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The map label for this gene is FtsI2 [H]

Identifier: 20807707

GI number: 20807707

Start: 1257977

End: 1259575

Strand: Direct

Name: FtsI2 [H]

Synonym: TTE1258

Alternate gene names: 20807707

Gene position: 1257977-1259575 (Clockwise)

Preceding gene: 20807706

Following gene: 20807708

Centisome position: 46.77

GC content: 38.46

Gene sequence:

>1599_bases
ATGGAGAAAAGGATAGTTTTTTTGCGTATAGTTTTGGCCCTTATGATTTTTATATTGGCTGGAAGGCTTTTTTACATACA
GGTAGTAAAATATAATTTTTATTCTGAAAAAGCAATGGAACAGAGAATTAAAAGCTTTAAAATTTCAGAAAAGCGCGGAG
ATATATACGATAGAAACATGATACCTTTCACAGATAGAGACTACAAAGAGTATGTCTTTGCAATACCCAAAATGATAAAT
GATAAAAAAAGGGCAGCAGAAATACTCAGTGAGATTACAGAAATTTCTTCCGAAAAGATTAGAGAAGATTTAAAGAGAAA
TAAAGACTATATCAGATATGAGATAAGAAGGGATGTAGATTTTTCTCTTCCTGTTGGAATTTTTAAACTCGAGCTTCCAC
AGAGGTATTCTTCAAACTCTCTTGCAAGGCATGTGATAGGATATCTTGGAGATAAAAAGATGGGGTTGGAGGAATCTTTT
GATGAGGTTTTGGCTACAGATGCCAGCGACAGCATTGCAGTCTTTACTGATGGCAGCAGAAATGACTATATAAAGGGATT
AGGTGTAAAAATACAAACCGTTCACGACAAAGTTTTTGGTGTAAAAACCACTCTAGACTACCATATACAGAAGGTGGTGG
AAGATGTACTTGACAGGCGTAGGATAGAAGGAGCAGCAGTTGTACTGGAGGTAAAAACAGGGAATATACTAGCGATGGCG
AGTAGGCCTAATTTTGACCAGAACAGGATAGAAGATTATTTAAAAAGCTCTAATGAAGAGTTTATAAATAAGGCTGTATC
TGGCTATCCCCCTGGATCTATTTTTAAAATCATAGTTGCTGCGGCAGCTTTAGAATCTGGGAAAGTCAGCTTAGAAGATA
CTTTTTACTGCAGTGGAAGTTACGATATAAATGGAGTTGTCTTTCACGATTTTAAGGGAGAGAGCCATGGCTTGATAAAT
ATAGTCAAAGGTTTTGCAGTTTCCTGCAATACAACTTTTATAAGGATAGGGGAGATAACAGGTGCAAAAGCTATTTTAGA
CATGGCAAGAAAATTTGGGATAGAGAAAGACGATGGTCTTCCAATACCGGAGCAAATAGGAAGGCTTCCAAAGCTTTCTG
ACACATACGGCGCTGGCATTGGAAATCTTTCGATAGGCCAGGGAGAAGTTTTGATGACTCCGCTTCAAGCTGCCGATATA
GTAGCTACAATTGCGAATGATGGTATAAGGAATGTACCGCGTCTTGTGGAGGCAGTGGTGGATGAAAAGGGAGAGGAGGT
TAAGAGATTTCCGCCTCGAGAATCATATAGAGTGTTAGAAAGTAACACAGCCAAAATTTTGAGGTATATGATGAGGCAAG
TGGTGGTTGACCCGGAGGGGACAGGCAAAAGAGCAGAGACTTTTTGCAAAAGTGCTGGAAAGACAGGTTCTGCAGAGGTC
AACAAAGAATTAAATATATATCATGCCTGGTTTGTAGGCTTTGTGCCTTATGAAAATCCCAAGTATTCTATTGCTGTATT
TGTTAAAAACGGAGACACAGGGGGAATAAAGGCCGCTCCTATTTTCAAAGAAATAGCCGAAGAGATAATTAAATACTGA

Upstream 100 bases:

>100_bases
TAATCCTGTTGAAGAGCTTTATATTTTAAGAAGAGAATCTAAAAATAATGTTTAAAAAAGCTCCTTTTGGGAATACTGGT
TCCTGAAAGGAGCTATTTTT

Downstream 100 bases:

>100_bases
TGTACAGGCACCTTTTTCAGATAAAACCATATAATAAATGTGTAATTTATTAAAAAAGAAGAGGTGGCGGCCGTGTGGGA
AGTTATTGCTGCACTTGTAG

Product: cell division protein FtsI/penicillin-binding protein 2

Products: NA

Alternate protein names: Sporulation-specific penicillin-binding protein [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MEKRIVFLRIVLALMIFILAGRLFYIQVVKYNFYSEKAMEQRIKSFKISEKRGDIYDRNMIPFTDRDYKEYVFAIPKMIN
DKKRAAEILSEITEISSEKIREDLKRNKDYIRYEIRRDVDFSLPVGIFKLELPQRYSSNSLARHVIGYLGDKKMGLEESF
DEVLATDASDSIAVFTDGSRNDYIKGLGVKIQTVHDKVFGVKTTLDYHIQKVVEDVLDRRRIEGAAVVLEVKTGNILAMA
SRPNFDQNRIEDYLKSSNEEFINKAVSGYPPGSIFKIIVAAAALESGKVSLEDTFYCSGSYDINGVVFHDFKGESHGLIN
IVKGFAVSCNTTFIRIGEITGAKAILDMARKFGIEKDDGLPIPEQIGRLPKLSDTYGAGIGNLSIGQGEVLMTPLQAADI
VATIANDGIRNVPRLVEAVVDEKGEEVKRFPPRESYRVLESNTAKILRYMMRQVVVDPEGTGKRAETFCKSAGKTGSAEV
NKELNIYHAWFVGFVPYENPKYSIAVFVKNGDTGGIKAAPIFKEIAEEIIKY

Sequences:

>Translated_532_residues
MEKRIVFLRIVLALMIFILAGRLFYIQVVKYNFYSEKAMEQRIKSFKISEKRGDIYDRNMIPFTDRDYKEYVFAIPKMIN
DKKRAAEILSEITEISSEKIREDLKRNKDYIRYEIRRDVDFSLPVGIFKLELPQRYSSNSLARHVIGYLGDKKMGLEESF
DEVLATDASDSIAVFTDGSRNDYIKGLGVKIQTVHDKVFGVKTTLDYHIQKVVEDVLDRRRIEGAAVVLEVKTGNILAMA
SRPNFDQNRIEDYLKSSNEEFINKAVSGYPPGSIFKIIVAAAALESGKVSLEDTFYCSGSYDINGVVFHDFKGESHGLIN
IVKGFAVSCNTTFIRIGEITGAKAILDMARKFGIEKDDGLPIPEQIGRLPKLSDTYGAGIGNLSIGQGEVLMTPLQAADI
VATIANDGIRNVPRLVEAVVDEKGEEVKRFPPRESYRVLESNTAKILRYMMRQVVVDPEGTGKRAETFCKSAGKTGSAEV
NKELNIYHAWFVGFVPYENPKYSIAVFVKNGDTGGIKAAPIFKEIAEEIIKY
>Mature_532_residues
MEKRIVFLRIVLALMIFILAGRLFYIQVVKYNFYSEKAMEQRIKSFKISEKRGDIYDRNMIPFTDRDYKEYVFAIPKMIN
DKKRAAEILSEITEISSEKIREDLKRNKDYIRYEIRRDVDFSLPVGIFKLELPQRYSSNSLARHVIGYLGDKKMGLEESF
DEVLATDASDSIAVFTDGSRNDYIKGLGVKIQTVHDKVFGVKTTLDYHIQKVVEDVLDRRRIEGAAVVLEVKTGNILAMA
SRPNFDQNRIEDYLKSSNEEFINKAVSGYPPGSIFKIIVAAAALESGKVSLEDTFYCSGSYDINGVVFHDFKGESHGLIN
IVKGFAVSCNTTFIRIGEITGAKAILDMARKFGIEKDDGLPIPEQIGRLPKLSDTYGAGIGNLSIGQGEVLMTPLQAADI
VATIANDGIRNVPRLVEAVVDEKGEEVKRFPPRESYRVLESNTAKILRYMMRQVVVDPEGTGKRAETFCKSAGKTGSAEV
NKELNIYHAWFVGFVPYENPKYSIAVFVKNGDTGGIKAAPIFKEIAEEIIKY

Specific function: Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan. Pore cortex formation is determined primarily by the mother cell [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PASTA domain [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=603, Percent_Identity=25.3731343283582, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=24.2957746478873, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR011927 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 59805; Mature: 59805

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRIVFLRIVLALMIFILAGRLFYIQVVKYNFYSEKAMEQRIKSFKISEKRGDIYDRNM
CCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCC
IPFTDRDYKEYVFAIPKMINDKKRAAEILSEITEISSEKIREDLKRNKDYIRYEIRRDVD
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
FSLPVGIFKLELPQRYSSNSLARHVIGYLGDKKMGLEESFDEVLATDASDSIAVFTDGSR
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
NDYIKGLGVKIQTVHDKVFGVKTTLDYHIQKVVEDVLDRRRIEGAAVVLEVKTGNILAMA
CCCEEECCEEEEEEHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEE
SRPNFDQNRIEDYLKSSNEEFINKAVSGYPPGSIFKIIVAAAALESGKVSLEDTFYCSGS
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECEEEEECCC
YDINGVVFHDFKGESHGLINIVKGFAVSCNTTFIRIGEITGAKAILDMARKFGIEKDDGL
CCCCEEEEEECCCCCCCHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCC
PIPEQIGRLPKLSDTYGAGIGNLSIGQGEVLMTPLQAADIVATIANDGIRNVPRLVEAVV
CCHHHHCCCCCCCCHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DEKGEEVKRFPPRESYRVLESNTAKILRYMMRQVVVDPEGTGKRAETFCKSAGKTGSAEV
CCCCCHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCC
NKELNIYHAWFVGFVPYENPKYSIAVFVKNGDTGGIKAAPIFKEIAEEIIKY
CCCCEEEEEEEEEEECCCCCCEEEEEEEEECCCCCEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MEKRIVFLRIVLALMIFILAGRLFYIQVVKYNFYSEKAMEQRIKSFKISEKRGDIYDRNM
CCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCC
IPFTDRDYKEYVFAIPKMINDKKRAAEILSEITEISSEKIREDLKRNKDYIRYEIRRDVD
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
FSLPVGIFKLELPQRYSSNSLARHVIGYLGDKKMGLEESFDEVLATDASDSIAVFTDGSR
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
NDYIKGLGVKIQTVHDKVFGVKTTLDYHIQKVVEDVLDRRRIEGAAVVLEVKTGNILAMA
CCCEEECCEEEEEEHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEE
SRPNFDQNRIEDYLKSSNEEFINKAVSGYPPGSIFKIIVAAAALESGKVSLEDTFYCSGS
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECEEEEECCC
YDINGVVFHDFKGESHGLINIVKGFAVSCNTTFIRIGEITGAKAILDMARKFGIEKDDGL
CCCCEEEEEECCCCCCCHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCC
PIPEQIGRLPKLSDTYGAGIGNLSIGQGEVLMTPLQAADIVATIANDGIRNVPRLVEAVV
CCHHHHCCCCCCCCHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DEKGEEVKRFPPRESYRVLESNTAKILRYMMRQVVVDPEGTGKRAETFCKSAGKTGSAEV
CCCCCHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCC
NKELNIYHAWFVGFVPYENPKYSIAVFVKNGDTGGIKAAPIFKEIAEEIIKY
CCCCEEEEEEEEEEECCCCCCEEEEEEEEECCCCCEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8289242; 9384377; 8244929; 8436954 [H]