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The map label for this gene is KamA [H]

Identifier: 20807210

GI number: 20807210

Start: 724887

End: 726140

Strand: Direct

Name: KamA [H]

Synonym: TTE0723

Alternate gene names: 20807210

Gene position: 724887-726140 (Clockwise)

Preceding gene: 20807209

Following gene: 20807211

Centisome position: 26.95

GC content: 41.39

Gene sequence:

>1254_bases
ATGAGAGTTAACAGAAGACATGAACTTTTTGGGCATGTACCAGACAGCGATTGGTACAACTGGAAGTGGCAGATTGCAAA
TAGAATAGAGACAGTGGAAGAGTTGAAAAAATACCTTCCATTGTCGGAAGAAGAGGAAGAAGCTATTTCTAAGGCATTGC
AGAAGTTGAGAATGGCAATTACGCCCTATTACCTTTCTTTGATAGACCCCAATGACCCTAATGACCCGATAAGAAAAAGA
GCAGTGCCGACAATCCATGAGCTTTATCAGGCACCGGAGGACTTAGTGGACCCGCTTTATGAGGATGTGGATTCACCTGT
ACCTGGACTTACCCACAGGTATCCTGACAGGGTATTGATGCTTGTTACAGACCAGTGCTCCATGTACTGCAGACACTGCA
CAAGGAGAAGGTTTGCTGGAGAAACTGATGCTCCCATGCCGATGGATAAAATAGAAAAGCAGATTGAGTATATAAGGAAT
ACCCCACAGATAAGAGATGTGCTGATCTCAGGTGGAGATCCTCTCACTTTATCTGATTCACGGCTTGAAGAAATTATAAA
GAGATTAAGAGAAATTCCTCATGTGGAGATAATAAGAATTGGTTCATCAGTACCTGTAGTGCTGCCTATGAGAATAACTC
CGGAGCTTGTCAATATGCTTAAAAAATATCATCCAATATGGCTCAACACCCACTTCAACCATCCGCATGAGATAACAGAG
GATTCAAAGAGAGCATGTGAAATGCTAGCAGATGCTGGAATACCATTAGGAAACCAGACAGTACTTCTAAGGGGAGTAAA
TGACTGTGTCCATGTTATGAAAAAGCTGGTGCATGAATTGGTAAAAATAAGGGTAAGACCTTACTACATCTATCAGTGCG
ATTTGTCATTTGGGCTTTCTCATTTTAGAACTCCCGTTTCCAAAGGTATTGAAATTATAGAAGGTTTAAGAGGGCACACT
TCTGGTTACTGCGTACCTACATTTGTAGTTGATGCACCGGGAGGAGGAGGAAAGATTCCTGTTGGACCAAACTACGTAAT
TTCTCAGTCCCATGATAAAATAGTTTTGAGAAATTATGAAGGCGTCATTGTGACGTATGTTGAGCCAAAAGATTACACTC
CAGGTCCTTGTGTATGCGATGAAGAAGTTCCAAAATCTGAAGGTGTTGCAGGCCTTATGCAAAAGGATACTATTGGAGTA
TTAGAGCCAGAGAATTTAGAAAGGAAAAAGAGAAGGAGAAAAGATGAGAAGTGA

Upstream 100 bases:

>100_bases
CTGCAGGAGCTCAGGGAAAATGAAAAATTGAGAAAAGTTTTTGAAGAAATGTATGCTAAATGAGGACAGCTGTAATGAAT
TTAAGGGGGAGATGTATAAA

Downstream 100 bases:

>100_bases
TATTCTTGACCTTATAAAAAATTACAGGACTATCTCTATAATAGGAATGGCAAAAAATGTAGGAAAAACAACTGTATTAA
ATTATCTTATCAGTAAGGCC

Product: lysine 2,3-aminomutase

Products: NA

Alternate protein names: LAM; KAM [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRVNRRHELFGHVPDSDWYNWKWQIANRIETVEELKKYLPLSEEEEEAISKALQKLRMAITPYYLSLIDPNDPNDPIRKR
AVPTIHELYQAPEDLVDPLYEDVDSPVPGLTHRYPDRVLMLVTDQCSMYCRHCTRRRFAGETDAPMPMDKIEKQIEYIRN
TPQIRDVLISGGDPLTLSDSRLEEIIKRLREIPHVEIIRIGSSVPVVLPMRITPELVNMLKKYHPIWLNTHFNHPHEITE
DSKRACEMLADAGIPLGNQTVLLRGVNDCVHVMKKLVHELVKIRVRPYYIYQCDLSFGLSHFRTPVSKGIEIIEGLRGHT
SGYCVPTFVVDAPGGGGKIPVGPNYVISQSHDKIVLRNYEGVIVTYVEPKDYTPGPCVCDEEVPKSEGVAGLMQKDTIGV
LEPENLERKKRRRKDEK

Sequences:

>Translated_417_residues
MRVNRRHELFGHVPDSDWYNWKWQIANRIETVEELKKYLPLSEEEEEAISKALQKLRMAITPYYLSLIDPNDPNDPIRKR
AVPTIHELYQAPEDLVDPLYEDVDSPVPGLTHRYPDRVLMLVTDQCSMYCRHCTRRRFAGETDAPMPMDKIEKQIEYIRN
TPQIRDVLISGGDPLTLSDSRLEEIIKRLREIPHVEIIRIGSSVPVVLPMRITPELVNMLKKYHPIWLNTHFNHPHEITE
DSKRACEMLADAGIPLGNQTVLLRGVNDCVHVMKKLVHELVKIRVRPYYIYQCDLSFGLSHFRTPVSKGIEIIEGLRGHT
SGYCVPTFVVDAPGGGGKIPVGPNYVISQSHDKIVLRNYEGVIVTYVEPKDYTPGPCVCDEEVPKSEGVAGLMQKDTIGV
LEPENLERKKRRRKDEK
>Mature_417_residues
MRVNRRHELFGHVPDSDWYNWKWQIANRIETVEELKKYLPLSEEEEEAISKALQKLRMAITPYYLSLIDPNDPNDPIRKR
AVPTIHELYQAPEDLVDPLYEDVDSPVPGLTHRYPDRVLMLVTDQCSMYCRHCTRRRFAGETDAPMPMDKIEKQIEYIRN
TPQIRDVLISGGDPLTLSDSRLEEIIKRLREIPHVEIIRIGSSVPVVLPMRITPELVNMLKKYHPIWLNTHFNHPHEITE
DSKRACEMLADAGIPLGNQTVLLRGVNDCVHVMKKLVHELVKIRVRPYYIYQCDLSFGLSHFRTPVSKGIEIIEGLRGHT
SGYCVPTFVVDAPGGGGKIPVGPNYVISQSHDKIVLRNYEGVIVTYVEPKDYTPGPCVCDEEVPKSEGVAGLMQKDTIGV
LEPENLERKKRRRKDEK

Specific function: Catalyzes the interconversion of L-alpha-lysine and L- beta-lysine [H]

COG id: COG1509

COG function: function code E; Lysine 2,3-aminomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KamA family [H]

Homologues:

Organism=Escherichia coli, GI1790589, Length=324, Percent_Identity=32.4074074074074, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003739
- InterPro:   IPR022459
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =5.4.3.2 [H]

Molecular weight: Translated: 47883; Mature: 47883

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVNRRHELFGHVPDSDWYNWKWQIANRIETVEELKKYLPLSEEEEEAISKALQKLRMAI
CCCCCCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPYYLSLIDPNDPNDPIRKRAVPTIHELYQAPEDLVDPLYEDVDSPVPGLTHRYPDRVLM
CCCEEEEECCCCCCCHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LVTDQCSMYCRHCTRRRFAGETDAPMPMDKIEKQIEYIRNTPQIRDVLISGGDPLTLSDS
EEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECHH
RLEEIIKRLREIPHVEIIRIGSSVPVVLPMRITPELVNMLKKYHPIWLNTHFNHPHEITE
HHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHCH
DSKRACEMLADAGIPLGNQTVLLRGVNDCVHVMKKLVHELVKIRVRPYYIYQCDLSFGLS
HHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHCHH
HFRTPVSKGIEIIEGLRGHTSGYCVPTFVVDAPGGGGKIPVGPNYVISQSHDKIVLRNYE
HHHCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEECC
GVIVTYVEPKDYTPGPCVCDEEVPKSEGVAGLMQKDTIGVLEPENLERKKRRRKDEK
CEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MRVNRRHELFGHVPDSDWYNWKWQIANRIETVEELKKYLPLSEEEEEAISKALQKLRMAI
CCCCCCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPYYLSLIDPNDPNDPIRKRAVPTIHELYQAPEDLVDPLYEDVDSPVPGLTHRYPDRVLM
CCCEEEEECCCCCCCHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LVTDQCSMYCRHCTRRRFAGETDAPMPMDKIEKQIEYIRNTPQIRDVLISGGDPLTLSDS
EEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECHH
RLEEIIKRLREIPHVEIIRIGSSVPVVLPMRITPELVNMLKKYHPIWLNTHFNHPHEITE
HHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHCH
DSKRACEMLADAGIPLGNQTVLLRGVNDCVHVMKKLVHELVKIRVRPYYIYQCDLSFGLS
HHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHCHH
HFRTPVSKGIEIIEGLRGHTSGYCVPTFVVDAPGGGGKIPVGPNYVISQSHDKIVLRNYE
HHHCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEECC
GVIVTYVEPKDYTPGPCVCDEEVPKSEGVAGLMQKDTIGVLEPENLERKKRRRKDEK
CEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10629195 [H]