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The map label for this gene is Aro8 [H]

Identifier: 20807321

GI number: 20807321

Start: 848363

End: 849796

Strand: Direct

Name: Aro8 [H]

Synonym: TTE0839

Alternate gene names: 20807321

Gene position: 848363-849796 (Clockwise)

Preceding gene: 20807320

Following gene: 20807324

Centisome position: 31.54

GC content: 37.87

Gene sequence:

>1434_bases
ATGAATAAAATTGTTATTGACAGGAACAAAGAGACACCAATATACCTTCAGCTTTACTCTCAGCTCAAAAGGTTTATAGA
AAATGGGAGCTTGCCACCTGGGTATAAGCTTCCAACAATAAGGAGCATGGCAAAAGAGTTGGGAGTCAATATTATAACTG
TGGTCAATGCTTACAGGCTTTTAGAAGAAAACGGATATGTGTACACCAGAGTGGGAAGTGGAACTTACGTCTGTGAGGGC
ATTCAGAGGGATAGAGATTTGATAGAAGATATTGAACTTTCTGAGCACAGAGAGATACCTGTCAAAAAGGGGACTATAAA
TTTTGCCTCTTCATCCTTAAATCCAGAACTTTTCCCTGTGGATGAGTTTGCAGAGCTTATAAACAGAGTATTAAAAAGGG
ATAGAGGGTATGCTTTTGAGTATCAGGACAGCAGGGGATATAAGCCTTTAAGAGAGTCTATCCTCAAGTTTGTGAGGCTT
TATGGAATAGAAACGGGAGTTGAAAACATTCAGGTCATCTCAGGAGGCCAGCAGGGGATAGACGTTGTGTCAAAAGCTTT
GATCAATTTTGGTGACACAATAGTCGTAGAAAGACCCACATATTCATGGGCTTTAGCCTCTTTTCAATCGAGAGGAGCAG
ATATTCTAGAGGTAAATTTAAATAAAGACGGAATTGACATAGAGGATCTGGAAGATAAATTGAAGAAATTTAAGCCTAAG
TTCATATACGTGATGCCGAATTTTCACAATCCCACAGGTATTTTATATAGCGATGAGAAAAAAGAAAAACTTGTAGGGCT
GGCGGAGAAGTATGAAACTTACCTTTTAGAAGATGACTTTGCAATTGAATTATCTTTTACAGAAACAGATGTATTCCCTC
TCAAAGCTTTTGATAAGTACGACAGGGTGATATACCTAAAAAGCTTTTCTAAGGTTCACATGCCGGGATTGCGTCTTGGA
TTTATCATAGCCCCGGAAAAACTTGTGAGCAGTTTTCTCAAGGCAAAATATGTTACAGACCTCACTACTTCTGGGCTGAT
GCAGAGGGCTTTCGATTTATATTTGAGGGAAAACATCTGGAAGAAACACATTGAAGAAGTGAAAGGCGTAATGAGAGAAA
GGTTTGAAAAGATGAAAGAAGGGCTTACCCAGTTAAAAAGCTATTTTGAGTTTGATATTCCAAAAGGAGGTTTTTACTAC
TGGGTAAAGCTTAAAGATAACTGGAAAGCGGTAGACTTTTATCAGAAATGTCTTGAGAGAGGGTTATTGGTAGTTCCGGG
GGATATGTTTTTTGGAATAAAAAAAGAAGACAATTTTCTGAGATTAAGTTTTGCCTCATGCGATGTGCAAGAGATAGAAA
AAGGAATTGAAATATTAAGACAGGTTTTAAGCGAAGGGCAGAATGAAAATGAGATGTATCTTCCTATAATATAA

Upstream 100 bases:

>100_bases
ATCTTGACACTATCCCGATTATAATTCATTTTGAAAAAGGATAGAATTTTTGTTATGATAAATATAGAAAATTGTAACGA
TACAATTGTGAGGGGAAAGT

Downstream 100 bases:

>100_bases
AACAGGAGGAGGATAAAAAGGTCACTCCTCTACCTTTTTATCCTCCTCCTGAGGGAAAGATTTGGACATTTTTGATTTGC
CTTCAAAAACAGCTCCTTCT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNKIVIDRNKETPIYLQLYSQLKRFIENGSLPPGYKLPTIRSMAKELGVNIITVVNAYRLLEENGYVYTRVGSGTYVCEG
IQRDRDLIEDIELSEHREIPVKKGTINFASSSLNPELFPVDEFAELINRVLKRDRGYAFEYQDSRGYKPLRESILKFVRL
YGIETGVENIQVISGGQQGIDVVSKALINFGDTIVVERPTYSWALASFQSRGADILEVNLNKDGIDIEDLEDKLKKFKPK
FIYVMPNFHNPTGILYSDEKKEKLVGLAEKYETYLLEDDFAIELSFTETDVFPLKAFDKYDRVIYLKSFSKVHMPGLRLG
FIIAPEKLVSSFLKAKYVTDLTTSGLMQRAFDLYLRENIWKKHIEEVKGVMRERFEKMKEGLTQLKSYFEFDIPKGGFYY
WVKLKDNWKAVDFYQKCLERGLLVVPGDMFFGIKKEDNFLRLSFASCDVQEIEKGIEILRQVLSEGQNENEMYLPII

Sequences:

>Translated_477_residues
MNKIVIDRNKETPIYLQLYSQLKRFIENGSLPPGYKLPTIRSMAKELGVNIITVVNAYRLLEENGYVYTRVGSGTYVCEG
IQRDRDLIEDIELSEHREIPVKKGTINFASSSLNPELFPVDEFAELINRVLKRDRGYAFEYQDSRGYKPLRESILKFVRL
YGIETGVENIQVISGGQQGIDVVSKALINFGDTIVVERPTYSWALASFQSRGADILEVNLNKDGIDIEDLEDKLKKFKPK
FIYVMPNFHNPTGILYSDEKKEKLVGLAEKYETYLLEDDFAIELSFTETDVFPLKAFDKYDRVIYLKSFSKVHMPGLRLG
FIIAPEKLVSSFLKAKYVTDLTTSGLMQRAFDLYLRENIWKKHIEEVKGVMRERFEKMKEGLTQLKSYFEFDIPKGGFYY
WVKLKDNWKAVDFYQKCLERGLLVVPGDMFFGIKKEDNFLRLSFASCDVQEIEKGIEILRQVLSEGQNENEMYLPII
>Mature_477_residues
MNKIVIDRNKETPIYLQLYSQLKRFIENGSLPPGYKLPTIRSMAKELGVNIITVVNAYRLLEENGYVYTRVGSGTYVCEG
IQRDRDLIEDIELSEHREIPVKKGTINFASSSLNPELFPVDEFAELINRVLKRDRGYAFEYQDSRGYKPLRESILKFVRL
YGIETGVENIQVISGGQQGIDVVSKALINFGDTIVVERPTYSWALASFQSRGADILEVNLNKDGIDIEDLEDKLKKFKPK
FIYVMPNFHNPTGILYSDEKKEKLVGLAEKYETYLLEDDFAIELSFTETDVFPLKAFDKYDRVIYLKSFSKVHMPGLRLG
FIIAPEKLVSSFLKAKYVTDLTTSGLMQRAFDLYLRENIWKKHIEEVKGVMRERFEKMKEGLTQLKSYFEFDIPKGGFYY
WVKLKDNWKAVDFYQKCLERGLLVVPGDMFFGIKKEDNFLRLSFASCDVQEIEKGIEILRQVLSEGQNENEMYLPII

Specific function: Unknown

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=403, Percent_Identity=27.7915632754342, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI33469970, Length=403, Percent_Identity=27.7915632754342, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787710, Length=464, Percent_Identity=27.3706896551724, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1790797, Length=456, Percent_Identity=26.0964912280702, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788722, Length=328, Percent_Identity=23.780487804878, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI48994949, Length=236, Percent_Identity=25, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=382, Percent_Identity=24.3455497382199, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=384, Percent_Identity=23.4375, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=384, Percent_Identity=23.4375, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321236, Length=389, Percent_Identity=23.6503856041131, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321929, Length=404, Percent_Identity=24.7524752475248, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321000, Length=263, Percent_Identity=24.7148288973384, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356535, Length=371, Percent_Identity=27.4932614555256, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 55264; Mature: 55264

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIVIDRNKETPIYLQLYSQLKRFIENGSLPPGYKLPTIRSMAKELGVNIITVVNAYRL
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEHHHHHHHH
LEENGYVYTRVGSGTYVCEGIQRDRDLIEDIELSEHREIPVKKGTINFASSSLNPELFPV
HHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCH
DEFAELINRVLKRDRGYAFEYQDSRGYKPLRESILKFVRLYGIETGVENIQVISGGQQGI
HHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
DVVSKALINFGDTIVVERPTYSWALASFQSRGADILEVNLNKDGIDIEDLEDKLKKFKPK
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
FIYVMPNFHNPTGILYSDEKKEKLVGLAEKYETYLLEDDFAIELSFTETDVFPLKAFDKY
EEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCEECHHHCCC
DRVIYLKSFSKVHMPGLRLGFIIAPEKLVSSFLKAKYVTDLTTSGLMQRAFDLYLRENIW
CCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKHIEEVKGVMRERFEKMKEGLTQLKSYFEFDIPKGGFYYWVKLKDNWKAVDFYQKCLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHC
GLLVVPGDMFFGIKKEDNFLRLSFASCDVQEIEKGIEILRQVLSEGQNENEMYLPII
CEEEECCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MNKIVIDRNKETPIYLQLYSQLKRFIENGSLPPGYKLPTIRSMAKELGVNIITVVNAYRL
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEHHHHHHHH
LEENGYVYTRVGSGTYVCEGIQRDRDLIEDIELSEHREIPVKKGTINFASSSLNPELFPV
HHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCH
DEFAELINRVLKRDRGYAFEYQDSRGYKPLRESILKFVRLYGIETGVENIQVISGGQQGI
HHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
DVVSKALINFGDTIVVERPTYSWALASFQSRGADILEVNLNKDGIDIEDLEDKLKKFKPK
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
FIYVMPNFHNPTGILYSDEKKEKLVGLAEKYETYLLEDDFAIELSFTETDVFPLKAFDKY
EEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCEECHHHCCC
DRVIYLKSFSKVHMPGLRLGFIIAPEKLVSSFLKAKYVTDLTTSGLMQRAFDLYLRENIW
CCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKHIEEVKGVMRERFEKMKEGLTQLKSYFEFDIPKGGFYYWVKLKDNWKAVDFYQKCLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHC
GLLVVPGDMFFGIKKEDNFLRLSFASCDVQEIEKGIEILRQVLSEGQNENEMYLPII
CEEEECCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]