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The map label for this gene is WecC [H]

Identifier: 20807144

GI number: 20807144

Start: 654117

End: 655454

Strand: Direct

Name: WecC [H]

Synonym: TTE0652

Alternate gene names: 20807144

Gene position: 654117-655454 (Clockwise)

Preceding gene: 20807143

Following gene: 20807145

Centisome position: 24.32

GC content: 35.13

Gene sequence:

>1338_bases
GTGGAGAGGGAAAAAGAGTTTAACAGTACATACTATGAACTTTTGGACAAAATAGAGAGCAAAAAGGCAGTAATAGGGGT
AATAGGATTGGGCTATGTAGGATTGCCTCTTGCAGTGGAAAAAGCTAAAGCAGGATATAAAGTAATAGGATTTGATATTC
AAAAGCACAAGGTGGAAAAAGTAAACAACGGTATAAATTACATTGGTGATATCCTAGATGGAGACTTAAAAGAAGTAGTT
GAGCAGGGAAGATTAAAAGCCACAAATGATTATGCTTTTTTAAAAGATGTGGATGCAGTTGCAATATGTGTTCCTACTCC
TCTTGATAAAAATAAACAGCCTGATTTATCCTATATAATTAACTCTACCAAAGAAATAGCGAAATATTTACATAAAGGCA
TGTTGGTCGTACTTGAAAGCACTACATATCCTGGTACCACTGAAGAAGTTGTAAAACCTATTTTAGACGAGACTGGCTTG
ATATGCGGAGAGGACTTTTTTTTAGCCTATTCTCCTGAAAGAGTAGACCCCGGTAACAAGGAGTATAAGACAAAAAATAC
TCCTAAAGTGGTAGGCGGCGTCACAAAACAGTGTACTAAAATTGCTGCTGCTCTTTATAGAAATGTCCTTGAAAGTGAAG
TGTTTGAAGTATCAAGTCCCAAAGTAGCAGAGATGGAAAAAATTTACGAAAACACTTTTAGAAATATCAATATAGCATTA
GCTAATGAAATGGCTATTATATGTTATCGCATGGGTATAGATGTATGGGAAGTAATTGAGGCAGCTAAAACAAAGCCCTA
TGGCTTTATGGCTTTTTATCCCGGGCCAGGACTTGGTGGCCATTGCATCCCTATAGATCCTTTTTATCTTGCTTGGAAAG
CAAGAGAATATGACTATCATACAAGGCTTATTGAAACCTCAGGTGAAATAAATAATTACATGCCAGAATTTGTGGTAGAA
CGCATTTCAAGGATTTTAAATAGATTCAAAAAGCCAATCAATGGTTCAACTATACTCCTTTTAGGAGTAGCCTATAAAAA
AGATATAGATGACATAAGAGAATCACCAGCCCTAAAGATAATCTCAATATTGGAAAAAGAAGGAGCAGTAGTAAAATATA
ACGATCCTCATGTACCTGAGTTTAAACACAATGGCAAATTGTATCATTCAGAGAACCTAACTGATGATTTACTAAGTTCC
TCTGACCTTGTTGTAATTACAACAGACCACACAAAGTACGATTATGAGCATATAGTTAAGACAGCAAAATTTGTATTTGA
TACGAGAAATGCTACAAAAAATTTAAAAGAATCAAGAGAAAAAATAGAAGTGCTGTAG

Upstream 100 bases:

>100_bases
AAAATTTTTGCTATACCGATGTATCCTGAAATTACTGATGAAGAGATTAGCTATATCAGTAAGGTACTGCACAAAATTGT
AAACGAAGGAGATTGAGATT

Downstream 100 bases:

>100_bases
GTGATAAAATGGATAAAAAATTAAGATTTGGATTAATTGGTTGTGGCAGGATTTCTTTTAAACATATTGAAGCTTTAGTG
AATAATCATGATAATGCAGA

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MEREKEFNSTYYELLDKIESKKAVIGVIGLGYVGLPLAVEKAKAGYKVIGFDIQKHKVEKVNNGINYIGDILDGDLKEVV
EQGRLKATNDYAFLKDVDAVAICVPTPLDKNKQPDLSYIINSTKEIAKYLHKGMLVVLESTTYPGTTEEVVKPILDETGL
ICGEDFFLAYSPERVDPGNKEYKTKNTPKVVGGVTKQCTKIAAALYRNVLESEVFEVSSPKVAEMEKIYENTFRNINIAL
ANEMAIICYRMGIDVWEVIEAAKTKPYGFMAFYPGPGLGGHCIPIDPFYLAWKAREYDYHTRLIETSGEINNYMPEFVVE
RISRILNRFKKPINGSTILLLGVAYKKDIDDIRESPALKIISILEKEGAVVKYNDPHVPEFKHNGKLYHSENLTDDLLSS
SDLVVITTDHTKYDYEHIVKTAKFVFDTRNATKNLKESREKIEVL

Sequences:

>Translated_445_residues
MEREKEFNSTYYELLDKIESKKAVIGVIGLGYVGLPLAVEKAKAGYKVIGFDIQKHKVEKVNNGINYIGDILDGDLKEVV
EQGRLKATNDYAFLKDVDAVAICVPTPLDKNKQPDLSYIINSTKEIAKYLHKGMLVVLESTTYPGTTEEVVKPILDETGL
ICGEDFFLAYSPERVDPGNKEYKTKNTPKVVGGVTKQCTKIAAALYRNVLESEVFEVSSPKVAEMEKIYENTFRNINIAL
ANEMAIICYRMGIDVWEVIEAAKTKPYGFMAFYPGPGLGGHCIPIDPFYLAWKAREYDYHTRLIETSGEINNYMPEFVVE
RISRILNRFKKPINGSTILLLGVAYKKDIDDIRESPALKIISILEKEGAVVKYNDPHVPEFKHNGKLYHSENLTDDLLSS
SDLVVITTDHTKYDYEHIVKTAKFVFDTRNATKNLKESREKIEVL
>Mature_445_residues
MEREKEFNSTYYELLDKIESKKAVIGVIGLGYVGLPLAVEKAKAGYKVIGFDIQKHKVEKVNNGINYIGDILDGDLKEVV
EQGRLKATNDYAFLKDVDAVAICVPTPLDKNKQPDLSYIINSTKEIAKYLHKGMLVVLESTTYPGTTEEVVKPILDETGL
ICGEDFFLAYSPERVDPGNKEYKTKNTPKVVGGVTKQCTKIAAALYRNVLESEVFEVSSPKVAEMEKIYENTFRNINIAL
ANEMAIICYRMGIDVWEVIEAAKTKPYGFMAFYPGPGLGGHCIPIDPFYLAWKAREYDYHTRLIETSGEINNYMPEFVVE
RISRILNRFKKPINGSTILLLGVAYKKDIDDIRESPALKIISILEKEGAVVKYNDPHVPEFKHNGKLYHSENLTDDLLSS
SDLVVITTDHTKYDYEHIVKTAKFVFDTRNATKNLKESREKIEVL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=457, Percent_Identity=26.2582056892779, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296040438, Length=363, Percent_Identity=25.3443526170799, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI296040443, Length=295, Percent_Identity=26.4406779661017, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=36.7647058823529, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17560350, Length=390, Percent_Identity=24.1025641025641, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136908, Length=381, Percent_Identity=25.4593175853018, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 50277; Mature: 50277

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREKEFNSTYYELLDKIESKKAVIGVIGLGYVGLPLAVEKAKAGYKVIGFDIQKHKVEK
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHCCCCEEHHHCCCCEEEEEEHHHHHHHH
VNNGINYIGDILDGDLKEVVEQGRLKATNDYAFLKDVDAVAICVPTPLDKNKQPDLSYII
HHCCHHHHHHHCCCHHHHHHHCCCCEECCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHH
NSTKEIAKYLHKGMLVVLESTTYPGTTEEVVKPILDETGLICGEDFFLAYSPERVDPGNK
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCC
EYKTKNTPKVVGGVTKQCTKIAAALYRNVLESEVFEVSSPKVAEMEKIYENTFRNINIAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEE
ANEMAIICYRMGIDVWEVIEAAKTKPYGFMAFYPGPGLGGHCIPIDPFYLAWKAREYDYH
ECCEEEEEHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCEEEEEEECCCCHH
TRLIETSGEINNYMPEFVVERISRILNRFKKPINGSTILLLGVAYKKDIDDIRESPALKI
HHEEECCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCHHHHHCCCHHHH
ISILEKEGAVVKYNDPHVPEFKHNGKLYHSENLTDDLLSSSDLVVITTDHTKYDYEHIVK
HHHHHHCCCEEEECCCCCCCCCCCCEEEECCCCCHHHHCCCCEEEEEECCCCCCHHHHHH
TAKFVFDTRNATKNLKESREKIEVL
HHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEREKEFNSTYYELLDKIESKKAVIGVIGLGYVGLPLAVEKAKAGYKVIGFDIQKHKVEK
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHCCCCEEHHHCCCCEEEEEEHHHHHHHH
VNNGINYIGDILDGDLKEVVEQGRLKATNDYAFLKDVDAVAICVPTPLDKNKQPDLSYII
HHCCHHHHHHHCCCHHHHHHHCCCCEECCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHH
NSTKEIAKYLHKGMLVVLESTTYPGTTEEVVKPILDETGLICGEDFFLAYSPERVDPGNK
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCC
EYKTKNTPKVVGGVTKQCTKIAAALYRNVLESEVFEVSSPKVAEMEKIYENTFRNINIAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEE
ANEMAIICYRMGIDVWEVIEAAKTKPYGFMAFYPGPGLGGHCIPIDPFYLAWKAREYDYH
ECCEEEEEHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCEEEEEEECCCCHH
TRLIETSGEINNYMPEFVVERISRILNRFKKPINGSTILLLGVAYKKDIDDIRESPALKI
HHEEECCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCHHHHHCCCHHHH
ISILEKEGAVVKYNDPHVPEFKHNGKLYHSENLTDDLLSSSDLVVITTDHTKYDYEHIVK
HHHHHHCCCEEEECCCCCCCCCCCCEEEECCCCCHHHHCCCCEEEEEECCCCCCHHHHHH
TAKFVFDTRNATKNLKESREKIEVL
HHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]