Click here to switch to the map view.

The map label for this gene is LspA

Identifier: 20807975

GI number: 20807975

Start: 1500870

End: 1501307

Strand: Reverse

Name: LspA

Synonym: TTE1539

Alternate gene names: 20807975

Gene position: 1501307-1500870 (Counterclockwise)

Preceding gene: 20807976

Following gene: 20807974

Centisome position: 55.82

GC content: 34.93

Gene sequence:

>438_bases
TTGGCGATAGTTATTGTAGCTTTTGTGGTTTTTCTTGACCAGTTTACAAAATACCTCGCGGCGAAGTATTTGATGCCTAT
AGGAAGTTATCCGGTTATAAAGCATTTTTTTCATCTGACTTATGTGGAGAATAGAGGGGCAGCTTTTGGAATGTTACAGA
ATAAGACTTTATTTTTTATTGTGATAACTGTGGTGGTGGGAATTGTCTTGATTTATTCAATGATTAAGCTTCCAGAAAAT
AGTTTGTATAATTATACGCTTGCTATGATTTTAGGGGGAGCCATAGGGAATCTCATAGATAGGGTAAGACTTGGATATGT
AGTGGATTTTATTGATTTTAAGTTTTTCCCTGCTGTTTTTAACGTTGCCGATTCTTTTATTGTTGTGGGAGCAATTATAC
TTGGATATCTTATGATTTTTAAGGGCGGGATAAGATGA

Upstream 100 bases:

>100_bases
TTACTTTTTAAGCACATTGCTTTAAAATGCCTTGATTTTTTGTATAATATACTTGTGTGGGTAAAGAGCTAAGCAAACAA
AATAACAGGAGGAATTGGCA

Downstream 100 bases:

>100_bases
ACATTGTAGACAGAATAGTTTTGCAAGGAGAAAAAGAGGACGAAGGAAAGAGAATAGACGTATTTCTTGCTTCAGAGCTT
GACTATTCCAGGTCATATAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MAIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFIVITVVVGIVLIYSMIKLPEN
SLYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVFNVADSFIVVGAIILGYLMIFKGGIR

Sequences:

>Translated_145_residues
MAIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFIVITVVVGIVLIYSMIKLPEN
SLYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVFNVADSFIVVGAIILGYLMIFKGGIR
>Mature_144_residues
AIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFIVITVVVGIVLIYSMIKLPENS
LYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVFNVADSFIVVGAIILGYLMIFKGGIR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=138, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_THETN (Q8R9R0)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623146.1
- MEROPS:   A08.001
- GeneID:   996593
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1539
- NMPDR:   fig|273068.3.peg.1493
- HOGENOM:   HBG724422
- OMA:   ADACITI
- ProtClustDB:   PRK14791
- BioCyc:   TTEN273068:TTE1539-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 16280; Mature: 16149

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 100-100 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

HASH(0xe084b38)-; HASH(0xb7a8008)-; HASH(0xc9b5f34)-; HASH(0xeac3f60)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEHHCCCHHHHH
VITVVVGIVLIYSMIKLPENSLYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVADSFIVVGAIILGYLMIFKGGIR
HHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
AIVIVAFVVFLDQFTKYLAAKYLMPIGSYPVIKHFFHLTYVENRGAAFGMLQNKTLFFI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEHHCCCHHHHH
VITVVVGIVLIYSMIKLPENSLYNYTLAMILGGAIGNLIDRVRLGYVVDFIDFKFFPAVF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVADSFIVVGAIILGYLMIFKGGIR
HHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336