Click here to switch to the map view.

The map label for this gene is MurA

Identifier: 20806684

GI number: 20806684

Start: 153997

End: 155244

Strand: Direct

Name: MurA

Synonym: TTE0158

Alternate gene names: 20806684

Gene position: 153997-155244 (Clockwise)

Preceding gene: 20806683

Following gene: 20806685

Centisome position: 5.73

GC content: 42.63

Gene sequence:

>1248_bases
ATGAAGACGAAATTTGTTGTTGAAAAAAGCCCGCCCCTTAAAGGAACGGTTAAGATAAGCGGTGCGAAGAATTCGGTTTT
GCCTATAATTGCTGCTTCACTGCTTTCATCTGATGAAGTGATATTAGAAGATATACCCTCTCTGGAAGACGTCAATGTAA
TGATAGAACTCATAAAGAATTTTGGAGCCCTGTGTGAGTTGGACAATGGGAAATTGAAGATAAAGGTAGATATAAAGGAC
GTAGAAGCGCCTTATGAACTTGTTAAAAAGATGAGGGCATCCTTTTTGGTGATGGGACCCATACTGGCAAAGCTGGGACA
TGCCAAAATTTCCATGCCTGGAGGTTGTGCAATAGGGGCTCGACCTATAGACCTACATTTAAAGGGGTTTCAAAGTCTGG
GAGCTGATATAACTATCGGACACGGATATGTTGAGGCAAGAGCTAAAAAATTGACAGGCAAAAAGATATACCTTGATTTT
CCCAGTGTAGGAGCAACTGAGAATATAATGATGGCTGCAGTTTTTGCCGACGGTGTTACTGTAATTGAAAATGCTGCTGA
GGAGCCTGAGATTGTGGATTTGGCGAATTTTTTGAACAAGATGGGGGCCAATATCAAAGGAGCAGGTACTGACACTATAC
GAATTGAAGGAGTAAAGGAATTGAAAGGAGCAGAACACACTGTCATACCTGATAGAATTGAAGCAGGAACTTTTATGGTG
GCAGCGGCCATGACAGGCGGGAATGTGCTCATTGAAAATGTGATAGTGGACCATGTGAGGTCTGTAATTGCAAAATTGAC
AGAATGCGGAGTTAAGATAACGGAAGAAAAGGGAGGCCTCAGGGTAAAAGGGGTAAAAAATTACAAGGCTGTTGACATAA
AGACCCTTCCATATCCGGGATTTCCAACGGACATGCAAGCGCAGATGATGGCCATGATGACCGTGGCAAAGGGTACCAGC
GTCATAATAGAGACAGTTTTTGAAAACAGATTTATGCATGTGAGCGAATTAAAGAGAATGGGCGCAAATATAAAAATTGA
GGGCAGAAGTGCAATGATTACAGGTGTAGACCATTTGACAGGAGCCGAAGTGAAAGCTACTGATTTGAGGGCAGGAGCAG
CTTTGGTGCTGGCAGGGCTTATAGCAGAGGGGAGAACAGAGATTAACGATATCTACCATGTAGACAGAGGATATGTGAAG
ATGGAAGAGAAGTTAAGAGCTCTGGGTGCAAAAATATACAGAAAATAG

Upstream 100 bases:

>100_bases
AATAAATTTACAGGTAGCTTTAAGGTACAATTCTTATGACGATAGAACTTATATATGGATTGCTAGTCCTTTGATAGCTA
CAGAATATTAAAAGAGGGTG

Downstream 100 bases:

>100_bases
ATTAAAAATTTTTTAGAAGTATTAGAAGGATTTTTTTAGCTTTTGAAGAATAATAATTATTGTGGCAAATTAAGAGACTT
TCTTCTCAAAAAAACGTTTA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKTKFVVEKSPPLKGTVKISGAKNSVLPIIAASLLSSDEVILEDIPSLEDVNVMIELIKNFGALCELDNGKLKIKVDIKD
VEAPYELVKKMRASFLVMGPILAKLGHAKISMPGGCAIGARPIDLHLKGFQSLGADITIGHGYVEARAKKLTGKKIYLDF
PSVGATENIMMAAVFADGVTVIENAAEEPEIVDLANFLNKMGANIKGAGTDTIRIEGVKELKGAEHTVIPDRIEAGTFMV
AAAMTGGNVLIENVIVDHVRSVIAKLTECGVKITEEKGGLRVKGVKNYKAVDIKTLPYPGFPTDMQAQMMAMMTVAKGTS
VIIETVFENRFMHVSELKRMGANIKIEGRSAMITGVDHLTGAEVKATDLRAGAALVLAGLIAEGRTEINDIYHVDRGYVK
MEEKLRALGAKIYRK

Sequences:

>Translated_415_residues
MKTKFVVEKSPPLKGTVKISGAKNSVLPIIAASLLSSDEVILEDIPSLEDVNVMIELIKNFGALCELDNGKLKIKVDIKD
VEAPYELVKKMRASFLVMGPILAKLGHAKISMPGGCAIGARPIDLHLKGFQSLGADITIGHGYVEARAKKLTGKKIYLDF
PSVGATENIMMAAVFADGVTVIENAAEEPEIVDLANFLNKMGANIKGAGTDTIRIEGVKELKGAEHTVIPDRIEAGTFMV
AAAMTGGNVLIENVIVDHVRSVIAKLTECGVKITEEKGGLRVKGVKNYKAVDIKTLPYPGFPTDMQAQMMAMMTVAKGTS
VIIETVFENRFMHVSELKRMGANIKIEGRSAMITGVDHLTGAEVKATDLRAGAALVLAGLIAEGRTEINDIYHVDRGYVK
MEEKLRALGAKIYRK
>Mature_415_residues
MKTKFVVEKSPPLKGTVKISGAKNSVLPIIAASLLSSDEVILEDIPSLEDVNVMIELIKNFGALCELDNGKLKIKVDIKD
VEAPYELVKKMRASFLVMGPILAKLGHAKISMPGGCAIGARPIDLHLKGFQSLGADITIGHGYVEARAKKLTGKKIYLDF
PSVGATENIMMAAVFADGVTVIENAAEEPEIVDLANFLNKMGANIKGAGTDTIRIEGVKELKGAEHTVIPDRIEAGTFMV
AAAMTGGNVLIENVIVDHVRSVIAKLTECGVKITEEKGGLRVKGVKNYKAVDIKTLPYPGFPTDMQAQMMAMMTVAKGTS
VIIETVFENRFMHVSELKRMGANIKIEGRSAMITGVDHLTGAEVKATDLRAGAALVLAGLIAEGRTEINDIYHVDRGYVK
MEEKLRALGAKIYRK

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=417, Percent_Identity=51.7985611510791, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_THETN (Q8RD88)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621855.1
- ProteinModelPortal:   Q8RD88
- GeneID:   996500
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0158
- NMPDR:   fig|273068.3.peg.575
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   TTEN273068:TTE0158-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 44670; Mature: 44670

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFVVEKSPPLKGTVKISGAKNSVLPIIAASLLSSDEVILEDIPSLEDVNVMIELIKN
CCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHC
FGALCELDNGKLKIKVDIKDVEAPYELVKKMRASFLVMGPILAKLGHAKISMPGGCAIGA
CCCEEEECCCEEEEEEEEECCCCHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCEECC
RPIDLHLKGFQSLGADITIGHGYVEARAKKLTGKKIYLDFPSVGATENIMMAAVFADGVT
CEEEEEEECHHHCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCHHEEEEEHHCCHH
VIENAAEEPEIVDLANFLNKMGANIKGAGTDTIRIEGVKELKGAEHTVIPDRIEAGTFMV
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCEEEE
AAAMTGGNVLIENVIVDHVRSVIAKLTECGVKITEEKGGLRVKGVKNYKAVDIKTLPYPG
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEEEEEECCCCC
FPTDMQAQMMAMMTVAKGTSVIIETVFENRFMHVSELKRMGANIKIEGRSAMITGVDHLT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCCCEEECCCEEEEECCCCCC
GAEVKATDLRAGAALVLAGLIAEGRTEINDIYHVDRGYVKMEEKLRALGAKIYRK
CCCEEEHHCCCCHHHHHHHHHHCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTKFVVEKSPPLKGTVKISGAKNSVLPIIAASLLSSDEVILEDIPSLEDVNVMIELIKN
CCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHC
FGALCELDNGKLKIKVDIKDVEAPYELVKKMRASFLVMGPILAKLGHAKISMPGGCAIGA
CCCEEEECCCEEEEEEEEECCCCHHHHHHHHHHHEEHHHHHHHHCCCCEEECCCCCEECC
RPIDLHLKGFQSLGADITIGHGYVEARAKKLTGKKIYLDFPSVGATENIMMAAVFADGVT
CEEEEEEECHHHCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCHHEEEEEHHCCHH
VIENAAEEPEIVDLANFLNKMGANIKGAGTDTIRIEGVKELKGAEHTVIPDRIEAGTFMV
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCEEEE
AAAMTGGNVLIENVIVDHVRSVIAKLTECGVKITEEKGGLRVKGVKNYKAVDIKTLPYPG
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEEEEEECCCCC
FPTDMQAQMMAMMTVAKGTSVIIETVFENRFMHVSELKRMGANIKIEGRSAMITGVDHLT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCCCEEECCCEEEEECCCCCC
GAEVKATDLRAGAALVLAGLIAEGRTEINDIYHVDRGYVKMEEKLRALGAKIYRK
CCCEEEHHCCCCHHHHHHHHHHCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336