Click here to switch to the map view.

The map label for this gene is GRS1

Identifier: 20807458

GI number: 20807458

Start: 979522

End: 980907

Strand: Direct

Name: GRS1

Synonym: TTE0978

Alternate gene names: 20807458

Gene position: 979522-980907 (Clockwise)

Preceding gene: 20807457

Following gene: 20807459

Centisome position: 36.42

GC content: 40.26

Gene sequence:

>1386_bases
ATGCCTGTCAAAGTTACAATGGATAAAATAGTGGCTCTTGCAAAAAACAGGGGTTTTGTGTTTCCTGGGTCTGAGATATA
CGGCGGGCTTGCGAACACATGGGACTATGGGCCTTTGGGAGTGGAGATGAAAAACAATATAAAAAGGATATGGTGGAAGA
AATTTATACAGGAAAGCCCTTATAATGTGGGAATTGATTCTGCTATTTTGATGAACAGAGAAGTGTGGGTTGCTTCAGGT
CACGTGGCTAGTTTTAGCGATCCTCTGATGGACTGCAAGGAATGCAAGTCTCGCTTCAGAGCTGACCAGCTAATTGAAGA
TTACATAAAAGAAAAGGGACTTGATATTTCGATTGAAGGATGGACAAATGAGCAGATGATGGAATTTATAAAAGAGCACA
AAGTTCCATGTCCCAAGTGTGGAGCCCACAATTTTACAGAGATAAGGAAGTTTAACCTGATGTTTAAAACTTATGTAGGG
GTTACAGAGGATTCAAAATCTGAAGTTTTTTTGAGGCCTGAGACAGCTCAGGGAATATTTGTGAATTTTAAAAATGTCCA
GAGGACAAGCCGCAAGAAAATTCCTTTTGGTATCGGGCAGATTGGCAAATCTTTTAGAAATGAAATTACGCCTGGCAATT
TCATATTTAGAACGAGGGAATTTGAACAGATGGAGCTGGAATTTTTCTGTAAGCCAGGGGAAGACATGGAGTGGTTCAAT
TACTGGAGACAATTTTGCATGGATTGGCTTGTAGAATTTGGCTTAAAGAGGGAGAATTTAAGGTTCAGAGACCACAAAAA
AGAAGAGCTGTCTCATTACAGCACTGCCACAACCGACATAGAGTACAATTTTCCCTTTGGATGGGGAGAACTGTGGGGAA
TTGCTAATAGAACTGACTATGATTTAAGACAGCATATGGAACATTCGGGAGAAGACATGACTTACACTGACCCTGTCACA
GGAGAAAAGTACATACCCTATTGTATTGAGCCTTCAGTGGGAGTGGATAGACTAATGCTTGCTTTTTTGGTTGATGCTTA
CGATGAAGAGGAAGTGGAAGGAGAAACAAGAGTAGTTTTAAGGCTTCACCCAGCTATCGCACCTGTTAAAGTGGCGGTTT
TCCCTCTTTCCAAGAAGCTTAATGAAGCAGCTTATAAAATCTACTTAGACCTTAAAAAGAAGTTTCCTGCAGAGTATGAC
GAATCAGGTAGCATAGGAAGAAGGTATAGAAGACAGGATGAGATTGGAACGCCTTTCTGCGTAACTTACGATTTTGACTC
AGAAAATGACCACAAAGTTACAATAAGAGACAGAGATACTATGGAGCAAATAAGGATAGACATAGACCAAGTGGATAAAT
ACCTGGAGGAGAAACTCAAGTTTTAA

Upstream 100 bases:

>100_bases
ATATTACTCAATTTGATATTCTAAAATAAGTAATGCTAAAACCTTTCTCCCCGAAAGGGGATGAAGGGTTTTTGTATAAT
TGGGAAAAGGAGTGTTATTG

Downstream 100 bases:

>100_bases
GGGGAATCAGTTTTCGCTGATTTCCCTTTCTTAAAAATTAAAAAACAAGTTGGTTATGCCTTTATTTTGTGGTATAATTA
TAGTAAAGTGTTAAACAGAA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPVKVTMDKIVALAKNRGFVFPGSEIYGGLANTWDYGPLGVEMKNNIKRIWWKKFIQESPYNVGIDSAILMNREVWVASG
HVASFSDPLMDCKECKSRFRADQLIEDYIKEKGLDISIEGWTNEQMMEFIKEHKVPCPKCGAHNFTEIRKFNLMFKTYVG
VTEDSKSEVFLRPETAQGIFVNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEDMEWFN
YWRQFCMDWLVEFGLKRENLRFRDHKKEELSHYSTATTDIEYNFPFGWGELWGIANRTDYDLRQHMEHSGEDMTYTDPVT
GEKYIPYCIEPSVGVDRLMLAFLVDAYDEEEVEGETRVVLRLHPAIAPVKVAVFPLSKKLNEAAYKIYLDLKKKFPAEYD
ESGSIGRRYRRQDEIGTPFCVTYDFDSENDHKVTIRDRDTMEQIRIDIDQVDKYLEEKLKF

Sequences:

>Translated_461_residues
MPVKVTMDKIVALAKNRGFVFPGSEIYGGLANTWDYGPLGVEMKNNIKRIWWKKFIQESPYNVGIDSAILMNREVWVASG
HVASFSDPLMDCKECKSRFRADQLIEDYIKEKGLDISIEGWTNEQMMEFIKEHKVPCPKCGAHNFTEIRKFNLMFKTYVG
VTEDSKSEVFLRPETAQGIFVNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEDMEWFN
YWRQFCMDWLVEFGLKRENLRFRDHKKEELSHYSTATTDIEYNFPFGWGELWGIANRTDYDLRQHMEHSGEDMTYTDPVT
GEKYIPYCIEPSVGVDRLMLAFLVDAYDEEEVEGETRVVLRLHPAIAPVKVAVFPLSKKLNEAAYKIYLDLKKKFPAEYD
ESGSIGRRYRRQDEIGTPFCVTYDFDSENDHKVTIRDRDTMEQIRIDIDQVDKYLEEKLKF
>Mature_460_residues
PVKVTMDKIVALAKNRGFVFPGSEIYGGLANTWDYGPLGVEMKNNIKRIWWKKFIQESPYNVGIDSAILMNREVWVASGH
VASFSDPLMDCKECKSRFRADQLIEDYIKEKGLDISIEGWTNEQMMEFIKEHKVPCPKCGAHNFTEIRKFNLMFKTYVGV
TEDSKSEVFLRPETAQGIFVNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEDMEWFNY
WRQFCMDWLVEFGLKRENLRFRDHKKEELSHYSTATTDIEYNFPFGWGELWGIANRTDYDLRQHMEHSGEDMTYTDPVTG
EKYIPYCIEPSVGVDRLMLAFLVDAYDEEEVEGETRVVLRLHPAIAPVKVAVFPLSKKLNEAAYKIYLDLKKKFPAEYDE
SGSIGRRYRRQDEIGTPFCVTYDFDSENDHKVTIRDRDTMEQIRIDIDQVDKYLEEKLKF

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=379, Percent_Identity=29.5514511873351, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI70887790, Length=437, Percent_Identity=21.0526315789474, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564541, Length=357, Percent_Identity=35.2941176470588, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17554996, Length=357, Percent_Identity=35.2941176470588, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325338, Length=366, Percent_Identity=30.8743169398907, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319597, Length=405, Percent_Identity=28.641975308642, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357965, Length=368, Percent_Identity=32.6086956521739, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24664462, Length=368, Percent_Identity=33.1521739130435, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_THETN (Q8RB46)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622629.1
- ProteinModelPortal:   Q8RB46
- GeneID:   995821
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0978
- NMPDR:   fig|273068.3.peg.401
- HOGENOM:   HBG319978
- OMA:   GSEWGEL
- ProtClustDB:   PRK04173
- BioCyc:   TTEN273068:TTE0978-MONOMER
- BRENDA:   6.1.1.14
- GO:   GO:0005737
- HAMAP:   MF_00253_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 54121; Mature: 53990

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 100-100 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVTMDKIVALAKNRGFVFPGSEIYGGLANTWDYGPLGVEMKNNIKRIWWKKFIQESP
CCCEEEHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
YNVGIDSAILMNREVWVASGHVASFSDPLMDCKECKSRFRADQLIEDYIKEKGLDISIEG
CCCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
WTNEQMMEFIKEHKVPCPKCGAHNFTEIRKFNLMFKTYVGVTEDSKSEVFLRPETAQGIF
CCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEEHHHCCCCCCCCCEEEECCCCCCEEE
VNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEDMEWFN
EEEHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHEEEEEEECCCCCCHHHH
YWRQFCMDWLVEFGLKRENLRFRDHKKEELSHYSTATTDIEYNFPFGWGELWGIANRTDY
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCCH
DLRQHMEHSGEDMTYTDPVTGEKYIPYCIEPSVGVDRLMLAFLVDAYDEEEVEGETRVVL
HHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCHHCCCCEEEEE
RLHPAIAPVKVAVFPLSKKLNEAAYKIYLDLKKKFPAEYDESGSIGRRYRRQDEIGTPFC
EECCCCCCEEEEEEEHHHHHHHHHEEEEEEEHHHCCCCCCCCCCHHHHHHHHHCCCCCEE
VTYDFDSENDHKVTIRDRDTMEQIRIDIDQVDKYLEEKLKF
EEEECCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVKVTMDKIVALAKNRGFVFPGSEIYGGLANTWDYGPLGVEMKNNIKRIWWKKFIQESP
CCEEEHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
YNVGIDSAILMNREVWVASGHVASFSDPLMDCKECKSRFRADQLIEDYIKEKGLDISIEG
CCCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
WTNEQMMEFIKEHKVPCPKCGAHNFTEIRKFNLMFKTYVGVTEDSKSEVFLRPETAQGIF
CCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEEHHHCCCCCCCCCEEEECCCCCCEEE
VNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEDMEWFN
EEEHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHEEEEEEECCCCCCHHHH
YWRQFCMDWLVEFGLKRENLRFRDHKKEELSHYSTATTDIEYNFPFGWGELWGIANRTDY
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCCH
DLRQHMEHSGEDMTYTDPVTGEKYIPYCIEPSVGVDRLMLAFLVDAYDEEEVEGETRVVL
HHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCHHCCCCEEEEE
RLHPAIAPVKVAVFPLSKKLNEAAYKIYLDLKKKFPAEYDESGSIGRRYRRQDEIGTPFC
EECCCCCCEEEEEEEHHHHHHHHHEEEEEEEHHHCCCCCCCCCCHHHHHHHHHCCCCCEE
VTYDFDSENDHKVTIRDRDTMEQIRIDIDQVDKYLEEKLKF
EEEECCCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336