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The map label for this gene is PurE [H]

Identifier: 20807081

GI number: 20807081

Start: 588003

End: 588470

Strand: Direct

Name: PurE [H]

Synonym: TTE0585

Alternate gene names: 20807081

Gene position: 588003-588470 (Clockwise)

Preceding gene: 20807080

Following gene: 20807082

Centisome position: 21.86

GC content: 41.67

Gene sequence:

>468_bases
TTGAAAATGCCAAAAATTGCTGTGGTAGTGGGTAGCAAGTCAGACCTCCCTGTAATTGAAAGGTGTACAGATATTTTAGA
TGAATTTGGAATTTCATATGACGTAAAAGTTCTGTCTGCCCATCGAACTCCTTTTGAGACGCAGGAATTTGCAGTAGAAG
CAGAGAAATATTACGACCTTATAATAGCGGCGGCAGGAAAAGCTGCTCATCTCCCAGGGGTCATTGCTTCTTACACTTTA
CTTCCTGTCATTGGGCTTCCCATCAAGTCTTCCACTCTAGATGGACTGGATTCTCTCCTTTCAATTGTGCAGATGCCAAA
AGGAGTTCCAGTAGCTACGGTTGCTATAGATGGAGCTGAGAATGCTGCTCTTTTAGCCTGTCATATTCTCTCTTTGAAGT
ATCCCCATCTAAAAGAAAAGCTTGCTAATTACAGGGAGAAAATGGCGGAGGAAGTGTTAAATAATTAA

Upstream 100 bases:

>100_bases
ATGATGTATGTAATTGCTGCTGCCTTTACAATAAATTTTGTTTTGAGATAAGAGGGGTTTTCCCCTCTTATTCATCAAAA
TTTAAAATAGGAGGTTTTTA

Downstream 100 bases:

>100_bases
TATTGGAGGTTATAGCAGTTGACGATAATCATGCAAAGAGGTATAATTTTAATTAGGTGATAATAAATGTTATTAAGTAT
GCAAAAAGTAAGAGAAATAT

Product: phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MKMPKIAVVVGSKSDLPVIERCTDILDEFGISYDVKVLSAHRTPFETQEFAVEAEKYYDLIIAAAGKAAHLPGVIASYTL
LPVIGLPIKSSTLDGLDSLLSIVQMPKGVPVATVAIDGAENAALLACHILSLKYPHLKEKLANYREKMAEEVLNN

Sequences:

>Translated_155_residues
MKMPKIAVVVGSKSDLPVIERCTDILDEFGISYDVKVLSAHRTPFETQEFAVEAEKYYDLIIAAAGKAAHLPGVIASYTL
LPVIGLPIKSSTLDGLDSLLSIVQMPKGVPVATVAIDGAENAALLACHILSLKYPHLKEKLANYREKMAEEVLNN
>Mature_155_residues
MKMPKIAVVVGSKSDLPVIERCTDILDEFGISYDVKVLSAHRTPFETQEFAVEAEKYYDLIIAAAGKAAHLPGVIASYTL
LPVIGLPIKSSTLDGLDSLLSIVQMPKGVPVATVAIDGAENAALLACHILSLKYPHLKEKLANYREKMAEEVLNN

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=44.1558441558442, Blast_Score=120, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=50, Blast_Score=148, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16762; Mature: 16762

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPKIAVVVGSKSDLPVIERCTDILDEFGISYDVKVLSAHRTPFETQEFAVEAEKYYDL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
IIAAAGKAAHLPGVIASYTLLPVIGLPIKSSTLDGLDSLLSIVQMPKGVPVATVAIDGAE
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NAALLACHILSLKYPHLKEKLANYREKMAEEVLNN
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMPKIAVVVGSKSDLPVIERCTDILDEFGISYDVKVLSAHRTPFETQEFAVEAEKYYDL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
IIAAAGKAAHLPGVIASYTLLPVIGLPIKSSTLDGLDSLLSIVQMPKGVPVATVAIDGAE
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NAALLACHILSLKYPHLKEKLANYREKMAEEVLNN
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]