| Definition | Thermoanaerobacter tengcongensis MB4, complete genome. |
|---|---|
| Accession | NC_003869 |
| Length | 2,689,445 |
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The map label for this gene is fabG [C]
Identifier: 20806601
GI number: 20806601
Start: 77044
End: 77811
Strand: Direct
Name: fabG [C]
Synonym: TTE0069
Alternate gene names: 20806601
Gene position: 77044-77811 (Clockwise)
Preceding gene: 20806600
Following gene: 20806602
Centisome position: 2.86
GC content: 40.76
Gene sequence:
>768_bases ATGAATTTTAAAGATAAAGTTGTAATAGTAACAGGGGGAGGACAGGGGATTGGAAGATGTATTGCTCAGACTTTTGCTAG CAAAGGAGCAAAAGTAGTCATTGCAGAAATTGACGATGAGGCAGGGCTGGAGAATGAAGAGTACATAAGAAAAAATGGAG GAGAGGCGCTTTTTGTACATACAGATGTGGCTTTAGAGGAAGATGTAAAAAATATGGTAAATAAGACTATAGAGACCTAC GGCAAAATCGATATTTTAATAAACAATGCAGGGATAGGTTCTGGAGGTACGATTTACACCAGACCCATGGAAGAATGGGA TAGGGTCATAAATGTTAACTTAAAAGGAGCTTACATGTGCGCAAAGTATGTAGCTCCCCATATGAGGGATAATGGGGGAG GGGTTATAATAAACATAGCCTCCACAAGAGCCTTTATGTCAGAGCCTCACACAGAACCTTATTCTGCCTCAAAAGGAGGG CTTATAGCTTTAACTCACTCTCTTGCAATAAGTTTAGCTTATGATAAAATAAGAGTGAATTCTATAAGTCCTGGCTGGAT TGAAGTATCTGAATGGAAGAAATCGAGAGAAGCTAAAAAGCCGGAGCTGACTGAACAAGATCATCTACAGCATCCGGCAG GGCGAGTAGGTAAACCGGAAGACGTGGCAAATGCGTGCCTTTTCTTGTGTTCTGAGGAAGCTTCTTTTATAACAGGTGCA AATTTGATTGTCGACGGCGGCATGACAGTAAAAATGATTTATCTGTAG
Upstream 100 bases:
>100_bases CTTTTAGCGTGAACTTGATTTTTGTGCGGAGTTTATATACACTTTGAGTAAGGCATGTTTTTGCCTTATTTTCTTTTTTA GTTAGAAAGGAGGGAATTTT
Downstream 100 bases:
>100_bases AGGAAAGGAAAGAAAATGAGCAGTACGAAAGAGAGGATATTTAAGGCTGCTTTAGAGACTTTTTCTAAAAGAGGATTTTA CAAGGCTACTATGGATGAGA
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: NA
Number of amino acids: Translated: 255; Mature: 255
Protein sequence:
>255_residues MNFKDKVVIVTGGGQGIGRCIAQTFASKGAKVVIAEIDDEAGLENEEYIRKNGGEALFVHTDVALEEDVKNMVNKTIETY GKIDILINNAGIGSGGTIYTRPMEEWDRVINVNLKGAYMCAKYVAPHMRDNGGGVIINIASTRAFMSEPHTEPYSASKGG LIALTHSLAISLAYDKIRVNSISPGWIEVSEWKKSREAKKPELTEQDHLQHPAGRVGKPEDVANACLFLCSEEASFITGA NLIVDGGMTVKMIYL
Sequences:
>Translated_255_residues MNFKDKVVIVTGGGQGIGRCIAQTFASKGAKVVIAEIDDEAGLENEEYIRKNGGEALFVHTDVALEEDVKNMVNKTIETY GKIDILINNAGIGSGGTIYTRPMEEWDRVINVNLKGAYMCAKYVAPHMRDNGGGVIINIASTRAFMSEPHTEPYSASKGG LIALTHSLAISLAYDKIRVNSISPGWIEVSEWKKSREAKKPELTEQDHLQHPAGRVGKPEDVANACLFLCSEEASFITGA NLIVDGGMTVKMIYL >Mature_255_residues MNFKDKVVIVTGGGQGIGRCIAQTFASKGAKVVIAEIDDEAGLENEEYIRKNGGEALFVHTDVALEEDVKNMVNKTIETY GKIDILINNAGIGSGGTIYTRPMEEWDRVINVNLKGAYMCAKYVAPHMRDNGGGVIINIASTRAFMSEPHTEPYSASKGG LIALTHSLAISLAYDKIRVNSISPGWIEVSEWKKSREAKKPELTEQDHLQHPAGRVGKPEDVANACLFLCSEEASFITGA NLIVDGGMTVKMIYL
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=35.0393700787402, Blast_Score=144, Evalue=9e-35, Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=33.8709677419355, Blast_Score=130, Evalue=1e-30, Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=35.4978354978355, Blast_Score=127, Evalue=9e-30, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=5e-29, Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=32.6771653543307, Blast_Score=120, Evalue=2e-27, Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=30.859375, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=33.0677290836653, Blast_Score=113, Evalue=1e-25, Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=29.8387096774194, Blast_Score=112, Evalue=4e-25, Organism=Homo sapiens, GI4758504, Length=262, Percent_Identity=31.2977099236641, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI66933014, Length=248, Percent_Identity=30.241935483871, Blast_Score=104, Evalue=8e-23, Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=29.3172690763052, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI4504505, Length=241, Percent_Identity=30.2904564315353, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=32.2033898305085, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=32.6086956521739, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI83715985, Length=184, Percent_Identity=33.695652173913, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=30.0813008130081, Blast_Score=92, Evalue=3e-19, Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=32.9842931937173, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI109715829, Length=249, Percent_Identity=30.1204819277108, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI25282469, Length=225, Percent_Identity=26.2222222222222, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI302344755, Length=107, Percent_Identity=36.4485981308411, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI209862901, Length=217, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI19923983, Length=217, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI142976729, Length=208, Percent_Identity=27.4038461538462, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI40807363, Length=191, Percent_Identity=27.7486910994764, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI4503301, Length=255, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI40254986, Length=140, Percent_Identity=33.5714285714286, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI210032110, Length=167, Percent_Identity=26.9461077844311, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=29.3193717277487, Blast_Score=68, Evalue=6e-12, Organism=Homo sapiens, GI310128830, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI310115468, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI7657478, Length=248, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=23.9819004524887, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=38.7096774193548, Blast_Score=156, Evalue=1e-39, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=35.8870967741936, Blast_Score=151, Evalue=4e-38, Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=32.3886639676113, Blast_Score=133, Evalue=1e-32, Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=2e-31, Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=32.6693227091633, Blast_Score=124, Evalue=6e-30, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=31.5789473684211, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-28, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=31.640625, Blast_Score=115, Evalue=3e-27, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=30.3501945525292, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=1e-24, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.0916334661355, Blast_Score=97, Evalue=2e-21, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1787820, Length=240, Percent_Identity=29.5833333333333, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1787526, Length=249, Percent_Identity=20.8835341365462, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=36.71875, Blast_Score=151, Evalue=2e-37, Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=33.6032388663968, Blast_Score=132, Evalue=2e-31, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=33.4558823529412, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=32.6612903225806, Blast_Score=125, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=30.8300395256917, Blast_Score=124, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=31.8352059925094, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=34.8148148148148, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=32.9545454545455, Blast_Score=120, Evalue=7e-28, Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=32.1285140562249, Blast_Score=118, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=4e-27, Organism=Caenorhabditis elegans, GI193204405, Length=267, Percent_Identity=31.0861423220974, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=32.319391634981, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=32.6996197718631, Blast_Score=113, Evalue=7e-26, Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=30.7692307692308, Blast_Score=113, Evalue=8e-26, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=30.7984790874525, Blast_Score=113, Evalue=9e-26, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=32.9365079365079, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=33.4600760456274, Blast_Score=110, Evalue=9e-25, Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=30.0380228136882, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=30.1115241635688, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=31.9548872180451, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=31.3432835820896, Blast_Score=107, Evalue=9e-24, Organism=Caenorhabditis elegans, GI115534694, Length=255, Percent_Identity=33.7254901960784, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=29.0566037735849, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=31.1538461538462, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=32, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17538182, Length=257, Percent_Identity=29.9610894941634, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17562990, Length=266, Percent_Identity=30.0751879699248, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=34.2105263157895, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17568967, Length=193, Percent_Identity=32.6424870466321, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17508895, Length=198, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17508651, Length=253, Percent_Identity=28.8537549407115, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI193203115, Length=210, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI193203117, Length=184, Percent_Identity=28.804347826087, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17567345, Length=167, Percent_Identity=29.940119760479, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI86565303, Length=204, Percent_Identity=31.8627450980392, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI71982365, Length=259, Percent_Identity=27.4131274131274, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI71997099, Length=204, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17561272, Length=241, Percent_Identity=28.6307053941909, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=30.5418719211823, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17558628, Length=257, Percent_Identity=27.2373540856031, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=242, Percent_Identity=33.0578512396694, Blast_Score=107, Evalue=2e-24, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=30.8, Blast_Score=102, Evalue=7e-23, Organism=Saccharomyces cerevisiae, GI6320089, Length=196, Percent_Identity=28.0612244897959, Blast_Score=67, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6323882, Length=196, Percent_Identity=30.1020408163265, Blast_Score=65, Evalue=1e-11, Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=36, Blast_Score=147, Evalue=5e-36, Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=34.9397590361446, Blast_Score=142, Evalue=3e-34, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=36.078431372549, Blast_Score=140, Evalue=8e-34, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=35.7142857142857, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=32.9317269076305, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.9838056680162, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=31.6205533596838, Blast_Score=114, Evalue=5e-26, Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=28.0155642023346, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI18859837, Length=241, Percent_Identity=29.4605809128631, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=31.0077519379845, Blast_Score=93, Evalue=1e-19, Organism=Drosophila melanogaster, GI281364892, Length=184, Percent_Identity=31.5217391304348, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI21356301, Length=206, Percent_Identity=31.0679611650485, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI24581726, Length=211, Percent_Identity=32.7014218009479, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=28.2722513089005, Blast_Score=82, Evalue=4e-16, Organism=Drosophila melanogaster, GI21357673, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24649181, Length=189, Percent_Identity=25.3968253968254, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI24665243, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI221331218, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI116007236, Length=236, Percent_Identity=28.8135593220339, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI24665247, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI221331216, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI28571387, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=23.5897435897436, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21355631, Length=168, Percent_Identity=27.3809523809524, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI116007234, Length=244, Percent_Identity=28.2786885245902, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24641232, Length=239, Percent_Identity=26.3598326359833, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI221510726, Length=187, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 27691; Mature: 27691
Theoretical pI: Translated: 5.66; Mature: 5.66
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 4.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNFKDKVVIVTGGGQGIGRCIAQTFASKGAKVVIAEIDDEAGLENEEYIRKNGGEALFVH CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCEEEEE TDVALEEDVKNMVNKTIETYGKIDILINNAGIGSGGTIYTRPMEEWDRVINVNLKGAYMC ECCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCHHHHCCEEEECCCHHHHH AKYVAPHMRDNGGGVIINIASTRAFMSEPHTEPYSASKGGLIALTHSLAISLAYDKIRVN HHHHCCCEECCCCEEEEEEECCHHHHCCCCCCCCCCCCCCEEEEEEHEEEEEEEEEEEEC SISPGWIEVSEWKKSREAKKPELTEQDHLQHPAGRVGKPEDVANACLFLCSEEASFITGA CCCCCEEEHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHEEECCCCCEEECC NLIVDGGMTVKMIYL EEEEECCCEEEEEEC >Mature Secondary Structure MNFKDKVVIVTGGGQGIGRCIAQTFASKGAKVVIAEIDDEAGLENEEYIRKNGGEALFVH CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCEEEEE TDVALEEDVKNMVNKTIETYGKIDILINNAGIGSGGTIYTRPMEEWDRVINVNLKGAYMC ECCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCHHHHCCEEEECCCHHHHH AKYVAPHMRDNGGGVIINIASTRAFMSEPHTEPYSASKGGLIALTHSLAISLAYDKIRVN HHHHCCCEECCCCEEEEEEECCHHHHCCCCCCCCCCCCCCEEEEEEHEEEEEEEEEEEEC SISPGWIEVSEWKKSREAKKPELTEQDHLQHPAGRVGKPEDVANACLFLCSEEASFITGA CCCCCEEEHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHEEECCCCCEEECC NLIVDGGMTVKMIYL EEEEECCCEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8550425; 10360571 [H]