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The map label for this gene is TrxA2 [H]

Identifier: 20807685

GI number: 20807685

Start: 1235015

End: 1235686

Strand: Direct

Name: TrxA2 [H]

Synonym: TTE1233

Alternate gene names: 20807685

Gene position: 1235015-1235686 (Clockwise)

Preceding gene: 20807684

Following gene: 20807686

Centisome position: 45.92

GC content: 37.8

Gene sequence:

>672_bases
ATGGCAGAAGTGGTTATAACAAGTAAAAACTGGGAAGAAGAAGTTGTAAACTCAGATGTGCCAGTTTTAATTGACTTTTG
GGCAGAATGGTGCATGCCCTGCAGGTTGGTTGCTCCTATTATTGAGGAACTAGCAAAGGAGTATGAAGGTAAAATCAAAG
TAGGCAAAGTCAATGTAGACGAAGAAGATGAACTTGCAATGAAGTTCAGAATAATGAGCATACCTACAATTGGGCTTTTC
AAAAACGGTAAAATGGTAGGAAAGCTAATAGGTGCAAGGCCAAAAGCTGACTTTGTGAAATTTATAGAAAAGTATTTGAA
TGAGGATACATTCCAGAAAGAAGAATCACTAGAAGTAGAAATTACATACGACAACTGGGAAGAAGAAGTTGTGAATTCAG
ACGTACCAGTTTTGATAGATTTCTGGGCAGAATGGTGTGCGCCCTGTAGGTTAGTCGCTCCTATTGTAGAAGAGCTGGCT
CATGAATACAAGGGCAGATTGAAAGTAGGAAAAGTTAATGTGGATGAAGAACAGGAATTAGCGATGAAATTCAGGATAAT
GAGCATTCCTACTATCGGACTATTTAAGAAAGGCAAGATGGTTGATAAGATAATAGGAGCAAGGCCAAAAGCTGATTTTG
TAAGGTTTATAGAAAAACACCTAAACAATTAA

Upstream 100 bases:

>100_bases
AGTTCATGAGGTAGTTTTAAAAAGCATTTTGCTTTTAAAATGCATAAAGCAATTGCTTTGTACAAAAATAAAAATGAAAT
AAAAGTATAGGAGTGGTTTT

Downstream 100 bases:

>100_bases
AAATCCTGCCTCGGGCAGGATTTTTAATTTTGCTGTGTGAATAAATATGAAAGGAATTGCTTAATTTTCCAAAAAATTTA
GAAAATCGAAACATAATAAG

Product: Thiol-disulfide isomerase and thioredoxins

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MAEVVITSKNWEEEVVNSDVPVLIDFWAEWCMPCRLVAPIIEELAKEYEGKIKVGKVNVDEEDELAMKFRIMSIPTIGLF
KNGKMVGKLIGARPKADFVKFIEKYLNEDTFQKEESLEVEITYDNWEEEVVNSDVPVLIDFWAEWCAPCRLVAPIVEELA
HEYKGRLKVGKVNVDEEQELAMKFRIMSIPTIGLFKKGKMVDKIIGARPKADFVRFIEKHLNN

Sequences:

>Translated_223_residues
MAEVVITSKNWEEEVVNSDVPVLIDFWAEWCMPCRLVAPIIEELAKEYEGKIKVGKVNVDEEDELAMKFRIMSIPTIGLF
KNGKMVGKLIGARPKADFVKFIEKYLNEDTFQKEESLEVEITYDNWEEEVVNSDVPVLIDFWAEWCAPCRLVAPIVEELA
HEYKGRLKVGKVNVDEEQELAMKFRIMSIPTIGLFKKGKMVDKIIGARPKADFVRFIEKHLNN
>Mature_222_residues
AEVVITSKNWEEEVVNSDVPVLIDFWAEWCMPCRLVAPIIEELAKEYEGKIKVGKVNVDEEDELAMKFRIMSIPTIGLFK
NGKMVGKLIGARPKADFVKFIEKYLNEDTFQKEESLEVEITYDNWEEEVVNSDVPVLIDFWAEWCAPCRLVAPIVEELAH
EYKGRLKVGKVNVDEEQELAMKFRIMSIPTIGLFKKGKMVDKIIGARPKADFVRFIEKHLNN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=220, Percent_Identity=30.4545454545455, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI42794771, Length=235, Percent_Identity=26.8085106382979, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI224493972, Length=235, Percent_Identity=26.8085106382979, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI5031973, Length=235, Percent_Identity=25.531914893617, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=32.6530612244898, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI24308127, Length=182, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI5803121, Length=217, Percent_Identity=23.963133640553, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=40.7766990291262, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI1788936, Length=107, Percent_Identity=47.6635514018692, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI87081747, Length=140, Percent_Identity=30.7142857142857, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144092, Length=217, Percent_Identity=29.4930875576037, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17556044, Length=237, Percent_Identity=25.7383966244726, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549970, Length=239, Percent_Identity=26.3598326359833, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=38.7755102040816, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532380, Length=212, Percent_Identity=25.4716981132075, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115532378, Length=231, Percent_Identity=25.1082251082251, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=104, Percent_Identity=39.4230769230769, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=83, Percent_Identity=34.9397590361446, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=42.4657534246575, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=40.4761904761905, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=35.5555555555556, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921434, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=37.7551020408163, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859803, Length=228, Percent_Identity=24.5614035087719, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=35.1063829787234, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358065, Length=87, Percent_Identity=39.0804597701149, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664269, Length=115, Percent_Identity=29.5652173913043, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=118, Percent_Identity=30.5084745762712, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18860011, Length=122, Percent_Identity=32.7868852459016, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642439, Length=122, Percent_Identity=32.7868852459016, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642441, Length=122, Percent_Identity=32.7868852459016, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647799, Length=202, Percent_Identity=28.2178217821782, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642443, Length=120, Percent_Identity=32.5, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 25712; Mature: 25581

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVVITSKNWEEEVVNSDVPVLIDFWAEWCMPCRLVAPIIEELAKEYEGKIKVGKVNVD
CCEEEEECCCCHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCC
EEDELAMKFRIMSIPTIGLFKNGKMVGKLIGARPKADFVKFIEKYLNEDTFQKEESLEVE
CCHHHHHEEEEEECCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCCCEEEE
ITYDNWEEEVVNSDVPVLIDFWAEWCAPCRLVAPIVEELAHEYKGRLKVGKVNVDEEQEL
EEECCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHH
AMKFRIMSIPTIGLFKKGKMVDKIIGARPKADFVRFIEKHLNN
HHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEVVITSKNWEEEVVNSDVPVLIDFWAEWCMPCRLVAPIIEELAKEYEGKIKVGKVNVD
CEEEEECCCCHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCC
EEDELAMKFRIMSIPTIGLFKNGKMVGKLIGARPKADFVKFIEKYLNEDTFQKEESLEVE
CCHHHHHEEEEEECCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCCCEEEE
ITYDNWEEEVVNSDVPVLIDFWAEWCAPCRLVAPIVEELAHEYKGRLKVGKVNVDEEQEL
EEECCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHH
AMKFRIMSIPTIGLFKKGKMVDKIIGARPKADFVRFIEKHLNN
HHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]