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The map label for this gene is gltX

Identifier: 20807410

GI number: 20807410

Start: 934091

End: 935536

Strand: Direct

Name: gltX

Synonym: TTE0929

Alternate gene names: 20807410

Gene position: 934091-935536 (Clockwise)

Preceding gene: 20807408

Following gene: 20807411

Centisome position: 34.73

GC content: 41.42

Gene sequence:

>1446_bases
ATGATGAGCGAAGTCAGAGTGAGATTTGCGCCAAGTCCTACGGGTAGTTTGCACATAGGTGGAGCGAGAACAGCGCTTTT
TAACTGGCTTTTTGCCAGGCATCACGGCGGCAAATTTATTTTAAGGGTTGATGACACAGATTTAGAAAGGTCTACAGAAG
AATCTATGAGGGGAATACTAGAAGGACTTCAGTGGCTGGGAATTGATTGGGATGAAGGGCCTATATATCAGTCCCAGAGA
TTGGATGAATATAGGAAGTTTGCAAATAAACTGCTTGAAGAGGGGAAAGCCTATTATTGTTTCTGCACAAAAGAAGAGCT
GGAAGAGATGAGAAAGCAGGCGGAAAGAGAAGGCAGGCCTTTTATGTACACAGGAAAGTGCAGGAATTTGACAAAAGAAC
AGATAGAGAATTACCTCAAAGAGGGTAAGAAGCCTGTCATACGCTTGAAAACGCCGAGAGAAGGAAAAACTGTCGTCCAT
GACATAATAAGGGGAGATGTTGAGTTTGACAATTCTACAATTGATGACTTTATAATAATGAAGTCAGATGGGATGCCGAC
TTACAATTTCGCTACAGTCGTGGATGACTACCAGATGGGAATTACCCATATTATAAGGGCGGAAGAGCATCTTTCTAACA
CCCCCAAGCAGATACTCATCTACGAAGCGTTAGGAGTGCCATTGCCCCAATTTGCCCATGTGTCCATGGTTTTGGCTCCT
GACAGGACTAAACTTTCAAAAAGGCATGGGGCTACCTCTGTTCAGGAATTCAGAGACCAGGGGTATCTGCCTGAGGCGAT
TGTGAACTACATCACTCTTTTGGGATGGGCTCCTCTAGATGGGGAAGAAATTTTTGACGTGAGAAAAAGCATAAGGGAAT
TTTCTCTAGAGAGGGTTTCCAAAAATCCAGCGGTTTACGATGTTCAAAAGCTTACCTGGATAAATGGCCACTACATTAGA
AGCTATGACCTCGATAAATTGACACAAGCTATAATACCGTTTTTGCAGAAAAAAGGGCTAATAGGTGAAAATTACGATTA
CGAGTATATAAAAAAGATAGTGAGTGTAGTGAGAGAGAGGGAAAAAACGCTTGTGGATATAGCAGATGCTATGACGTATT
ATTTTAAAGAAGTAGAGAGCTACGAGGAAAAGGGCGTGCAAAAATACTTTACCAAAGAAGGGGTAGTGGACATTCTTAAA
AAGGCAGCTGAAACGCTGAAAAATTTGGAGCCTTTTAATAAATTTACTGCTGAAGAGGCTTACAGAAAATTGGTTGAAGA
GTTGGGCATATCCAGTAGCGCTCTTTTCCACCCGACAAGATTAGCTATTTCTGGCAGAACTTTTGGGCCAGGGCTATTTG
ATATAATGGAATTTTTGGGCAAAGAAAAGACAGTTGCTCGAATTGAAAGGGCTATAAAATTCATTGAAGAAAACATAAAA
GGATGA

Upstream 100 bases:

>100_bases
AATTTTACATATACCAATTATACCACATTTTTATTTTCTTGAAAAAATAAATCAGTTAAAGTATAATCAAAAATAGTTTA
AACCTATAGAAGAAGGTGAG

Downstream 100 bases:

>100_bases
TATCACCTATACAGGGGTGATATCATCCTTTTAACCCATGAAAGGGTGAAATAAAATGTACTTTGTGATTACTGCTGACA
TAGTAAGGTCAAGAGAGCTT

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase 1; GluRS 1

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MMSEVRVRFAPSPTGSLHIGGARTALFNWLFARHHGGKFILRVDDTDLERSTEESMRGILEGLQWLGIDWDEGPIYQSQR
LDEYRKFANKLLEEGKAYYCFCTKEELEEMRKQAEREGRPFMYTGKCRNLTKEQIENYLKEGKKPVIRLKTPREGKTVVH
DIIRGDVEFDNSTIDDFIIMKSDGMPTYNFATVVDDYQMGITHIIRAEEHLSNTPKQILIYEALGVPLPQFAHVSMVLAP
DRTKLSKRHGATSVQEFRDQGYLPEAIVNYITLLGWAPLDGEEIFDVRKSIREFSLERVSKNPAVYDVQKLTWINGHYIR
SYDLDKLTQAIIPFLQKKGLIGENYDYEYIKKIVSVVREREKTLVDIADAMTYYFKEVESYEEKGVQKYFTKEGVVDILK
KAAETLKNLEPFNKFTAEEAYRKLVEELGISSSALFHPTRLAISGRTFGPGLFDIMEFLGKEKTVARIERAIKFIEENIK
G

Sequences:

>Translated_481_residues
MMSEVRVRFAPSPTGSLHIGGARTALFNWLFARHHGGKFILRVDDTDLERSTEESMRGILEGLQWLGIDWDEGPIYQSQR
LDEYRKFANKLLEEGKAYYCFCTKEELEEMRKQAEREGRPFMYTGKCRNLTKEQIENYLKEGKKPVIRLKTPREGKTVVH
DIIRGDVEFDNSTIDDFIIMKSDGMPTYNFATVVDDYQMGITHIIRAEEHLSNTPKQILIYEALGVPLPQFAHVSMVLAP
DRTKLSKRHGATSVQEFRDQGYLPEAIVNYITLLGWAPLDGEEIFDVRKSIREFSLERVSKNPAVYDVQKLTWINGHYIR
SYDLDKLTQAIIPFLQKKGLIGENYDYEYIKKIVSVVREREKTLVDIADAMTYYFKEVESYEEKGVQKYFTKEGVVDILK
KAAETLKNLEPFNKFTAEEAYRKLVEELGISSSALFHPTRLAISGRTFGPGLFDIMEFLGKEKTVARIERAIKFIEENIK
G
>Mature_481_residues
MMSEVRVRFAPSPTGSLHIGGARTALFNWLFARHHGGKFILRVDDTDLERSTEESMRGILEGLQWLGIDWDEGPIYQSQR
LDEYRKFANKLLEEGKAYYCFCTKEELEEMRKQAEREGRPFMYTGKCRNLTKEQIENYLKEGKKPVIRLKTPREGKTVVH
DIIRGDVEFDNSTIDDFIIMKSDGMPTYNFATVVDDYQMGITHIIRAEEHLSNTPKQILIYEALGVPLPQFAHVSMVLAP
DRTKLSKRHGATSVQEFRDQGYLPEAIVNYITLLGWAPLDGEEIFDVRKSIREFSLERVSKNPAVYDVQKLTWINGHYIR
SYDLDKLTQAIIPFLQKKGLIGENYDYEYIKKIVSVVREREKTLVDIADAMTYYFKEVESYEEKGVQKYFTKEGVVDILK
KAAETLKNLEPFNKFTAEEAYRKLVEELGISSSALFHPTRLAISGRTFGPGLFDIMEFLGKEKTVARIERAIKFIEENIK
G

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI134288884, Length=489, Percent_Identity=33.1288343558282, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI62241042, Length=254, Percent_Identity=30.7086614173228, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788743, Length=478, Percent_Identity=40.1673640167364, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI226510925, Length=248, Percent_Identity=34.2741935483871, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786895, Length=333, Percent_Identity=24.9249249249249, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993394, Length=491, Percent_Identity=33.6048879837067, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17511007, Length=275, Percent_Identity=28.7272727272727, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17543332, Length=236, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324540, Length=494, Percent_Identity=35.0202429149798, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6321192, Length=253, Percent_Identity=32.0158102766798, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324742, Length=302, Percent_Identity=28.1456953642384, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24665321, Length=495, Percent_Identity=34.1414141414141, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI17864488, Length=298, Percent_Identity=27.8523489932886, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24649466, Length=221, Percent_Identity=28.0542986425339, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYE1_THETN (Q8RB93)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622581.1
- ProteinModelPortal:   Q8RB93
- SMR:   Q8RB93
- GeneID:   995885
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0929
- NMPDR:   fig|273068.3.peg.227
- HOGENOM:   HBG628189
- OMA:   ICREKVN
- ProtClustDB:   PRK01406
- BioCyc:   TTEN273068:TTE0929-MONOMER
- BRENDA:   6.1.1.17
- GO:   GO:0005737
- HAMAP:   MF_00022_B
- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:1.10.1160.10
- Gene3D:   G3DSA:3.40.50.620
- Gene3D:   G3DSA:1.10.10.350
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR00464

Pfam domain/function: PF00749 tRNA-synt_1c; SSF48163 tRNA-synt_bind

EC number: =6.1.1.17

Molecular weight: Translated: 55544; Mature: 55544

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSEVRVRFAPSPTGSLHIGGARTALFNWLFARHHGGKFILRVDDTDLERSTEESMRGIL
CCCCCEEEECCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
EGLQWLGIDWDEGPIYQSQRLDEYRKFANKLLEEGKAYYCFCTKEELEEMRKQAEREGRP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCC
FMYTGKCRNLTKEQIENYLKEGKKPVIRLKTPREGKTVVHDIIRGDVEFDNSTIDDFIIM
EEEECCHHCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
KSDGMPTYNFATVVDDYQMGITHIIRAEEHLSNTPKQILIYEALGVPLPQFAHVSMVLAP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCCCHHCEEEEECC
DRTKLSKRHGATSVQEFRDQGYLPEAIVNYITLLGWAPLDGEEIFDVRKSIREFSLERVS
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
KNPAVYDVQKLTWINGHYIRSYDLDKLTQAIIPFLQKKGLIGENYDYEYIKKIVSVVRER
CCCCEEEHHHEEEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
EKTLVDIADAMTYYFKEVESYEEKGVQKYFTKEGVVDILKKAAETLKNLEPFNKFTAEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YRKLVEELGISSSALFHPTRLAISGRTFGPGLFDIMEFLGKEKTVARIERAIKFIEENIK
HHHHHHHHCCCCCCEECCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MMSEVRVRFAPSPTGSLHIGGARTALFNWLFARHHGGKFILRVDDTDLERSTEESMRGIL
CCCCCEEEECCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHH
EGLQWLGIDWDEGPIYQSQRLDEYRKFANKLLEEGKAYYCFCTKEELEEMRKQAEREGRP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCC
FMYTGKCRNLTKEQIENYLKEGKKPVIRLKTPREGKTVVHDIIRGDVEFDNSTIDDFIIM
EEEECCHHCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
KSDGMPTYNFATVVDDYQMGITHIIRAEEHLSNTPKQILIYEALGVPLPQFAHVSMVLAP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCCCHHCEEEEECC
DRTKLSKRHGATSVQEFRDQGYLPEAIVNYITLLGWAPLDGEEIFDVRKSIREFSLERVS
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
KNPAVYDVQKLTWINGHYIRSYDLDKLTQAIIPFLQKKGLIGENYDYEYIKKIVSVVRER
CCCCEEEHHHEEEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
EKTLVDIADAMTYYFKEVESYEEKGVQKYFTKEGVVDILKKAAETLKNLEPFNKFTAEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YRKLVEELGISSSALFHPTRLAISGRTFGPGLFDIMEFLGKEKTVARIERAIKFIEENIK
HHHHHHHHCCCCCCEECCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336