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The map label for this gene is MetC3 [H]

Identifier: 20808014

GI number: 20808014

Start: 1541332

End: 1542516

Strand: Reverse

Name: MetC3 [H]

Synonym: TTE1585

Alternate gene names: 20808014

Gene position: 1542516-1541332 (Counterclockwise)

Preceding gene: 20808015

Following gene: 20808013

Centisome position: 57.35

GC content: 40.0

Gene sequence:

>1185_bases
GTGAAAAAAGAGTTTAGATTTGATACAAAGGCGATTCACGGCGAAGAGCTTAAGAAAAATCCTGAAAACGCATTGAATCC
CCCTATTTTTCAAACCACTACTTTTGTCTTTGAAGATTTGGACCATGTTGAGAAGGTAATGTCTTTTGAGTCTCAAGACT
ATGTTTACACACGCGGCAACAATCCCACCCTGAGGCTGTTTGAAAACAGAATGGCAGAGCTGGAGTACGGGAAGGGAGCT
GTAGCATTTTCATCGGGAATGGCGGCAATAAGTTCTGTGCTCTTTTCTCTTTTAAGGCCTAATGACAAAGTTTTAGCACA
CAAAACTCTGTACGGCTCAAGCTACAACGTGATAACTAACCTTTTGCCCAAATACGGGGTTAAATATAAACTCATAGACA
TGACAAGTTTAGAAGAGTTAAAAGAGAGTTTAGATGATACCGTGAAGGTGATTTACTTTGAAACTCCCTCCAATCCTGAT
TTGTCAATAATAGACATAGAAGAAGTGAGTAAGATAGCCTATCAAAGAGGTATAAAAGTAGTGGTAGACAACACTTTTGC
CACACCTTGTTTTCAAAATCCTCTTCTTTTGGGAGCCGATGTGGTAGTACATAGTGCTACTAAGTATATATGCGGGCATG
GGGATGCGCTGGGAGGAGTTGCTATTTCAAAAGATGAAGCCTATATTCACTATTTAAAATTCGACTACATGTGCGAGTTT
GGAGGGGTTATGAGCCCTTTTAACGCTTGGCTTATGTTAAGGGGTATAAAGACTTTAGGGCTCAGGATGAGGCAGCATGA
GAAGAATGCCATGGAGGTCGCAAAATTTTTGAGTAGGCATCCCAAAGTGAAAAATGTTTTGTACCCTGGTCTTGAATCCT
TTAAAGGACATGGAATTGCAAAAAAGCAGATGAGAGGATTTGGAGCTATAATAAGTTTTGAGATAGAGGGTGGAAGGAAA
GAATTAGAAGAATTCATAAAAGGGTTGAAACTTTGCCAGCTGGCGGTGAGTCTGGGGGACGCAGAGACTTTGGTGGAAGT
TCCTTCTATTATGACCCACAGAGGATATCCAAAGGAAAAACTAGAAGATTTTGGATTTAAAGAAAATACCGTGAGGATTT
CAGTAGGGCTTGAAGATTACAACGACATAATAGAGGATTTAGAAGATGCCTTGAAGAGAATTTAA

Upstream 100 bases:

>100_bases
TTCAACTATCATTTTTATACTGGCGAGTCTTTTATAATGATACCAGCAGGGTGTACCTAAAAAGGTACGCCCTGTAAGTT
TTAGCAAAGGAGTGAGGGGT

Downstream 100 bases:

>100_bases
CACTCAAGAGGTGATTTTATGCCAATTGTCAATTTGAGCTTACAGGTATTGCCTTTAGTCCCAGAAGAGAAAGTGTATCC
AATTGTGGATAAAGTGATAA

Product: cystathionine beta-lyase/cystathionine gamma-synthase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKKEFRFDTKAIHGEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRGNNPTLRLFENRMAELEYGKGA
VAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVITNLLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPD
LSIIDIEEVSKIAYQRGIKVVVDNTFATPCFQNPLLLGADVVVHSATKYICGHGDALGGVAISKDEAYIHYLKFDYMCEF
GGVMSPFNAWLMLRGIKTLGLRMRQHEKNAMEVAKFLSRHPKVKNVLYPGLESFKGHGIAKKQMRGFGAIISFEIEGGRK
ELEEFIKGLKLCQLAVSLGDAETLVEVPSIMTHRGYPKEKLEDFGFKENTVRISVGLEDYNDIIEDLEDALKRI

Sequences:

>Translated_394_residues
MKKEFRFDTKAIHGEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRGNNPTLRLFENRMAELEYGKGA
VAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVITNLLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPD
LSIIDIEEVSKIAYQRGIKVVVDNTFATPCFQNPLLLGADVVVHSATKYICGHGDALGGVAISKDEAYIHYLKFDYMCEF
GGVMSPFNAWLMLRGIKTLGLRMRQHEKNAMEVAKFLSRHPKVKNVLYPGLESFKGHGIAKKQMRGFGAIISFEIEGGRK
ELEEFIKGLKLCQLAVSLGDAETLVEVPSIMTHRGYPKEKLEDFGFKENTVRISVGLEDYNDIIEDLEDALKRI
>Mature_394_residues
MKKEFRFDTKAIHGEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRGNNPTLRLFENRMAELEYGKGA
VAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVITNLLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPD
LSIIDIEEVSKIAYQRGIKVVVDNTFATPCFQNPLLLGADVVVHSATKYICGHGDALGGVAISKDEAYIHYLKFDYMCEF
GGVMSPFNAWLMLRGIKTLGLRMRQHEKNAMEVAKFLSRHPKVKNVLYPGLESFKGHGIAKKQMRGFGAIISFEIEGGRK
ELEEFIKGLKLCQLAVSLGDAETLVEVPSIMTHRGYPKEKLEDFGFKENTVRISVGLEDYNDIIEDLEDALKRI

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=389, Percent_Identity=37.7892030848329, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI299473759, Length=389, Percent_Identity=34.9614395886889, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI25453487, Length=388, Percent_Identity=32.7319587628866, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1790375, Length=366, Percent_Identity=37.9781420765027, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=27.5689223057644, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=391, Percent_Identity=40.920716112532, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17538055, Length=391, Percent_Identity=39.386189258312, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=34.2318059299191, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6319307, Length=400, Percent_Identity=37.25, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323333, Length=442, Percent_Identity=33.710407239819, Blast_Score=215, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6321254, Length=411, Percent_Identity=30.6569343065693, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=329, Percent_Identity=29.1793313069909, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=401, Percent_Identity=30.9226932668329, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322970, Length=269, Percent_Identity=24.907063197026, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=39.4871794871795, Blast_Score=267, Evalue=9e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 44456; Mature: 44456

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEFRFDTKAIHGEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRGN
CCCCCCCCHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
NPTLRLFENRMAELEYGKGAVAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVITN
CCEEHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHH
LLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPDLSIIDIEEVSKIAYQRGIKV
HHHHCCCEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCCEE
VVDNTFATPCFQNPLLLGADVVVHSATKYICGHGDALGGVAISKDEAYIHYLKFDYMCEF
EEECCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEHHHHHC
GGVMSPFNAWLMLRGIKTLGLRMRQHEKNAMEVAKFLSRHPKVKNVLYPGLESFKGHGIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCC
KKQMRGFGAIISFEIEGGRKELEEFIKGLKLCQLAVSLGDAETLVEVPSIMTHRGYPKEK
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
LEDFGFKENTVRISVGLEDYNDIIEDLEDALKRI
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKEFRFDTKAIHGEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRGN
CCCCCCCCHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
NPTLRLFENRMAELEYGKGAVAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVITN
CCEEHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHH
LLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPDLSIIDIEEVSKIAYQRGIKV
HHHHCCCEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCCEE
VVDNTFATPCFQNPLLLGADVVVHSATKYICGHGDALGGVAISKDEAYIHYLKFDYMCEF
EEECCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEHHHHHC
GGVMSPFNAWLMLRGIKTLGLRMRQHEKNAMEVAKFLSRHPKVKNVLYPGLESFKGHGIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCC
KKQMRGFGAIISFEIEGGRKELEEFIKGLKLCQLAVSLGDAETLVEVPSIMTHRGYPKEK
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
LEDFGFKENTVRISVGLEDYNDIIEDLEDALKRI
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]