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The map label for this gene is MutS [H]

Identifier: 20807212

GI number: 20807212

Start: 727145

End: 728647

Strand: Direct

Name: MutS [H]

Synonym: TTE0725

Alternate gene names: 20807212

Gene position: 727145-728647 (Clockwise)

Preceding gene: 20807211

Following gene: 20807213

Centisome position: 27.04

GC content: 34.13

Gene sequence:

>1503_bases
GTGGTGATTGATATTAAATTCTTAACTGAAAAAGAAAGAGAACAAGTAGGATTTAACTATGTTATTTCAAAGCTTCAAGT
TATAACTCCATATGGAAGAGAAGAGCTAAAAAATGCAAGGCCTTATAAGAGAGAAGAAAGAGAAAAACTTGAAAGGGAAT
ATGAGTACATCGACCTTTTGAAGGAAAGTTTAGAGAAGGATAAGGAAATATTTTTTAAGATTTTAAAACCGCTATTCAAG
ATAAAAGATATAAGAAACAGCCTTAAAAGGTGCATAGAAGGGAAAGTGTTAGATGAGGTGGAATTTTATGAGATAAAAAT
TTTCGCTCTACTGAGCGAAGAGTTAAGGCTTTTGATTGGAAGGTTGAATTTAGATATTGAAGATATAAAGCTTGTTTCTT
TAACTCCTGTATTGGATCTTTTGGACCCTCAGAAAAAGAGAATTGCTACTTTTTATGTTTACGATGAATATTCTAGTAAT
TTGAAAGAGATAAGAGAAAAGAAAAGGGAAATTGAGAGGCAGATATTTGCAGAAACTGACAGAGAAAAAATTGAAAAATT
AAGGGAGAAAAGGCTTGATATAGTCGCATTGGAACAAAGAGAGGAACTTGAGGTAAAAAAGAGTCTATCTGAAAAGTTAC
GCAAATATGTAGACCTTATTGAAAAAAATATAAAAGCTATAGGAAGGTTCGATTTTTTGATGGCAAAGGCTAAACTGGCA
ATCGAGTACAATGGAGTGAAACCCACGATAAATGACGAGATAAAAATACTTTTTGAAGATGTTATAAATCCTCAAGTTGC
AGATATTTTAAAAACCCAAGAAAAAGAGTTTACCCCTCTAACTATTGAATTAAAGAGCGGGACAACTGTTATCACAGGAG
CCAATATGGGTGGAAAAACTGTAGCACTTAGGACTTTTGCGCTAAATCTTCTTCTTTCTATGATGGGATTTTTCCCTTTT
GCTAAAAAAGTATCTTTTCCTATGCTGGATTTTATTCATTTTATCTCAGAAGACCTGCAATCAATTTCAAGAGGTCTGAG
CAGTTTTGGTGCAGAAGTTATGAAGTTAAAAGAAGTAATAGAAGATGTAAAAAAAGGGACAGGATTTGTGGCATTAGACG
AAATAGCAAGGGGCACAAATCCTGAAGAGGGACTTTATATTGTGAAAGCTATCTCAAAATATTTGAACGGTTTTTCTTCT
ATGACTGTATTAGCTACCCATTATGAAGGGGTGATAGAGGATGACATGGTGCACTATCAGGTCGTAGGGCTTAAAAATGT
AAATTTTGAAGAGTTAAGGCAAAAAATCGTTATAGACGAAGAAAACTCGGTAAAAATTCTCCAGGAACACATGGATTATC
GATTAGAAAGAGTAGACCCTAATTGTGAGGTTCCAAAAGATGCCCTTAACATATGCAGAATATTTGGACTTGAAAGAGAA
GTTATAGAGCTGGCTGAGACCTATTATAAGAGGAGGAGAAGGTATGAGAGAGAGCAAGCTTAA

Upstream 100 bases:

>100_bases
ACTGTAAATCCTATATCTCCTACAGGTTACAGATATAATGGAAAAGAATTTTTAAATAGATTGAGAGAGAAATTAGATCT
TCCTGTCTTTGATGTGATGG

Downstream 100 bases:

>100_bases
TCTTGATTGGGAATTAGTGGATAAAGCCAGAGAAGCTGCGAGAAACATTGTTAAAGATACGCAGAAATTTATAGATGCCC
ATACGACTGTGTCAGTTGAA

Product: MutS-like ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVIDIKFLTEKEREQVGFNYVISKLQVITPYGREELKNARPYKREEREKLEREYEYIDLLKESLEKDKEIFFKILKPLFK
IKDIRNSLKRCIEGKVLDEVEFYEIKIFALLSEELRLLIGRLNLDIEDIKLVSLTPVLDLLDPQKKRIATFYVYDEYSSN
LKEIREKKREIERQIFAETDREKIEKLREKRLDIVALEQREELEVKKSLSEKLRKYVDLIEKNIKAIGRFDFLMAKAKLA
IEYNGVKPTINDEIKILFEDVINPQVADILKTQEKEFTPLTIELKSGTTVITGANMGGKTVALRTFALNLLLSMMGFFPF
AKKVSFPMLDFIHFISEDLQSISRGLSSFGAEVMKLKEVIEDVKKGTGFVALDEIARGTNPEEGLYIVKAISKYLNGFSS
MTVLATHYEGVIEDDMVHYQVVGLKNVNFEELRQKIVIDEENSVKILQEHMDYRLERVDPNCEVPKDALNICRIFGLERE
VIELAETYYKRRRRYEREQA

Sequences:

>Translated_500_residues
MVIDIKFLTEKEREQVGFNYVISKLQVITPYGREELKNARPYKREEREKLEREYEYIDLLKESLEKDKEIFFKILKPLFK
IKDIRNSLKRCIEGKVLDEVEFYEIKIFALLSEELRLLIGRLNLDIEDIKLVSLTPVLDLLDPQKKRIATFYVYDEYSSN
LKEIREKKREIERQIFAETDREKIEKLREKRLDIVALEQREELEVKKSLSEKLRKYVDLIEKNIKAIGRFDFLMAKAKLA
IEYNGVKPTINDEIKILFEDVINPQVADILKTQEKEFTPLTIELKSGTTVITGANMGGKTVALRTFALNLLLSMMGFFPF
AKKVSFPMLDFIHFISEDLQSISRGLSSFGAEVMKLKEVIEDVKKGTGFVALDEIARGTNPEEGLYIVKAISKYLNGFSS
MTVLATHYEGVIEDDMVHYQVVGLKNVNFEELRQKIVIDEENSVKILQEHMDYRLERVDPNCEVPKDALNICRIFGLERE
VIELAETYYKRRRRYEREQA
>Mature_500_residues
MVIDIKFLTEKEREQVGFNYVISKLQVITPYGREELKNARPYKREEREKLEREYEYIDLLKESLEKDKEIFFKILKPLFK
IKDIRNSLKRCIEGKVLDEVEFYEIKIFALLSEELRLLIGRLNLDIEDIKLVSLTPVLDLLDPQKKRIATFYVYDEYSSN
LKEIREKKREIERQIFAETDREKIEKLREKRLDIVALEQREELEVKKSLSEKLRKYVDLIEKNIKAIGRFDFLMAKAKLA
IEYNGVKPTINDEIKILFEDVINPQVADILKTQEKEFTPLTIELKSGTTVITGANMGGKTVALRTFALNLLLSMMGFFPF
AKKVSFPMLDFIHFISEDLQSISRGLSSFGAEVMKLKEVIEDVKKGTGFVALDEIARGTNPEEGLYIVKAISKYLNGFSS
MTVLATHYEGVIEDDMVHYQVVGLKNVNFEELRQKIVIDEENSVKILQEHMDYRLERVDPNCEVPKDALNICRIFGLERE
VIELAETYYKRRRRYEREQA

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=469, Percent_Identity=22.3880597014925, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI36949366, Length=228, Percent_Identity=27.6315789473684, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789089, Length=310, Percent_Identity=26.7741935483871, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=218, Percent_Identity=28.8990825688073, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=206, Percent_Identity=25.7281553398058, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=323, Percent_Identity=24.1486068111455, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=214, Percent_Identity=25.2336448598131, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321109, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 58550; Mature: 58550

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDIKFLTEKEREQVGFNYVISKLQVITPYGREELKNARPYKREEREKLEREYEYIDLL
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KESLEKDKEIFFKILKPLFKIKDIRNSLKRCIEGKVLDEVEFYEIKIFALLSEELRLLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLNLDIEDIKLVSLTPVLDLLDPQKKRIATFYVYDEYSSNLKEIREKKREIERQIFAETD
HHCCCHHHEEEEEHHHHHHHCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
REKIEKLREKRLDIVALEQREELEVKKSLSEKLRKYVDLIEKNIKAIGRFDFLMAKAKLA
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IEYNGVKPTINDEIKILFEDVINPQVADILKTQEKEFTPLTIELKSGTTVITGANMGGKT
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCH
VALRTFALNLLLSMMGFFPFAKKVSFPMLDFIHFISEDLQSISRGLSSFGAEVMKLKEVI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDVKKGTGFVALDEIARGTNPEEGLYIVKAISKYLNGFSSMTVLATHYEGVIEDDMVHYQ
HHHHHCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEE
VVGLKNVNFEELRQKIVIDEENSVKILQEHMDYRLERVDPNCEVPKDALNICRIFGLERE
EEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
VIELAETYYKRRRRYEREQA
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVIDIKFLTEKEREQVGFNYVISKLQVITPYGREELKNARPYKREEREKLEREYEYIDLL
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KESLEKDKEIFFKILKPLFKIKDIRNSLKRCIEGKVLDEVEFYEIKIFALLSEELRLLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLNLDIEDIKLVSLTPVLDLLDPQKKRIATFYVYDEYSSNLKEIREKKREIERQIFAETD
HHCCCHHHEEEEEHHHHHHHCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
REKIEKLREKRLDIVALEQREELEVKKSLSEKLRKYVDLIEKNIKAIGRFDFLMAKAKLA
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IEYNGVKPTINDEIKILFEDVINPQVADILKTQEKEFTPLTIELKSGTTVITGANMGGKT
EEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCH
VALRTFALNLLLSMMGFFPFAKKVSFPMLDFIHFISEDLQSISRGLSSFGAEVMKLKEVI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDVKKGTGFVALDEIARGTNPEEGLYIVKAISKYLNGFSSMTVLATHYEGVIEDDMVHYQ
HHHHHCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEE
VVGLKNVNFEELRQKIVIDEENSVKILQEHMDYRLERVDPNCEVPKDALNICRIFGLERE
EEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
VIELAETYYKRRRRYEREQA
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA