTGAGGACATACCTGGAGTTACAAGGGACAGAATATACGGAAATGCAGAATGGCTTAACAGGAAGTTTA
TTTTGGTAGACACTGGTGGATTGGATCCTGACCCAAAGGACGTGATCTTTTCGAAAGTGAAATTGCAAGTAGAAGCGGCT
ATTGAAGCAGCAGACTTGATTTTGTTTGTGGTTGATGCGAGAGAGGGACTTGTCCCTGAAGATGAAGAAATAGCCAATAT
GCTAAGGAAAACCAAAAAAGAAGTGATTTTGGTTTGCAATAAAGTGGATAGTTTCAAAGAGATGCCTGCGAGTTTTTATG
ACTTTTTCAAGCTGGGTTTAGGAGAACCTATACCCATCTCTGCTTCAAATGGGCTTGGAATAGGTGAACTTTTGGATGAA
GTGATAAAGAGGTTGCCTGAAAATGATGTAGAATATGAAGAAGAAACGATTAAAATTGCTGTGATTGGGAGACCCAACGT
AGGAAAATCTTCTTTAGTAAATCGCATACTAGGGGAAGAAAGAGTTATTGTAAGTGATATACCAGGAACTACTCGAGATG
CAATAGATACTCCTTTTACTAAAGATGGAAGGAATTATATATTAATTGATACTGCTGGAATAAGAAGGAAAAGTAGGATA
AGCGAGTCAATAGAAAGGTACAGCGTTTTAAGGGCATTGGCTGCAATTGAGAGGGCTGATATATGCCTTCTCATGATAGA
TGCTACAGAAGGTCCTACGGAGCAGGATACAAAAATTGCTGGTTATGCTTTTGAAAACGGGAAGGGAATTATAATTCTTG
TGAACAAGTGGGACATTGTTGAGAAAGATAGCAATACTTATAAAGAATATACAGAGATGATTAGAGAAAAACTGGCTTTT
ATCTCTTTTGCTCCTATACTATTTATATCTGCCAAGACAGGTCAAAGAATTCACAAAGTTTTGGAAACTGTAGATAAAGT
GTGGGAAGAATATAATAAGAGAATTACTACAGGGCTTTTAAACAATGTCTTAAATGAAGCAATGCTCATGTTTCCGCCAC
CTTCTTCTAAAGGAAGACCTATAAAAATATACTATGCTACACAAGTAGGAACAAAGCCACCAACTTTTGTAATTTTTGTG
AATGAGCCTGAATTATTACATTTCTCTTATGTGAGATTTCTTGAAAACACTATAAGGCAAAATTTTGGTTTTGAGGGAGT
GCCTATTGTGATTTCTACTAAAAAAAGAGGAGAAGATTAA

Upstream 100 bases:

>100_bases
AAGTGAGAGAAGTGGAGGATGCCTTGGGAGCGGAAGTAATTGTTTCCGAAGTTGATGGAAGAGAGTTTTTACAAAAGATA
TACAGAGGTAGGTGAGGCAA

Downstream 100 bases:

>100_bases
AGGGAAAGGGGGGAGAAGATGAAATTTGTACTCGTTGCTGTTTTGGCTTATTTAATTGGCTGTATAAATAATGCATATAT
TTTCACAAAATACACTAGAA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSRAMVAIVGRPNVGKSTLFNRILKRRISIVEDIPGVTRDRIYGNAEWLNRKFILVDTGGLDPDPKDVIFSKVKLQVEAA
IEAADLILFVVDAREGLVPEDEEIANMLRKTKKEVILVCNKVDSFKEMPASFYDFFKLGLGEPIPISASNGLGIGELLDE
VIKRLPENDVEYEEETIKIAVIGRPNVGKSSLVNRILGEERVIVSDIPGTTRDAIDTPFTKDGRNYILIDTAGIRRKSRI
SESIERYSVLRALAAIERADICLLMIDATEGPTEQDTKIAGYAFENGKGIIILVNKWDIVEKDSNTYKEYTEMIREKLAF
ISFAPILFISAKTGQRIHKVLETVDKVWEEYNKRITTGLLNNVLNEAMLMFPPPSSKGRPIKIYYATQVGTKPPTFVIFV
NEPELLHFSYVRFLENTIRQNFGFEGVPIVISTKKRGED

Sequences:

>Translated_439_residues
MSRAMVAIVGRPNVGKSTLFNRILKRRISIVEDIPGVTRDRIYGNAEWLNRKFILVDTGGLDPDPKDVIFSKVKLQVEAA
IEAADLILFVVDAREGLVPEDEEIANMLRKTKKEVILVCNKVDSFKEMPASFYDFFKLGLGEPIPISASNGLGIGELLDE
VIKRLPENDVEYEEETIKIAVIGRPNVGKSSLVNRILGEERVIVSDIPGTTRDAIDTPFTKDGRNYILIDTAGIRRKSRI
SESIERYSVLRALAAIERADICLLMIDATEGPTEQDTKIAGYAFENGKGIIILVNKWDIVEKDSNTYKEYTEMIREKLAF
ISFAPILFISAKTGQRIHKVLETVDKVWEEYNKRITTGLLNNVLNEAMLMFPPPSSKGRPIKIYYATQVGTKPPTFVIFV
NEPELLHFSYVRFLENTIRQNFGFEGVPIVISTKKRGED
>Mature_438_residues
SRAMVAIVGRPNVGKSTLFNRILKRRISIVEDIPGVTRDRIYGNAEWLNRKFILVDTGGLDPDPKDVIFSKVKLQVEAAI
EAADLILFVVDAREGLVPEDEEIANMLRKTKKEVILVCNKVDSFKEMPASFYDFFKLGLGEPIPISASNGLGIGELLDEV
IKRLPENDVEYEEETIKIAVIGRPNVGKSSLVNRILGEERVIVSDIPGTTRDAIDTPFTKDGRNYILIDTAGIRRKSRIS
ESIERYSVLRALAAIERADICLLMIDATEGPTEQDTKIAGYAFENGKGIIILVNKWDIVEKDSNTYKEYTEMIREKLAFI
SFAPILFISAKTGQRIHKVLETVDKVWEEYNKRITTGLLNNVLNEAMLMFPPPSSKGRPIKIYYATQVGTKPPTFVIFVN
EPELLHFSYVRFLENTIRQNFGFEGVPIVISTKKRGED

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Homo sapiens, GI193082988, Length=94, Percent_Identity=42.5531914893617, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI193082991, Length=94, Percent_Identity=42.5531914893617, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI87082120, Length=462, Percent_Identity=42.2077922077922, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788919, Length=178, Percent_Identity=36.5168539325843, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI2367268, Length=95, Percent_Identity=46.3157894736842, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17507259, Length=115, Percent_Identity=37.3913043478261, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=207, Percent_Identity=37.1980676328502, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45550813, Length=92, Percent_Identity=40.2173913043478, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_THETN (Q8R9J1)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623217.1
- ProteinModelPortal:   Q8R9J1
- SMR:   Q8R9J1
- GeneID:   996138
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1619
- NMPDR:   fig|273068.3.peg.1594
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   TTEN273068:TTE1619-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49433; Mature: 49302

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAMVAIVGRPNVGKSTLFNRILKRRISIVEDIPGVTRDRIYGNAEWLNRKFILVDTGG
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHCCEEEEEECCC
LDPDPKDVIFSKVKLQVEAAIEAADLILFVVDAREGLVPEDEEIANMLRKTKKEVILVCN
CCCCHHHHHHHHHHEEHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEC
KVDSFKEMPASFYDFFKLGLGEPIPISASNGLGIGELLDEVIKRLPENDVEYEEETIKIA
CHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEE
VIGRPNVGKSSLVNRILGEERVIVSDIPGTTRDAIDTPFTKDGRNYILIDTAGIRRKSRI
EEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHH
SESIERYSVLRALAAIERADICLLMIDATEGPTEQDTKIAGYAFENGKGIIILVNKWDIV
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEEEECCCEE
EKDSNTYKEYTEMIREKLAFISFAPILFISAKTGQRIHKVLETVDKVWEEYNKRITTGLL
ECCCCHHHHHHHHHHHHHHHHEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NNVLNEAMLMFPPPSSKGRPIKIYYATQVGTKPPTFVIFVNEPELLHFSYVRFLENTIRQ
HHHHHCCEEEECCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
NFGFEGVPIVISTKKRGED
HCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SRAMVAIVGRPNVGKSTLFNRILKRRISIVEDIPGVTRDRIYGNAEWLNRKFILVDTGG
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHCCEEEEEECCC
LDPDPKDVIFSKVKLQVEAAIEAADLILFVVDAREGLVPEDEEIANMLRKTKKEVILVCN
CCCCHHHHHHHHHHEEHHHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEC
KVDSFKEMPASFYDFFKLGLGEPIPISASNGLGIGELLDEVIKRLPENDVEYEEETIKIA
CHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEE
VIGRPNVGKSSLVNRILGEERVIVSDIPGTTRDAIDTPFTKDGRNYILIDTAGIRRKSRI
EEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHH
SESIERYSVLRALAAIERADICLLMIDATEGPTEQDTKIAGYAFENGKGIIILVNKWDIV
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEEEECCCEE
EKDSNTYKEYTEMIREKLAFISFAPILFISAKTGQRIHKVLETVDKVWEEYNKRITTGLL
ECCCCHHHHHHHHHHHHHHHHEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NNVLNEAMLMFPPPSSKGRPIKIYYATQVGTKPPTFVIFVNEPELLHFSYVRFLENTIRQ
HHHHHCCEEEECCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
NFGFEGVPIVISTKKRGED
HCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336