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The map label for this gene is hgdC [H]

Identifier: 20806836

GI number: 20806836

Start: 335983

End: 336945

Strand: Direct

Name: hgdC [H]

Synonym: TTE0319

Alternate gene names: 20806836

Gene position: 335983-336945 (Clockwise)

Preceding gene: 20806835

Following gene: 20806837

Centisome position: 12.49

GC content: 39.15

Gene sequence:

>963_bases
GTGGAAAAGGTGTACATTGGTGTTGATGTAGGATCAGTGAGCATTAAGGTTGTGGCTATTGACAATGATAACAATATTTT
ATTTAGGTCCTACGTCAGAAATGTAGGACAGCCTATTGATATTGTAAAGGAAGAGCTTAAGAAATTGCACAATGAATTGC
CTGACAAAGAGATAGGTGGAGTAGGTGTTACTGGAAGCGGTAGACAGCTAATCGGCTATGTCTTAGGGGCTGATGTGGTT
AAAAATGAAATTACTGCCCATGCAACTGCTACAATTTATTTTCACCCAGATGTCAGCACTATTTTTGAAATCGGGGGACA
AGATTCGAAACTGATCATAATAAATGATGGCACAATAGCTGATTTTGCTATGAATACTGTTTGTGCTGCTGGTACAGGGT
CATTTTTGGATCACCAGGCCCAAAGGCTTGGGATAAAGATTGAGGAATTTGGAGAGATTGCTCTTACTGCGAAAAGAGAG
GTTCGCATTGCTGGAAGATGTACAGTTTTTGCTGAATCGGATATGATATCAAAACAGCAGTACGGTTTTAGTAAGGCAGA
GATATTAAAAGGACTGTCAAAAGCCTTGGTGAGGAATTATATGAATAATCTAGTAAGAGGAAGAGAATTAAAACCCGCTT
TTGTGTTCCAGGGAGGAGTTGCGGCGAATATTGCTATAAGGAAGGCTTTTGAAGAAGAGGTAGGTCATGAGGTGATAGTG
CCTAAACATTATGATATAATGGGTGCTATAGGGATTGCGATGATTGCTAAAGAAGAGGTAAAGAGGACAGGTAGACCTAC
CAAGTTTAAAGGTTTTGATGTATCGGGAGAAAAATTTGAAACCACCACCTTTATATGCAAAGCTTGTCCCAATGAGTGCG
AAATAATACAGATTAAGGCGAATGGAAAGATAATTGCTATGACAGGAGATAGATGTGGGAGATATTCAAATTCTGTAATA
TGA

Upstream 100 bases:

>100_bases
TGAACAGATGGCTATTGCCAATACTTTGACTAGGATAGAAGCTTTTTTGGATGTCATAAGGTTAAAAAAACGTAAAAAAA
GGATAGTGAGGTAGGACAAA

Downstream 100 bases:

>100_bases
AAATGAGGGGATAACCCCCTTTTTATTTTTTGATTGATTTTTTTATGGCTAAGAGGTAAAATTTAATTAAATGTAACAGT
TGTTACAACAAGGAGGTGGT

Product: 2-hydroxyglutaryl-CoA dehydratase activator

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MEKVYIGVDVGSVSIKVVAIDNDNNILFRSYVRNVGQPIDIVKEELKKLHNELPDKEIGGVGVTGSGRQLIGYVLGADVV
KNEITAHATATIYFHPDVSTIFEIGGQDSKLIIINDGTIADFAMNTVCAAGTGSFLDHQAQRLGIKIEEFGEIALTAKRE
VRIAGRCTVFAESDMISKQQYGFSKAEILKGLSKALVRNYMNNLVRGRELKPAFVFQGGVAANIAIRKAFEEEVGHEVIV
PKHYDIMGAIGIAMIAKEEVKRTGRPTKFKGFDVSGEKFETTTFICKACPNECEIIQIKANGKIIAMTGDRCGRYSNSVI

Sequences:

>Translated_320_residues
MEKVYIGVDVGSVSIKVVAIDNDNNILFRSYVRNVGQPIDIVKEELKKLHNELPDKEIGGVGVTGSGRQLIGYVLGADVV
KNEITAHATATIYFHPDVSTIFEIGGQDSKLIIINDGTIADFAMNTVCAAGTGSFLDHQAQRLGIKIEEFGEIALTAKRE
VRIAGRCTVFAESDMISKQQYGFSKAEILKGLSKALVRNYMNNLVRGRELKPAFVFQGGVAANIAIRKAFEEEVGHEVIV
PKHYDIMGAIGIAMIAKEEVKRTGRPTKFKGFDVSGEKFETTTFICKACPNECEIIQIKANGKIIAMTGDRCGRYSNSVI
>Mature_320_residues
MEKVYIGVDVGSVSIKVVAIDNDNNILFRSYVRNVGQPIDIVKEELKKLHNELPDKEIGGVGVTGSGRQLIGYVLGADVV
KNEITAHATATIYFHPDVSTIFEIGGQDSKLIIINDGTIADFAMNTVCAAGTGSFLDHQAQRLGIKIEEFGEIALTAKRE
VRIAGRCTVFAESDMISKQQYGFSKAEILKGLSKALVRNYMNNLVRGRELKPAFVFQGGVAANIAIRKAFEEEVGHEVIV
PKHYDIMGAIGIAMIAKEEVKRTGRPTKFKGFDVSGEKFETTTFICKACPNECEIIQIKANGKIIAMTGDRCGRYSNSVI

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=258, Percent_Identity=32.5581395348837, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 34937; Mature: 34937

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVYIGVDVGSVSIKVVAIDNDNNILFRSYVRNVGQPIDIVKEELKKLHNELPDKEIGG
CCEEEEEEEECCEEEEEEEEECCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
VGVTGSGRQLIGYVLGADVVKNEITAHATATIYFHPDVSTIFEIGGQDSKLIIINDGTIA
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHCCCCCCEEEEEECCCCH
DFAMNTVCAAGTGSFLDHQAQRLGIKIEEFGEIALTAKREVRIAGRCTVFAESDMISKQQ
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCEEEEECEEEEEEEEEEEEECCCCCCHHH
YGFSKAEILKGLSKALVRNYMNNLVRGRELKPAFVFQGGVAANIAIRKAFEEEVGHEVIV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHCCCEEEC
PKHYDIMGAIGIAMIAKEEVKRTGRPTKFKGFDVSGEKFETTTFICKACPNECEIIQIKA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEHEEEEEECCCCCCEEEEEEC
NGKIIAMTGDRCGRYSNSVI
CCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MEKVYIGVDVGSVSIKVVAIDNDNNILFRSYVRNVGQPIDIVKEELKKLHNELPDKEIGG
CCEEEEEEEECCEEEEEEEEECCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
VGVTGSGRQLIGYVLGADVVKNEITAHATATIYFHPDVSTIFEIGGQDSKLIIINDGTIA
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHCCCCCCEEEEEECCCCH
DFAMNTVCAAGTGSFLDHQAQRLGIKIEEFGEIALTAKREVRIAGRCTVFAESDMISKQQ
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCEEEEECEEEEEEEEEEEEECCCCCCHHH
YGFSKAEILKGLSKALVRNYMNNLVRGRELKPAFVFQGGVAANIAIRKAFEEEVGHEVIV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHCCCEEEC
PKHYDIMGAIGIAMIAKEEVKRTGRPTKFKGFDVSGEKFETTTFICKACPNECEIIQIKA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEHEEEEEECCCCCCEEEEEEC
NGKIIAMTGDRCGRYSNSVI
CCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]