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The map label for this gene is Gcd14

Identifier: 20806980

GI number: 20806980

Start: 487618

End: 488409

Strand: Reverse

Name: Gcd14

Synonym: TTE0474

Alternate gene names: NA

Gene position: 488409-487618 (Counterclockwise)

Preceding gene: 20806981

Following gene: 20806975

Centisome position: 18.16

GC content: 40.15

Gene sequence:

>792_bases
GTGAAGTCAATACATAATAAGCGCATTATAGTTGGACCTGACAATTTTAAAAAAGTAGTAGATATAACTTCATCTGGCAA
AGTAGGACTTCCAAAAGGGCAGGTAGATGTCCAATTTTTAGCTAAGCTTGCGCCCGGCACAAGCTTTGAGATTCAGGGAG
AGAAATATTATCTCCTTGAGTGCGACACCTTTGATTACATCATGTACTCTCTAAAAAGGCAGACACAAATTGTATACCCA
AAAGAGGGAAGTTACATTGCCATGAGGTTAGACATTTTCCCGGGCAAAAGAGTTGGGGAAGCCGGAACTGGGTCCGGCGC
CTTTACCGTTTACTTATCTAGATTGGTAGGTCCTCATGGAAGAGTATATACTTATGAACAAAGAGAGGAATTTTTCAAAC
TTGCCCGAAAAAATCTTGATGAGTTTTGCGAATACGACAACGTCATTATGTACAATAAATCCATCTCCGATGGAATTGAA
GAAAAAGAGTTAGACGCTTTTTTCTTAGACGTTAGAAAACCCTGGGAAGTGCTAGAACAAGTAAGTGGAGCTTTAAAGCT
TGGCGGGCATTTAGGAATATTAGTTCCGACCACAAATCAAGTTTCAGAAGCGCTTGTGGCATTAGAAAAAAGCGGATTTT
ATACCATTGAAGTCAGTGAAATCCTCCTTAGAAAGTACAAAATAAACCCTGAAAGGCTAAGGCCAGAAGACCTCATGATA
GGGCACACAGGATATTTAATCTTCGCAAGAAAAATATCAGACAGAGGGGACGGTTCCTCTCATCCGATTTAA

Upstream 100 bases:

>100_bases
CGTGCCTGAAAATGAAAAACCCACTTTTGAAAACATATTTTAAAATTTGTGTTATAATATAGACATGTGTACCCTTTAAA
GAAAAAGGGGGAATGAAAGG

Downstream 100 bases:

>100_bases
AAATAGGCACCTCTTTGGTGAGGTGCCTCAATTTGTTTTATTTTTACTTTTTACATAATTTATCATTCCACCTGCAATGA
GGATTTCCCGATTTCTATCA

Product: SAM-dependent methyltransferase involved in tRNA-Met maturation

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKSIHNKRIIVGPDNFKKVVDITSSGKVGLPKGQVDVQFLAKLAPGTSFEIQGEKYYLLECDTFDYIMYSLKRQTQIVYP
KEGSYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRLVGPHGRVYTYEQREEFFKLARKNLDEFCEYDNVIMYNKSISDGIE
EKELDAFFLDVRKPWEVLEQVSGALKLGGHLGILVPTTNQVSEALVALEKSGFYTIEVSEILLRKYKINPERLRPEDLMI
GHTGYLIFARKISDRGDGSSHPI

Sequences:

>Translated_263_residues
MKSIHNKRIIVGPDNFKKVVDITSSGKVGLPKGQVDVQFLAKLAPGTSFEIQGEKYYLLECDTFDYIMYSLKRQTQIVYP
KEGSYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRLVGPHGRVYTYEQREEFFKLARKNLDEFCEYDNVIMYNKSISDGIE
EKELDAFFLDVRKPWEVLEQVSGALKLGGHLGILVPTTNQVSEALVALEKSGFYTIEVSEILLRKYKINPERLRPEDLMI
GHTGYLIFARKISDRGDGSSHPI
>Mature_263_residues
MKSIHNKRIIVGPDNFKKVVDITSSGKVGLPKGQVDVQFLAKLAPGTSFEIQGEKYYLLECDTFDYIMYSLKRQTQIVYP
KEGSYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRLVGPHGRVYTYEQREEFFKLARKNLDEFCEYDNVIMYNKSISDGIE
EKELDAFFLDVRKPWEVLEQVSGALKLGGHLGILVPTTNQVSEALVALEKSGFYTIEVSEILLRKYKINPERLRPEDLMI
GHTGYLIFARKISDRGDGSSHPI

Specific function: Unknown

COG id: COG2519

COG function: function code J; tRNA(1-methyladenosine) methyltransferase and related methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TRM61 family [H]

Homologues:

Organism=Homo sapiens, GI123173772, Length=227, Percent_Identity=29.5154185022026, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI222831587, Length=232, Percent_Identity=30.1724137931034, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17509459, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322336, Length=190, Percent_Identity=30, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650257, Length=211, Percent_Identity=28.436018957346, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014816 [H]

Pfam domain/function: PF08704 GCD14 [H]

EC number: =2.1.1.36 [H]

Molecular weight: Translated: 29763; Mature: 29763

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIHNKRIIVGPDNFKKVVDITSSGKVGLPKGQVDVQFLAKLAPGTSFEIQGEKYYLLE
CCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCEEEEEE
CDTFDYIMYSLKRQTQIVYPKEGSYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRLVGPHG
ECCHHHHHHHHHHCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCC
RVYTYEQREEFFKLARKNLDEFCEYDNVIMYNKSISDGIEEKELDAFFLDVRKPWEVLEQ
CEEEHHHHHHHHHHHHHCHHHHHCCCCEEEECCCHHCCCCHHHHHEEEEECCCHHHHHHH
VSGALKLGGHLGILVPTTNQVSEALVALEKSGFYTIEVSEILLRKYKINPERLRPEDLMI
HHHHEEECCEEEEEEECCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHCCCCCEEE
GHTGYLIFARKISDRGDGSSHPI
ECCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKSIHNKRIIVGPDNFKKVVDITSSGKVGLPKGQVDVQFLAKLAPGTSFEIQGEKYYLLE
CCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCEEEEEE
CDTFDYIMYSLKRQTQIVYPKEGSYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRLVGPHG
ECCHHHHHHHHHHCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCC
RVYTYEQREEFFKLARKNLDEFCEYDNVIMYNKSISDGIEEKELDAFFLDVRKPWEVLEQ
CEEEHHHHHHHHHHHHHCHHHHHCCCCEEEECCCHHCCCCHHHHHEEEEECCCHHHHHHH
VSGALKLGGHLGILVPTTNQVSEALVALEKSGFYTIEVSEILLRKYKINPERLRPEDLMI
HHHHEEECCEEEEEEECCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHCCCCCEEE
GHTGYLIFARKISDRGDGSSHPI
ECCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]