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The map label for this gene is Dfp [H]

Identifier: 20807952

GI number: 20807952

Start: 1475302

End: 1476498

Strand: Reverse

Name: Dfp [H]

Synonym: TTE1509

Alternate gene names: 20807952

Gene position: 1476498-1475302 (Counterclockwise)

Preceding gene: 20807953

Following gene: 20807951

Centisome position: 54.9

GC content: 39.18

Gene sequence:

>1197_bases
ATGAATAACAAGAAAAATGTGGTGCTAGGTGTTACAGGAGGTATAGCAGCATATAAAGCTGCGGACCTCACCTCGAGGCT
TGTAAAAAAGGATATAAATGTAGATGTCATTATGACTAAAGAAGCTACAAATTTTATAAATCCTTTGACTTTTGAAGCCT
TAACCCACAATAAAGTAACTGTAGATATGTTTACAGATAGGAAGTATTGGGAGATTGAGCATATCTCTCTTGCAGAAAAA
GCGGACCTTTTCGCTATAGTTCCAGCAACTGCTAATATAATTGCAAAGATTGCTCATGGAATTGCAGATGACATGCTGAC
CACCACTTTACTTGCAACAAAAAGCCCAGTTCTAATTGCTCCGGCTATGAATACCAACATGTACACAAATCCTTTAACTC
AAAGGAATATTAAGACTTTAAAAGAGATCGGGTTTATTTTTGTTGAACCAGCAGCAGGCAGACTTGCCTGTGGGACATAC
GGGGCAGGGAAACTGGCTGATGTGGAAGAAATTGAAAAAGCCATACTAGACCTTTTGTACAGAGAAAAAGAGAAAGACTT
TGAAGGTAAGAAAGTTTTGATAACAGCGGGTCCTACGAGAGAGCCCCTCGATCCGGTTAGATACATTACAAACCGCTCCT
CGGGGAAAATGGGGTATGAGATTGCCAAGGCTTTTGTGGAAAGAGGAGCTCGTGTAGTGCTCGTGTCTGGACCTACTCAC
ATAGATATTCCTAAGGGAGTTACATTTATTCCTGTTGAAACAGCTGCTGATATGTACAACGCTGTGATGATGCACCTTGA
GGAAGCTGACATAATAGTTGGAGCAGCTGCTGTTGCTGACTATAGGCCTAAAGAGGTAAAAAAGGAAAAAATAAAAAAAG
ATGAAGAAACTATGGTGATTGAGCTTGTAAAAAATCCAGACATAATGTATGAAGTAGGACAAAAGAAGGGAAATAAAATT
TCAGTCGGCTTTGCAGCTGAAACTGAAAATCTGATAGACTATGCTAAGAAGAAGTTAAAAGAGAAAAATATGGATTTAAT
AGTGGCAAATGACGTTTCTCAAGAAGGAGCAGGCTTTGAAGTGGACACGAACATAATAAAAGTTATCAACAAAGACCTTG
AAGTGAAGGAGTATCCGATGATGACGAAAAGGGAAGCAGCTCATGTCATTTTAGATGAGATAGCAAAGTTGTTGTGA

Upstream 100 bases:

>100_bases
GACTCTGATAAACCTGTCACAATTGCTACGGAGGAAGTGTACAGGGGACTCATCACTTATGAAAGACCTCAAAAGTATGG
AATAAAATAGAGGTGTTATG

Downstream 100 bases:

>100_bases
GCCTTTTTCGGCTTTTTTTATTTATCTAAAATTTTATCGGGCGGAGGTTGCCATGTTCGCCGAAGTCATAGTGGAAATAA
AAGCTTCGAATACTGACAGG

Product: phosphopantothenoylcysteine synthetase/decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNNKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTHNKVTVDMFTDRKYWEIEHISLAEK
ADLFAIVPATANIIAKIAHGIADDMLTTTLLATKSPVLIAPAMNTNMYTNPLTQRNIKTLKEIGFIFVEPAAGRLACGTY
GAGKLADVEEIEKAILDLLYREKEKDFEGKKVLITAGPTREPLDPVRYITNRSSGKMGYEIAKAFVERGARVVLVSGPTH
IDIPKGVTFIPVETAADMYNAVMMHLEEADIIVGAAAVADYRPKEVKKEKIKKDEETMVIELVKNPDIMYEVGQKKGNKI
SVGFAAETENLIDYAKKKLKEKNMDLIVANDVSQEGAGFEVDTNIIKVINKDLEVKEYPMMTKREAAHVILDEIAKLL

Sequences:

>Translated_398_residues
MNNKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTHNKVTVDMFTDRKYWEIEHISLAEK
ADLFAIVPATANIIAKIAHGIADDMLTTTLLATKSPVLIAPAMNTNMYTNPLTQRNIKTLKEIGFIFVEPAAGRLACGTY
GAGKLADVEEIEKAILDLLYREKEKDFEGKKVLITAGPTREPLDPVRYITNRSSGKMGYEIAKAFVERGARVVLVSGPTH
IDIPKGVTFIPVETAADMYNAVMMHLEEADIIVGAAAVADYRPKEVKKEKIKKDEETMVIELVKNPDIMYEVGQKKGNKI
SVGFAAETENLIDYAKKKLKEKNMDLIVANDVSQEGAGFEVDTNIIKVINKDLEVKEYPMMTKREAAHVILDEIAKLL
>Mature_398_residues
MNNKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTHNKVTVDMFTDRKYWEIEHISLAEK
ADLFAIVPATANIIAKIAHGIADDMLTTTLLATKSPVLIAPAMNTNMYTNPLTQRNIKTLKEIGFIFVEPAAGRLACGTY
GAGKLADVEEIEKAILDLLYREKEKDFEGKKVLITAGPTREPLDPVRYITNRSSGKMGYEIAKAFVERGARVVLVSGPTH
IDIPKGVTFIPVETAADMYNAVMMHLEEADIIVGAAAVADYRPKEVKKEKIKKDEETMVIELVKNPDIMYEVGQKKGNKI
SVGFAAETENLIDYAKKKLKEKNMDLIVANDVSQEGAGFEVDTNIIKVINKDLEVKEYPMMTKREAAHVILDEIAKLL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=194, Percent_Identity=32.9896907216495, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=43.1472081218274, Blast_Score=289, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17560194, Length=180, Percent_Identity=34.4444444444444, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=191, Percent_Identity=31.9371727748691, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=31.413612565445, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44001; Mature: 44001

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTHNKVT
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEE
VDMFTDRKYWEIEHISLAEKADLFAIVPATANIIAKIAHGIADDMLTTTLLATKSPVLIA
EEEECCCCEEEEEEECHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAMNTNMYTNPLTQRNIKTLKEIGFIFVEPAAGRLACGTYGAGKLADVEEIEKAILDLLY
ECCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
REKEKDFEGKKVLITAGPTREPLDPVRYITNRSSGKMGYEIAKAFVERGARVVLVSGPTH
HHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCE
IDIPKGVTFIPVETAADMYNAVMMHLEEADIIVGAAAVADYRPKEVKKEKIKKDEETMVI
EECCCCCEEEECHHHHHHHHHHHHHHHHCCEEEEEHHHHCCCHHHHHHHHCCCCCCEEEE
ELVKNPDIMYEVGQKKGNKISVGFAAETENLIDYAKKKLKEKNMDLIVANDVSQEGAGFE
EEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEE
VDTNIIKVINKDLEVKEYPMMTKREAAHVILDEIAKLL
ECHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNNKKNVVLGVTGGIAAYKAADLTSRLVKKDINVDVIMTKEATNFINPLTFEALTHNKVT
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEE
VDMFTDRKYWEIEHISLAEKADLFAIVPATANIIAKIAHGIADDMLTTTLLATKSPVLIA
EEEECCCCEEEEEEECHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAMNTNMYTNPLTQRNIKTLKEIGFIFVEPAAGRLACGTYGAGKLADVEEIEKAILDLLY
ECCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
REKEKDFEGKKVLITAGPTREPLDPVRYITNRSSGKMGYEIAKAFVERGARVVLVSGPTH
HHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCE
IDIPKGVTFIPVETAADMYNAVMMHLEEADIIVGAAAVADYRPKEVKKEKIKKDEETMVI
EECCCCCEEEECHHHHHHHHHHHHHHHHCCEEEEEHHHHCCCHHHHHHHHCCCCCCEEEE
ELVKNPDIMYEVGQKKGNKISVGFAAETENLIDYAKKKLKEKNMDLIVANDVSQEGAGFE
EEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEE
VDTNIIKVINKDLEVKEYPMMTKREAAHVILDEIAKLL
ECHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]