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The map label for this gene is napA_1 [H]

Identifier: 203284357

GI number: 203284357

Start: 480231

End: 482351

Strand: Reverse

Name: napA_1 [H]

Synonym: BDU_446

Alternate gene names: 203284357

Gene position: 482351-480231 (Counterclockwise)

Preceding gene: 203284358

Following gene: 203284356

Centisome position: 51.77

GC content: 26.87

Gene sequence:

>2121_bases
ATGAGAAAGAAACTTTTATATACAATATTGTTTAACATAAATCCTATTCTTTCATTTGGAATGGTAGACTATATGAAAGA
CACGGGACATAACATTGATGCCAAAATCTCTTCTTTTATAATGAGTCTAGCAATCATTGTAATATCAGCAAGTCTTCTTG
GCAATTTGGTAAATAGATTTGGAATTCCAAAAGTAATAGGACAAATAACAGCAGGAATACTTTTAAGTCCAACATGTCTT
GGTAAAATTAAAGTACCTTTATTATTTCCATTAGGAATCATTAATAGCGGAGAAAATTATCTAATAAATGAAGACATATT
TGCAATATCAACAATAGCTTCAATAATACTACTATTTATGGCAGGTCTTGAGACAGATCTAAAATTATTTCTTAAGTTTT
TACCACGTGGAGGATTAATAGGTATAACAGAAGTAATTGGTACTTTTACAAGTTTTGCACTAATATCCACCATTTTATTT
GATGTACAATTAATAAATCCCACATCTCTTTTTATAGGAATTATTGCAACACCTTCTTCTGCAGGCATTGCTGCAAGCAT
ACTCTCAGCAAAGAAAAAAATGAGTACATCAGAAGGAGTTACAATAATATCAACATCAATAATTGATGATGTCCTCTCAA
TGATTATGCTCACAAGTGTAATTACAATATCGAGATCTCTATCTGATCTTGACATTACAATTTCAATTAGATCTACAATT
CAAAACATATTAATTTGGTTTTGTTTAACATTCATACTGATCTTACTATCAAAACCAATTTCACAATTACTAAAAAGCTT
TAATAGTGTAACCTTAGCAACTGTAATAACTCTTACATTTACCTTTATTATTTCAAGTATTTTTCAAAATTTAGGAATGT
CATTTGTAATTGGAGCTTACATATTTGGGCTTGCAATGTCAAAAACAGATATTGTATATGTAATTCAGGATAAATTAACA
CTATTTGAAAGATTTTTTATACCAATATTCTTCACATCAATAGGAATGATGGCCGATATTAACGTAATATTATCAAAAGA
AGTTTTAATAATTGGCACTTTGCTTAGTTTGATAGCAATAGCAACAAAAGTAGTATATTGCTTTATCCCATCATACTTTT
TAGGATTTAACAAACTAGGTGCACTAAGAATAGCTTTTGGAATGGTTCCAAGAGGTGAAATATCACTAATTATTGCAAAT
GTAGCTCTCTCTTCCGAATTTATAAGCCAAAAAATATTTGGAATAATAATAATTATAGTTTTTCTTCCAACAATTATCGC
AACACCAATAATAAATATCTTATTTCAAATAAATAAAAATGGATTAAAGAAAGAAATGAAAATAGAACAAAATACTCAAA
TTACAATAGCACTGAAATATGATAATCTAACAAAAATATTTGTATGGGACTTAAAAAACGAGTTAAGAAACGAAGGATTT
TTTACACAACAAATAAAAAATGATTTCTCACAATACATAAATGCAAGACGAAATGATATATCACTTTCAATTAAAAGAGA
AGGAAGCAAAATCACATTTGAATGTCCAAAAAAACATTTAATAATCATACAAGATCTACTAAGAGAAACTATTTTAAATT
TAGAAAAAATCACAGAAGAAGTAAAAATAGTTTCTGTAAAAGCACAAAAATTAAATTACTCAATAAACTACGATAAAATA
CGCAGTAATATTGCTTTAGATAAAAGAATAAAAAAAGAAAATATAATATTAAATTTAAAAGCAACAAATAAAATTGAAGT
ACTAAGAGAATTACTTAGTATAATAAAAGTTGACATTGACAAAGAAACAATATTACAAGACCTCATGGAGAGAGAAAAAC
TTATAACCACAGCTCTCAAAGAAGGATTTGCAATACCTCACTTAAAAACTAATTTAATAAAAAAAATGCACATTGCAATC
GGAATCAGCCACGATGGAATTGACTTTAATGCTATTGATAAAAATTTAAGTTATATCTTTATATTAATATTATACCCAGC
AAAAGAACATGTTAATTATCCACGCATTTTATCATCTATTGTAGGTAAAGTAGATTCTAATAAAAAAGCAATGCTTAAAG
CTAAAACTGACAAAGAAATTTATAACATATTAATAGGATAG

Upstream 100 bases:

>100_bases
AAGAAAAAATAACAATTGTTGCAAATGGTAAAGACGAAATTGAAATAATTGATGAGCTAAAAAAATTAATACAATCAAAC
TTTAAAAAAGAGATTCAAAA

Downstream 100 bases:

>100_bases
GTTATGTTTAAAATCATTAAATGCAATCAAATAAATAATAAACTTATAAATAAAAAGATAGAAATAAATGGATGGGTAAA
AAAAATAAGAAATCATGGAA

Product: Na+/H+ antiporter

Products: protein histidine; sugarphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MRKKLLYTILFNINPILSFGMVDYMKDTGHNIDAKISSFIMSLAIIVISASLLGNLVNRFGIPKVIGQITAGILLSPTCL
GKIKVPLLFPLGIINSGENYLINEDIFAISTIASIILLFMAGLETDLKLFLKFLPRGGLIGITEVIGTFTSFALISTILF
DVQLINPTSLFIGIIATPSSAGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMIMLTSVITISRSLSDLDITISIRSTI
QNILIWFCLTFILILLSKPISQLLKSFNSVTLATVITLTFTFIISSIFQNLGMSFVIGAYIFGLAMSKTDIVYVIQDKLT
LFERFFIPIFFTSIGMMADINVILSKEVLIIGTLLSLIAIATKVVYCFIPSYFLGFNKLGALRIAFGMVPRGEISLIIAN
VALSSEFISQKIFGIIIIIVFLPTIIATPIINILFQINKNGLKKEMKIEQNTQITIALKYDNLTKIFVWDLKNELRNEGF
FTQQIKNDFSQYINARRNDISLSIKREGSKITFECPKKHLIIIQDLLRETILNLEKITEEVKIVSVKAQKLNYSINYDKI
RSNIALDKRIKKENIILNLKATNKIEVLRELLSIIKVDIDKETILQDLMEREKLITTALKEGFAIPHLKTNLIKKMHIAI
GISHDGIDFNAIDKNLSYIFILILYPAKEHVNYPRILSSIVGKVDSNKKAMLKAKTDKEIYNILIG

Sequences:

>Translated_706_residues
MRKKLLYTILFNINPILSFGMVDYMKDTGHNIDAKISSFIMSLAIIVISASLLGNLVNRFGIPKVIGQITAGILLSPTCL
GKIKVPLLFPLGIINSGENYLINEDIFAISTIASIILLFMAGLETDLKLFLKFLPRGGLIGITEVIGTFTSFALISTILF
DVQLINPTSLFIGIIATPSSAGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMIMLTSVITISRSLSDLDITISIRSTI
QNILIWFCLTFILILLSKPISQLLKSFNSVTLATVITLTFTFIISSIFQNLGMSFVIGAYIFGLAMSKTDIVYVIQDKLT
LFERFFIPIFFTSIGMMADINVILSKEVLIIGTLLSLIAIATKVVYCFIPSYFLGFNKLGALRIAFGMVPRGEISLIIAN
VALSSEFISQKIFGIIIIIVFLPTIIATPIINILFQINKNGLKKEMKIEQNTQITIALKYDNLTKIFVWDLKNELRNEGF
FTQQIKNDFSQYINARRNDISLSIKREGSKITFECPKKHLIIIQDLLRETILNLEKITEEVKIVSVKAQKLNYSINYDKI
RSNIALDKRIKKENIILNLKATNKIEVLRELLSIIKVDIDKETILQDLMEREKLITTALKEGFAIPHLKTNLIKKMHIAI
GISHDGIDFNAIDKNLSYIFILILYPAKEHVNYPRILSSIVGKVDSNKKAMLKAKTDKEIYNILIG
>Mature_706_residues
MRKKLLYTILFNINPILSFGMVDYMKDTGHNIDAKISSFIMSLAIIVISASLLGNLVNRFGIPKVIGQITAGILLSPTCL
GKIKVPLLFPLGIINSGENYLINEDIFAISTIASIILLFMAGLETDLKLFLKFLPRGGLIGITEVIGTFTSFALISTILF
DVQLINPTSLFIGIIATPSSAGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMIMLTSVITISRSLSDLDITISIRSTI
QNILIWFCLTFILILLSKPISQLLKSFNSVTLATVITLTFTFIISSIFQNLGMSFVIGAYIFGLAMSKTDIVYVIQDKLT
LFERFFIPIFFTSIGMMADINVILSKEVLIIGTLLSLIAIATKVVYCFIPSYFLGFNKLGALRIAFGMVPRGEISLIIAN
VALSSEFISQKIFGIIIIIVFLPTIIATPIINILFQINKNGLKKEMKIEQNTQITIALKYDNLTKIFVWDLKNELRNEGF
FTQQIKNDFSQYINARRNDISLSIKREGSKITFECPKKHLIIIQDLLRETILNLEKITEEVKIVSVKAQKLNYSINYDKI
RSNIALDKRIKKENIILNLKATNKIEVLRELLSIIKVDIDKETILQDLMEREKLITTALKEGFAIPHLKTNLIKKMHIAI
GISHDGIDFNAIDKNLSYIFILILYPAKEHVNYPRILSSIVGKVDSNKKAMLKAKTDKEIYNILIG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=443, Percent_Identity=25.2821670428894, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: 2.7.1.69 [C]

Molecular weight: Translated: 78821; Mature: 78821

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKLLYTILFNINPILSFGMVDYMKDTGHNIDAKISSFIMSLAIIVISASLLGNLVNRF
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIPKVIGQITAGILLSPTCLGKIKVPLLFPLGIINSGENYLINEDIFAISTIASIILLFM
CHHHHHHHHHHHHHCCCCCCCCEEECEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
AGLETDLKLFLKFLPRGGLIGITEVIGTFTSFALISTILFDVQLINPTSLFIGIIATPSS
HCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCC
AGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMIMLTSVITISRSLSDLDITISIRSTI
CCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHH
QNILIWFCLTFILILLSKPISQLLKSFNSVTLATVITLTFTFIISSIFQNLGMSFVIGAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IFGLAMSKTDIVYVIQDKLTLFERFFIPIFFTSIGMMADINVILSKEVLIIGTLLSLIAI
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ATKVVYCFIPSYFLGFNKLGALRIAFGMVPRGEISLIIANVALSSEFISQKIFGIIIIIV
HHHHHHHHHHHHHHCHHHCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
FLPTIIATPIINILFQINKNGLKKEMKIEQNTQITIALKYDNLTKIFVWDLKNELRNEGF
HHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCEEEEEEEECCCEEEEEEEHHHHHCCCCC
FTQQIKNDFSQYINARRNDISLSIKREGSKITFECPKKHLIIIQDLLRETILNLEKITEE
HHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VKIVSVKAQKLNYSINYDKIRSNIALDKRIKKENIILNLKATNKIEVLRELLSIIKVDID
HHEEEEEHHHCCEECCHHHHHHCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
KETILQDLMEREKLITTALKEGFAIPHLKTNLIKKMHIAIGISHDGIDFNAIDKNLSYIF
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCHHHCCCCEEEE
ILILYPAKEHVNYPRILSSIVGKVDSNKKAMLKAKTDKEIYNILIG
EEEEECCHHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCC
>Mature Secondary Structure
MRKKLLYTILFNINPILSFGMVDYMKDTGHNIDAKISSFIMSLAIIVISASLLGNLVNRF
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIPKVIGQITAGILLSPTCLGKIKVPLLFPLGIINSGENYLINEDIFAISTIASIILLFM
CHHHHHHHHHHHHHCCCCCCCCEEECEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
AGLETDLKLFLKFLPRGGLIGITEVIGTFTSFALISTILFDVQLINPTSLFIGIIATPSS
HCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCC
AGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMIMLTSVITISRSLSDLDITISIRSTI
CCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHH
QNILIWFCLTFILILLSKPISQLLKSFNSVTLATVITLTFTFIISSIFQNLGMSFVIGAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IFGLAMSKTDIVYVIQDKLTLFERFFIPIFFTSIGMMADINVILSKEVLIIGTLLSLIAI
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ATKVVYCFIPSYFLGFNKLGALRIAFGMVPRGEISLIIANVALSSEFISQKIFGIIIIIV
HHHHHHHHHHHHHHCHHHCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
FLPTIIATPIINILFQINKNGLKKEMKIEQNTQITIALKYDNLTKIFVWDLKNELRNEGF
HHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCEEEEEEEECCCEEEEEEEHHHHHCCCCC
FTQQIKNDFSQYINARRNDISLSIKREGSKITFECPKKHLIIIQDLLRETILNLEKITEE
HHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VKIVSVKAQKLNYSINYDKIRSNIALDKRIKKENIILNLKATNKIEVLRELLSIIKVDID
HHEEEEEHHHCCEECCHHHHHHCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
KETILQDLMEREKLITTALKEGFAIPHLKTNLIKKMHIAIGISHDGIDFNAIDKNLSYIF
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCHHHCCCCEEEE
ILILYPAKEHVNYPRILSSIVGKVDSNKKAMLKAKTDKEIYNILIG
EEEEECCHHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Protein Npi-phosphohistidine; sugar [C]

Specific reaction: Protein Npi-phosphohistidine + sugar = protein histidine + sugarphosphate [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]