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The map label for this gene is TIF6

Identifier: 20095052

GI number: 20095052

Start: 1622531

End: 1623196

Strand: Reverse

Name: TIF6

Synonym: MK1616

Alternate gene names: 20095052

Gene position: 1623196-1622531 (Counterclockwise)

Preceding gene: 20095053

Following gene: 20095051

Centisome position: 95.77

GC content: 61.56

Gene sequence:

>666_bases
ATGACCGTAGTCAAGGCCTCGGTCCACGGGGACCCCAACATCGGGGCGTGGATAGCGGCCTCCGAGGAATACGCCGTCGT
CGCTCCCAAAGTCCCGGACGACATCGTTGAAAGAGTGAAAGAAGCGTTGGACGTCGAAGTCGTTCGGACCACCGTGGCCG
GCAGCAACCTCGTAGGCGCCCTACTGGCCGTGAACTCCAACGGCGCCCTGTTCCCTAGACACGCTCGGGAGCACGAGATA
CGGGTCGTCCGTGAGCTGGGCGTGGAAGTCGACGTGCTCCCCTCCAAAATGAACGCCGTCGGCAACCTCGTTCTCACTAA
CGATCACGGGGCACTGGTTCATCCGGATCTCGACGATCACGCATTAGAGGTGATCGAGTCAGTCCTCGGCGGGAGAGTGG
TACGTGGTGAGCTCGGTGGTGTGAAGACCGTAGGGTCAGCGGGTGTGGCGAACTCTAAGGGGGCCGTGGTACACCCAGGA
GCGACGGAGGAGGAAATGGAACGTGTCTCGGAGGTGCTAGGGGTGGACGTGGAGGTCGGCACAGTGAACCGCGGATCCCC
CTACGTCGGTGTGGGTATCGTGGTGAACTCTAAAGGTGCTGTTGTCGGTGAGGATACGACGGGTCCCGAGCTCGCCCGTT
TGGAGGATGCCCTGTACCTCATCTGA

Upstream 100 bases:

>100_bases
AGATCTGGGAGCGGGGCATCAAGAAGCCACCCTCTAAGATCAGAGTTCGCGCCGTGAAGTACGCGGACGGTACCGTCGAA
GTCAGGCTGGCGGAGTAAGC

Downstream 100 bases:

>100_bases
ATCCGGGGGTATTCCCGATGTCCGAGGTGAAGGTGTTCGAGGTCCGTGGTACGTTCCGCATGGGTGACGAGCCTCGACAA
CCGTTCACGCGTCAGGTTCC

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTVVKASVHGDPNIGAWIAASEEYAVVAPKVPDDIVERVKEALDVEVVRTTVAGSNLVGALLAVNSNGALFPRHAREHEI
RVVRELGVEVDVLPSKMNAVGNLVLTNDHGALVHPDLDDHALEVIESVLGGRVVRGELGGVKTVGSAGVANSKGAVVHPG
ATEEEMERVSEVLGVDVEVGTVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALYLI

Sequences:

>Translated_221_residues
MTVVKASVHGDPNIGAWIAASEEYAVVAPKVPDDIVERVKEALDVEVVRTTVAGSNLVGALLAVNSNGALFPRHAREHEI
RVVRELGVEVDVLPSKMNAVGNLVLTNDHGALVHPDLDDHALEVIESVLGGRVVRGELGGVKTVGSAGVANSKGAVVHPG
ATEEEMERVSEVLGVDVEVGTVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALYLI
>Mature_220_residues
TVVKASVHGDPNIGAWIAASEEYAVVAPKVPDDIVERVKEALDVEVVRTTVAGSNLVGALLAVNSNGALFPRHAREHEIR
VVRELGVEVDVLPSKMNAVGNLVLTNDHGALVHPDLDDHALEVIESVLGGRVVRGELGGVKTVGSAGVANSKGAVVHPGA
TEEEMERVSEVLGVDVEVGTVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALYLI

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=222, Percent_Identity=31.981981981982, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI31563378, Length=222, Percent_Identity=31.981981981982, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506075, Length=222, Percent_Identity=28.3783783783784, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325273, Length=215, Percent_Identity=35.8139534883721, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21492634, Length=222, Percent_Identity=30.6306306306306, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METKA (Q8TUY5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614899.1
- ProteinModelPortal:   Q8TUY5
- SMR:   Q8TUY5
- GeneID:   1478211
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1616
- NMPDR:   fig|190192.1.peg.1612
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- BioCyc:   MKAN190192:MK1616-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 22980; Mature: 22849

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVKASVHGDPNIGAWIAASEEYAVVAPKVPDDIVERVKEALDVEVVRTTVAGSNLVGA
CEEEEEECCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCHHEEEEECCCCCCEEE
LLAVNSNGALFPRHAREHEIRVVRELGVEVDVLPSKMNAVGNLVLTNDHGALVHPDLDDH
EEEECCCCCCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHEEEEEECCCCEEECCCCCHH
ALEVIESVLGGRVVRGELGGVKTVGSAGVANSKGAVVHPGATEEEMERVSEVLGVDVEVG
HHHHHHHHHCCEEEEECCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCEEEC
TVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALYLI
CCCCCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHEECC
>Mature Secondary Structure 
TVVKASVHGDPNIGAWIAASEEYAVVAPKVPDDIVERVKEALDVEVVRTTVAGSNLVGA
EEEEEECCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCHHEEEEECCCCCCEEE
LLAVNSNGALFPRHAREHEIRVVRELGVEVDVLPSKMNAVGNLVLTNDHGALVHPDLDDH
EEEECCCCCCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHEEEEEECCCCEEECCCCCHH
ALEVIESVLGGRVVRGELGGVKTVGSAGVANSKGAVVHPGATEEEMERVSEVLGVDVEVG
HHHHHHHHHCCEEEEECCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCEEEC
TVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALYLI
CCCCCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014