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The map label for this gene is dfp [H]

Identifier: 203284708

GI number: 203284708

Start: 876399

End: 877661

Strand: Reverse

Name: dfp [H]

Synonym: BDU_820

Alternate gene names: 203284708

Gene position: 877661-876399 (Counterclockwise)

Preceding gene: 203284722

Following gene: 203284692

Centisome position: 94.2

GC content: 26.13

Gene sequence:

>1263_bases
ATGACACTTGCAAAAAATACTTTATTTATCAATAAAAATCCTTTTAAAAATATTAAATACAATTATATAATATTCTATAA
AATAAATATGAAAAAACACAAAAATATATTAATAGGAGTATGCGGGGGAATCGCAGCTTATAAAGCAGCTTATATTATCT
CAAATTTAATTAAAATGGGATATAACGTTAAGGTCATAATGACAGAAAATGCAACTAAATTCATTACACCCCTCACACTA
GAAACTCTTTCTAAGAGTAAAGTTATTACAAACCTGTGGAATACCAATCATGAAGAAGTAGAACACATAAACTTAGCAAG
ATGGGCTGATTTAATATTAATTATTCCAGCAACATATAATTTTATCTCTAAAATTGCAGCTGGAATTGCTGATGATATTT
TAAGCATAGTATTATCCGCAAGTAAAGCACCAACTTATTTTGCAATAGCAATGAACAACATAATGTATCAAAATCCCATT
TTACAAGAAAACATTAAAAAATTACAAAAATACAATTACAAATTTATTGAACCCGATAAAGGTTTTTTGGCATGTTCTTT
AAATGCTATTGGACGCCTTAAAAACGAAAATGATATTTTAAGTATCATATCAAATTCACCCATGACAAAATTACCATTAA
AAAACAAAAAAATATTAATAACTGCTTCAAGAACCGAAGAAGAATTAGATCCTATTCGTTATTTTTCTAATAAATCAACA
GGACAAATGGGTTTCAATATAGGTATTGAAGCACAAAATCTTGGAGCCAATGTTACAATCATTACAGGGCCAAGCAATGA
AGAAACACCTTATGGAATAAATGTCATTAGAATAAAAACAGCAGCAGAAATGTACAAGGCAACAATAGACATATACAAAG
AATTTGACATAATAATTGGAACCGCTGCTGTAGCAGACTTTAGACCTGATAAAATTTATAAAACTAAAATTGAAAAAAAT
AATATAGAAGAACTTAATATTAAATTGGTCAAAAACTTAGACATAATTGAACACATAGGAAAAAACAAAACTAAAAACCA
AATTGTCATCGGATTTTGCGCTCAAAAAGATGAAATTTTAATAAAAAAAGCCAGAGAAAAATTAGAAACAAAAAATTTAG
ACTATATTATTGCAAATGACTTAAAATATTTTGGATCAAATGTAAATAAAATTTACATAATAAATAAAGATAAAGTTGAA
AAATTTCCAGAAATGTCAAAAAAAGAAACAGCAATAGAAATCTTAAAAATTTTATATCAATAA

Upstream 100 bases:

>100_bases
AATACATAATAATAAAAACCAAATAGGAATATTAAATATAGCAATAAAAAAATAAGATAAACAAGATGCAATACACCACC
AGACAAATAAAAATAAATAT

Downstream 100 bases:

>100_bases
TTTACTAAAAGCTTTTTTAAATATTCTGAATTAGTTGTTTTTTTAATTTCTTTAAGTCTATCTAAAAGTAATGCTGATTT
ATTATAAACAGCTCCCTTAA

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTLAKNTLFINKNPFKNIKYNYIIFYKINMKKHKNILIGVCGGIAAYKAAYIISNLIKMGYNVKVIMTENATKFITPLTL
ETLSKSKVITNLWNTNHEEVEHINLARWADLILIIPATYNFISKIAAGIADDILSIVLSASKAPTYFAIAMNNIMYQNPI
LQENIKKLQKYNYKFIEPDKGFLACSLNAIGRLKNENDILSIISNSPMTKLPLKNKKILITASRTEEELDPIRYFSNKST
GQMGFNIGIEAQNLGANVTIITGPSNEETPYGINVIRIKTAAEMYKATIDIYKEFDIIIGTAAVADFRPDKIYKTKIEKN
NIEELNIKLVKNLDIIEHIGKNKTKNQIVIGFCAQKDEILIKKAREKLETKNLDYIIANDLKYFGSNVNKIYIINKDKVE
KFPEMSKKETAIEILKILYQ

Sequences:

>Translated_420_residues
MTLAKNTLFINKNPFKNIKYNYIIFYKINMKKHKNILIGVCGGIAAYKAAYIISNLIKMGYNVKVIMTENATKFITPLTL
ETLSKSKVITNLWNTNHEEVEHINLARWADLILIIPATYNFISKIAAGIADDILSIVLSASKAPTYFAIAMNNIMYQNPI
LQENIKKLQKYNYKFIEPDKGFLACSLNAIGRLKNENDILSIISNSPMTKLPLKNKKILITASRTEEELDPIRYFSNKST
GQMGFNIGIEAQNLGANVTIITGPSNEETPYGINVIRIKTAAEMYKATIDIYKEFDIIIGTAAVADFRPDKIYKTKIEKN
NIEELNIKLVKNLDIIEHIGKNKTKNQIVIGFCAQKDEILIKKAREKLETKNLDYIIANDLKYFGSNVNKIYIINKDKVE
KFPEMSKKETAIEILKILYQ
>Mature_419_residues
TLAKNTLFINKNPFKNIKYNYIIFYKINMKKHKNILIGVCGGIAAYKAAYIISNLIKMGYNVKVIMTENATKFITPLTLE
TLSKSKVITNLWNTNHEEVEHINLARWADLILIIPATYNFISKIAAGIADDILSIVLSASKAPTYFAIAMNNIMYQNPIL
QENIKKLQKYNYKFIEPDKGFLACSLNAIGRLKNENDILSIISNSPMTKLPLKNKKILITASRTEEELDPIRYFSNKSTG
QMGFNIGIEAQNLGANVTIITGPSNEETPYGINVIRIKTAAEMYKATIDIYKEFDIIIGTAAVADFRPDKIYKTKIEKNN
IEELNIKLVKNLDIIEHIGKNKTKNQIVIGFCAQKDEILIKKAREKLETKNLDYIIANDLKYFGSNVNKIYIINKDKVEK
FPEMSKKETAIEILKILYQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=32, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI87082301, Length=391, Percent_Identity=37.8516624040921, Blast_Score=238, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17560194, Length=183, Percent_Identity=32.7868852459016, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=201, Percent_Identity=28.8557213930348, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657262, Length=169, Percent_Identity=35.5029585798817, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 47756; Mature: 47624

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAKNTLFINKNPFKNIKYNYIIFYKINMKKHKNILIGVCGGIAAYKAAYIISNLIKMG
CCCCCCEEEEECCCCCCCEEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
YNVKVIMTENATKFITPLTLETLSKSKVITNLWNTNHEEVEHINLARWADLILIIPATYN
CCEEEEEECCCCEEECCHHHHHHCCCHHHHHHCCCCHHHHHHCCHHHHCCEEEEECCHHH
FISKIAAGIADDILSIVLSASKAPTYFAIAMNNIMYQNPILQENIKKLQKYNYKFIEPDK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCC
GFLACSLNAIGRLKNENDILSIISNSPMTKLPLKNKKILITASRTEEELDPIRYFSNKST
CEEEEECHHHHCCCCCCCEEEEECCCCCEECCCCCCEEEEEECCCCHHCCHHHHHCCCCC
GQMGFNIGIEAQNLGANVTIITGPSNEETPYGINVIRIKTAAEMYKATIDIYKEFDIIIG
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEE
TAAVADFRPDKIYKTKIEKNNIEELNIKLVKNLDIIEHIGKNKTKNQIVIGFCAQKDEIL
EEHHCCCCCCCEEEEECCCCCCCEEEEEEEECCHHHHHHCCCCCCCEEEEEEECCCCHHH
IKKAREKLETKNLDYIIANDLKYFGSNVNKIYIINKDKVEKFPEMSKKETAIEILKILYQ
HHHHHHHHHHCCCCEEEECCHHHHCCCCCEEEEEECHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLAKNTLFINKNPFKNIKYNYIIFYKINMKKHKNILIGVCGGIAAYKAAYIISNLIKMG
CCCCCEEEEECCCCCCCEEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
YNVKVIMTENATKFITPLTLETLSKSKVITNLWNTNHEEVEHINLARWADLILIIPATYN
CCEEEEEECCCCEEECCHHHHHHCCCHHHHHHCCCCHHHHHHCCHHHHCCEEEEECCHHH
FISKIAAGIADDILSIVLSASKAPTYFAIAMNNIMYQNPILQENIKKLQKYNYKFIEPDK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCC
GFLACSLNAIGRLKNENDILSIISNSPMTKLPLKNKKILITASRTEEELDPIRYFSNKST
CEEEEECHHHHCCCCCCCEEEEECCCCCEECCCCCCEEEEEECCCCHHCCHHHHHCCCCC
GQMGFNIGIEAQNLGANVTIITGPSNEETPYGINVIRIKTAAEMYKATIDIYKEFDIIIG
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEE
TAAVADFRPDKIYKTKIEKNNIEELNIKLVKNLDIIEHIGKNKTKNQIVIGFCAQKDEIL
EEHHCCCCCCCEEEEECCCCCCCEEEEEEEECCHHHHHHCCCCCCCEEEEEEECCCCHHH
IKKAREKLETKNLDYIIANDLKYFGSNVNKIYIINKDKVEKFPEMSKKETAIEILKILYQ
HHHHHHHHHHCCCCEEEECCHHHHCCCCCEEEEEECHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]