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The map label for this gene is FabD [H]

Identifier: 20807920

GI number: 20807920

Start: 1444913

End: 1445842

Strand: Reverse

Name: FabD [H]

Synonym: TTE1473

Alternate gene names: 20807920

Gene position: 1445842-1444913 (Counterclockwise)

Preceding gene: 20807921

Following gene: 20807919

Centisome position: 53.76

GC content: 43.44

Gene sequence:

>930_bases
ATGAAAATAGCTTTTATATACCCGGGCCAAGGTGCCCAGTACGCAGGGATGGGAAAGGAAATATACGAAAAATACGAAGA
AGCGAAAGAAATTTTTGAAAGAGCAGATGAGGCTTTAGGTTTTAACATATCTAAACTGTGCTTTGAAGGGCCTGAAGAAG
AGCTTATGAAGACGGAGAACACACAGCCGGCCATTTTGACAGTTTCAGTGGCCTTGACAAGGGTTTTGCAGAAAAGAGGT
GTAAAACCTGATGTGACAGCAGGTTTAAGTTTAGGAGAGTATTCATCTCTTGTACTGGCAGAAGCTTTAGATTTTGAGGA
TGCAGTGAGACTTGTCAAAAAGAGAGGAAAGTACATGCAGGAAGTGGTCCCAGAAGGAGTCGGCACAATGGCAGCAATAC
TTGGACTTCCCAATGAGGAAGTTGAGGAAATATGCCGGATTGCATCAGAGGTCGGTGTGGTAGAACCTGCTAACTACAAC
TGTCCGGGTCAATTAGTGGTCTCTGGGGAAGTTAAGGCTGTAGAAAGAGCTGTGGAACTAGCGAAGGAGAGAGGAGCTAA
GAAAGCAGTAGTGCTTGCAGTAAGTGCGCCTTTCCACTGCAGCATGTTGAAAGAAGCTGGAGAACTTCTAGCAAAGGAAT
TGGATAAAGTAGAGATAAAGGACTTGAAGGTTCCTGTGATATCAAATGTTACTGCCGATTACGTGCAAAAAGATAAGGTT
AAAGAATTACTCATAAAACAGGTGAGTCATCCCGTCCTCTGGGAGCAGTCTGTGAGAAAAATGATAGAAGACGGTGTGGA
TACTTTCATAGAAATAGGACCTGGAAAGACTTTGAGCGGATTTGTCAAGAAAATTGATAGAAGCAGGACTGTTTTGAATT
TTGAGGATGAGGAGTCTCTCATGAAGGCTCTCTCAGCTTTGGGGGTATAG

Upstream 100 bases:

>100_bases
GGACTCATTAAAGACATAAAGCCAGTTAAAGAGATAATTGAAGACATCATAAAACAAGCTGCTGAAGTTATTGAAAACTT
GAATAAAATGAGGTGAAAGG

Downstream 100 bases:

>100_bases
TTTATGGTAGATGAAAAGAGGGTGGCATTTGTCACAGGAGGTTCTAGAGGTATAGGCAGAGCTATTGCTGTAAGACTTGC
TAAAGATGGCTTTAATATTG

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKIAFIYPGQGAQYAGMGKEIYEKYEEAKEIFERADEALGFNISKLCFEGPEEELMKTENTQPAILTVSVALTRVLQKRG
VKPDVTAGLSLGEYSSLVLAEALDFEDAVRLVKKRGKYMQEVVPEGVGTMAAILGLPNEEVEEICRIASEVGVVEPANYN
CPGQLVVSGEVKAVERAVELAKERGAKKAVVLAVSAPFHCSMLKEAGELLAKELDKVEIKDLKVPVISNVTADYVQKDKV
KELLIKQVSHPVLWEQSVRKMIEDGVDTFIEIGPGKTLSGFVKKIDRSRTVLNFEDEESLMKALSALGV

Sequences:

>Translated_309_residues
MKIAFIYPGQGAQYAGMGKEIYEKYEEAKEIFERADEALGFNISKLCFEGPEEELMKTENTQPAILTVSVALTRVLQKRG
VKPDVTAGLSLGEYSSLVLAEALDFEDAVRLVKKRGKYMQEVVPEGVGTMAAILGLPNEEVEEICRIASEVGVVEPANYN
CPGQLVVSGEVKAVERAVELAKERGAKKAVVLAVSAPFHCSMLKEAGELLAKELDKVEIKDLKVPVISNVTADYVQKDKV
KELLIKQVSHPVLWEQSVRKMIEDGVDTFIEIGPGKTLSGFVKKIDRSRTVLNFEDEESLMKALSALGV
>Mature_309_residues
MKIAFIYPGQGAQYAGMGKEIYEKYEEAKEIFERADEALGFNISKLCFEGPEEELMKTENTQPAILTVSVALTRVLQKRG
VKPDVTAGLSLGEYSSLVLAEALDFEDAVRLVKKRGKYMQEVVPEGVGTMAAILGLPNEEVEEICRIASEVGVVEPANYN
CPGQLVVSGEVKAVERAVELAKERGAKKAVVLAVSAPFHCSMLKEAGELLAKELDKVEIKDLKVPVISNVTADYVQKDKV
KELLIKQVSHPVLWEQSVRKMIEDGVDTFIEIGPGKTLSGFVKKIDRSRTVLNFEDEESLMKALSALGV

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=304, Percent_Identity=32.5657894736842, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI27477045, Length=109, Percent_Identity=34.8623853211009, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI41872631, Length=291, Percent_Identity=26.4604810996564, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787334, Length=305, Percent_Identity=45.9016393442623, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71984332, Length=295, Percent_Identity=32.8813559322034, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17550940, Length=312, Percent_Identity=26.9230769230769, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=330, Percent_Identity=26.0606060606061, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24665753, Length=300, Percent_Identity=37.6666666666667, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19920632, Length=297, Percent_Identity=24.9158249158249, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=297, Percent_Identity=24.9158249158249, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33892; Mature: 33892

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIYPGQGAQYAGMGKEIYEKYEEAKEIFERADEALGFNISKLCFEGPEEELMKTEN
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHCCC
TQPAILTVSVALTRVLQKRGVKPDVTAGLSLGEYSSLVLAEALDFEDAVRLVKKRGKYMQ
CCCCEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVVPEGVGTMAAILGLPNEEVEEICRIASEVGVVEPANYNCPGQLVVSGEVKAVERAVEL
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHH
AKERGAKKAVVLAVSAPFHCSMLKEAGELLAKELDKVEIKDLKVPVISNVTADYVQKDKV
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCHHHHHHHHHH
KELLIKQVSHPVLWEQSVRKMIEDGVDTFIEIGPGKTLSGFVKKIDRSRTVLNFEDEESL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCEECCCCHHHH
MKALSALGV
HHHHHHHCC
>Mature Secondary Structure
MKIAFIYPGQGAQYAGMGKEIYEKYEEAKEIFERADEALGFNISKLCFEGPEEELMKTEN
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHCCC
TQPAILTVSVALTRVLQKRGVKPDVTAGLSLGEYSSLVLAEALDFEDAVRLVKKRGKYMQ
CCCCEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVVPEGVGTMAAILGLPNEEVEEICRIASEVGVVEPANYNCPGQLVVSGEVKAVERAVEL
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHH
AKERGAKKAVVLAVSAPFHCSMLKEAGELLAKELDKVEIKDLKVPVISNVTADYVQKDKV
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCHHHHHHHHHH
KELLIKQVSHPVLWEQSVRKMIEDGVDTFIEIGPGKTLSGFVKKIDRSRTVLNFEDEESL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCEECCCCHHHH
MKALSALGV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]