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The map label for this gene is FtsI [H]

Identifier: 20807382

GI number: 20807382

Start: 909259

End: 911559

Strand: Direct

Name: FtsI [H]

Synonym: TTE0901

Alternate gene names: 20807382

Gene position: 909259-911559 (Clockwise)

Preceding gene: 20807381

Following gene: 20807383

Centisome position: 33.81

GC content: 41.85

Gene sequence:

>2301_bases
TTGAGTGAAGCCTTAAAAAAGAGGTTTTACGTCCTTGCCTCCATAATAGGGATACTGCTTTTACTTCTTGTTTCCCGACT
GGTTTACCTGCAGCTTATAAAGGGAGACTATTATAGAGAAATTTCCATAAAGCAGGCGATTCGCTTGATTCCCATTGATG
CCCCAAGAGGCGAGATTGTAGATAGGTACGGTGTAAAACTTGCTACAAACAGGCCTAGCTTTTCTGTAGACATTTTAAAA
GGTGAAGTTGTGGACAGCCATTTGAATGAGACTATATTGAAGTTAATACATTTACTAGAAAAAAATAATGTAAAGTATAA
AGATGACCTTCCTCTTTATTTGAACGACAAAGGAGAGCCTTATTTTAACTTTAAAAATCCTGATGAAGGAGATGTCTCAC
CTGAAACCTTAAAAGAGAGGGAAAAGGCGTGGAAGAAGGCAAACAATATAAATGAGAGCGCCACAGCAAAAGAGACGTGG
GATATTTTAATGAAAAAATTTAAGATTTCAAAAGATTTGAGCCCTCAGGATGCAAGAAAGATAATGGTTGTGAGGCAGCT
CATGGAAGAGCAGGGATACAATCAGTACCAACCAGTCGAAATAGCAGTAGATGTGGACCAGAAAACAGTGGCAGAGATTG
AAGAAAGGCATTTAGAGCTTCCTGGCGTGATGATCAACATAAAGCCGATAAGGTATTATCCATATGGGACCCTATTATCT
CAAACCTTAGGCTATATTGGCCGCATTACTCCTGAGGATTTAAAGAAACTAGATATAAAGAAGTACAAGCTGACAGACTT
AGTGGGACATTCAGGAATTGAAGCTTTGTATGAAGAGTATTTACACGGGAAAGATGGAGGGCAGCAGGTGGTAGTTGATA
ATTACGGAAGGCTTATCAAAAATTTAAGCACAGTGCCACCTGTTCCGGGAGATACAGTTTTTCTCACTATAGACAAGAAT
ATTCAAGAGGCTGCAGAGGAAGCCCTCATAAATACTATGCAAAAATTAAGGGAGGGCAAATTGGGGAAACCGCGCCCCAA
CGCAAAAATTGGAGCAGCAGTAGTTGTGGACATACACTCAGGGAAGATTTTGGCTTTGGCCAGCGTGCCTGGTTTTGACC
CCAATATATTTGCTACGGGAAGTCCCCCAAAGGATGTAGTAAATGAGCTTTTTAGGGAAAGAGATGCAACTGTTGATCCG
AGCCCTATCTTCAATTACGCCACCCAAGGAGCAGTGCCTCCAGGGTCTACTTTTAAAATGATAGTTGCTCTAGCGGCGCT
TGAGACAGGTGTCACTACTGTGGATGAGAAGTATCTAGACCCCGGTGTATACATTACCGGGCAGACAAACTGGCTGTGGA
ATGAATACGGTAGGACACAGGGCTGGGTCAATGTGTCAGATGCTATCAAGTACTCAACAGACACCTATTTTTATGAGATG
GGAAGGAGAATGGGAATAGATAAAATAGTGGAATATGCTAAAAAATTTGGCTTAGACCAGAAGACAGGCATTGAGCTTCC
GGAAGCTAAAGGGATTATCGCAAGTCCCCAGTATAAAAGAGAGTTTTATCTGGCACTTATAAGGTCTATGGTAAAAAGCG
AAAGAAACCCCGATGGCCCTATAACTGAAGAGCAGTACAATAAAATTGTAGAGATTGTAGACAAAGGAGACTTGAGTGAC
TACAATACTTTTCTCAAGTTAGAGAAAATGGGAATAAAAGATCCAAAATTGCAGAGAAAACTTTGGGAGATGATGTATTA
CGCCAGACATTGGAGCCTGGCTGACACCTGCAGTGCGGCTATTGGGCAGGGAGACAATCAGTTTACCCCTCTTGAGATTG
CAAGTTACATCTCAACCTTGGTAAATGGTGGAATTCGGTATAGACTCCACCTTGTAGACAAGATTGTAGATGCTGAAGGG
AATATAGTCAAAAAGACAGAGCCAGAAATTTTAGGCAAAATAGACATTCCTAAAAAGTACCTAGATGCGATAAAGCTAGG
CATGAAGGGAGTTACTGAAAGAGGGGGAACGGCAAGCGCTGCATTTGACGGTTTTCCCATGACTGTAGGAGGTAAAACTG
GTACTGCAGAGGTAGGCATAAAGGGAAGGGATAATTACGCCTGGTTCGTAGGTTTTGCCCCCTATGACAATCCTCAAATT
GTGGTAGTTACTGTTATTTATCAAGGGGGAGGCGGTTCATACGCTGCTTACGTGGCAAGAGATATATTTGACGCCTACTT
TGGGCTGAGCAAAAGCGGAGAAAGAGAGACGTTTAATCTTGTAAATACTCCTTTAAGGTAA

Upstream 100 bases:

>100_bases
TTGTTGCCTTTGTGTACAGGTACATCGTGGCTTTTAACAGATATGTGAGTGAGAATAAAAAACTTTTTTCTAGAAAAAGT
TGGTTTTGAAGGTGATAGAG

Downstream 100 bases:

>100_bases
AGAGGTTTACCCTCTTTTTTCTTTTATAAAGCAGGAAAAATGCATTTTGTGGAGAATATAGATATTTAGATGAAATTACA
CTGGAGGTAAATTATGGTAA

Product: cell division protein FtsI/penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MSEALKKRFYVLASIIGILLLLLVSRLVYLQLIKGDYYREISIKQAIRLIPIDAPRGEIVDRYGVKLATNRPSFSVDILK
GEVVDSHLNETILKLIHLLEKNNVKYKDDLPLYLNDKGEPYFNFKNPDEGDVSPETLKEREKAWKKANNINESATAKETW
DILMKKFKISKDLSPQDARKIMVVRQLMEEQGYNQYQPVEIAVDVDQKTVAEIEERHLELPGVMINIKPIRYYPYGTLLS
QTLGYIGRITPEDLKKLDIKKYKLTDLVGHSGIEALYEEYLHGKDGGQQVVVDNYGRLIKNLSTVPPVPGDTVFLTIDKN
IQEAAEEALINTMQKLREGKLGKPRPNAKIGAAVVVDIHSGKILALASVPGFDPNIFATGSPPKDVVNELFRERDATVDP
SPIFNYATQGAVPPGSTFKMIVALAALETGVTTVDEKYLDPGVYITGQTNWLWNEYGRTQGWVNVSDAIKYSTDTYFYEM
GRRMGIDKIVEYAKKFGLDQKTGIELPEAKGIIASPQYKREFYLALIRSMVKSERNPDGPITEEQYNKIVEIVDKGDLSD
YNTFLKLEKMGIKDPKLQRKLWEMMYYARHWSLADTCSAAIGQGDNQFTPLEIASYISTLVNGGIRYRLHLVDKIVDAEG
NIVKKTEPEILGKIDIPKKYLDAIKLGMKGVTERGGTASAAFDGFPMTVGGKTGTAEVGIKGRDNYAWFVGFAPYDNPQI
VVVTVIYQGGGGSYAAYVARDIFDAYFGLSKSGERETFNLVNTPLR

Sequences:

>Translated_766_residues
MSEALKKRFYVLASIIGILLLLLVSRLVYLQLIKGDYYREISIKQAIRLIPIDAPRGEIVDRYGVKLATNRPSFSVDILK
GEVVDSHLNETILKLIHLLEKNNVKYKDDLPLYLNDKGEPYFNFKNPDEGDVSPETLKEREKAWKKANNINESATAKETW
DILMKKFKISKDLSPQDARKIMVVRQLMEEQGYNQYQPVEIAVDVDQKTVAEIEERHLELPGVMINIKPIRYYPYGTLLS
QTLGYIGRITPEDLKKLDIKKYKLTDLVGHSGIEALYEEYLHGKDGGQQVVVDNYGRLIKNLSTVPPVPGDTVFLTIDKN
IQEAAEEALINTMQKLREGKLGKPRPNAKIGAAVVVDIHSGKILALASVPGFDPNIFATGSPPKDVVNELFRERDATVDP
SPIFNYATQGAVPPGSTFKMIVALAALETGVTTVDEKYLDPGVYITGQTNWLWNEYGRTQGWVNVSDAIKYSTDTYFYEM
GRRMGIDKIVEYAKKFGLDQKTGIELPEAKGIIASPQYKREFYLALIRSMVKSERNPDGPITEEQYNKIVEIVDKGDLSD
YNTFLKLEKMGIKDPKLQRKLWEMMYYARHWSLADTCSAAIGQGDNQFTPLEIASYISTLVNGGIRYRLHLVDKIVDAEG
NIVKKTEPEILGKIDIPKKYLDAIKLGMKGVTERGGTASAAFDGFPMTVGGKTGTAEVGIKGRDNYAWFVGFAPYDNPQI
VVVTVIYQGGGGSYAAYVARDIFDAYFGLSKSGERETFNLVNTPLR
>Mature_765_residues
SEALKKRFYVLASIIGILLLLLVSRLVYLQLIKGDYYREISIKQAIRLIPIDAPRGEIVDRYGVKLATNRPSFSVDILKG
EVVDSHLNETILKLIHLLEKNNVKYKDDLPLYLNDKGEPYFNFKNPDEGDVSPETLKEREKAWKKANNINESATAKETWD
ILMKKFKISKDLSPQDARKIMVVRQLMEEQGYNQYQPVEIAVDVDQKTVAEIEERHLELPGVMINIKPIRYYPYGTLLSQ
TLGYIGRITPEDLKKLDIKKYKLTDLVGHSGIEALYEEYLHGKDGGQQVVVDNYGRLIKNLSTVPPVPGDTVFLTIDKNI
QEAAEEALINTMQKLREGKLGKPRPNAKIGAAVVVDIHSGKILALASVPGFDPNIFATGSPPKDVVNELFRERDATVDPS
PIFNYATQGAVPPGSTFKMIVALAALETGVTTVDEKYLDPGVYITGQTNWLWNEYGRTQGWVNVSDAIKYSTDTYFYEMG
RRMGIDKIVEYAKKFGLDQKTGIELPEAKGIIASPQYKREFYLALIRSMVKSERNPDGPITEEQYNKIVEIVDKGDLSDY
NTFLKLEKMGIKDPKLQRKLWEMMYYARHWSLADTCSAAIGQGDNQFTPLEIASYISTLVNGGIRYRLHLVDKIVDAEGN
IVKKTEPEILGKIDIPKKYLDAIKLGMKGVTERGGTASAAFDGFPMTVGGKTGTAEVGIKGRDNYAWFVGFAPYDNPQIV
VVTVIYQGGGGSYAAYVARDIFDAYFGLSKSGERETFNLVNTPLR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=460, Percent_Identity=29.1304347826087, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786272, Length=291, Percent_Identity=24.3986254295533, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 85890; Mature: 85759

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEALKKRFYVLASIIGILLLLLVSRLVYLQLIKGDYYREISIKQAIRLIPIDAPRGEIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCEEEEECCCCCCHHH
DRYGVKLATNRPSFSVDILKGEVVDSHLNETILKLIHLLEKNNVKYKDDLPLYLNDKGEP
HHCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCE
YFNFKNPDEGDVSPETLKEREKAWKKANNINESATAKETWDILMKKFKISKDLSPQDARK
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
IMVVRQLMEEQGYNQYQPVEIAVDVDQKTVAEIEERHLELPGVMINIKPIRYYPYGTLLS
HHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHH
QTLGYIGRITPEDLKKLDIKKYKLTDLVGHSGIEALYEEYLHGKDGGQQVVVDNYGRLIK
HHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHH
NLSTVPPVPGDTVFLTIDKNIQEAAEEALINTMQKLREGKLGKPRPNAKIGAAVVVDIHS
HCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
GKILALASVPGFDPNIFATGSPPKDVVNELFRERDATVDPSPIFNYATQGAVPPGSTFKM
CCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHH
IVALAALETGVTTVDEKYLDPGVYITGQTNWLWNEYGRTQGWVNVSDAIKYSTDTYFYEM
HHHHHHHHCCCCHHHHHHCCCCEEEECCCCCHHHHCCCCCCCEEHHHHHCCCCCHHHHHH
GRRMGIDKIVEYAKKFGLDQKTGIELPEAKGIIASPQYKREFYLALIRSMVKSERNPDGP
HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ITEEQYNKIVEIVDKGDLSDYNTFLKLEKMGIKDPKLQRKLWEMMYYARHWSLADTCSAA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
IGQGDNQFTPLEIASYISTLVNGGIRYRLHLVDKIVDAEGNIVKKTEPEILGKIDIPKKY
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCEEECCCHHHEECCCCCHHH
LDAIKLGMKGVTERGGTASAAFDGFPMTVGGKTGTAEVGIKGRDNYAWFVGFAPYDNPQI
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCE
VVVTVIYQGGGGSYAAYVARDIFDAYFGLSKSGERETFNLVNTPLR
EEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SEALKKRFYVLASIIGILLLLLVSRLVYLQLIKGDYYREISIKQAIRLIPIDAPRGEIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCEEEEECCCCCCHHH
DRYGVKLATNRPSFSVDILKGEVVDSHLNETILKLIHLLEKNNVKYKDDLPLYLNDKGEP
HHCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCE
YFNFKNPDEGDVSPETLKEREKAWKKANNINESATAKETWDILMKKFKISKDLSPQDARK
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
IMVVRQLMEEQGYNQYQPVEIAVDVDQKTVAEIEERHLELPGVMINIKPIRYYPYGTLLS
HHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHH
QTLGYIGRITPEDLKKLDIKKYKLTDLVGHSGIEALYEEYLHGKDGGQQVVVDNYGRLIK
HHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHH
NLSTVPPVPGDTVFLTIDKNIQEAAEEALINTMQKLREGKLGKPRPNAKIGAAVVVDIHS
HCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
GKILALASVPGFDPNIFATGSPPKDVVNELFRERDATVDPSPIFNYATQGAVPPGSTFKM
CCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHH
IVALAALETGVTTVDEKYLDPGVYITGQTNWLWNEYGRTQGWVNVSDAIKYSTDTYFYEM
HHHHHHHHCCCCHHHHHHCCCCEEEECCCCCHHHHCCCCCCCEEHHHHHCCCCCHHHHHH
GRRMGIDKIVEYAKKFGLDQKTGIELPEAKGIIASPQYKREFYLALIRSMVKSERNPDGP
HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ITEEQYNKIVEIVDKGDLSDYNTFLKLEKMGIKDPKLQRKLWEMMYYARHWSLADTCSAA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
IGQGDNQFTPLEIASYISTLVNGGIRYRLHLVDKIVDAEGNIVKKTEPEILGKIDIPKKY
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCEEECCCHHHEECCCCCHHH
LDAIKLGMKGVTERGGTASAAFDGFPMTVGGKTGTAEVGIKGRDNYAWFVGFAPYDNPQI
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCE
VVVTVIYQGGGGSYAAYVARDIFDAYFGLSKSGERETFNLVNTPLR
EEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]