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The map label for this gene is ArgB

Identifier: 20095067

GI number: 20095067

Start: 1632739

End: 1633479

Strand: Direct

Name: ArgB

Synonym: MK1631

Alternate gene names: 20095067

Gene position: 1632739-1633479 (Clockwise)

Preceding gene: 20095065

Following gene: 20095068

Centisome position: 96.33

GC content: 64.51

Gene sequence:

>741_bases
GTGGAGGTCATCAAGGTGGGCGGAGAGGTACTGGACCGTGTTGAAGACCTAGCCCGGGTCATCGACGATTCCATTTTGGT
GCACGGTGGCGGTCCGGAGGTCTCGGACGTGATGGAGCGCATGGGACTAGAACCGAGGTTCGTCCGCGGGCTCAGGGTCA
CCGACCGGGAGACGCTGCAGGTGGTGATGATGGTCTTGGCCGGTTTAGTGAACAAGCGTCTGGTGGCTGAGCTGCGCTCG
GAGGGCATCAACGCGTTGGGCTTGTCCGGGGTCGACGGCGGTCTCCTGATAGCCGAGAAGAGATCGGAGGTAGTCGACGG
GGAGGAGGTGGATCTCGGGTACGTGGGTGACGTCAAGCGCGTCAACGCCGAGCTACTCGAATCACTGCTGGACGCCGGGT
ACGTCCCGGTGGTCGCCCCCCTTGGGGCGGGCGAAGACGGGACCGTGTACAACGTGAACGCCGATACAGCCGCGGGGGCC
ATCGCCGGAGCGGTGCGTGCGGATCGGCTCGTACTGCTGACGGACGTACCCGGGGTCCTGGAAGATCTGGACGACCCCGA
GACCCTTATCGAGCGGGTGCGCCCGGAGGACGTCGAGGAGCTCGAAGAAAAGGGAATCGTCACCGGAGGTATGGTGCCGA
AGCTCGAAGCCGCCAAGATGGCGGTGGAGGCGGGATGCCGAGAGGCCGTGATCACGAACCTGGAAGGGTTGCTCGAGGGG
AGGGGAACCATCGTGAGGTAG

Upstream 100 bases:

>100_bases
ACGGCCTCGGGTATCGGCATTCCTCGGGTTTCCACGAGGACCAAGGCTTTAACCGCCAGCAGCTGGTTCTCCATGCATCG
CCACCCCGGCGGGTGATACG

Downstream 100 bases:

>100_bases
CTGCGCACCTCGGCGAGAAAATCGAAAAATATATCTCCAAACTCCCAAGCGTGTTGAACGAATGCAAACCCAGAGACCGT
GCCGGAGAGCGTCTGCTAGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MEVIKVGGEVLDRVEDLARVIDDSILVHGGGPEVSDVMERMGLEPRFVRGLRVTDRETLQVVMMVLAGLVNKRLVAELRS
EGINALGLSGVDGGLLIAEKRSEVVDGEEVDLGYVGDVKRVNAELLESLLDAGYVPVVAPLGAGEDGTVYNVNADTAAGA
IAGAVRADRLVLLTDVPGVLEDLDDPETLIERVRPEDVEELEEKGIVTGGMVPKLEAAKMAVEAGCREAVITNLEGLLEG
RGTIVR

Sequences:

>Translated_246_residues
MEVIKVGGEVLDRVEDLARVIDDSILVHGGGPEVSDVMERMGLEPRFVRGLRVTDRETLQVVMMVLAGLVNKRLVAELRS
EGINALGLSGVDGGLLIAEKRSEVVDGEEVDLGYVGDVKRVNAELLESLLDAGYVPVVAPLGAGEDGTVYNVNADTAAGA
IAGAVRADRLVLLTDVPGVLEDLDDPETLIERVRPEDVEELEEKGIVTGGMVPKLEAAKMAVEAGCREAVITNLEGLLEG
RGTIVR
>Mature_246_residues
MEVIKVGGEVLDRVEDLARVIDDSILVHGGGPEVSDVMERMGLEPRFVRGLRVTDRETLQVVMMVLAGLVNKRLVAELRS
EGINALGLSGVDGGLLIAEKRSEVVDGEEVDLGYVGDVKRVNAELLESLLDAGYVPVVAPLGAGEDGTVYNVNADTAAGA
IAGAVRADRLVLLTDVPGVLEDLDDPETLIERVRPEDVEELEEKGIVTGGMVPKLEAAKMAVEAGCREAVITNLEGLLEG
RGTIVR

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=227, Percent_Identity=36.1233480176211, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789181, Length=250, Percent_Identity=24.4, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320913, Length=186, Percent_Identity=31.7204301075269, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_METKA (Q8TUX2)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614914.1
- ProteinModelPortal:   Q8TUX2
- SMR:   Q8TUX2
- GeneID:   1478226
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1631
- NMPDR:   fig|190192.1.peg.1627
- HOGENOM:   HBG497643
- OMA:   MVLCGST
- BioCyc:   MKAN190192:MK1631-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_A
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 26086; Mature: 26086

Theoretical pI: Translated: 4.10; Mature: 4.10

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVIKVGGEVLDRVEDLARVIDDSILVHGGGPEVSDVMERMGLEPRFVRGLRVTDRETLQ
CCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHH
VVMMVLAGLVNKRLVAELRSEGINALGLSGVDGGLLIAEKRSEVVDGEEVDLGYVGDVKR
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCHHHCCCCCCCCCCCCCCHHH
VNAELLESLLDAGYVPVVAPLGAGEDGTVYNVNADTAAGAIAGAVRADRLVLLTDVPGVL
HHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCHHH
EDLDDPETLIERVRPEDVEELEEKGIVTGGMVPKLEAAKMAVEAGCREAVITNLEGLLEG
HCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RGTIVR
CCCCCC
>Mature Secondary Structure
MEVIKVGGEVLDRVEDLARVIDDSILVHGGGPEVSDVMERMGLEPRFVRGLRVTDRETLQ
CCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHH
VVMMVLAGLVNKRLVAELRSEGINALGLSGVDGGLLIAEKRSEVVDGEEVDLGYVGDVKR
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCHHHCCCCCCCCCCCCCCHHH
VNAELLESLLDAGYVPVVAPLGAGEDGTVYNVNADTAAGAIAGAVRADRLVLLTDVPGVL
HHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCHHH
EDLDDPETLIERVRPEDVEELEEKGIVTGGMVPKLEAAKMAVEAGCREAVITNLEGLLEG
HCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RGTIVR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014