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The map label for this gene is PgsA [H]

Identifier: 20807242

GI number: 20807242

Start: 757076

End: 757588

Strand: Direct

Name: PgsA [H]

Synonym: TTE0757

Alternate gene names: 20807242

Gene position: 757076-757588 (Clockwise)

Preceding gene: 20807241

Following gene: 20807243

Centisome position: 28.15

GC content: 34.7

Gene sequence:

>513_bases
TTGATGAATATACCAAATATTTTAACTTTAGTAAGATTTTTGTTAATACCCGGTTTTGTATATGCTTTTTTTTACATGAC
AGAAGGAAATGTGTATGCAGCAATTATTTTTATACTCTCCGGCATTACAGATGTTTTGGATGGATACATTGCCAGGCATT
TTAATCAGGTGACTAAGCTTGGGACTTTGTTAGATCCCCTTGCGGACAAGCTTATGGTGCTCACTGTTTTGACGAGTCTA
TGGCTTAAAGGTTTTATTCCTTTTTTCATAATAGGAGTTCTAGCAGTAAAGGAACTTGCCATGATAGTAGGAGCAGCTTT
TCTCTACCGCAAGCAAAAAATTGCCATACCGGCTAATGCTTATGGAAAGGCAGCAACCTTTTTGTTTTACGTTGCCATAA
TTTTTTCTCTTTTTAGATGGCCCTACAACCTTTTTTTAATGATTTTAGCTCTTGGTTTAGCTCTTATTGCCTTTTTTGTC
TATGCCTTTGAATTTTTTAAAAAAACTATCTAA

Upstream 100 bases:

>100_bases
TATAGCTTTAAGGTGGCTCTTGATAATAATACGTTAAGTCTCAATGCGGCCCGATAAGGGTCTTTTACTTTTGTAAAAGT
TTTAATTTGCAAGGGGTGTC

Downstream 100 bases:

>100_bases
AATTAAACTTTTTCGCAAAAAAGGACGATATAAAAGACGTAGATTAAAATTGCAGGAGGTAATAAAAGTTGACGAAGAAA
GCAATTGGATTTTACAGGGT

Product: phosphatidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MMNIPNILTLVRFLLIPGFVYAFFYMTEGNVYAAIIFILSGITDVLDGYIARHFNQVTKLGTLLDPLADKLMVLTVLTSL
WLKGFIPFFIIGVLAVKELAMIVGAAFLYRKQKIAIPANAYGKAATFLFYVAIIFSLFRWPYNLFLMILALGLALIAFFV
YAFEFFKKTI

Sequences:

>Translated_170_residues
MMNIPNILTLVRFLLIPGFVYAFFYMTEGNVYAAIIFILSGITDVLDGYIARHFNQVTKLGTLLDPLADKLMVLTVLTSL
WLKGFIPFFIIGVLAVKELAMIVGAAFLYRKQKIAIPANAYGKAATFLFYVAIIFSLFRWPYNLFLMILALGLALIAFFV
YAFEFFKKTI
>Mature_170_residues
MMNIPNILTLVRFLLIPGFVYAFFYMTEGNVYAAIIFILSGITDVLDGYIARHFNQVTKLGTLLDPLADKLMVLTVLTSL
WLKGFIPFFIIGVLAVKELAMIVGAAFLYRKQKIAIPANAYGKAATFLFYVAIIFSLFRWPYNLFLMILALGLALIAFFV
YAFEFFKKTI

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=116, Percent_Identity=35.3448275862069, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI10092647, Length=116, Percent_Identity=35.3448275862069, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788220, Length=72, Percent_Identity=48.6111111111111, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71984834, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984838, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320059, Length=177, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650130, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650126, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650128, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 19251; Mature: 19251

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNIPNILTLVRFLLIPGFVYAFFYMTEGNVYAAIIFILSGITDVLDGYIARHFNQVTKL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLLDPLADKLMVLTVLTSLWLKGFIPFFIIGVLAVKELAMIVGAAFLYRKQKIAIPANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YGKAATFLFYVAIIFSLFRWPYNLFLMILALGLALIAFFVYAFEFFKKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMNIPNILTLVRFLLIPGFVYAFFYMTEGNVYAAIIFILSGITDVLDGYIARHFNQVTKL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLLDPLADKLMVLTVLTSLWLKGFIPFFIIGVLAVKELAMIVGAAFLYRKQKIAIPANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
YGKAATFLFYVAIIFSLFRWPYNLFLMILALGLALIAFFVYAFEFFKKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]