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The map label for this gene is Pcp2

Identifier: 20808040

GI number: 20808040

Start: 1566324

End: 1566944

Strand: Direct

Name: Pcp2

Synonym: TTE1612

Alternate gene names: 20808040

Gene position: 1566324-1566944 (Clockwise)

Preceding gene: 20808039

Following gene: 20808041

Centisome position: 58.24

GC content: 33.98

Gene sequence:

>621_bases
ATGAAAATACTTGTAACAGCTTTTGATCCTTTTGGTGGGGAAAGTATTAATCCTTCTTATGAAGTATTAAAAAACTTAAA
AGATAATATAGAAGGTGCGGAGATAGTTAAGATTCAAGTTCCTACTGTTTTTTATCTCTCTGTTGAGAAGGCAATAGAAA
AAATAAAGGAAGTTAATCCGGATGCAGTTTTAAGTATTGGACAAGCTGGAGGACGATATGATATAAGTGTGGAGAGAGTA
GCCATCAATATCGATGATGCTAGAATTCCAGATAATATAGGACAGCAGCCAATTGATACACCGATTGACCCTGAAGGAGC
TCCAGCTTATTTTGCCACTATTCCAATAAAAGAGATAGTGGAAGAGATAAAGAAAGAAAATATACCGGCATCAATTTCCA
ATACAGCAGGTACGTATGTGTGCAATCATCTAATGTATGGAATTCTAAATTACATTCACAAAAACAAATTAAACATTAAA
GCGGGCTTTATTCACATACCTTATTTGCCAGTGCAAGTTTTGAATAAGCCTTCTACTCCTTCCATGTCTTTAGGGGATAT
GGTTAAAGCTATAGAAACTGCTATAAAAGTAATTGTAAAAAGTTGTAAAAAAAGTAGATAG

Upstream 100 bases:

>100_bases
TAAAATATCAAGTTCCTGTAGCTATTGCCATGCTCATTATTCACATAGTACTAATGTATGTTTGGGCATTTTAATATTTT
TATGAAAGGGTGATGTGGTA

Downstream 100 bases:

>100_bases
CAGTTATTTGGGAGAAGTGAAAAAACTATTTGTATATGGAACTTTAATGAGAGGTTTTGAAAATTACAACAAATATTTAA
AAGATAAAGTTAAAGAGATA

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 2; Pyroglutamyl-peptidase I 2; PGP-I 2; Pyrase 2

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MKILVTAFDPFGGESINPSYEVLKNLKDNIEGAEIVKIQVPTVFYLSVEKAIEKIKEVNPDAVLSIGQAGGRYDISVERV
AINIDDARIPDNIGQQPIDTPIDPEGAPAYFATIPIKEIVEEIKKENIPASISNTAGTYVCNHLMYGILNYIHKNKLNIK
AGFIHIPYLPVQVLNKPSTPSMSLGDMVKAIETAIKVIVKSCKKSR

Sequences:

>Translated_206_residues
MKILVTAFDPFGGESINPSYEVLKNLKDNIEGAEIVKIQVPTVFYLSVEKAIEKIKEVNPDAVLSIGQAGGRYDISVERV
AINIDDARIPDNIGQQPIDTPIDPEGAPAYFATIPIKEIVEEIKKENIPASISNTAGTYVCNHLMYGILNYIHKNKLNIK
AGFIHIPYLPVQVLNKPSTPSMSLGDMVKAIETAIKVIVKSCKKSR
>Mature_206_residues
MKILVTAFDPFGGESINPSYEVLKNLKDNIEGAEIVKIQVPTVFYLSVEKAIEKIKEVNPDAVLSIGQAGGRYDISVERV
AINIDDARIPDNIGQQPIDTPIDPEGAPAYFATIPIKEIVEEIKKENIPASISNTAGTYVCNHLMYGILNYIHKNKLNIK
AGFIHIPYLPVQVLNKPSTPSMSLGDMVKAIETAIKVIVKSCKKSR

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP2_THETN (Q8R9J6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623211.1
- ProteinModelPortal:   Q8R9J6
- SMR:   Q8R9J6
- MEROPS:   C15.001
- GeneID:   996115
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1612
- NMPDR:   fig|273068.3.peg.1588
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   TTEN273068:TTE1612-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22618; Mature: 22618

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTAFDPFGGESINPSYEVLKNLKDNIEGAEIVKIQVPTVFYLSVEKAIEKIKEVNP
CEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEEEHHHHHHHHHHCCC
DAVLSIGQAGGRYDISVERVAINIDDARIPDNIGQQPIDTPIDPEGAPAYFATIPIKEIV
HHEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
EEIKKENIPASISNTAGTYVCNHLMYGILNYIHKNKLNIKAGFIHIPYLPVQVLNKPSTP
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCCCCC
SMSLGDMVKAIETAIKVIVKSCKKSR
CCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKILVTAFDPFGGESINPSYEVLKNLKDNIEGAEIVKIQVPTVFYLSVEKAIEKIKEVNP
CEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEEEHHHHHHHHHHCCC
DAVLSIGQAGGRYDISVERVAINIDDARIPDNIGQQPIDTPIDPEGAPAYFATIPIKEIV
HHEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
EEIKKENIPASISNTAGTYVCNHLMYGILNYIHKNKLNIKAGFIHIPYLPVQVLNKPSTP
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCCCCC
SMSLGDMVKAIETAIKVIVKSCKKSR
CCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336