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The map label for this gene is mtlR [H]

Identifier: 20807093

GI number: 20807093

Start: 600684

End: 602768

Strand: Direct

Name: mtlR [H]

Synonym: TTE0598

Alternate gene names: 20807093

Gene position: 600684-602768 (Clockwise)

Preceding gene: 20807092

Following gene: 20807094

Centisome position: 22.33

GC content: 34.72

Gene sequence:

>2085_bases
ATGGTTAAGTTAAACAGCCGACAGCTACAGATTTTGAAAAAAATATTGTTGTCCTCCAAGTTAACTGTGTCAGATATTGA
AAGAGAATTTCATGTAAGCAGAAGGACTGCGTACCGCGACATAGCTGGAATTGGAGAATTTGTGAAAAAATACAACCTAA
TTTTTGTCAACACTTCAGAAGGATTTACATTGAATGGAGATGCTGCAGGCATAGAGAAGTTGAGACTGGACGTTATAGGA
TATTTCCCGGTTGACGCAGAGGAAAGAAGAAAAATGATACTTTCTGAACTCCTTCAGCTGAAAGAGCCTGTAAAATTAGA
ATATTTTAGCAAAAAGTTCAAGGTTACGACTGCCACTATAAGTTATGACCTCAAAGAATTGGAGAAATGGCTTGAAAAAC
AGGGGTTAACTTTGGTTACAAAGCCGGGATATGGAGTTTACATCTCTGGAAATGAAAATTCTTTTAGACGAGCTATTGCT
AATTTTTTGTATGAAAATTTTGATACCGCTGAGCTGGCTAATTTTTTGCAAAGAGGATACCTATCTAAAAGTGGTATTGA
GAGAAATATAGACTTAAGGCTTTTAAACTTGATTGATTACGACACTGTTTCAAAAATAGAAAAAGCTATTTTGAGGTTAA
AACAGCAGATTGATTACGAAATTGTTGAGAGCTCTTACATGGCTTTAGTAGTTCATTTGGCTCTTGCGATAAAGAGACTT
CAAGAAGGAGAAACTATTCAAATAGGGGAAGAGACTTTAGAGGACCTTAAAAAAACAGAAGAGTATCTATTTGCCAAGAA
ACTAGGGGAATATCTCGAAGAAGAACTTAATATTGACATACCTGAAGATGAAATAGGGTATATTACAATTCATCTTTTAG
CTGCAAGATACAGGTCTACTGCCCAAAATTATACTGACAGTGAAATTGAAAGTATAGTTGAAGAGATAATAAAAGAAGCC
TCAAAGGTATTTGAGGTAGATTTTTCAGAAGATAAGCTTTTAGAAGAAGGACTTCAAAGTCATTTAGCTCCTGCACTTTA
CAGGTTGGAAATGGGACTTGACATAAGGAACCCGCTGTTAGGTGATATAAAGGCCAAATATCCTGTGCTTTTTGAAAAAA
GCAATAAAGTGTGTGATGTCCTAAGAAAAAAATTAAAAAGGGACATTCCAGAAGACGAAGTCGGATATATTGCAATGCAT
TTTGGAGCTGCACTTGAAAGAAAAAAAGAAACTTTTAGAAAATATAACATACTGGTGGTGTGTGCTAGTGGCATAGGAAC
TTCTAGGATGTTGATGTCTAAACTGCAAATGTTTCCTCAGTTAAACGTGGTGGAAGTTGCCTCCAGTGTAAAGCTAAAAG
AATTGGAAAAGAGAAAAGATATAGATTTAATTGTTTCCACAATACCACTTAAGTTGACCAGCAAAAAGGTAGTAGTTGTA
AATCCTCTTTTGTTAGAAGAAGACGTAGAAAAATTAAAAAAGGCATTAAATACTGACTTTATCTTGGAATATGATTTGGT
CCCAGAAAATAAGCAGAGAGAAGAAGGATACGTCAAAAAAGCAGAACACATAGCTAAATATGGAAAGAGGATTTTAGAGC
TACAGGATAGCCTTGTGTTCATGGAAGTAGAGGGAGAAAATTCGTCCCAAATAGTGGAAGAAATTCTTGAATATTTAAAG
ATTCAGGGAGGCATAGAAGAATTTCAAAAAGAGGAAATTAAAGAGAGGCTTTTACAAAGAGAAAGTTTAGGTAAAATAGT
ACTTCCTAATAAAGGATTCGTAATATATCATTGCGCTGTAAAAAGTTTAAAAAAGCCTATACTGGCTGTAGCGAAAATGA
AGAACAAGGTTAAAATGAAAAATCTTATAGGAAGTTATGAAAATATAGAAACAGTTTTTTTAATGGTAGCTCCCGAAGGA
GATAGGGAGGGAATTGAAGTTTTGGGAGATTTGAGCGTTTCTTTGATTGAAAGAGAGGATTTTCTGGATTCCATCAATAG
TTCAAAGTCTTGCGAGGAAATAAAGAAGAGAATAGGAGAAGTGTTGTTGGGTAAATTTTATGAAGAGATAAAAAGGACAG
TCTAG

Upstream 100 bases:

>100_bases
TTACATCTTTTTCTTGTTAATTAGGCGATTAGAGTTATAATTGTAGATGTGTAAGGAGAAAATATTATTAAATTCCTGTC
ATAAAGTGTGATGATGAAAA

Downstream 100 bases:

>100_bases
GAGGATAGAGATGTTTAGCATACCTTCTTCTCAGATAAAAATATTTTACCTCCTTTTAGGTGTAGTGTGGTTTTCAACAG
GAATTTATTACATGTTTCGC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MVKLNSRQLQILKKILLSSKLTVSDIEREFHVSRRTAYRDIAGIGEFVKKYNLIFVNTSEGFTLNGDAAGIEKLRLDVIG
YFPVDAEERRKMILSELLQLKEPVKLEYFSKKFKVTTATISYDLKELEKWLEKQGLTLVTKPGYGVYISGNENSFRRAIA
NFLYENFDTAELANFLQRGYLSKSGIERNIDLRLLNLIDYDTVSKIEKAILRLKQQIDYEIVESSYMALVVHLALAIKRL
QEGETIQIGEETLEDLKKTEEYLFAKKLGEYLEEELNIDIPEDEIGYITIHLLAARYRSTAQNYTDSEIESIVEEIIKEA
SKVFEVDFSEDKLLEEGLQSHLAPALYRLEMGLDIRNPLLGDIKAKYPVLFEKSNKVCDVLRKKLKRDIPEDEVGYIAMH
FGAALERKKETFRKYNILVVCASGIGTSRMLMSKLQMFPQLNVVEVASSVKLKELEKRKDIDLIVSTIPLKLTSKKVVVV
NPLLLEEDVEKLKKALNTDFILEYDLVPENKQREEGYVKKAEHIAKYGKRILELQDSLVFMEVEGENSSQIVEEILEYLK
IQGGIEEFQKEEIKERLLQRESLGKIVLPNKGFVIYHCAVKSLKKPILAVAKMKNKVKMKNLIGSYENIETVFLMVAPEG
DREGIEVLGDLSVSLIEREDFLDSINSSKSCEEIKKRIGEVLLGKFYEEIKRTV

Sequences:

>Translated_694_residues
MVKLNSRQLQILKKILLSSKLTVSDIEREFHVSRRTAYRDIAGIGEFVKKYNLIFVNTSEGFTLNGDAAGIEKLRLDVIG
YFPVDAEERRKMILSELLQLKEPVKLEYFSKKFKVTTATISYDLKELEKWLEKQGLTLVTKPGYGVYISGNENSFRRAIA
NFLYENFDTAELANFLQRGYLSKSGIERNIDLRLLNLIDYDTVSKIEKAILRLKQQIDYEIVESSYMALVVHLALAIKRL
QEGETIQIGEETLEDLKKTEEYLFAKKLGEYLEEELNIDIPEDEIGYITIHLLAARYRSTAQNYTDSEIESIVEEIIKEA
SKVFEVDFSEDKLLEEGLQSHLAPALYRLEMGLDIRNPLLGDIKAKYPVLFEKSNKVCDVLRKKLKRDIPEDEVGYIAMH
FGAALERKKETFRKYNILVVCASGIGTSRMLMSKLQMFPQLNVVEVASSVKLKELEKRKDIDLIVSTIPLKLTSKKVVVV
NPLLLEEDVEKLKKALNTDFILEYDLVPENKQREEGYVKKAEHIAKYGKRILELQDSLVFMEVEGENSSQIVEEILEYLK
IQGGIEEFQKEEIKERLLQRESLGKIVLPNKGFVIYHCAVKSLKKPILAVAKMKNKVKMKNLIGSYENIETVFLMVAPEG
DREGIEVLGDLSVSLIEREDFLDSINSSKSCEEIKKRIGEVLLGKFYEEIKRTV
>Mature_694_residues
MVKLNSRQLQILKKILLSSKLTVSDIEREFHVSRRTAYRDIAGIGEFVKKYNLIFVNTSEGFTLNGDAAGIEKLRLDVIG
YFPVDAEERRKMILSELLQLKEPVKLEYFSKKFKVTTATISYDLKELEKWLEKQGLTLVTKPGYGVYISGNENSFRRAIA
NFLYENFDTAELANFLQRGYLSKSGIERNIDLRLLNLIDYDTVSKIEKAILRLKQQIDYEIVESSYMALVVHLALAIKRL
QEGETIQIGEETLEDLKKTEEYLFAKKLGEYLEEELNIDIPEDEIGYITIHLLAARYRSTAQNYTDSEIESIVEEIIKEA
SKVFEVDFSEDKLLEEGLQSHLAPALYRLEMGLDIRNPLLGDIKAKYPVLFEKSNKVCDVLRKKLKRDIPEDEVGYIAMH
FGAALERKKETFRKYNILVVCASGIGTSRMLMSKLQMFPQLNVVEVASSVKLKELEKRKDIDLIVSTIPLKLTSKKVVVV
NPLLLEEDVEKLKKALNTDFILEYDLVPENKQREEGYVKKAEHIAKYGKRILELQDSLVFMEVEGENSSQIVEEILEYLK
IQGGIEEFQKEEIKERLLQRESLGKIVLPNKGFVIYHCAVKSLKKPILAVAKMKNKVKMKNLIGSYENIETVFLMVAPEG
DREGIEVLGDLSVSLIEREDFLDSINSSKSCEEIKKRIGEVLLGKFYEEIKRTV

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 79670; Mature: 79670

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLNSRQLQILKKILLSSKLTVSDIEREFHVSRRTAYRDIAGIGEFVKKYNLIFVNTSE
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GFTLNGDAAGIEKLRLDVIGYFPVDAEERRKMILSELLQLKEPVKLEYFSKKFKVTTATI
CEEECCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEEE
SYDLKELEKWLEKQGLTLVTKPGYGVYISGNENSFRRAIANFLYENFDTAELANFLQRGY
HHHHHHHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCC
LSKSGIERNIDLRLLNLIDYDTVSKIEKAILRLKQQIDYEIVESSYMALVVHLALAIKRL
CCCCCCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEGETIQIGEETLEDLKKTEEYLFAKKLGEYLEEELNIDIPEDEIGYITIHLLAARYRST
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AQNYTDSEIESIVEEIIKEASKVFEVDFSEDKLLEEGLQSHLAPALYRLEMGLDIRNPLL
HCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDIKAKYPVLFEKSNKVCDVLRKKLKRDIPEDEVGYIAMHFGAALERKKETFRKYNILVV
CCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHCEEHHHHHHHHHHHHHHHHHCCEEEE
CASGIGTSRMLMSKLQMFPQLNVVEVASSVKLKELEKRKDIDLIVSTIPLKLTSKKVVVV
EECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEEECCCEEEEE
NPLLLEEDVEKLKKALNTDFILEYDLVPENKQREEGYVKKAEHIAKYGKRILELQDSLVF
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
MEVEGENSSQIVEEILEYLKIQGGIEEFQKEEIKERLLQRESLGKIVLPNKGFVIYHCAV
EEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEHHHH
KSLKKPILAVAKMKNKVKMKNLIGSYENIETVFLMVAPEGDREGIEVLGDLSVSLIERED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
FLDSINSSKSCEEIKKRIGEVLLGKFYEEIKRTV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKLNSRQLQILKKILLSSKLTVSDIEREFHVSRRTAYRDIAGIGEFVKKYNLIFVNTSE
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GFTLNGDAAGIEKLRLDVIGYFPVDAEERRKMILSELLQLKEPVKLEYFSKKFKVTTATI
CEEECCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEEE
SYDLKELEKWLEKQGLTLVTKPGYGVYISGNENSFRRAIANFLYENFDTAELANFLQRGY
HHHHHHHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCC
LSKSGIERNIDLRLLNLIDYDTVSKIEKAILRLKQQIDYEIVESSYMALVVHLALAIKRL
CCCCCCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEGETIQIGEETLEDLKKTEEYLFAKKLGEYLEEELNIDIPEDEIGYITIHLLAARYRST
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AQNYTDSEIESIVEEIIKEASKVFEVDFSEDKLLEEGLQSHLAPALYRLEMGLDIRNPLL
HCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDIKAKYPVLFEKSNKVCDVLRKKLKRDIPEDEVGYIAMHFGAALERKKETFRKYNILVV
CCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHCEEHHHHHHHHHHHHHHHHHCCEEEE
CASGIGTSRMLMSKLQMFPQLNVVEVASSVKLKELEKRKDIDLIVSTIPLKLTSKKVVVV
EECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEEECCCEEEEE
NPLLLEEDVEKLKKALNTDFILEYDLVPENKQREEGYVKKAEHIAKYGKRILELQDSLVF
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
MEVEGENSSQIVEEILEYLKIQGGIEEFQKEEIKERLLQRESLGKIVLPNKGFVIYHCAV
EEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEHHHH
KSLKKPILAVAKMKNKVKMKNLIGSYENIETVFLMVAPEGDREGIEVLGDLSVSLIERED
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
FLDSINSSKSCEEIKKRIGEVLLGKFYEEIKRTV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]