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The map label for this gene is UppS

Identifier: 20807851

GI number: 20807851

Start: 1388655

End: 1389398

Strand: Reverse

Name: UppS

Synonym: TTE1404

Alternate gene names: 20807851

Gene position: 1389398-1388655 (Counterclockwise)

Preceding gene: 20807852

Following gene: 20807850

Centisome position: 51.66

GC content: 38.44

Gene sequence:

>744_bases
ATGATTTTTTTTAATGAAGAAAAACTTATAAAAAAGTTGGACAAAACCCGGTTGCCACAGCACGTAGGCATTATAATGGA
TGGAAATGGAAGATGGGCTCAGAAGAGAGGAATGCCTAGGGTTTACGGGCATAAAGCGGGAGTAAATGCAGTAAGAGAAG
TTATAAGGTCCTGCAGAGAGCTTGGAATAAAGTACCTCACTTTGTACGCTTTTTCTACAGAAAATTGGAAGAGACCTAAA
GAAGAAGTGGACTTTTTAATGGACCTCTTGGTAGAGTATCTCTCTAAAGAAGTTGATGAACTCAATAAAAACAATGTAGT
AGTAAAGTTCATTGGAGACATATCTAGATTGCCAGAAAAATGCCAGATTGAAATAGAAAAGGCTCAAAAACTCACAGAAA
AAAATACCGGTCTTGTGGTCAACATCGCTTTAAATTACGGAGGAAGGGATGAAATTGTAAAAGCTACCCAAAATATATGC
AAAAAAGTGCTCAATCGCGAGTTATCACCAGAAGACATAACAGAAGATACTATAACTCAGCACCTTTACACTGCATCTCA
GCCAGACCCCGACCTCATCATACGTACTAGCGGGGAAAAAAGACTTAGCAATTTTTTACTATGGCAGTCGGCTTATTCAG
AGTTGTGGTTTACCGAGGTCCTCTGGCCTGATTTTAAAAAAAGGCATTTGATTGAAGCTTTGCTTTATTATCAAACTCGG
AAAAGAAGGTTTGGGGGAGTTTAA

Upstream 100 bases:

>100_bases
GTGCGAATTAAAGAAAAGGGTGAATTTGTCGAAATTACCGTGATTCGCATATAATCCCCCTCTTTAGAGGGGGTCCTTGT
CCAAATGAGGAGGAAAATTT

Downstream 100 bases:

>100_bases
ATATGTTAAAAACTCGAATAATAAGCGCTCTGGTAGGACTGCCCCTTCTATTTTTAGTCTTAATAAAAGGGGGGGCTCTT
TTAACTTTTTCACTGGTAGC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRELGIKYLTLYAFSTENWKRPK
EEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEKCQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNIC
KKVLNRELSPEDITEDTITQHLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTR
KRRFGGV

Sequences:

>Translated_247_residues
MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRELGIKYLTLYAFSTENWKRPK
EEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEKCQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNIC
KKVLNRELSPEDITEDTITQHLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTR
KRRFGGV
>Mature_247_residues
MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRELGIKYLTLYAFSTENWKRPK
EEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEKCQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNIC
KKVLNRELSPEDITEDTITQHLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTR
KRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=42.4107142857143, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=42.4107142857143, Blast_Score=180, Evalue=1e-45,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=50.4385964912281, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.283185840708, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=229, Percent_Identity=37.9912663755458, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.9464285714286, Blast_Score=175, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_THETN (Q8RA26)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623022.1
- ProteinModelPortal:   Q8RA26
- SMR:   Q8RA26
- GeneID:   997572
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1404
- NMPDR:   fig|273068.3.peg.1369
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   TTEN273068:TTE1404-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28836; Mature: 28836

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 27-27

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRE
CEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHH
LGIKYLTLYAFSTENWKRPKEEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEK
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCHH
CQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNICKKVLNRELSPEDITEDTITQ
HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
HLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTR
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KRRFGGV
HHHCCCC
>Mature Secondary Structure
MIFFNEEKLIKKLDKTRLPQHVGIIMDGNGRWAQKRGMPRVYGHKAGVNAVREVIRSCRE
CEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHH
LGIKYLTLYAFSTENWKRPKEEVDFLMDLLVEYLSKEVDELNKNNVVVKFIGDISRLPEK
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCHH
CQIEIEKAQKLTEKNTGLVVNIALNYGGRDEIVKATQNICKKVLNRELSPEDITEDTITQ
HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
HLYTASQPDPDLIIRTSGEKRLSNFLLWQSAYSELWFTEVLWPDFKKRHLIEALLYYQTR
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KRRFGGV
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336