Click here to switch to the map view.

The map label for this gene is Gcd1 [H]

Identifier: 20806597

GI number: 20806597

Start: 72589

End: 73638

Strand: Direct

Name: Gcd1 [H]

Synonym: TTE0065

Alternate gene names: 20806597

Gene position: 72589-73638 (Clockwise)

Preceding gene: 20806596

Following gene: 20806598

Centisome position: 2.7

GC content: 41.33

Gene sequence:

>1050_bases
ATGAAGGCGCTTCTTCTAGCGGGGGGACTGGGAACCAGGTTAAGGCCCCTTACTGACGATTTGCCAAAGCCTATGGTTCC
TATAATGGGAAAGCCGCTTTTGGAGCGCATTATTTTAAATCTTAAAAAAAGTGGAGTAGACGAAGTGGTCATAAGCACTC
ATTATAAATCCGACTACATTGAAAACTACTTCAAAGGCAAGAGCAAAGAACTAGGGGTAAAGATTCATTATGTCACAGAA
GAGACTCCTTTAGGCACGGGAGGAGCTATAAAAAATGCTGAAAAGTTTTTTGACGACACTTTCTTAATTCTCAACTCCGA
TATAGTGAGCGATATAGACTATGCAGACTTGGTGAAATATCACAAGAGAAGGAGAGCACAGGTTACTATTGCTTCCATAG
AAGTGAGAGATACTTCCCAGTACGGGGTCATAGAGTTTGACAGCAAGGGTTTTATCACTGCTTTTAAAGAGAAGCCAAAG
CCTGGGGAGTCAAATTCTAAGTATATAAATGCAGGAGTTTATGTGTTTGAGCCGGAGGTCTTAAAGGAAATTCCAGCTAA
CACTCAGGTATCTGTAGAAAGGGAAACATATCCTTTGCTTCTTTCAAAAGGCTATAAAATGGCTATATATAAGTTTACTG
GCTATTGGATGGACATAGGGACTGTGGACAAATATAAAAAGGTACATGAAGACATCCTCAAAGGCAAATCTAGATTTGTA
GCAGGATTGTCCACGAGAGGGATAATCCTCGGAGAGAATGTGAAAATCCACCCTACAGCCAGTGTAATTGGGCCAGCCTA
TATTGGGGATAATACAGAAGTTGATGCTTATGCTACTGTAGGGCCTTACACTGTGATAGGCAGTAACTGCAGGATAGGAC
AGGAGAGCAAGGTTTCCAATAGCGTGCTGTGGGACAACATAAAGGTGAGAAGATTTGCAAGATTGGAAAATAGCGTGGTT
ACCTCGGAATGCGTAGTGGAAGTGAATATGGAGATTAAAAACACGGTTTTTACTGCTAATAAGTTAGCTGATATTACGCT
CACACCTTGA

Upstream 100 bases:

>100_bases
AGCAGCCCAATCATTAGAGTGCTAATATCGCTTTTGCCCTTCCAACCTTCATGTCTTGTTCTTCAACTAAAGCCATTTTT
ACAAAAAAGGAGGGGTTTTT

Downstream 100 bases:

>100_bases
TACTAAGTAAAAGGGGGGATACTTGTGAGCATCTTGGGGAGAAATATAGCTTTTTTGAGCACTTATCCTCCAAGGGAATG
TGGAATAGCGACTTTTACTC

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKALLLAGGLGTRLRPLTDDLPKPMVPIMGKPLLERIILNLKKSGVDEVVISTHYKSDYIENYFKGKSKELGVKIHYVTE
ETPLGTGGAIKNAEKFFDDTFLILNSDIVSDIDYADLVKYHKRRRAQVTIASIEVRDTSQYGVIEFDSKGFITAFKEKPK
PGESNSKYINAGVYVFEPEVLKEIPANTQVSVERETYPLLLSKGYKMAIYKFTGYWMDIGTVDKYKKVHEDILKGKSRFV
AGLSTRGIILGENVKIHPTASVIGPAYIGDNTEVDAYATVGPYTVIGSNCRIGQESKVSNSVLWDNIKVRRFARLENSVV
TSECVVEVNMEIKNTVFTANKLADITLTP

Sequences:

>Translated_349_residues
MKALLLAGGLGTRLRPLTDDLPKPMVPIMGKPLLERIILNLKKSGVDEVVISTHYKSDYIENYFKGKSKELGVKIHYVTE
ETPLGTGGAIKNAEKFFDDTFLILNSDIVSDIDYADLVKYHKRRRAQVTIASIEVRDTSQYGVIEFDSKGFITAFKEKPK
PGESNSKYINAGVYVFEPEVLKEIPANTQVSVERETYPLLLSKGYKMAIYKFTGYWMDIGTVDKYKKVHEDILKGKSRFV
AGLSTRGIILGENVKIHPTASVIGPAYIGDNTEVDAYATVGPYTVIGSNCRIGQESKVSNSVLWDNIKVRRFARLENSVV
TSECVVEVNMEIKNTVFTANKLADITLTP
>Mature_349_residues
MKALLLAGGLGTRLRPLTDDLPKPMVPIMGKPLLERIILNLKKSGVDEVVISTHYKSDYIENYFKGKSKELGVKIHYVTE
ETPLGTGGAIKNAEKFFDDTFLILNSDIVSDIDYADLVKYHKRRRAQVTIASIEVRDTSQYGVIEFDSKGFITAFKEKPK
PGESNSKYINAGVYVFEPEVLKEIPANTQVSVERETYPLLLSKGYKMAIYKFTGYWMDIGTVDKYKKVHEDILKGKSRFV
AGLSTRGIILGENVKIHPTASVIGPAYIGDNTEVDAYATVGPYTVIGSNCRIGQESKVSNSVLWDNIKVRRFARLENSVV
TSECVVEVNMEIKNTVFTANKLADITLTP

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=344, Percent_Identity=33.1395348837209, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI11761619, Length=330, Percent_Identity=33.9393939393939, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI31881779, Length=365, Percent_Identity=24.3835616438356, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI45447090, Length=365, Percent_Identity=24.3835616438356, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1788351, Length=254, Percent_Identity=28.3464566929134, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790224, Length=239, Percent_Identity=26.7782426778243, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788355, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787488, Length=217, Percent_Identity=26.2672811059908, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=338, Percent_Identity=34.6153846153846, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17509979, Length=323, Percent_Identity=29.1021671826625, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17509981, Length=310, Percent_Identity=28.3870967741935, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320148, Length=325, Percent_Identity=32.9230769230769, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355443, Length=333, Percent_Identity=32.7327327327327, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24644084, Length=333, Percent_Identity=32.7327327327327, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24653912, Length=378, Percent_Identity=25.1322751322751, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38891; Mature: 38891

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLLAGGLGTRLRPLTDDLPKPMVPIMGKPLLERIILNLKKSGVDEVVISTHYKSDYI
CCEEEEECCCCCCCCCCHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
ENYFKGKSKELGVKIHYVTEETPLGTGGAIKNAEKFFDDTFLILNSDIVSDIDYADLVKY
HHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCEEEEEECCHHCCCCHHHHHHH
HKRRRAQVTIASIEVRDTSQYGVIEFDSKGFITAFKEKPKPGESNSKYINAGVYVFEPEV
HHHCCEEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEEEEEEECHHH
LKEIPANTQVSVERETYPLLLSKGYKMAIYKFTGYWMDIGTVDKYKKVHEDILKGKSRFV
HHHCCCCCEEEEECCCEEEEECCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCHHEE
AGLSTRGIILGENVKIHPTASVIGPAYIGDNTEVDAYATVGPYTVIGSNCRIGQESKVSN
EECCCCCEEECCCEEEEECHHHCCCEEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCC
SVLWDNIKVRRFARLENSVVTSECVVEVNMEIKNTVFTANKLADITLTP
CEEECCHHHHHHHHHHCCEECEEEEEEEEEEECCEEEECCCEEEEEECC
>Mature Secondary Structure
MKALLLAGGLGTRLRPLTDDLPKPMVPIMGKPLLERIILNLKKSGVDEVVISTHYKSDYI
CCEEEEECCCCCCCCCCHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
ENYFKGKSKELGVKIHYVTEETPLGTGGAIKNAEKFFDDTFLILNSDIVSDIDYADLVKY
HHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCEEEEEECCHHCCCCHHHHHHH
HKRRRAQVTIASIEVRDTSQYGVIEFDSKGFITAFKEKPKPGESNSKYINAGVYVFEPEV
HHHCCEEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCCCCCCCCEEEEEEEEECHHH
LKEIPANTQVSVERETYPLLLSKGYKMAIYKFTGYWMDIGTVDKYKKVHEDILKGKSRFV
HHHCCCCCEEEEECCCEEEEECCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCHHEE
AGLSTRGIILGENVKIHPTASVIGPAYIGDNTEVDAYATVGPYTVIGSNCRIGQESKVSN
EECCCCCEEECCCEEEEECHHHCCCEEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCC
SVLWDNIKVRRFARLENSVVTSECVVEVNMEIKNTVFTANKLADITLTP
CEEECCHHHHHHHHHHCCEECEEEEEEEEEEECCEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]