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The map label for this gene is LytB

Identifier: 20807799

GI number: 20807799

Start: 1333522

End: 1334388

Strand: Direct

Name: LytB

Synonym: TTE1352

Alternate gene names: 20807799

Gene position: 1333522-1334388 (Clockwise)

Preceding gene: 20807798

Following gene: 20807800

Centisome position: 49.58

GC content: 35.99

Gene sequence:

>867_bases
ATGGAAATTTTAATTGCTGAACACGCGGGATTTTGTTTTGGTGTAAAGAGGGCAATTGAAATAGCTTATGAGGAACTAAA
CAAACAAAAAGATACAAGGCTATACACCTTAGGAGAAATCATTCACAATCCTCAAGTGGTGAAAGACTTAGAAGAAAAAG
GGGTAAGAGTTATAGAAGAAGAGGAGCTAGAAAAGCTTTTAAAAGGGGATAGGTTGATAATAAGGAGTCATGGAATTTCA
AAAAAGTTGTACGAATTCCTAGAACAAAAGGGTGTAGAAATCATAGATGTAACTTGTCCTTTTGTAAAGAAAGTGCAGAA
CATAGTTGAAGAGTACTATAAAAAAGGGTATGATATAGTGATTGTGGGAGATAAGAACCATCCAGAAGTTATAGGGGTAA
ATGGATGGTGTGAAGATAAAGCTTACATAGTAAATTCTGTAGAGGAAGCAGAGAATTTACCTTTTTTTGAAAAAGCTTGC
GCAGTATCTCAGACTACCCTGATTGAAAAGCACTGGGAAGACATACTTGAAGTTTTAAAAAGCAAGGCCAAAGAGCTGGT
TTACTTTAACACAATCTGTAATGCTACACAAAAGAGGCAGGAAGCAGCAGATGCCCTTTCTAAAAAGGTGGATGTGATGT
TTGTGATAGGTGGCAAACACAGTTCCAATACTCAGAAGTTGCGAAAAATATGTGAAAAGAACTGTAAAAACACCTATCAC
ATAGAAAGGGCCGATGAAATTACTTTCGAAATGTTAAAAGGGCATGATATTATCGGCATAACCGCTGGAGCTTCTACACC
TGATTATGTGATTGAAGAAGTCATAGAGAAAATTAAATCATTAAAAGGAGAAGATGAGAATGAATGA

Upstream 100 bases:

>100_bases
TTTGAGAAATATTATGATTCCAAGCTTTCCTCCCAACAGTTAGCAGAAATTGGTGAAGAAATAATGAAAGAGATTGCTAA
ATTAATTTAGGAGGATTGAG

Downstream 100 bases:

>100_bases
TTTTTTAGAAGGGTATGTTTTTAGGCCCATTAAGGCGGGAGACATTGTGAAAGGCAAGGTAGTAAAAGTACTGGAAGATG
GAGTTGTTGCAGACATAGGA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEEEELEKLLKGDRLIIRSHGIS
KKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIVIVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKAC
AVSQTTLIEKHWEDILEVLKSKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYH
IERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE

Sequences:

>Translated_288_residues
MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEEEELEKLLKGDRLIIRSHGIS
KKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIVIVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKAC
AVSQTTLIEKHWEDILEVLKSKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYH
IERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE
>Mature_288_residues
MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEEEELEKLLKGDRLIIRSHGIS
KKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIVIVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKAC
AVSQTTLIEKHWEDILEVLKSKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYH
IERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=290, Percent_Identity=33.1034482758621, Blast_Score=157, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_THETN (Q8RA76)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622970.1
- ProteinModelPortal:   Q8RA76
- GeneID:   997730
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1352
- NMPDR:   fig|273068.3.peg.111
- HOGENOM:   HBG335228
- OMA:   HMQVARA
- ProtClustDB:   PRK12360
- BioCyc:   TTEN273068:TTE1352-MONOMER
- BRENDA:   1.17.1.2
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 32908; Mature: 32908

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEE
CEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECH
EELEKLLKGDRLIIRSHGISKKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIV
HHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCEEE
IVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKACAVSQTTLIEKHWEDILEVLK
EEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEE
IERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE
ECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEILIAEHAGFCFGVKRAIEIAYEELNKQKDTRLYTLGEIIHNPQVVKDLEEKGVRVIEE
CEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECH
EELEKLLKGDRLIIRSHGISKKLYEFLEQKGVEIIDVTCPFVKKVQNIVEEYYKKGYDIV
HHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCEEE
IVGDKNHPEVIGVNGWCEDKAYIVNSVEEAENLPFFEKACAVSQTTLIEKHWEDILEVLK
EEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAKELVYFNTICNATQKRQEAADALSKKVDVMFVIGGKHSSNTQKLRKICEKNCKNTYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEE
IERADEITFEMLKGHDIIGITAGASTPDYVIEEVIEKIKSLKGEDENE
ECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336