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The map label for this gene is AcoB2 [H]

Identifier: 20807176

GI number: 20807176

Start: 693541

End: 694560

Strand: Direct

Name: AcoB2 [H]

Synonym: TTE0689

Alternate gene names: 20807176

Gene position: 693541-694560 (Clockwise)

Preceding gene: 20807175

Following gene: 20807177

Centisome position: 25.79

GC content: 44.12

Gene sequence:

>1020_bases
ATGTCTGCGATAACTTCGCGAAAGCTTACTATGGCAAAGGCAATTGCTGAAGCTATTAGTTTGGAAATGGAAAGAGATCC
GAGAGTTTTTGTCATGGGTGAGGACGTAGGCGTATATGGAGGCATATTTGGTGCCACAGCTGGGTTGTATGAAAAATTTG
GACCAGAAAGAGTTATCGATACACCTATTTCCGAAGCAGGTTTTATAGGTGCTGCTTTAGGAGCTGCTATGGAAGGTATG
CGTCCCATAGTAGAATTAATGTTTGTAGATTTCTTTGGCGTGGCTATGGATCAAATTTATAATCACATTGCCAAAAACAC
TTACTTTTCAGGAGGAAATATTCGAGTACCTTTGGTACTCATGACGGCGGTTGGCGGTGGTTACAATGATGCGGGGCAGC
ATTCACAGTGTCTTTGGGGGACTTTTGCTCATCTGCCTGGTCTTAAAGTAGTTGTACCTTCTACTCCTTATGACGCCAAA
GGTTTGATGATTTCAGCCATACGGGATGACAACCCTGTTATATACATGTTCCACAAGGGGTTACTTGGTCTGGGATGGAT
GACCCTTATTAAGGACAGCACGGGCCCTGTCCCTGAGGAGCCTTATACGATCCCGTTTGGTAAAGCAGAGGTAAAACGGG
AAGGAAAAGATGTTTCAATAATCAGCGTGGCTATGGGTGTCTATCAAGCATTAGAGGCGGCCAAAGAACTGGAAAAAGAA
GGTATAAGCGTTGAGGTTCTGGACCTCAGGACATTGGTGCCGTTAGACCGCGAAGCCATAATAAATACTGTAAAAAAGAC
CCACAGAGTATTGGTGGTGGATGAAGACTACCTGAGCTATGGTATGAGCGGAGAAGTTGCTGCAACTATAGTTGAGCATG
CTTTTGACTACTTGGAAGCGCCTGTAAAAAGATTGGCGGTTCCAGACGTGCCTATCCCATATTCTCGTCCTTTGGAACAG
TTTGTATTACCTTCAAGTTCTAAAATTGTGAATGCAGTTAAGGAATTGCTCAGGTCATAA

Upstream 100 bases:

>100_bases
GGGAGTCACCCTATCCAGCGCCGGAAGAAGCCCTACTTCACGTGTTTGTAGAATAGTGAATTGCGGTCTAGTTGAATAAT
ATTTAAAGGAGGAGAAAATT

Downstream 100 bases:

>100_bases
TAATGAGATTTCAAAGCAGGAGGACTGATATCTTATGCCATACGAATTTCGCATGCCTAACGTAGTATCAAATGGAATAG
AAGGGTTTGTGGTGAATTGG

Product: thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSAITSRKLTMAKAIAEAISLEMERDPRVFVMGEDVGVYGGIFGATAGLYEKFGPERVIDTPISEAGFIGAALGAAMEGM
RPIVELMFVDFFGVAMDQIYNHIAKNTYFSGGNIRVPLVLMTAVGGGYNDAGQHSQCLWGTFAHLPGLKVVVPSTPYDAK
GLMISAIRDDNPVIYMFHKGLLGLGWMTLIKDSTGPVPEEPYTIPFGKAEVKREGKDVSIISVAMGVYQALEAAKELEKE
GISVEVLDLRTLVPLDREAIINTVKKTHRVLVVDEDYLSYGMSGEVAATIVEHAFDYLEAPVKRLAVPDVPIPYSRPLEQ
FVLPSSSKIVNAVKELLRS

Sequences:

>Translated_339_residues
MSAITSRKLTMAKAIAEAISLEMERDPRVFVMGEDVGVYGGIFGATAGLYEKFGPERVIDTPISEAGFIGAALGAAMEGM
RPIVELMFVDFFGVAMDQIYNHIAKNTYFSGGNIRVPLVLMTAVGGGYNDAGQHSQCLWGTFAHLPGLKVVVPSTPYDAK
GLMISAIRDDNPVIYMFHKGLLGLGWMTLIKDSTGPVPEEPYTIPFGKAEVKREGKDVSIISVAMGVYQALEAAKELEKE
GISVEVLDLRTLVPLDREAIINTVKKTHRVLVVDEDYLSYGMSGEVAATIVEHAFDYLEAPVKRLAVPDVPIPYSRPLEQ
FVLPSSSKIVNAVKELLRS
>Mature_338_residues
SAITSRKLTMAKAIAEAISLEMERDPRVFVMGEDVGVYGGIFGATAGLYEKFGPERVIDTPISEAGFIGAALGAAMEGMR
PIVELMFVDFFGVAMDQIYNHIAKNTYFSGGNIRVPLVLMTAVGGGYNDAGQHSQCLWGTFAHLPGLKVVVPSTPYDAKG
LMISAIRDDNPVIYMFHKGLLGLGWMTLIKDSTGPVPEEPYTIPFGKAEVKREGKDVSIISVAMGVYQALEAAKELEKEG
ISVEVLDLRTLVPLDREAIINTVKKTHRVLVVDEDYLSYGMSGEVAATIVEHAFDYLEAPVKRLAVPDVPIPYSRPLEQF
VLPSSSKIVNAVKELLRS

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=338, Percent_Identity=40.2366863905325, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI291084858, Length=337, Percent_Identity=38.8724035608309, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557353, Length=334, Percent_Identity=36.8263473053892, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI34101272, Length=334, Percent_Identity=36.8263473053892, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI225637463, Length=344, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI225637459, Length=344, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI133778974, Length=267, Percent_Identity=29.5880149812734, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI225637461, Length=344, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538422, Length=342, Percent_Identity=42.6900584795322, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17506935, Length=338, Percent_Identity=37.5739644970414, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17539652, Length=274, Percent_Identity=27.7372262773723, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=335, Percent_Identity=41.4925373134328, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21358145, Length=336, Percent_Identity=40.7738095238095, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24650940, Length=336, Percent_Identity=40.7738095238095, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI160714828, Length=342, Percent_Identity=38.8888888888889, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI160714832, Length=343, Percent_Identity=38.7755102040816, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24650943, Length=98, Percent_Identity=43.8775510204082, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650945, Length=98, Percent_Identity=43.8775510204082, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551847, Length=314, Percent_Identity=28.6624203821656, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550715, Length=314, Percent_Identity=28.6624203821656, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24645119, Length=314, Percent_Identity=28.6624203821656, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36858; Mature: 36727

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAITSRKLTMAKAIAEAISLEMERDPRVFVMGEDVGVYGGIFGATAGLYEKFGPERVID
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHC
TPISEAGFIGAALGAAMEGMRPIVELMFVDFFGVAMDQIYNHIAKNTYFSGGNIRVPLVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEE
MTAVGGGYNDAGQHSQCLWGTFAHLPGLKVVVPSTPYDAKGLMISAIRDDNPVIYMFHKG
EEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEECC
LLGLGWMTLIKDSTGPVPEEPYTIPFGKAEVKREGKDVSIISVAMGVYQALEAAKELEKE
HHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GISVEVLDLRTLVPLDREAIINTVKKTHRVLVVDEDYLSYGMSGEVAATIVEHAFDYLEA
CCEEEEEEHHHHCCCCHHHHHHHHHHHCEEEEEECHHHHCCCCCHHHHHHHHHHHHHHHH
PVKRLAVPDVPIPYSRPLEQFVLPSSSKIVNAVKELLRS
HHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SAITSRKLTMAKAIAEAISLEMERDPRVFVMGEDVGVYGGIFGATAGLYEKFGPERVID
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHC
TPISEAGFIGAALGAAMEGMRPIVELMFVDFFGVAMDQIYNHIAKNTYFSGGNIRVPLVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEE
MTAVGGGYNDAGQHSQCLWGTFAHLPGLKVVVPSTPYDAKGLMISAIRDDNPVIYMFHKG
EEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEECC
LLGLGWMTLIKDSTGPVPEEPYTIPFGKAEVKREGKDVSIISVAMGVYQALEAAKELEKE
HHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GISVEVLDLRTLVPLDREAIINTVKKTHRVLVVDEDYLSYGMSGEVAATIVEHAFDYLEA
CCEEEEEEHHHHCCCCHHHHHHHHHHHCEEEEEECHHHHCCCCCHHHHHHHHHHHHHHHH
PVKRLAVPDVPIPYSRPLEQFVLPSSSKIVNAVKELLRS
HHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]