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The map label for this gene is AccA [C]

Identifier: 20807675

GI number: 20807675

Start: 1221644

End: 1223194

Strand: Direct

Name: AccA [C]

Synonym: TTE1220

Alternate gene names: 20807675

Gene position: 1221644-1223194 (Clockwise)

Preceding gene: 20807674

Following gene: 20807676

Centisome position: 45.42

GC content: 40.49

Gene sequence:

>1551_bases
ATGGATGTTCAGGCAAAAATAGAGGAACTAAAAAGAAGGTATGAAAAAATAAAAGAAGGGGGAGGTCAGAAAAGAATAGA
AAAGCAGCATGAAGCGGGAAAGCTTACGGCTCGTGAAAGACTAAATATTCTGCTGGATGAACACAGCTTTATAGAAATTG
ATCCTTTTGTGGAACACAGGTGTACGGACTTCGGTATGGAAAAGACAGAAGCGCCAGGAGACGGAGTTGTAACAGGCTAT
GGCACAATTGATGGCAGACTTGTATTTGTATTTGCACAAGACTTCACCGTTCTTGGAGGATCTCTCGGAGAGTACCATGC
AAAGAAAATAACAAAAGTGATGGACATGGCGATGAAGATGGGAGCACCACTAATAGGGCTTAACGACTCAGGAGGTGCCA
GGATTCAAGAAGGAGTAGATGCATTATCAGGTTATGGTCAGATCTTTTACAGAAACACACTGGCTTCAGGAGTAATACCC
CAGATTTCAGTAATAATGGGGCCATGTGCGGGAGGTGCAGTATACTCACCTGCTTTAACAGATTTCATATTTATGGTTGA
TAAGACGAGCTACATGTTCATAACAGGTCCCCAAGTGATAAAAGCAGTGACAGGGGAAGAAGTGACCCATGAGCAATTAG
GAGGAGCGACAACCCATAACACATTGAGTGGAGTAGCCCATTTTGTATTTCCAGACGAAAAACAAACTTTAATAGCTGTA
AGAAAATTGTTAAGTTACTTACCTTCAAACAATATGGAAGACCCTCCAGTCGTTGAAACGGGAGACAGTCCTAATAGAGT
GGAAGTGGATTTAAACACAGTAATTCCTGATAACCCCAATAAGGCCTACAATATGAAAGATGTAATAAAATTAATAGTTG
ACAATGGCGAATTTTTTGAAGTTCAGCCATATTATGCTCAAAATATTATCACTGGGTTTGCAAGGCTTAATGGCCGTAGT
GTAGGAATAATAGCAAATAATCCGAGTGTTCTTGCAGGAGTACTTGATATAAATGCATCTGATAAAGCAGCAAGATTTAT
ACGTTTTTGCGATGCTTTTAATATTCCAATACTCAACTTGGTGGACGTTCCAGGATTTTTGCCAGGTACAGACCAAGAGT
ATGGCGGGATAATAAGGCATGGGGCTAAGATGCTTTATGCCTATTCAGAAGCGACAGTTCCAAAAGTTACTTTGATAATA
AGAAAAGCTTATGGTGGGGCTTATCTTGCAATGTGCAGCAGAGATTTAGGAGCAGATATGGTTTTGGCATGGCCAACAGC
AGAGATTGCAGTGATGGGACCTGAAGGGGCAGCTAATATAATTTTCAAAAAAGAAATAGAAGAAGCAGAAAATCCAGCGG
AAGTAAGGCAGCAAAAGATAGAAGAATATAGAACCAGCTTTGCAAATCCATACAGGGCAGCTGCAAGAGGCTATATAGAT
AACGTAATTGAACCAGCTGTAACTCGTCCGATTCTTATCTCAGCTTTTGATATGCTTATGTCAAAAAGAGAAACAAGACC
GGCTAAAAAGCATGGGAATATACCGCTGTAA

Upstream 100 bases:

>100_bases
GGGCGAAAATTGCCTTTGTCCACCCAAAGAACGCAAATGGAGTATTGTTAGAGCTTTGCGAGAGAGATTAAAACCACAAC
GTTCCTGGAGGTATGATAGA

Downstream 100 bases:

>100_bases
AGGAGGGTAAAAATGAGAAATTATTTTACACTTTTTAGAAAAAGGACAAAAATTGAAGAAGAAAAGGTAACAAGAGTTGA
AGAAACAGATAATGAAGAAA

Product: Acetyl-CoA carboxylase alpha subunit

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MDVQAKIEELKRRYEKIKEGGGQKRIEKQHEAGKLTARERLNILLDEHSFIEIDPFVEHRCTDFGMEKTEAPGDGVVTGY
GTIDGRLVFVFAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIP
QISVIMGPCAGGAVYSPALTDFIFMVDKTSYMFITGPQVIKAVTGEEVTHEQLGGATTHNTLSGVAHFVFPDEKQTLIAV
RKLLSYLPSNNMEDPPVVETGDSPNRVEVDLNTVIPDNPNKAYNMKDVIKLIVDNGEFFEVQPYYAQNIITGFARLNGRS
VGIIANNPSVLAGVLDINASDKAARFIRFCDAFNIPILNLVDVPGFLPGTDQEYGGIIRHGAKMLYAYSEATVPKVTLII
RKAYGGAYLAMCSRDLGADMVLAWPTAEIAVMGPEGAANIIFKKEIEEAENPAEVRQQKIEEYRTSFANPYRAAARGYID
NVIEPAVTRPILISAFDMLMSKRETRPAKKHGNIPL

Sequences:

>Translated_516_residues
MDVQAKIEELKRRYEKIKEGGGQKRIEKQHEAGKLTARERLNILLDEHSFIEIDPFVEHRCTDFGMEKTEAPGDGVVTGY
GTIDGRLVFVFAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIP
QISVIMGPCAGGAVYSPALTDFIFMVDKTSYMFITGPQVIKAVTGEEVTHEQLGGATTHNTLSGVAHFVFPDEKQTLIAV
RKLLSYLPSNNMEDPPVVETGDSPNRVEVDLNTVIPDNPNKAYNMKDVIKLIVDNGEFFEVQPYYAQNIITGFARLNGRS
VGIIANNPSVLAGVLDINASDKAARFIRFCDAFNIPILNLVDVPGFLPGTDQEYGGIIRHGAKMLYAYSEATVPKVTLII
RKAYGGAYLAMCSRDLGADMVLAWPTAEIAVMGPEGAANIIFKKEIEEAENPAEVRQQKIEEYRTSFANPYRAAARGYID
NVIEPAVTRPILISAFDMLMSKRETRPAKKHGNIPL
>Mature_516_residues
MDVQAKIEELKRRYEKIKEGGGQKRIEKQHEAGKLTARERLNILLDEHSFIEIDPFVEHRCTDFGMEKTEAPGDGVVTGY
GTIDGRLVFVFAQDFTVLGGSLGEYHAKKITKVMDMAMKMGAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIP
QISVIMGPCAGGAVYSPALTDFIFMVDKTSYMFITGPQVIKAVTGEEVTHEQLGGATTHNTLSGVAHFVFPDEKQTLIAV
RKLLSYLPSNNMEDPPVVETGDSPNRVEVDLNTVIPDNPNKAYNMKDVIKLIVDNGEFFEVQPYYAQNIITGFARLNGRS
VGIIANNPSVLAGVLDINASDKAARFIRFCDAFNIPILNLVDVPGFLPGTDQEYGGIIRHGAKMLYAYSEATVPKVTLII
RKAYGGAYLAMCSRDLGADMVLAWPTAEIAVMGPEGAANIIFKKEIEEAENPAEVRQQKIEEYRTSFANPYRAAARGYID
NVIEPAVTRPILISAFDMLMSKRETRPAKKHGNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=518, Percent_Identity=60.2316602316602, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=538, Percent_Identity=57.9925650557621, Blast_Score=624, Evalue=1e-179,
Organism=Homo sapiens, GI11545863, Length=514, Percent_Identity=34.8249027237354, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI134142062, Length=396, Percent_Identity=24.4949494949495, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI38679971, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679974, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679977, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679967, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679960, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788655, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=59.4961240310077, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=59.4961240310077, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=516, Percent_Identity=35.4651162790698, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71997163, Length=397, Percent_Identity=23.4256926952141, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=346, Percent_Identity=23.6994219653179, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=36.1702127659575, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56550; Mature: 56550

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQAKIEELKRRYEKIKEGGGQKRIEKQHEAGKLTARERLNILLDEHSFIEIDPFVEHR
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHEEECCCCEEEECHHHHHH
CTDFGMEKTEAPGDGVVTGYGTIDGRLVFVFAQDFTVLGGSLGEYHAKKITKVMDMAMKM
HHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHH
GAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIPQISVIMGPCAGGAVYSPALT
CCCEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCEEHHEECCCCCCCCCCHHHH
DFIFMVDKTSYMFITGPQVIKAVTGEEVTHEQLGGATTHNTLSGVAHFVFPDEKQTLIAV
HHEEEEECCCEEEEECHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEEEECCCCCHHHHHH
RKLLSYLPSNNMEDPPVVETGDSPNRVEVDLNTVIPDNPNKAYNMKDVIKLIVDNGEFFE
HHHHHHCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEE
VQPYYAQNIITGFARLNGRSVGIIANNPSVLAGVLDINASDKAARFIRFCDAFNIPILNL
ECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
VDVPGFLPGTDQEYGGIIRHGAKMLYAYSEATVPKVTLIIRKAYGGAYLAMCSRDLGADM
ECCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEHHHHCCCCCE
VLAWPTAEIAVMGPEGAANIIFKKEIEEAENPAEVRQQKIEEYRTSFANPYRAAARGYID
EEEECCCEEEEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVIEPAVTRPILISAFDMLMSKRETRPAKKHGNIPL
HHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MDVQAKIEELKRRYEKIKEGGGQKRIEKQHEAGKLTARERLNILLDEHSFIEIDPFVEHR
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHEEECCCCEEEECHHHHHH
CTDFGMEKTEAPGDGVVTGYGTIDGRLVFVFAQDFTVLGGSLGEYHAKKITKVMDMAMKM
HHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHH
GAPLIGLNDSGGARIQEGVDALSGYGQIFYRNTLASGVIPQISVIMGPCAGGAVYSPALT
CCCEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCEEHHEECCCCCCCCCCHHHH
DFIFMVDKTSYMFITGPQVIKAVTGEEVTHEQLGGATTHNTLSGVAHFVFPDEKQTLIAV
HHEEEEECCCEEEEECHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEEEECCCCCHHHHHH
RKLLSYLPSNNMEDPPVVETGDSPNRVEVDLNTVIPDNPNKAYNMKDVIKLIVDNGEFFE
HHHHHHCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEE
VQPYYAQNIITGFARLNGRSVGIIANNPSVLAGVLDINASDKAARFIRFCDAFNIPILNL
ECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
VDVPGFLPGTDQEYGGIIRHGAKMLYAYSEATVPKVTLIIRKAYGGAYLAMCSRDLGADM
ECCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEHHHHCCCCCE
VLAWPTAEIAVMGPEGAANIIFKKEIEEAENPAEVRQQKIEEYRTSFANPYRAAARGYID
EEEECCCEEEEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVIEPAVTRPILISAFDMLMSKRETRPAKKHGNIPL
HHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]