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The map label for this gene is obgE

Identifier: 20807398

GI number: 20807398

Start: 922355

End: 923629

Strand: Direct

Name: obgE

Synonym: TTE0917

Alternate gene names: 20807398

Gene position: 922355-923629 (Clockwise)

Preceding gene: 20807397

Following gene: 20807399

Centisome position: 34.3

GC content: 41.33

Gene sequence:

>1275_bases
ATGGTGTTTATAGATACAGCCCGCATATATATAAAAGCCGGAGATGGGGGCAATGGCTTTATTTCTTTCAGGAGAGAAAA
GTATGTTCCTTATGGGGGACCTGACGGAGGAGATGGGGGAAAAGGCGGAGATGTGATTTTTATAGCAGACCCAAATCTTT
CTACACTGTTGGATTTTAAGTACAAAAGAAAATATATTGCTGAAAATGGAGAGAATGGCAAGAGTAAAAATCAGTATGGA
AAAGATGGTGAAGACCTCTATATTAAGGTGCCTGTGGGTACTACTATCATAAATGACGAAACTGGAGAAGTGATAGCGGA
TTTAATAAAGCCATATCAAAAGGCCATTGTGCTGAAGGGAGGAAAGGGAGGAAGGGGAAATGCCAAATTTGCCACTCCTA
CTTTAAAGACTCCCCGCTTTGCTGAAAGCGGTGAAAAAGGAAGAGAAATGTGGGTGAGATTAGAGCTTAAACTTCTCGCA
GATGTGGGACTGGTTGGGTTTCCCAATGCCGGAAAATCTACATTACTGGCAAGTTGCAGCAGAGCTAGACCCAAAATTGC
CAACTATCCTTTCACGACTCTGACCCCAAATTTAGGAGTTGTGGAGCACAAAGGAAAGTCCTTTGTAATGGCTGATATTC
CAGGGCTTATTGAAGGAGCCCACAGGGGTGAAGGATTGGGGCACGATTTTTTGAGGCATATTGAAAGGACAAAAATGCTT
ATCCACGTGGTAGACGTATCTGGCAGCGAGGGAAGGGACCCTGTAGAAGACTTTGAAAAAATAAATGAAGAGTTAAGACT
TTACGATGAAAGGCTTGTGACTTTGCCTCAGATTGTCGCAGCAAATAAGATGGATTTGCCTGAGGGGAAAGAAAAATATC
CTAGATTTGAAGAGGAGATAAAGAAAAGAGGATATGAGGTATATCCCATATCGGCTCTTACAAAAGAAGGGCTTGATGCT
CTTCTTGACAAGACTATTGAGATTTTGTCTTCTATTCCTGCCGAAAAAATAGAGGAAGTCCCTGAGGTAATAGTCTATAA
CCCGCCTGAGGAAGAGGAAACCCTGGAGGTAGAAGTCAAAGGAAACACTTATTATCTAAAGGGAAGTAAGATTGACAAGC
TTTTAAAGAGGATAAATTTACAGGATGAACATTCTCTGAGGTATTTTGAAATTCTCCTTAGAAAAAGTGGGGTAATAGAT
GCTCTTAAGGAGAAGGGTTTTAAAAGCGGGGACGTCATAAATGTGAGGGATTTTGAGTTCGAGTATTACGAGTAA

Upstream 100 bases:

>100_bases
AATGAGGAGAGAGAAATTTTTAACTGTGAAAATCCTCAGGAAATTATAAAAACTCTTTTGAAAAAGGCATAATAATTAGA
GAATGAATAAGGCAGGTGAT

Downstream 100 bases:

>100_bases
AAACTTCAAGTTGTGCATTTTCACTTTTTTAATGTATAATGTAAGTATACATTAAAAAAGCAGGGGGATATAAATTGGAA
AGGGAGCTCAGGCTTGGTAT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFKYKRKYIAENGENGKSKNQYG
KDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKGGKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLA
DVGLVGFPNAGKSTLLASCSRARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKML
IHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEIKKRGYEVYPISALTKEGLDA
LLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVKGNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVID
ALKEKGFKSGDVINVRDFEFEYYE

Sequences:

>Translated_424_residues
MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFKYKRKYIAENGENGKSKNQYG
KDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKGGKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLA
DVGLVGFPNAGKSTLLASCSRARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKML
IHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEIKKRGYEVYPISALTKEGLDA
LLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVKGNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVID
ALKEKGFKSGDVINVRDFEFEYYE
>Mature_424_residues
MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFKYKRKYIAENGENGKSKNQYG
KDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKGGKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLA
DVGLVGFPNAGKSTLLASCSRARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKML
IHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEIKKRGYEVYPISALTKEGLDA
LLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVKGNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVID
ALKEKGFKSGDVINVRDFEFEYYE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=321, Percent_Identity=43.613707165109, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI111955139, Length=347, Percent_Identity=38.6167146974063, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI111955063, Length=243, Percent_Identity=41.5637860082305, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=36.7647058823529, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI4758796, Length=126, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4557537, Length=91, Percent_Identity=39.5604395604396, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789574, Length=345, Percent_Identity=47.536231884058, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1787454, Length=134, Percent_Identity=38.0597014925373, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790615, Length=222, Percent_Identity=27.9279279279279, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=334, Percent_Identity=41.3173652694611, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=310, Percent_Identity=34.1935483870968, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=34.5323741007194, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555344, Length=87, Percent_Identity=41.3793103448276, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71981008, Length=91, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=227, Percent_Identity=37.8854625550661, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321649, Length=143, Percent_Identity=36.3636363636364, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321612, Length=112, Percent_Identity=34.8214285714286, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319281, Length=89, Percent_Identity=40.4494382022472, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319499, Length=135, Percent_Identity=39.2592592592593, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129375, Length=323, Percent_Identity=41.7956656346749, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24585318, Length=350, Percent_Identity=36.2857142857143, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24640873, Length=133, Percent_Identity=40.6015037593985, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640877, Length=133, Percent_Identity=40.6015037593985, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640875, Length=133, Percent_Identity=40.6015037593985, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356473, Length=88, Percent_Identity=38.6363636363636, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17981711, Length=85, Percent_Identity=44.7058823529412, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_THETN (Q8RBA5)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622569.1
- HSSP:   P20964
- ProteinModelPortal:   Q8RBA5
- SMR:   Q8RBA5
- GeneID:   995903
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0917
- NMPDR:   fig|273068.3.peg.215
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12297
- BioCyc:   TTEN273068:TTE0917-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 47373; Mature: 47373

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFK
CEEEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
YKRKYIAENGENGKSKNQYGKDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKG
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHEEEEEEC
GKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLADVGLVGFPNAGKSTLLASCS
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEEEEEHHCCCCEECCCCCCHHHHHHHH
RARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKML
HCCCCCCCCCCCEECCCCCEEEECCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHEEE
IHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEI
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHH
KKRGYEVYPISALTKEGLDALLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVK
HHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCEEEEEEC
GNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVIDALKEKGFKSGDVINVRDFEF
CCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCE
EYYE
EECC
>Mature Secondary Structure
MVFIDTARIYIKAGDGGNGFISFRREKYVPYGGPDGGDGGKGGDVIFIADPNLSTLLDFK
CEEEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
YKRKYIAENGENGKSKNQYGKDGEDLYIKVPVGTTIINDETGEVIADLIKPYQKAIVLKG
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHEEEEEEC
GKGGRGNAKFATPTLKTPRFAESGEKGREMWVRLELKLLADVGLVGFPNAGKSTLLASCS
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEEEEEHHCCCCEECCCCCCHHHHHHHH
RARPKIANYPFTTLTPNLGVVEHKGKSFVMADIPGLIEGAHRGEGLGHDFLRHIERTKML
HCCCCCCCCCCCEECCCCCEEEECCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHEEE
IHVVDVSGSEGRDPVEDFEKINEELRLYDERLVTLPQIVAANKMDLPEGKEKYPRFEEEI
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHH
KKRGYEVYPISALTKEGLDALLDKTIEILSSIPAEKIEEVPEVIVYNPPEEEETLEVEVK
HHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCEEEEEEC
GNTYYLKGSKIDKLLKRINLQDEHSLRYFEILLRKSGVIDALKEKGFKSGDVINVRDFEF
CCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCE
EYYE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336