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The map label for this gene is TktA [H]

Identifier: 20806716

GI number: 20806716

Start: 193423

End: 195426

Strand: Direct

Name: TktA [H]

Synonym: TTE0190

Alternate gene names: 20806716

Gene position: 193423-195426 (Clockwise)

Preceding gene: 20806715

Following gene: 20806717

Centisome position: 7.19

GC content: 44.11

Gene sequence:

>2004_bases
ATGGCAAAAAGAATAGAGCAGTTGGCCATAAACGCTATAAGAGTGCTGTCTATTGATGCCATTGAAAAGGCGAAATCAGG
CCATCCCGGGATGCCAATGGGAGCAGCTCCTATGGCGTATGTACTTTGGACAGAGTTTATGAATCACAATCCTCTCAATT
CTAAGTGGTTCAACCGCGACAGGTTTGTCCTGTCAGCAGGACATGCTTCAATGCTTTTGTACGCGCTTTTGCACCTTTCA
GGCTACAAAGTTTCCATGGAAGACATAAAGAATTTCCGCCAGTGGGGGTCAAAAACTCCTGGGCATCCGGAGTACGGCCT
TACTGATGGAGTAGAGGCGACGACTGGACCTTTAGGGCAGGGCCTTGGGATGGCAGTAGGAATGGCAATGGCTGAACGCT
TCCTTGCCAATAAGTATAACCGCGGTTCTTACAACATAATAGACCACTATACATATGTAATTGCAAGCGATGGAGACCTA
ATGGAAGGGATATCTCACGAAGCAGGTTCATTGGCAGGACATTTAAAGCTTGGCAAACTGATTGTGCTTTACGATTCTAA
CGATGTAACCTTGGATGGAGACAGGCACTTATCCTTTACAGAAAGCGTTGCAGATAGGTTCAAAGCCTATGGATGGCAGG
TTTTAAGAGTCGATGATGGCAATGACCTTGACGCTATAAGAAATGCTATAAGTGAAGCTAAGAAAAACACAGAACAGCCT
ACCTTAATTGAAGTAAAGACCGTCTTGGGTTACGGGGCTCCCAATAAAGCAGGCAAATCTGATGCACACGGGGCTCCACT
AGGTGAAGAGGAGGCTCGTTTGGCAAAAGAATATTATAAATGGGAGTATGAACCTTTCTTTATTCCAGAAGAAATATACG
AGCATTACAGGGCTAAAGTTCTTGAGAGAGGCAAAAAGGCAGAAGAAGAGTGGAATAAGCTATTTGAGGCTTATAAAAAA
GAATATCCTGAGTTAGCAAAAGAATTAGAAGATGCCATAAATGGAAACCTTCCAGAAGGCTGGGACAAAGACATGCCTTC
TTATGATAAAGGGGCCTATGCGACGAGAGATGTATCTGGAGAGATGATAAATGCTTTAGCGAAAAATATCCCCTACTTCA
TAGGTGGCAGTGCTGACCTTGCAAGTTCTAACAAGACAGCTATAAAAGGAGAACAGCCCTTTGGGCCTACCAGCAATTAC
ACTGGAAGAAACATATGGTTTGGTGTAAGGGAATTTGGAATGGCTACAGCTTTGAATGGGATGGCACTTCACGGAGGACT
TAAAGTCTATGGCGGAACATTCCTTGTATTTAGTGATTATCTCCGCCCCGCTTTAAGGCTTTCAGCTTTAATGGGAGTAC
CTGTAACTTATGTATTTACACATGACTCAATCGCTGTAGGAGAAGATGGACCTACACATCAGCCAGTAGAGCATCTTGCG
GCATTTCGCGCAATGCCAAATGTGTCAGTTATAAGGCCAGCAGACGGGAATGAGACAAGAGCTGCATGGAAATTAGCAGT
GCAGTCTAAGAATAAGCCTACTGTTTTGATTTTGACAAGGCAGAAGCTCCCCATTCTTCCTACAACAAAAGAAAAAGTTG
AAGAAGGCGTGGCAAAAGGTGCTTATATAGTATCCGACGGCGAAAAGGAAATACCGGATATTCTCCTTTTGGCATCTGGA
TCAGAAGTATCTTTAGCAGTTGAAGCGCAAAAGAAGTTAAAAGAAGAAGGGATAGACGCAAGAGTTATCAGTATGCCCTC
ATGGGATAGATTTGAGGAACAGGACAAGTCCTACAAGGACTACATACTGCCTCCAAATGTTAAAAAGAGACTGGCTATTG
AAGCGGCAGCACCTCTTGGATGGGAGCGCTATGTAGGAGATGAGGGTAAAGTATTGGGGGTAAATACATTTGGCGCTTCT
GCCCCGGGAGAAAAACTGATGGAGGAATACGGGTTTACAGTGGACAGAATAGTAAAAGAGGCAAAAGAGCTGCTCAGGAA
GTAA

Upstream 100 bases:

>100_bases
ATAATAATGGGGGAAGGGAATTTTACATTGTTTTTCAGCAGTTTTCATGTATAATAATATTAAAGAAATAAAGCAAAATA
TAGTTAAAGGAGGAGAAAAC

Downstream 100 bases:

>100_bases
ATAAATTTACAAGATTTAGGGAGTTTTACGCTGCTCCTGCTTTATAGGCAGGGGCAGTTTTATTTTCCTCTAAAATTTTT
TCGCTTTCTATGGTATACTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MAKRIEQLAINAIRVLSIDAIEKAKSGHPGMPMGAAPMAYVLWTEFMNHNPLNSKWFNRDRFVLSAGHASMLLYALLHLS
GYKVSMEDIKNFRQWGSKTPGHPEYGLTDGVEATTGPLGQGLGMAVGMAMAERFLANKYNRGSYNIIDHYTYVIASDGDL
MEGISHEAGSLAGHLKLGKLIVLYDSNDVTLDGDRHLSFTESVADRFKAYGWQVLRVDDGNDLDAIRNAISEAKKNTEQP
TLIEVKTVLGYGAPNKAGKSDAHGAPLGEEEARLAKEYYKWEYEPFFIPEEIYEHYRAKVLERGKKAEEEWNKLFEAYKK
EYPELAKELEDAINGNLPEGWDKDMPSYDKGAYATRDVSGEMINALAKNIPYFIGGSADLASSNKTAIKGEQPFGPTSNY
TGRNIWFGVREFGMATALNGMALHGGLKVYGGTFLVFSDYLRPALRLSALMGVPVTYVFTHDSIAVGEDGPTHQPVEHLA
AFRAMPNVSVIRPADGNETRAAWKLAVQSKNKPTVLILTRQKLPILPTTKEKVEEGVAKGAYIVSDGEKEIPDILLLASG
SEVSLAVEAQKKLKEEGIDARVISMPSWDRFEEQDKSYKDYILPPNVKKRLAIEAAAPLGWERYVGDEGKVLGVNTFGAS
APGEKLMEEYGFTVDRIVKEAKELLRK

Sequences:

>Translated_667_residues
MAKRIEQLAINAIRVLSIDAIEKAKSGHPGMPMGAAPMAYVLWTEFMNHNPLNSKWFNRDRFVLSAGHASMLLYALLHLS
GYKVSMEDIKNFRQWGSKTPGHPEYGLTDGVEATTGPLGQGLGMAVGMAMAERFLANKYNRGSYNIIDHYTYVIASDGDL
MEGISHEAGSLAGHLKLGKLIVLYDSNDVTLDGDRHLSFTESVADRFKAYGWQVLRVDDGNDLDAIRNAISEAKKNTEQP
TLIEVKTVLGYGAPNKAGKSDAHGAPLGEEEARLAKEYYKWEYEPFFIPEEIYEHYRAKVLERGKKAEEEWNKLFEAYKK
EYPELAKELEDAINGNLPEGWDKDMPSYDKGAYATRDVSGEMINALAKNIPYFIGGSADLASSNKTAIKGEQPFGPTSNY
TGRNIWFGVREFGMATALNGMALHGGLKVYGGTFLVFSDYLRPALRLSALMGVPVTYVFTHDSIAVGEDGPTHQPVEHLA
AFRAMPNVSVIRPADGNETRAAWKLAVQSKNKPTVLILTRQKLPILPTTKEKVEEGVAKGAYIVSDGEKEIPDILLLASG
SEVSLAVEAQKKLKEEGIDARVISMPSWDRFEEQDKSYKDYILPPNVKKRLAIEAAAPLGWERYVGDEGKVLGVNTFGAS
APGEKLMEEYGFTVDRIVKEAKELLRK
>Mature_666_residues
AKRIEQLAINAIRVLSIDAIEKAKSGHPGMPMGAAPMAYVLWTEFMNHNPLNSKWFNRDRFVLSAGHASMLLYALLHLSG
YKVSMEDIKNFRQWGSKTPGHPEYGLTDGVEATTGPLGQGLGMAVGMAMAERFLANKYNRGSYNIIDHYTYVIASDGDLM
EGISHEAGSLAGHLKLGKLIVLYDSNDVTLDGDRHLSFTESVADRFKAYGWQVLRVDDGNDLDAIRNAISEAKKNTEQPT
LIEVKTVLGYGAPNKAGKSDAHGAPLGEEEARLAKEYYKWEYEPFFIPEEIYEHYRAKVLERGKKAEEEWNKLFEAYKKE
YPELAKELEDAINGNLPEGWDKDMPSYDKGAYATRDVSGEMINALAKNIPYFIGGSADLASSNKTAIKGEQPFGPTSNYT
GRNIWFGVREFGMATALNGMALHGGLKVYGGTFLVFSDYLRPALRLSALMGVPVTYVFTHDSIAVGEDGPTHQPVEHLAA
FRAMPNVSVIRPADGNETRAAWKLAVQSKNKPTVLILTRQKLPILPTTKEKVEEGVAKGAYIVSDGEKEIPDILLLASGS
EVSLAVEAQKKLKEEGIDARVISMPSWDRFEEQDKSYKDYILPPNVKKRLAIEAAAPLGWERYVGDEGKVLGVNTFGASA
PGEKLMEEYGFTVDRIVKEAKELLRK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=28.719723183391, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=28.719723183391, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI133778974, Length=577, Percent_Identity=28.0762564991335, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI225637459, Length=580, Percent_Identity=23.448275862069, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI225637463, Length=510, Percent_Identity=24.7058823529412, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637461, Length=510, Percent_Identity=24.7058823529412, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=50.6807866868381, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=50.3770739064857, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=28.0068728522337, Blast_Score=162, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=672, Percent_Identity=47.9166666666667, Blast_Score=616, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=44.8736998514116, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI45551847, Length=573, Percent_Identity=26.5270506108202, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45550715, Length=573, Percent_Identity=26.5270506108202, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24666278, Length=577, Percent_Identity=25.9965337954939, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24645119, Length=545, Percent_Identity=26.0550458715596, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73760; Mature: 73628

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIEQLAINAIRVLSIDAIEKAKSGHPGMPMGAAPMAYVLWTEFMNHNPLNSKWFNRD
CCHHHHHHHHHHHHEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHASMLLYALLHLSGYKVSMEDIKNFRQWGSKTPGHPEYGLTDGVEATTGPLGQ
EEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GLGMAVGMAMAERFLANKYNRGSYNIIDHYTYVIASDGDLMEGISHEAGSLAGHLKLGKL
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHCCHHHHHHHCEEEECEE
IVLYDSNDVTLDGDRHLSFTESVADRFKAYGWQVLRVDDGNDLDAIRNAISEAKKNTEQP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLIEVKTVLGYGAPNKAGKSDAHGAPLGEEEARLAKEYYKWEYEPFFIPEEIYEHYRAKV
CEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHH
LERGKKAEEEWNKLFEAYKKEYPELAKELEDAINGNLPEGWDKDMPSYDKGAYATRDVSG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCH
EMINALAKNIPYFIGGSADLASSNKTAIKGEQPFGPTSNYTGRNIWFGVREFGMATALNG
HHHHHHHHCCCEEECCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCC
MALHGGLKVYGGTFLVFSDYLRPALRLSALMGVPVTYVFTHDSIAVGEDGPTHQPVEHLA
EEEECCEEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHH
AFRAMPNVSVIRPADGNETRAAWKLAVQSKNKPTVLILTRQKLPILPTTKEKVEEGVAKG
HHHCCCCCEEEECCCCCCCHHHEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AYIVSDGEKEIPDILLLASGSEVSLAVEAQKKLKEEGIDARVISMPSWDRFEEQDKSYKD
EEEEECCCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCC
YILPPNVKKRLAIEAAAPLGWERYVGDEGKVLGVNTFGASAPGEKLMEEYGFTVDRIVKE
CCCCCCCHHHEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHH
AKELLRK
HHHHHCC
>Mature Secondary Structure 
AKRIEQLAINAIRVLSIDAIEKAKSGHPGMPMGAAPMAYVLWTEFMNHNPLNSKWFNRD
CHHHHHHHHHHHHEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHASMLLYALLHLSGYKVSMEDIKNFRQWGSKTPGHPEYGLTDGVEATTGPLGQ
EEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GLGMAVGMAMAERFLANKYNRGSYNIIDHYTYVIASDGDLMEGISHEAGSLAGHLKLGKL
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHCCHHHHHHHCEEEECEE
IVLYDSNDVTLDGDRHLSFTESVADRFKAYGWQVLRVDDGNDLDAIRNAISEAKKNTEQP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLIEVKTVLGYGAPNKAGKSDAHGAPLGEEEARLAKEYYKWEYEPFFIPEEIYEHYRAKV
CEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHH
LERGKKAEEEWNKLFEAYKKEYPELAKELEDAINGNLPEGWDKDMPSYDKGAYATRDVSG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCH
EMINALAKNIPYFIGGSADLASSNKTAIKGEQPFGPTSNYTGRNIWFGVREFGMATALNG
HHHHHHHHCCCEEECCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCC
MALHGGLKVYGGTFLVFSDYLRPALRLSALMGVPVTYVFTHDSIAVGEDGPTHQPVEHLA
EEEECCEEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHH
AFRAMPNVSVIRPADGNETRAAWKLAVQSKNKPTVLILTRQKLPILPTTKEKVEEGVAKG
HHHCCCCCEEEECCCCCCCHHHEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AYIVSDGEKEIPDILLLASGSEVSLAVEAQKKLKEEGIDARVISMPSWDRFEEQDKSYKD
EEEEECCCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCC
YILPPNVKKRLAIEAAAPLGWERYVGDEGKVLGVNTFGASAPGEKLMEEYGFTVDRIVKE
CCCCCCCHHHEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHH
AKELLRK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]